RGD Reference Report - Pituitary adenylate cyclase-activating polypeptide-nerve terminals densely innervate corticotropin-releasing hormone-neurons in the hypothalamic paraventricular nucleus of the rat. - Rat Genome Database

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Pituitary adenylate cyclase-activating polypeptide-nerve terminals densely innervate corticotropin-releasing hormone-neurons in the hypothalamic paraventricular nucleus of the rat.

Authors: Legradi, G  Hannibal, J  Lechan, RM 
Citation: Legradi G, etal., Neurosci Lett. 1998 May 1;246(3):145-8.
RGD ID: 2312463
Pubmed: PMID:9792613   (View Abstract at PubMed)

Pituitary adenylate cyclase-activating polypeptide (PACAP) is widely distributed in many regions of the hypothalamus including the paraventricular nucleus (PVN). In this study, using well-characterized antibodies against PACAP and corticotropin-releasing hormone (CRH), we identified numerous nerve fibers with PACAP-immunoreactivity (ir) closely apposed to CRH neurons in the medial parvocellular subdivision of the rat PVN. Electron microscopy revealed the presence of synapses between PACAP-ir containing terminals and CRH-perikarya and -dendrites. These morphological observations suggest that PACAP may modulate the activation of the hypothalamic-pituitary-adrenal axis.




Cellular Component

  
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Species
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Original Reference(s)
Adcyap1Ratneuronal dense core vesicle lumen is_active_inIDA PMID:9792613SynGO 
Adcyap1Ratterminal bouton  IDA buttons in the medial parvocellular subdivision of rat PVN hypothalamus and apposed to CRH neuronsRGD 


Genes (Rattus norvegicus)
Adcyap1  (adenylate cyclase activating polypeptide 1)