Aldh1a2 (aldehyde dehydrogenase 1 family, member A2) - Rat Genome Database

Send us a Message



 Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap)  (beta) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer) Overgo Probe Designer
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease COVID-19 Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models PhenoMiner (Quantitative Phenotypes) Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Poster Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Aldh1a2 (aldehyde dehydrogenase 1 family, member A2) Rattus norvegicus
Analyze
Symbol: Aldh1a2
Name: aldehyde dehydrogenase 1 family, member A2
RGD ID: 620250
Description: Enables retinal binding activity and retinal dehydrogenase activity. Involved in several processes, including response to estradiol; response to vitamin A; and retinoic acid biosynthetic process. Located in cytosol and perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in congenital diaphragmatic hernia. Orthologous to human ALDH1A2 (aldehyde dehydrogenase 1 family member A2); PARTICIPATES IN retinoic acid metabolic pathway; retinol metabolic pathway; vitamin A deficiency pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: aldehyde dehydrogenase 1A2; aldehyde dehydrogenase family 1 member A2; aldehyde dehydrogenase family 1, subfamily A2; MGC114283; RALDH 2; RalDH(II); Raldh-2; ralDH2; retinal dehydrogenase 2; retinal dehydrogenase type II; retinal dehydrogenase, type II; retinaldehyde-specific dehydrogenase type 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2871,877,850 - 71,957,107 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl871,877,850 - 71,957,107 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx877,412,501 - 77,491,856 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0875,685,476 - 75,764,833 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0873,522,516 - 73,601,878 (+)NCBIRnor_WKY
Rnor_6.0877,640,234 - 77,719,488 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl877,640,222 - 77,719,489 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0875,363,285 - 75,442,554 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4875,692,099 - 75,771,159 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1875,711,165 - 75,790,204 (+)NCBI
Celera869,779,737 - 69,858,993 (-)NCBICelera
Cytogenetic Map8q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-Ethylhexanoic acid  (ISO)
2-hydroxypropanoic acid  (ISO)
22-Hydroxycholesterol  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(diethylamino)benzaldehyde  (ISO)
4-[3-(4-tert-butylphenyl)-2-methylpropyl]-2,6-dimethylmorpholine  (ISO)
4-hydroperoxycyclophosphamide  (ISO)
4-nitrophenol  (ISO)
6-propyl-2-thiouracil  (EXP)
abacavir  (ISO)
acetaldehyde  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinal  (EXP)
all-trans-retinoic acid  (EXP,ISO)
all-trans-retinol  (ISO)
ammonium chloride  (EXP)
arsenite(3-)  (ISO)
benzaldehydes  (ISO)
benzo[a]pyrene  (ISO)
Benzo[k]fluoranthene  (ISO)
bezafibrate  (ISO)
bictegravir  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butylated hydroxyanisole  (ISO)
butyric acid  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
CHIR 99021  (ISO)
chloroprene  (EXP)
choline  (ISO)
citral  (EXP)
cobalt dichloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
cylindrospermopsin  (ISO)
D-gluconic acid  (EXP)
dabigatran  (ISO)
daidzein  (ISO)
daidzein 7-O-beta-D-glucoside  (ISO)
decanal  (EXP)
deoxycholic acid  (EXP)
dexamethasone  (ISO)
dioxygen  (ISO)
disulfiram  (ISO)
dolutegravir  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
Doxylamine succinate  (ISO)
elvitegravir  (ISO)
entinostat  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
ethylene glycol  (ISO)
fenofibrate  (ISO)
fenpropidin  (ISO)
fulvestrant  (ISO)
furan  (EXP)
genistein  (ISO)
genistein 7-O-beta-D-glucoside  (ISO)
gentamycin  (EXP)
geranial  (EXP)
glycitein  (ISO)
glycitin  (ISO)
hexanal  (EXP)
Indeno[1,2,3-cd]pyrene  (ISO)
indirubin-3'-monoxime  (ISO)
indole-3-methanol  (ISO)
isotretinoin  (ISO)
lipopolysaccharide  (ISO)
methamphetamine  (ISO)
methylmercury chloride  (ISO)
methylparaben  (ISO)
metoclopramide  (ISO)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
nilotinib  (ISO)
nitrofen  (EXP)
ochratoxin A  (EXP)
ozone  (ISO)
panobinostat  (ISO)
paraquat  (EXP)
phenethyl caffeate  (EXP)
phenylmercury acetate  (ISO)
phenytoin  (ISO)
pirinixic acid  (ISO)
pravastatin  (ISO)
progesterone  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sotorasib  (ISO)
spiroxamine  (ISO)
thalidomide  (ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trametinib  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
WIN 18446  (EXP,ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
9-cis-retinoic acid biosynthetic process  (ISO)
anterior/posterior pattern specification  (ISO)
blood vessel development  (ISO)
camera-type eye development  (ISO)
cardiac muscle tissue development  (ISO)
cell population proliferation  (ISO)
cellular response to retinoic acid  (ISO)
determination of bilateral symmetry  (ISO)
embryonic camera-type eye development  (ISO)
embryonic digestive tract development  (ISO)
embryonic forelimb morphogenesis  (ISO)
embryonic limb morphogenesis  (ISO)
face development  (ISO)
forebrain development  (ISO)
heart morphogenesis  (ISO)
hindbrain development  (ISO)
kidney development  (IEP)
liver development  (IEP)
lung development  (ISO)
midgut development  (IEP)
morphogenesis of embryonic epithelium  (ISO)
negative regulation of cell population proliferation  (ISO)
neural crest cell development  (ISO)
neural tube development  (ISO)
neuron differentiation  (ISO)
pancreas development  (ISO)
pituitary gland development  (IEP)
positive regulation of apoptotic process  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of gene expression  (ISO)
protein homotetramerization  (ISO,ISS)
proximal/distal pattern formation  (ISO)
regulation of endothelial cell proliferation  (ISO)
regulation of vascular endothelial cell proliferation  (ISO)
response to cytokine  (ISO)
response to estradiol  (IEP)
response to vitamin A  (IEP)
retinal metabolic process  (ISO)
retinoic acid biosynthetic process  (IEP,IMP,ISO,ISS)
retinoic acid metabolic process  (IDA,ISO,TAS)
retinoic acid receptor signaling pathway  (ISO)
retinoic acid receptor signaling pathway involved in somitogenesis  (ISO)
retinol metabolic process  (IEA)
ureter maturation  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Upregulation of retinal dehydrogenase 2 in alternatively activated macrophages during retinoid-dependent type-2 immunity to helminth infection in mice. Broadhurst MJ, etal., PLoS Pathog. 2012;8(8):e1002883. doi: 10.1371/journal.ppat.1002883. Epub 2012 Aug 23.
2. Immunolocalization of retinoic acid biosynthesis systems in selected sites in rat. Everts HB, etal., Exp Cell Res. 2005 Aug 15;308(2):309-19.
3. Expression of retinaldehyde dehydrogenase (RALDH)2 and RALDH3 but not RALDH1 in the developing anterior pituitary glands of rats. Fujiwara K, etal., Cell Tissue Res. 2007 Apr;328(1):129-35. Epub 2006 Dec 19.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
7. Estrogen directly induces expression of retinoic acid biosynthetic enzymes, compartmentalized between the epithelium and underlying stromal cells in rat uterus. Li XH, etal., Endocrinology. 2004 Oct;145(10):4756-62. Epub 2004 Jun 17.
8. Mitochondrial Aldehyde Dehydrogenase 2 Regulates Revascularization in Chronic Ischemia: Potential Impact on the Development of Coronary Collateral Circulation. Liu X, etal., Arterioscler Thromb Vasc Biol. 2015 Oct;35(10):2196-206. doi: 10.1161/ATVBAHA.115.306012. Epub 2015 Aug 27.
9. Expression of retinoic acid-synthesizing and -metabolizing enzymes during nephrogenesis in the rat. Marlier A and Gilbert T, Gene Expr Patterns. 2004 Dec;5(2):179-85.
10. Retinal dehydrogenase-2 is inhibited by compounds that induce congenital diaphragmatic hernias in rodents. Mey J, etal., Am J Pathol. 2003 Feb;162(2):673-9.
11. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
12. Cardiovascular malformations in DiGeorge syndrome (congenital absence of hypoplasia of the thymus). Moerman P, etal., Br Heart J 1980 Oct;44(4):452-9.
13. Physiological insights into all-trans-retinoic acid biosynthesis. Napoli JL Biochim Biophys Acta. 2012 Jan;1821(1):152-67. Epub 2011 May 19.
14. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
15. Retinaldehyde dehydrogenase 2 is down-regulated during duodenal atresia formation in Fgfr2IIIb-/- mice. Nichol PF, etal., J Surg Res. 2012 Jun 1;175(1):82-7. doi: 10.1016/j.jss.2011.02.040. Epub 2011 Mar 21.
16. The regional pattern of retinoic acid synthesis by RALDH2 is essential for the development of posterior pharyngeal arches and the enteric nervous system. Niederreither K, etal., Development 2003 Jun;130(11):2525-34.
17. Postnatal changes in gene expression of retinal dehydrogenase and retinoid receptors in liver of rats. Ogura Y, etal., Life Sci. 2004 Feb 6;74(12):1519-28.
18. Developmental changes of the expression of the genes regulated by retinoic acid in the small intestine of rats. Ogura Y, etal., Life Sci. 2005 Oct 14;77(22):2804-13.
19. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
20. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
21. Haploinsufficiency of retinaldehyde dehydrogenase 2 decreases the severity and incidence of duodenal atresia in the fibroblast growth factor receptor 2IIIb-/- mouse model. Reeder AL, etal., Surgery. 2012 Oct;152(4):768-75; discussion 775-6. doi: 10.1016/j.surg.2012.07.022.
22. GOA pipeline RGD automated data pipeline
23. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
24. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
25. Decreased embryonic retinoic acid synthesis results in a DiGeorge syndrome phenotype in newborn mice. Vermot J, etal., Proc Natl Acad Sci U S A 2003 Feb 18;100(4):1763-8. Epub 2003 Jan 31.
26. Multiple retinol and retinal dehydrogenases catalyze all-trans-retinoic acid biosynthesis in astrocytes. Wang C, etal., J Biol Chem. 2011 Feb 25;286(8):6542-53. Epub 2010 Dec 7.
27. Cloning of a cDNA encoding an aldehyde dehydrogenase and its expression in Escherichia coli. Recognition of retinal as substrate. Wang X, etal., J Biol Chem 1996 Jul 5;271(27):16288-93.
28. Cellular expression of retinal dehydrogenase types 1 and 2: effects of vitamin A status on testis mRNA. Zhai Y, etal., J Cell Physiol. 2001 Feb;186(2):220-32.
Additional References at PubMed
PMID:8797830   PMID:8889548   PMID:9892670   PMID:10320326   PMID:11245568   PMID:11876656   PMID:12477932   PMID:12610736   PMID:14623241   PMID:14627725   PMID:15069081   PMID:15366004  
PMID:15489334   PMID:15652703   PMID:15731404   PMID:15739227   PMID:15753214   PMID:15872003   PMID:15889094   PMID:16026781   PMID:16166285   PMID:16237707   PMID:16368932   PMID:16427040  
PMID:16806149   PMID:17067568   PMID:17184764   PMID:18495959   PMID:18816858   PMID:20034106   PMID:21521737   PMID:29240402  


Genomics

Comparative Map Data
Aldh1a2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2871,877,850 - 71,957,107 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl871,877,850 - 71,957,107 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx877,412,501 - 77,491,856 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0875,685,476 - 75,764,833 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0873,522,516 - 73,601,878 (+)NCBIRnor_WKY
Rnor_6.0877,640,234 - 77,719,488 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl877,640,222 - 77,719,489 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0875,363,285 - 75,442,554 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4875,692,099 - 75,771,159 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1875,711,165 - 75,790,204 (+)NCBI
Celera869,779,737 - 69,858,993 (-)NCBICelera
Cytogenetic Map8q24NCBI
ALDH1A2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381557,953,429 - 58,065,711 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1557,953,424 - 58,497,866 (-)EnsemblGRCh38hg38GRCh38
GRCh371558,245,627 - 58,357,909 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361556,032,919 - 56,145,198 (-)NCBINCBI36Build 36hg18NCBI36
Build 341556,032,918 - 56,093,527NCBI
Celera1535,135,291 - 35,247,470 (-)NCBICelera
Cytogenetic Map15q21.3NCBI
HuRef1535,068,702 - 35,181,099 (-)NCBIHuRef
CHM1_11558,363,582 - 58,476,117 (-)NCBICHM1_1
T2T-CHM13v2.01555,755,851 - 55,868,018 (-)NCBIT2T-CHM13v2.0
Aldh1a2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39971,123,071 - 71,203,525 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl971,123,071 - 71,203,525 (+)EnsemblGRCm39 Ensembl
GRCm38971,215,789 - 71,296,243 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl971,215,789 - 71,296,243 (+)EnsemblGRCm38mm10GRCm38
MGSCv37971,063,596 - 71,144,050 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36971,014,409 - 71,094,803 (+)NCBIMGSCv36mm8
Celera968,414,967 - 68,495,534 (+)NCBICelera
Cytogenetic Map9DNCBI
cM Map939.85NCBI
Aldh1a2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545016,406,436 - 16,453,180 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545016,406,578 - 16,453,048 (+)NCBIChiLan1.0ChiLan1.0
ALDH1A2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11555,237,101 - 55,349,851 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1555,237,101 - 55,557,168 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01536,925,443 - 37,038,288 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
ALDH1A2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13023,074,432 - 23,170,374 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3023,074,432 - 23,340,030 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3023,045,955 - 23,141,851 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03023,233,206 - 23,329,111 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3023,233,206 - 23,498,331 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13023,164,758 - 23,260,609 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03023,250,334 - 23,346,246 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03023,392,036 - 23,488,058 (-)NCBIUU_Cfam_GSD_1.0
Aldh1a2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640101,327,905 - 101,415,451 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647119,175,992 - 19,263,335 (-)EnsemblSpeTri2.0
SpeTri2.0NW_00493647119,175,997 - 19,263,335 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ALDH1A2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1113,932,739 - 114,037,046 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11113,932,722 - 114,037,059 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21126,038,541 - 126,105,080 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ALDH1A2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12625,439,159 - 25,557,199 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2625,439,360 - 25,557,202 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666048115,756,952 - 115,875,731 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Aldh1a2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478113,756,390 - 13,845,479 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478113,756,469 - 13,845,253 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Aldh1a2
217 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:88
Count of miRNA genes:72
Interacting mature miRNAs:79
Transcripts:ENSRNOT00000021757
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
631271Lecl1Lens clarity QTL 10.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)81898416884531599Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)81933115293965294Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)82720571599103503Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)82720571599103503Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)82720571599103503Rat
1300146Rf17Renal function QTL 172.9renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)82824291273242912Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)82824291299525068Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)83018886794457446Rat
2313046Bss78Bone structure and strength QTL 783.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)83084815482460899Rat
2313057Bss76Bone structure and strength QTL 7630.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)83084815482460899Rat
2313067Bss77Bone structure and strength QTL 773.10.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)83084815482460899Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83084815482460899Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)830848154101699754Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)830848154101699754Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)830848154101699754Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)830848259105647037Rat
1298065Scl16Serum cholesterol level QTL 163.8blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)83085640475856404Rat
1582222Epfw2Epididymal fat weight QTL 23.20.0005epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)83173772976737729Rat
61358Bp39Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83555193880551938Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83558203280582032Rat
1331838Niddm61Non-insulin dependent diabetes mellitus QTL 613.530.0004blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83646953599083736Rat
737824Hcar10Hepatocarcinoma resistance QTL 102.9liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)84071306682925667Rat
1358906Bp253Blood pressure QTL 25340.0004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)84071306693965294Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
1331769Rf39Renal function QTL 393.871urine output (VT:0003620)timed urine volume (CMO:0000260)84186687675097878Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)84186687686866876Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84269268490165460Rat
12879882Am8Aortic mass QTL 80.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)84329616998968765Rat
12879878Bw183Body weight QTL 1830.001body mass (VT:0001259)body weight (CMO:0000012)84329616998968765Rat
12879879Cm99Cardiac mass QTL 990.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)84329616998968765Rat
12879880Cm100Cardiac mass QTL 1000.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)84329616998968765Rat
12879881Cm101Cardiac mass QTL 1010.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)84329616998968765Rat
12879883Kidm65Kidney mass QTL 650.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)84329616998968765Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)846531639119088624Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)846531639119088624Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)846531639119088624Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)846531639119088624Rat
1331837Bw23Body weight QTL 234.190.00007body mass (VT:0001259)body weight (CMO:0000012)84653172299083736Rat
2303570Gluco48Glucose level QTL 482blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)84980583194805831Rat
2313086Bss60Bone structure and strength QTL 604.10.0001tibia length (VT:0004357)tibia length (CMO:0000450)85009524982460899Rat
4889938Bss89Bone structure and strength QTL 893.8tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)85009524982460899Rat
5684973Bss100Bone structure and strength QTL 1004.7tibia area (VT:1000281)tibia area measurement (CMO:0001382)85009524982460899Rat
1358912Bw51Body weight QTL 512.95body mass (VT:0001259)body weight (CMO:0000012)851351728107062046Rat
10402857Bp380Blood pressure QTL 3800.95arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)85396876598968765Rat
2301402Bp316Blood pressure QTL 3160.005arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)85396876598968765Rat
2293697Bmd39Bone mineral density QTL 39femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)85404374498968765Rat
1582243Bw66Body weight QTL 663.40.0048body mass (VT:0001259)body weight (CMO:0000012)85423764485365202Rat
1582254Kidm31Kidney mass QTL 313kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)85423764485365202Rat
631664Hcar3Hepatocarcinoma resistance QTL 32.90.0005liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)85423764499103503Rat
1300177Cm2Cardiac mass QTL 23.65heart mass (VT:0007028)heart weight (CMO:0000017)854259986100382532Rat
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)861290298119084929Rat
631653Bp125Blood pressure QTL 1253.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)866142385111142385Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)869349194112783834Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)870513503118219066Rat
8694446Bw170Body weight QTL 17012.070.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)871888757116888757Rat
9590292Uminl3Urine mineral level QTL 33.620.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)871888757116888757Rat
8694200Abfw4Abdominal fat weight QTL 49.070.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)871888757116888757Rat
8694392Bw161Body weight QTL 1618.060.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)871888757116888757Rat

Markers in Region
D8Wox20  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2871,888,146 - 71,888,253 (+)MAPPERmRatBN7.2
Rnor_6.0877,650,530 - 77,650,636NCBIRnor6.0
Rnor_5.0875,432,152 - 75,432,258UniSTSRnor5.0
RGSC_v3.4875,702,394 - 75,702,501RGDRGSC3.4
RGSC_v3.4875,702,395 - 75,702,501UniSTSRGSC3.4
RGSC_v3.1875,721,448 - 75,721,555RGD
Celera869,848,591 - 69,848,697UniSTS
RH 2.0 Map8697.7RGD
Cytogenetic Map8q24UniSTS
RH133490  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2871,956,878 - 71,957,087 (+)MAPPERmRatBN7.2
Rnor_6.0877,719,260 - 77,719,468NCBIRnor6.0
Rnor_5.0875,363,305 - 75,363,513UniSTSRnor5.0
RGSC_v3.4875,770,931 - 75,771,139UniSTSRGSC3.4
Celera869,779,757 - 69,779,965UniSTS
Cytogenetic Map8q24UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 28 6 6 6 1 44 25 38 11
Low 3 15 49 33 19 33 8 10 28 10 3 8
Below cutoff 2 2 2 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000079115   ⟹   ENSRNOP00000073203
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl871,877,850 - 71,957,107 (+)Ensembl
Rnor_6.0 Ensembl877,640,222 - 77,719,489 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000113857   ⟹   ENSRNOP00000076670
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl871,877,850 - 71,957,107 (+)Ensembl
RefSeq Acc Id: NM_053896   ⟹   NP_446348
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2871,877,850 - 71,957,107 (+)NCBI
Rnor_6.0877,640,234 - 77,719,488 (+)NCBI
Rnor_5.0875,363,285 - 75,442,554 (-)NCBI
RGSC_v3.4875,692,099 - 75,771,159 (+)RGD
Celera869,779,737 - 69,858,993 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_446348 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC52637 (Get FASTA)   NCBI Sequence Viewer  
  AAH98910 (Get FASTA)   NCBI Sequence Viewer  
  EDL84165 (Get FASTA)   NCBI Sequence Viewer  
  Q63639 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_446348   ⟸   NM_053896
- UniProtKB: Q4FZY8 (UniProtKB/Swiss-Prot),   Q63639 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000073203   ⟸   ENSRNOT00000079115
RefSeq Acc Id: ENSRNOP00000076670   ⟸   ENSRNOT00000113857
Protein Domains
Aldedh

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63639-F1-model_v2 AlphaFold Q63639 1-518 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696110
Promoter ID:EPDNEW_R6635
Type:initiation region
Name:Aldh1a2_1
Description:aldehyde dehydrogenase 1 family, member A2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0877,640,211 - 77,640,271EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620250 AgrOrtholog
BioCyc Gene G2FUF-29902 BioCyc
BioCyc Pathway PWY-6872 [retinoate biosynthesis I] BioCyc
Ensembl Genes ENSRNOG00000055049 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000073203 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000076670.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000079115 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000113857.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.309.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.605.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7455646 IMAGE-MGC_LOAD
InterPro Ald_DH/histidinol_DH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ald_DH_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ald_DH_CS_CYS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ald_DH_CS_GLU UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ald_DH_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aldehyde_DH_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:116676 UniProtKB/Swiss-Prot
MGC_CLONE MGC:114283 IMAGE-MGC_LOAD
NCBI Gene 116676 ENTREZGENE
Pfam Aldedh UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Aldh1a2 PhenoGen
PROSITE ALDEHYDE_DEHYDR_CYS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ALDEHYDE_DEHYDR_GLU UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF53720 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5Y0L7_RAT UniProtKB/TrEMBL
  AL1A2_RAT UniProtKB/Swiss-Prot
  Q4FZY8 ENTREZGENE
  Q63639 ENTREZGENE
UniProt Secondary Q4FZY8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-26 Aldh1a2  aldehyde dehydrogenase 1 family, member A2  Aldh1a2  aldehyde dehydrogenase family 1, subfamily A2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-26 Aldh1a2  aldehyde dehydrogenase family 1, subfamily A2      Symbol and Name status set to approved 625702 APPROVED
2002-08-07 Aldh1a2  aldehyde dehydrogenase family 1, subfamily A2      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_function recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. does metabolize octanal and decanal but does not metabolize citral, benzaldehyde, acetaldehyde and propanal efficiently 724707