RGD Reference Report - Pituitary adenylate cyclase-activating polypeptide-nerve terminals densely innervate corticotropin-releasing hormone-neurons in the hypothalamic paraventricular nucleus of the rat. - Rat Genome Database

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Pituitary adenylate cyclase-activating polypeptide-nerve terminals densely innervate corticotropin-releasing hormone-neurons in the hypothalamic paraventricular nucleus of the rat.

Authors: Legradi, G  Hannibal, J  Lechan, RM 
Citation: Legradi G, etal., Neurosci Lett. 1998 May 1;246(3):145-8.
RGD ID: 2312463
Pubmed: PMID:9792613   (View Abstract at PubMed)

Pituitary adenylate cyclase-activating polypeptide (PACAP) is widely distributed in many regions of the hypothalamus including the paraventricular nucleus (PVN). In this study, using well-characterized antibodies against PACAP and corticotropin-releasing hormone (CRH), we identified numerous nerve fibers with PACAP-immunoreactivity (ir) closely apposed to CRH neurons in the medial parvocellular subdivision of the rat PVN. Electron microscopy revealed the presence of synapses between PACAP-ir containing terminals and CRH-perikarya and -dendrites. These morphological observations suggest that PACAP may modulate the activation of the hypothalamic-pituitary-adrenal axis.



Gene Ontology Annotations    Click to see Annotation Detail View

Cellular Component

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Adcyap1Ratneuronal dense core vesicle lumen is_active_inIDA PMID:9792613SynGO 
Adcyap1Ratterminal bouton  IDA buttons in the medial parvocellular subdivision of rat PVN hypothalamus and apposed to CRH neuronsRGD 

Objects Annotated

Genes (Rattus norvegicus)
Adcyap1  (adenylate cyclase activating polypeptide 1)


Additional Information