Adcyap1 (adenylate cyclase activating polypeptide 1) - Rat Genome Database

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Gene: Adcyap1 (adenylate cyclase activating polypeptide 1) Heterocephalus glaber
Analyze
Symbol: Adcyap1
Name: adenylate cyclase activating polypeptide 1
RGD ID: 18925164
Description: ENCODES a protein that exhibits pituitary adenylate cyclase-activating polypeptide receptor binding (ortholog); signaling receptor binding (ortholog); INVOLVED IN behavioral fear response (ortholog); cAMP-mediated signaling (ortholog); cellular response to glucocorticoid stimulus (ortholog); ASSOCIATED WITH acute necrotizing pancreatitis (ortholog); alcohol dependence (ortholog); autistic disorder (ortholog); FOUND IN extracellular space (ortholog); terminal bouton (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: pituitary adenylate cyclase-activating polypeptide
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477011,358,286 - 11,375,813 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477011,359,606 - 11,375,833 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adenylate cyclase-activating G protein-coupled receptor signaling pathway  (IEA)
behavioral fear response  (ISO)
cAMP-mediated signaling  (ISO)
cellular response to glucocorticoid stimulus  (ISO)
histamine secretion  (ISO)
insulin secretion  (IEA)
negative regulation of acute inflammatory response to antigenic stimulus  (ISO)
negative regulation of acute inflammatory response to non-antigenic stimulus  (ISO)
negative regulation of cell cycle  (IEA,ISO)
negative regulation of glial cell proliferation  (ISO)
negative regulation of GTPase activity  (ISO)
negative regulation of muscle cell apoptotic process  (ISO)
negative regulation of potassium ion transport  (ISO)
neuron projection development  (IEA)
neuropeptide signaling pathway  (IEA)
ovarian follicle development  (ISO)
pituitary gland development  (ISO)
positive regulation of cAMP-mediated signaling  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of chemokine (C-C motif) ligand 5 production  (ISO)
positive regulation of cold-induced thermogenesis  (IEA)
positive regulation of cytosolic calcium ion concentration  (ISO)
positive regulation of ERK1 and ERK2 cascade  (IEA)
positive regulation of gene expression  (IEA,ISO)
positive regulation of growth hormone secretion  (ISO)
positive regulation of interleukin-6 production  (ISO)
positive regulation of neuron projection development  (ISO)
positive regulation of somatostatin secretion  (ISO)
positive regulation of synaptic transmission, glutamatergic  (ISO)
positive regulation of transcription by RNA polymerase II  (IEA)
regulation of G protein-coupled receptor signaling pathway  (ISO)
regulation of oligodendrocyte progenitor proliferation  (ISO)
regulation of postsynaptic membrane potential  (ISO)
regulation of protein localization  (IEA)
regulation of protein phosphorylation  (ISO)
response to ethanol  (ISO)
response to starvation  (ISO)
vasodilation  (ISO)

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Adcyap1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477011,358,286 - 11,375,813 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477011,359,606 - 11,375,833 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
ADCYAP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3818904,411 - 912,172 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl18904,871 - 912,172 (+)EnsemblGRCh38hg38GRCh38
GRCh3718904,872 - 912,173 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3618894,944 - 902,173 (+)NCBINCBI36Build 36hg18NCBI36
Build 3418895,386 - 901,050NCBI
Celera18779,552 - 786,777 (+)NCBICelera
Cytogenetic Map18p11.32NCBI
HuRef18865,131 - 872,354 (+)NCBIHuRef
CHM1_118904,574 - 911,803 (+)NCBICHM1_1
T2T-CHM13v2.0181,058,628 - 1,066,467 (+)NCBIT2T-CHM13v2.0
Adcyap1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391793,506,448 - 93,513,967 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1793,506,445 - 93,513,965 (+)EnsemblGRCm39 Ensembl
GRCm381793,198,245 - 93,206,541 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1793,199,017 - 93,206,537 (+)EnsemblGRCm38mm10GRCm38
MGSCv371793,598,762 - 93,604,831 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361793,503,713 - 93,509,782 (+)NCBIMGSCv36mm8
Celera1797,603,693 - 97,609,773 (+)NCBICelera
Cytogenetic Map17E5NCBI
cM Map1760.67NCBI
Adcyap1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr89120,550,236 - 120,569,096 (-)NCBIGRCr8
mRatBN7.29113,102,632 - 113,122,500 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl9113,103,718 - 113,109,773 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx9121,581,877 - 121,587,073 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09126,711,026 - 126,716,222 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.09125,056,936 - 125,062,132 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.09121,705,897 - 121,725,736 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl9121,706,979 - 121,725,716 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.09121,155,213 - 121,175,023 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera9110,207,950 - 110,213,150 (-)NCBICelera
Cytogenetic Map9q38NCBI
Adcyap1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554029,091,725 - 9,099,803 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554029,091,927 - 9,099,803 (-)NCBIChiLan1.0ChiLan1.0
ADCYAP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21737,590,265 - 37,598,057 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11823,283,967 - 23,290,652 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01813,414,618 - 13,421,668 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11815,712,078 - 15,718,693 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1815,713,479 - 15,717,749 (-)Ensemblpanpan1.1panPan2
ADCYAP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1767,682,421 - 67,691,035 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha767,135,853 - 67,143,650 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0767,748,641 - 67,756,430 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl767,749,208 - 67,822,788 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1767,424,965 - 67,432,752 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0767,436,457 - 67,444,234 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0767,738,672 - 67,746,464 (+)NCBIUU_Cfam_GSD_1.0
Adcyap1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494464,074,352 - 64,081,544 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366723,460,383 - 3,468,255 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366723,461,387 - 3,468,053 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADCYAP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6105,414,631 - 105,422,294 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16105,414,628 - 105,422,294 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2698,531,534 - 98,539,159 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ADCYAP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11860,259,479 - 60,267,302 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605035,058,453 - 35,066,176 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSHGLT00000004971   ⟹   ENSHGLP00000004907
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462477011,358,286 - 11,375,813 (+)Ensembl
RefSeq Acc Id: XM_004853181   ⟹   XP_004853238
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462477011,359,843 - 11,375,833 (+)NCBI
RefSeq Acc Id: XM_004853182   ⟹   XP_004853239
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462477011,359,606 - 11,375,833 (+)NCBI
RefSeq Acc Id: XM_021265190   ⟹   XP_021120849
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462477011,359,606 - 11,375,833 (+)NCBI
Protein Sequences
Protein RefSeqs XP_004853238 (Get FASTA)   NCBI Sequence Viewer  
  XP_004853239 (Get FASTA)   NCBI Sequence Viewer  
  XP_021120849 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000004907
  ENSHGLP00000032150
  ENSHGLP00100046977
GenBank Protein JAO02164 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: XP_004853239   ⟸   XM_004853182
- Peptide Label: isoform X1
- UniProtKB: A0A0P6JCP4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021120849   ⟸   XM_021265190
- Peptide Label: isoform X2
RefSeq Acc Id: XP_004853238   ⟸   XM_004853181
- Peptide Label: isoform X1
- UniProtKB: A0A0P6JCP4 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSHGLP00000004907   ⟸   ENSHGLT00000004971


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000003599 Ensembl, ENTREZGENE
  ENSHGLG00000034296 UniProtKB/TrEMBL
  ENSHGLG00100041393 UniProtKB/TrEMBL
Ensembl Transcript ENSHGLT00000004971 ENTREZGENE
  ENSHGLT00000058859 UniProtKB/TrEMBL
  ENSHGLT00100080068 UniProtKB/TrEMBL
Gene3D-CATH 6.10.250.590 UniProtKB/TrEMBL
InterPro Glucagon_GIP_secretin_VIP UniProtKB/TrEMBL
  VIP/GHRH-like UniProtKB/TrEMBL
KEGG Report hgl:101722329 UniProtKB/TrEMBL
NCBI Gene Adcyap1 ENTREZGENE
PANTHER PTHR11213 UniProtKB/TrEMBL
  PTHR11213:SF1 UniProtKB/TrEMBL
Pfam Hormone_2 UniProtKB/TrEMBL
PRINTS GLUCAGON UniProtKB/TrEMBL
PROSITE GLUCAGON UniProtKB/TrEMBL
SMART GLUCA UniProtKB/TrEMBL
UniProt A0A0P6JCP4 ENTREZGENE, UniProtKB/TrEMBL