Mt-atp8 (mitochondrially encoded ATP synthase membrane subunit 8)

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Gene: Mt-atp8 (mitochondrially encoded ATP synthase membrane subunit 8) Rattus norvegicus

Analyze

Symbol:

Mt-atp8

Name:

mitochondrially encoded ATP synthase membrane subunit 8

RGD ID:

621240

Description:

Predicted to contribute to proton-transporting ATP synthase activity, rotational mechanism. Involved in response to hyperoxia. Localizes to mitochondrial proton-transporting ATP synthase complex. Human ortholog(s) of this gene implicated in multiple sclerosis and urinary bladder cancer. Orthologous to human MT-ATP8 (mitochondrially encoded ATP synthase membrane subunit 8); INTERACTS WITH 3-chloropropane-1,2-diol; apigenin; atrazine.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Also known as:

ATP synthase 8, mitochondrial; ATP synthase F0 subunit 8; Atp8; ATPase subunit 8; mitochondrially encoded ATP synthase 8

RGD Orthologs

Human

Mouse

Dog

Pig

Alliance Genes

More Info

more info ...

Latest Assembly:

Rnor_6.0 - RGSC Genome Assembly v6.0

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rnor_6.0	MT	7,758 - 7,961 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	MT	7,758 - 7,961 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	MT	7,758 - 7,961 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	MT	7,758 - 7,961 (+)	NCBI	RGSC3.4		rn4	RGSC3.4
Cytogenetic Map	MT		NCBI

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Acute Liver Failure (ISO)

Apical Hypertrophic Cardiomyopathy and Neuropathy (ISO)

bicuspid aortic valve disease (ISO)

dilated cardiomyopathy (ISO)

Experimental Arthritis (ISO)

Failure to Thrive (ISO)

Hammer Toe Syndrome (ISO)

infantile histiocytoid cardiomyopathy (ISO)

infantile hypertrophic cardiomyopathy (ISO)

Kearns-Sayre syndrome (ISO)

Leigh disease (ISO)

mitochondrial metabolism disease (ISO)

multiple sclerosis (ISO)

nephritis (ISO)

optic nerve disease (ISO)

pancreatitis (ISO)

Pearson syndrome (ISO)

Reperfusion Injury (IEP)

type 1 diabetes mellitus (ISO)

urinary bladder cancer (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-dexrazoxane (ISO)

3,4-methylenedioxymethamphetamine (ISO)

3-chloropropane-1,2-diol (EXP,ISO)

aflatoxin B1 (ISO)

aflatoxin B2 (ISO)

Aflatoxin G1 (ISO)

Aflatoxin G2 (ISO)

apigenin (EXP)

atrazine (EXP,ISO)

beauvericin (ISO)

bisphenol A (EXP,ISO)

desferrioxamine B (ISO)

doxorubicin (EXP,ISO)

enniatin (ISO)

methylparaben (ISO)

microcystin-LR (EXP)

N-acetyl-L-cysteine (EXP)

N-methyl-4-phenylpyridinium (EXP)

nefazodone (ISO)

paracetamol (ISO)

paraquat (EXP)

perfluorooctanoic acid (EXP)

progesterone (EXP)

sodium hydrogensulfite (EXP)

sulfur dioxide (EXP)

T-2 toxin (EXP)

thapsigargin (ISO)

titanium dioxide (ISO)

tributylstannane (ISO)

tunicamycin (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

mitochondrial ATP synthesis coupled proton transport (ISO)

response to hyperoxia (IEP)

Cellular Component

cellular_component (ND)

integral component of membrane (IEA)

mitochondrial proton-transporting ATP synthase complex (IDA,ISO)

mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) (IEA)

Molecular Function

molecular_function (ND)

proton-transporting ATP synthase activity, rotational mechanism (ISO)

References

References - curated


1.	Ahari SE, etal., Cell Mol Neurobiol. 2007 Sep;27(6):695-700. Epub 2007 Jul 6.
2.	Cai C, etal., J Huazhong Univ Sci Technolog Med Sci. 2008 Apr;28(2):207-10. Epub 2008 May 15.
3.	Cantatore P, etal., Nucleic Acids Res 1982 May 25;10(10):3279-89.
4.	Chen GF, etal., Oncol Rep. 2004 Aug;12(2):463-72.
5.	Eipel C, etal., Life Sci. 2011 Feb 14;88(7-8):343-9. Epub 2010 Dec 15.
6.	Gadaleta G, etal., J Mol Evol 1989 Jun;28(6):497-516.
7.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8.	KEGG
9.	Mathews CE, etal., FASEB J 1995 Dec;9(15):1638-42.
10.	Meyer B, etal., Mol Cell Proteomics. 2007 Oct;6(10):1690-9. Epub 2007 Jun 17.
11.	NCBI rat LocusLink and RefSeq merged data July 26, 2002
12.	OMIM Disease Annotation Pipeline
13.	RGD automated data pipeline
14.	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15.	RGD automated import pipeline for gene-chemical interactions
16.	RGD comprehensive gene curation
17.	Yu X, etal., Hum Mol Genet. 2009 Dec 15;18(24):4689-98. Epub 2009 Sep 16.
18.	Zhang Y, etal., Zhonghua Yi Xue Za Zhi. 2010 Mar 16;90(10):708-11.

Genomics

Comparative Map Data

Mt-atp8
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rnor_6.0	MT	7,758 - 7,961 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	MT	7,758 - 7,961 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	MT	7,758 - 7,961 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	MT	7,758 - 7,961 (+)	NCBI	RGSC3.4		rn4	RGSC3.4
Cytogenetic Map	MT		NCBI

MT-ATP8
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	MT	8,366 - 8,572 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	MT	8,366 - 8,572 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	MT	8,366 - 8,572 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	MT	8,367 - 8,573 (+)	NCBI	NCBI36		hg18	NCBI36

mt-Atp8
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	MT	7,766 - 7,969 (+)	NCBI	GRCm39		mm39
GRCm38	MT	7,766 - 7,969 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	MT	7,766 - 7,969 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	MT	7,766 - 7,969 (+)	NCBI	GRCm37		mm9	NCBIm37

MT-ATP8
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1 Ensembl	MT	7,803 - 8,006 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
CanFam3.1	MT	7,803 - 8,006 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1

MT-ATP8
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	MT	8,959 - 9,162 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	MT	8,959 - 9,162 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	MT	8,959 - 9,162 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	9
Count of miRNA genes:	9
Interacting mature miRNAs:	9
Transcripts:	ENSRNOT00000046201
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High	2	43	42	31	6	31	7	9	73	35	33	3	7
Medium	1		15	10	13	10	1	2	1		8	8	1
Low
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


GenBank Nucleotide	AY172581	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	KJ939360	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	KJ939361	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	KM009112	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	KM009113	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	KM009114	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	KM114603	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	KM114604	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	KM114605	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	KM114606	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	KM114607	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	KM114608	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	KM577635	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	KM657952	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	KM657953	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	KP244683	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000046201 ⟹ ENSRNOP00000042521

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	MT	7,758 - 7,961 (+)	Ensembl

Protein Sequences


Protein RefSeqs	YP_665633	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAN77598	(Get FASTA)	NCBI Sequence Viewer
	AIU45579	(Get FASTA)	NCBI Sequence Viewer
	AIU45592	(Get FASTA)	NCBI Sequence Viewer
	AIU45605	(Get FASTA)	NCBI Sequence Viewer
	AIU45618	(Get FASTA)	NCBI Sequence Viewer
	AIU45631	(Get FASTA)	NCBI Sequence Viewer
	AIU45644	(Get FASTA)	NCBI Sequence Viewer
	AIU45657	(Get FASTA)	NCBI Sequence Viewer
	AIU45670	(Get FASTA)	NCBI Sequence Viewer
	AIU45683	(Get FASTA)	NCBI Sequence Viewer
	AIU45696	(Get FASTA)	NCBI Sequence Viewer
	AIU45709	(Get FASTA)	NCBI Sequence Viewer
	AIY51546	(Get FASTA)	NCBI Sequence Viewer
	AIZ58326	(Get FASTA)	NCBI Sequence Viewer
	AIZ58339	(Get FASTA)	NCBI Sequence Viewer
	AJK30561	(Get FASTA)	NCBI Sequence Viewer
	P11608	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

ENSRNOP00000042521 ⟸ ENSRNOT00000046201

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Strain Variation

Strain Sequence Variants (Rnor 6.0)

ACI/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

ACI/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

ACI/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

BBDP/Wor (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

BN/SsN (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Buf/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

COP/CrCrl (MCW & UW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob) University of Wisconsin (Dr. James Shull)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Charles River Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)

F344/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

F344/NRrrc (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

FHH/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHH/EurMcwi (RGD)

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CSV

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

FHL/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHL/EurMcwi (RGD)

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CSV

TAB

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

GH/OmrMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

GK/Ox (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LE/Stm (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/Crl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/NCrlBR (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LH/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LL/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LN/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

M520/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

MHS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MNS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MR/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

SBH/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBH/Ygl sequenced by MCW

SBH/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SBN/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBN/Ygl sequenced by MCW

SBN/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHR/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHRSP/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SR/JrHsd (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Harlan Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SR/JrHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/Jr (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/JrHsdMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SS/JrHsdMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WAG/Rij (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

WKY/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WN/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:621240	AgrOrtholog
Ensembl Genes	ENSRNOG00000033299	Ensembl, UniProtKB/Swiss-Prot
Ensembl Protein	ENSRNOP00000042521	ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000046201	UniProtKB/Swiss-Prot
InterPro	ATP8_mammal	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ATP8_metazoa	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:26196	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene	26196	ENTREZGENE
PANTHER	PTHR13722	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	ATP-synt_8	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Mt-atp8	PhenoGen
UniProt	ATP8_RAT	UniProtKB/Swiss-Prot, ENTREZGENE
	Q8HIC8	ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary	Q35736	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2020-03-17	Mt-atp8	mitochondrially encoded ATP synthase membrane subunit 8	Mt-atp8	mitochondrially encoded ATP synthase 8	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-09-09	Mt-atp8	mitochondrially encoded ATP synthase 8	mt-Atp8	ATP synthase 8, mitochondrial	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2004-02-11	mt-Atp8	ATP synthase 8, mitochondrial			Symbol and Name status set to approved	625702	APPROVED
2002-08-07	mt-Atp8	ATP synthase 8, mitochondrial			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_disease	point mutations may be associated with diabetes
gene_process	may mediate mitochondrial translation and transcription mechanisms	631900

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM