Fmn2 (formin 2) - Rat Genome Database

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Gene: Fmn2 (formin 2) Rattus norvegicus
Analyze
Symbol: Fmn2
Name: formin 2
RGD ID: 2322099
Description: Predicted to enable actin binding activity. Predicted to be involved in several processes, including cytoskeleton organization; meiotic nuclear division; and positive regulation of double-strand break repair. Predicted to act upstream of or within actin filament bundle assembly and meiotic chromosome movement towards spindle pole. Predicted to be located in several cellular components, including microvillus; nucleolus; and spindle. Predicted to colocalize with actin cytoskeleton. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 47. Orthologous to human FMN2 (formin 2); INTERACTS WITH bisphenol A; 17alpha-ethynylestradiol (ortholog); 2,2',5,5'-tetrachlorobiphenyl (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AABR07021812.1; formin 2-like; formin-2; LOC100360457
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81388,986,863 - 89,303,789 (+)NCBIGRCr8
mRatBN7.21386,454,256 - 86,771,437 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1386,453,926 - 86,771,411 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01392,569,256 - 92,887,302 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1392,569,785 - 92,672,821 (+)NCBIRnor6.0rn6Rnor6.0
Rnor_5.01397,035,682 - 97,352,320 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41390,205,332 - 90,520,323 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1386,056,421 - 86,372,278 (+)NCBICelera
Cytogenetic Map13q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12447394   PMID:20082305   PMID:21620703   PMID:21983562   PMID:23375502   PMID:23439682   PMID:26287480  


Genomics

Comparative Map Data
Fmn2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81388,986,863 - 89,303,789 (+)NCBIGRCr8
mRatBN7.21386,454,256 - 86,771,437 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1386,453,926 - 86,771,411 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01392,569,256 - 92,887,302 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1392,569,785 - 92,672,821 (+)NCBIRnor6.0rn6Rnor6.0
Rnor_5.01397,035,682 - 97,352,320 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41390,205,332 - 90,520,323 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1386,056,421 - 86,372,278 (+)NCBICelera
Cytogenetic Map13q24NCBI
FMN2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381240,091,883 - 240,475,187 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1240,014,348 - 240,475,187 (+)EnsemblGRCh38hg38GRCh38
GRCh371240,255,183 - 240,638,487 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361238,321,604 - 238,705,112 (+)NCBINCBI36Build 36hg18NCBI36
Celera1213,510,402 - 213,893,529 (+)NCBICelera
Cytogenetic Map1q43NCBI
HuRef1210,713,436 - 211,096,763 (+)NCBIHuRef
CHM1_11241,528,744 - 241,910,469 (+)NCBICHM1_1
T2T-CHM13v2.01239,505,207 - 239,886,446 (+)NCBIT2T-CHM13v2.0
Fmn2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391174,324,079 - 174,650,295 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1174,329,391 - 174,650,295 (+)EnsemblGRCm39 Ensembl
GRCm381174,501,752 - 174,822,729 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1174,501,825 - 174,822,729 (+)EnsemblGRCm38mm10GRCm38
MGSCv371176,431,956 - 176,752,860 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361176,325,847 - 176,658,752 (+)NCBIMGSCv36mm8
Celera1181,581,367 - 181,911,120 (+)NCBICelera
Cytogenetic Map1H3NCBI
cM Map181.04NCBI
Fmn2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495540611,358,585 - 11,666,102 (-)NCBIChiLan1.0ChiLan1.0
FMN2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v218,686,548 - 9,078,536 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan118,909,570 - 9,303,709 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01215,626,889 - 216,023,590 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11220,621,414 - 221,008,892 (+)NCBIpanpan1.1PanPan1.1panPan2
FMN2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1731,657,371 - 32,024,777 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl731,697,245 - 32,023,472 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha731,194,870 - 31,564,912 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0731,478,304 - 31,849,271 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1731,315,799 - 31,687,109 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0731,348,230 - 31,718,511 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0731,586,597 - 31,957,372 (+)NCBIUU_Cfam_GSD_1.0
Fmn2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934444,577,814 - 44,914,520 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365269,833,128 - 10,169,267 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365269,832,790 - 10,169,488 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FMN2
(Sus scrofa - pig)
No map positions available.
FMN2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12577,187,572 - 77,585,773 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605579,293,686 - 79,693,875 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fmn2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477110,642,515 - 10,953,480 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477110,641,845 - 10,956,213 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Fmn2
2145 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:64
Count of miRNA genes:57
Interacting mature miRNAs:61
Transcripts:ENSRNOT00000072243
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134608804691088046Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
8655945Rf61Renal function QTL 613.6blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)136906051986800898Rat
8655959Pur32Proteinuria QTL 328.4urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)137402391897213863Rat
1331783Bp221Blood pressure QTL 2213.72886arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)136906051986800898Rat
1300166Kidm6Kidney mass QTL 63.93kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)136906051986800898Rat
1302791Stl29Serum triglyceride level QTL 293.30.0011blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)138473078886800898Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1330395351101056920Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1356056920101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat
1641901Alcrsp6Alcohol response QTL 6response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)135236217197362171Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
2293341Glom15Glomerulus QTL 159.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1374862117101339893Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1361825626106807694Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133124133193395974Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1365103704106807694Rat
12879471Bp398Blood pressure QTL 398arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134551471990514719Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1365103704106807694Rat
12879444Bp397Blood pressure QTL 397arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134504940490049404Rat
12879441Bp396Blood pressure QTL 396arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134569998390699983Rat
4889606Gluco63Glucose level QTL 632.860.003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1380753256106807694Rat

Markers in Region
D13Got77  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01392,845,528 - 92,845,714NCBIRnor6.0
Rnor_5.01397,310,645 - 97,310,831UniSTSRnor5.0
RGSC_v3.41390,480,373 - 90,480,560RGDRGSC3.4
RGSC_v3.41390,480,374 - 90,480,560UniSTSRGSC3.4
RGSC_v3.11390,669,258 - 90,669,444RGD
Celera1386,331,162 - 86,331,348UniSTS
RH 3.4 Map13575.6UniSTS
RH 3.4 Map13575.6RGD
RH 2.0 Map13637.2RGD
Cytogenetic Map13q24UniSTS
BF397101  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21386,640,710 - 86,640,950 (+)MAPPERmRatBN7.2
Rnor_6.01392,755,443 - 92,755,682NCBIRnor6.0
Rnor_5.01397,220,199 - 97,220,438UniSTSRnor5.0
RGSC_v3.41390,391,391 - 90,391,630UniSTSRGSC3.4
Celera1386,242,128 - 86,242,367UniSTS
RH 3.4 Map13585.7UniSTS
Cytogenetic Map13q24UniSTS
BF388231  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21386,570,078 - 86,570,242 (+)MAPPERmRatBN7.2
Rnor_6.01392,684,941 - 92,685,104NCBIRnor6.0
Rnor_5.01397,150,008 - 97,150,171UniSTSRnor5.0
RGSC_v3.41390,319,780 - 90,319,943UniSTSRGSC3.4
Celera1386,172,457 - 86,172,620UniSTS
RH 3.4 Map13575.9UniSTS
Cytogenetic Map13q24UniSTS
BF405930  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21386,620,170 - 86,620,393 (+)MAPPERmRatBN7.2
Rnor_6.01392,734,902 - 92,735,124NCBIRnor6.0
Rnor_5.01397,199,658 - 97,199,880UniSTSRnor5.0
RGSC_v3.41390,370,854 - 90,371,076UniSTSRGSC3.4
Celera1386,221,577 - 86,221,799UniSTS
RH 3.4 Map13574.5UniSTS
Cytogenetic Map13q24UniSTS
stSG628095  
Rat AssemblyChrPosition (strand)SourceJBrowse
Celera1386,265,119 - 86,266,359UniSTS
Cytogenetic Map13q24UniSTS


Expression


Sequence


RefSeq Acc Id: ENSRNOT00000082700   ⟹   ENSRNOP00000070887
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1386,453,926 - 86,558,299 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000102800   ⟹   ENSRNOP00000095777
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1386,453,926 - 86,771,411 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000105445   ⟹   ENSRNOP00000080507
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1386,453,926 - 86,771,411 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000118504   ⟹   ENSRNOP00000097445
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1386,453,926 - 86,771,411 (+)Ensembl
RefSeq Acc Id: NM_001427798   ⟹   NP_001414727
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81388,986,863 - 89,303,789 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001414727 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000070887.2
  ENSRNOP00000080507.1
  ENSRNOP00000095777.1
  ENSRNOP00000097445.1
RefSeq Acc Id: ENSRNOP00000070887   ⟸   ENSRNOT00000082700
RefSeq Acc Id: ENSRNOP00000095777   ⟸   ENSRNOT00000102800
RefSeq Acc Id: ENSRNOP00000097445   ⟸   ENSRNOT00000118504
RefSeq Acc Id: ENSRNOP00000080507   ⟸   ENSRNOT00000105445
RefSeq Acc Id: NP_001414727   ⟸   NM_001427798
Protein Domains
FH2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JZ27-F1-model_v2 AlphaFold A0A0G2JZ27 1-1201 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2322099 AgrOrtholog
BioCyc Gene G2FUF-17248 BioCyc
Ensembl Genes ENSRNOG00000061764 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000082700.2 UniProtKB/TrEMBL
  ENSRNOT00000102800.1 UniProtKB/TrEMBL
  ENSRNOT00000105445.1 UniProtKB/TrEMBL
  ENSRNOT00000118504.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.58.2220 UniProtKB/TrEMBL
InterPro FH2_Formin UniProtKB/TrEMBL
  FH2_Formin_sf UniProtKB/TrEMBL
  Formin_Cappuccino_subfam UniProtKB/TrEMBL
NCBI Gene 100360457 ENTREZGENE
PANTHER FORMIN UniProtKB/TrEMBL
  FORMIN-2 UniProtKB/TrEMBL
Pfam FH2 UniProtKB/TrEMBL
PhenoGen Fmn2 PhenoGen
PRINTS FORMIN UniProtKB/TrEMBL
PROSITE FH2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000061764 RatGTEx
SMART FH2 UniProtKB/TrEMBL
Superfamily-SCOP Formin homology 2 domain (FH2 domain) UniProtKB/TrEMBL
UniProt A0A0G2JZ27_RAT UniProtKB/TrEMBL
  A0A8I5ZQT5_RAT UniProtKB/TrEMBL
  A0A8I6AUE2_RAT UniProtKB/TrEMBL
  A0A8I6GLS8_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-02 Fmn2  formin 2  AABR07021812.1    Data merged from RGD:15014329 737654 PROVISIONAL
2019-11-08 AABR07021812.1        Symbol and Name status set to provisional 45752 PROVISIONAL
2013-08-02 Fmn2  formin 2  LOC100360457  formin 2-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-05-06 LOC100360457  formin 2-like      Symbol and Name status set to provisional 70820 PROVISIONAL