ADCYAP1 (adenylate cyclase activating polypeptide 1) - Rat Genome Database

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Gene: ADCYAP1 (adenylate cyclase activating polypeptide 1) Canis lupus familiaris
Analyze
Symbol: ADCYAP1
Name: adenylate cyclase activating polypeptide 1
RGD ID: 12217549
Description: ENCODES a protein that exhibits pituitary adenylate cyclase-activating polypeptide receptor binding (ortholog); type 1 vasoactive intestinal polypeptide receptor binding (ortholog); type 2 vasoactive intestinal polypeptide receptor binding (ortholog); INVOLVED IN behavioral fear response (ortholog); cellular response to glucocorticoid stimulus (ortholog); histamine secretion (ortholog); ASSOCIATED WITH acute necrotizing pancreatitis (ortholog); alcohol dependence (ortholog); autistic disorder (ortholog); FOUND IN extracellular space (ortholog); neuronal dense core vesicle lumen (ortholog); terminal bouton (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: pituitary adenylate cyclase-activating polypeptide
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1767,682,421 - 67,691,035 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha767,135,853 - 67,143,650 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0767,748,641 - 67,756,430 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl767,749,208 - 67,822,788 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1767,424,965 - 67,432,752 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0767,436,457 - 67,444,234 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0767,738,672 - 67,746,464 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adenylate cyclase-activating G protein-coupled receptor signaling pathway  (IEA)
adenylate cyclase-modulating G protein-coupled receptor signaling pathway  (IEA)
behavioral fear response  (ISO)
cellular response to glucocorticoid stimulus  (ISO)
histamine secretion  (ISO)
insulin secretion  (IEA)
negative regulation of acute inflammatory response to antigenic stimulus  (ISO)
negative regulation of acute inflammatory response to non-antigenic stimulus  (ISO)
negative regulation of cell cycle  (IEA,ISO)
negative regulation of glial cell proliferation  (ISO)
negative regulation of GTPase activity  (ISO)
negative regulation of muscle cell apoptotic process  (ISO)
negative regulation of potassium ion transport  (ISO)
neuron projection development  (IEA)
neuropeptide signaling pathway  (IEA)
ovarian follicle development  (ISO)
pituitary gland development  (ISO)
positive regulation of cAMP/PKA signal transduction  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of chemokine (C-C motif) ligand 5 production  (IEA)
positive regulation of cold-induced thermogenesis  (IEA)
positive regulation of cytosolic calcium ion concentration  (ISO)
positive regulation of ERK1 and ERK2 cascade  (IEA)
positive regulation of gene expression  (IEA,ISO)
positive regulation of growth hormone secretion  (ISO)
positive regulation of GTPase activity  (ISO)
positive regulation of interleukin-6 production  (ISO)
positive regulation of neuron projection development  (ISO)
positive regulation of protein kinase activity  (ISO)
positive regulation of somatostatin secretion  (ISO)
positive regulation of synaptic transmission, glutamatergic  (ISO)
positive regulation of transcription by RNA polymerase II  (IEA)
regulation of G protein-coupled receptor signaling pathway  (IEA)
regulation of oligodendrocyte progenitor proliferation  (ISO)
regulation of postsynaptic membrane potential  (ISO)
regulation of protein localization  (IEA)
regulation of protein phosphorylation  (ISO)
response to ethanol  (ISO)
response to starvation  (ISO)
vasodilation  (ISO)

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
ADCYAP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1767,682,421 - 67,691,035 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha767,135,853 - 67,143,650 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0767,748,641 - 67,756,430 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl767,749,208 - 67,822,788 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1767,424,965 - 67,432,752 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0767,436,457 - 67,444,234 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0767,738,672 - 67,746,464 (+)NCBIUU_Cfam_GSD_1.0
ADCYAP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3818904,411 - 912,172 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl18904,871 - 912,172 (+)EnsemblGRCh38hg38GRCh38
GRCh3718904,872 - 912,173 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3618894,944 - 902,173 (+)NCBINCBI36Build 36hg18NCBI36
Build 3418895,386 - 901,050NCBI
Celera18779,552 - 786,777 (+)NCBICelera
Cytogenetic Map18p11.32NCBI
HuRef18865,131 - 872,354 (+)NCBIHuRef
CHM1_118904,574 - 911,803 (+)NCBICHM1_1
T2T-CHM13v2.0181,058,628 - 1,066,467 (+)NCBIT2T-CHM13v2.0
Adcyap1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391793,506,448 - 93,513,967 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1793,506,445 - 93,513,965 (+)EnsemblGRCm39 Ensembl
GRCm381793,198,245 - 93,206,541 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1793,199,017 - 93,206,537 (+)EnsemblGRCm38mm10GRCm38
MGSCv371793,598,762 - 93,604,831 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361793,503,713 - 93,509,782 (+)NCBIMGSCv36mm8
Celera1797,603,693 - 97,609,773 (+)NCBICelera
Cytogenetic Map17E5NCBI
cM Map1760.67NCBI
Adcyap1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr89120,550,236 - 120,569,096 (-)NCBIGRCr8
mRatBN7.29113,102,632 - 113,122,500 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl9113,103,718 - 113,109,773 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx9121,581,877 - 121,587,073 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09126,711,026 - 126,716,222 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.09125,056,936 - 125,062,132 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.09121,705,897 - 121,725,736 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl9121,706,979 - 121,725,716 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.09121,155,213 - 121,175,023 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera9110,207,950 - 110,213,150 (-)NCBICelera
Cytogenetic Map9q38NCBI
Adcyap1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554029,091,725 - 9,099,803 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554029,091,927 - 9,099,803 (-)NCBIChiLan1.0ChiLan1.0
ADCYAP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21737,590,265 - 37,598,057 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11823,283,967 - 23,290,652 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01813,414,618 - 13,421,668 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11815,712,078 - 15,718,693 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1815,713,479 - 15,717,749 (-)Ensemblpanpan1.1panPan2
Adcyap1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494464,074,352 - 64,081,544 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366723,460,383 - 3,468,255 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366723,461,387 - 3,468,053 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADCYAP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6105,414,631 - 105,422,294 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16105,414,628 - 105,422,294 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2698,531,534 - 98,539,159 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ADCYAP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11860,259,479 - 60,267,302 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605035,058,453 - 35,066,176 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Adcyap1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477011,358,286 - 11,375,813 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477011,359,606 - 11,375,833 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in ADCYAP1
78 total Variants

Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSCAFT00845003980   ⟹   ENSCAFP00845003180
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl767,749,208 - 67,822,788 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845003992   ⟹   ENSCAFP00845003188
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl767,749,208 - 67,805,996 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845004008   ⟹   ENSCAFP00845003204
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl767,749,208 - 67,779,551 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845004028   ⟹   ENSCAFP00845003223
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl767,749,208 - 67,757,210 (+)Ensembl
RefSeq Acc Id: XM_038482267   ⟹   XP_038338195
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1767,424,965 - 67,432,752 (+)NCBI
RefSeq Acc Id: XM_038543703   ⟹   XP_038399631
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0767,738,672 - 67,746,464 (+)NCBI
RefSeq Acc Id: XM_038607828   ⟹   XP_038463756
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0767,436,457 - 67,444,234 (+)NCBI
RefSeq Acc Id: XM_038672511   ⟹   XP_038528439
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0767,748,641 - 67,756,430 (+)NCBI
RefSeq Acc Id: XM_844098   ⟹   XP_849191
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1767,682,421 - 67,691,035 (+)NCBI
Dog10K_Boxer_Tasha767,135,853 - 67,143,650 (+)NCBI
Sequence:
RefSeq Acc Id: XR_005328741
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1767,429,055 - 67,430,204 (+)NCBI
RefSeq Acc Id: XR_005362587
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0767,742,765 - 67,743,918 (+)NCBI
RefSeq Acc Id: XR_005379780
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha767,139,946 - 67,141,104 (+)NCBI
RefSeq Acc Id: XR_005397097
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0767,440,544 - 67,441,688 (+)NCBI
RefSeq Acc Id: XR_005430302
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0767,752,732 - 67,753,882 (+)NCBI
RefSeq Acc Id: XP_849191   ⟸   XM_844098
- UniProtKB: A0A8C0L3F3 (UniProtKB/TrEMBL),   A0A8C0PXE0 (UniProtKB/TrEMBL),   A0A8P0TUN2 (UniProtKB/TrEMBL),   A0A8P0T5E5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_038338195   ⟸   XM_038482267
RefSeq Acc Id: XP_038463756   ⟸   XM_038607828
RefSeq Acc Id: XP_038528439   ⟸   XM_038672511
- UniProtKB: A0A8I3RQL5 (UniProtKB/TrEMBL),   A0A8I3MKI9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038399631   ⟸   XM_038543703
- UniProtKB: A0A8I3MKI9 (UniProtKB/TrEMBL),   A0A8I3RQL5 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845003188   ⟸   ENSCAFT00845003992
Ensembl Acc Id: ENSCAFP00845003180   ⟸   ENSCAFT00845003980
Ensembl Acc Id: ENSCAFP00845003204   ⟸   ENSCAFT00845004008
Ensembl Acc Id: ENSCAFP00845003223   ⟸   ENSCAFT00845004028
Protein Domains
Glucagon / GIP / secretin / VIP family


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000047172 UniProtKB/TrEMBL
  ENSCAFG00040001709 UniProtKB/TrEMBL
  ENSCAFG00845002272 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000066769.2 UniProtKB/TrEMBL
  ENSCAFT00000068128.2 UniProtKB/TrEMBL
  ENSCAFT00000082259.2 UniProtKB/TrEMBL
  ENSCAFT00000087291.2 UniProtKB/TrEMBL
  ENSCAFT00000102369.1 UniProtKB/TrEMBL
  ENSCAFT00040003237.1 UniProtKB/TrEMBL
  ENSCAFT00040003242.1 UniProtKB/TrEMBL
  ENSCAFT00040003255.1 UniProtKB/TrEMBL
  ENSCAFT00040003270.1 UniProtKB/TrEMBL
  ENSCAFT00040003285.1 UniProtKB/TrEMBL
  ENSCAFT00040003296.1 UniProtKB/TrEMBL
  ENSCAFT00845003980.1 UniProtKB/TrEMBL
  ENSCAFT00845003992.1 UniProtKB/TrEMBL
  ENSCAFT00845004008.1 UniProtKB/TrEMBL
  ENSCAFT00845004028 ENTREZGENE
  ENSCAFT00845004028.1 UniProtKB/TrEMBL
Gene3D-CATH 6.10.250.590 UniProtKB/TrEMBL
InterPro Glucagon_GIP_secretin_VIP UniProtKB/TrEMBL
  VIP/GHRH-like UniProtKB/TrEMBL
KEGG Report cfa:607433 UniProtKB/TrEMBL
NCBI Gene ADCYAP1 ENTREZGENE
PANTHER PTHR11213 UniProtKB/TrEMBL
  PTHR11213:SF1 UniProtKB/TrEMBL
Pfam Hormone_2 UniProtKB/TrEMBL
PRINTS GLUCAGON UniProtKB/TrEMBL
PROSITE GLUCAGON UniProtKB/TrEMBL
SMART GLUCA UniProtKB/TrEMBL
UniProt A0A8C0L3F3 ENTREZGENE
  A0A8C0PQZ0_CANLF UniProtKB/TrEMBL
  A0A8C0PVA3_CANLF UniProtKB/TrEMBL
  A0A8C0PVJ2_CANLF UniProtKB/TrEMBL
  A0A8C0PXE0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0RVJ2_CANLF UniProtKB/TrEMBL
  A0A8C0RVR0_CANLF UniProtKB/TrEMBL
  A0A8I3MKI9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3MKK3_CANLF UniProtKB/TrEMBL
  A0A8I3MSI8_CANLF UniProtKB/TrEMBL
  A0A8I3RQL5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0P363_CANLF UniProtKB/TrEMBL
  A0A8P0T5E5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0TUN2 ENTREZGENE
UniProt Secondary A0A8P0T8W9 UniProtKB/TrEMBL
  A0A8P0TBU9 UniProtKB/TrEMBL
  A0A8P0TUN2 UniProtKB/TrEMBL
VGNC ID VGNC:110675 ENTREZGENE