Mt-co2 (mitochondrially encoded cytochrome c oxidase II) - Rat Genome Database

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Gene: Mt-co2 (mitochondrially encoded cytochrome c oxidase II) Rattus norvegicus
Analyze
Symbol: Mt-co2
Name: mitochondrially encoded cytochrome c oxidase II
RGD ID: 621872
Description: Predicted to enable copper ion binding activity. Predicted to contribute to cytochrome-c oxidase activity. Involved in lactation and response to hypoxia. Predicted to be located in mitochondrial inner membrane. Predicted to be part of mitochondrial respiratory chain complex IV. Biomarker of acute myocardial infarction; colorectal carcinoma; and type 2 diabetes mellitus. Orthologous to several human genes including MT-CO2 (mitochondrially encoded cytochrome c oxidase II); INTERACTS WITH 17alpha-ethynylestradiol; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Co2; COII; Cox2; cytochrome c oxidase 2, mitochondrial; cytochrome c oxidase II, mitochondrial; cytochrome c oxidase subunit 2; cytochrome c oxidase subunit II
RGD Orthologs
Human
Mouse
Dog
Pig
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2MT7,006 - 7,689 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2MT7,006 - 7,689 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2MT7,006 - 7,689 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2MT7,006 - 7,689 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2MT7,006 - 7,689 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2MT7,006 - 7,689 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblMT7,006 - 7,689 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0MT7,006 - 7,689 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblMT7,006 - 7,689 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0MT7,006 - 7,689 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4MT7,006 - 7,689 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Cytogenetic MapMT NCBI


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-epicatechin-3-O-gallate  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-di-tert-butyl-4-methylphenol  (ISO)
3,3'-diindolylmethane  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methyladenine  (ISO)
4,4'-sulfonyldiphenol  (EXP)
5-methyl-4-oxido-2-pyrazin-4-iumcarboxylic acid  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenic trichloride  (ISO)
arsenite(3-)  (ISO)
atrazine  (EXP,ISO)
bexarotene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
butylated hydroxyanisole  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
chloramphenicol  (ISO)
chlorogenic acid  (ISO)
chromium(6+)  (ISO)
cis-caffeic acid  (ISO)
cisplatin  (EXP)
clarithromycin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
curcumin  (ISO)
cycloastragenol  (EXP)
D-glucose  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (EXP,ISO)
Di-n-octyl phthalate  (ISO)
diallyl trisulfide  (ISO)
didanosine  (ISO)
doxorubicin  (EXP,ISO)
enniatin  (ISO)
ethidium  (ISO)
fenthion  (ISO)
flutamide  (ISO)
fructose  (EXP)
gallic acid  (ISO)
gallocatechin  (ISO)
gentamycin  (EXP)
glucose  (ISO)
glycidyl methacrylate  (ISO)
hydrogen peroxide  (ISO)
hydrogen sulfide  (ISO)
ivermectin  (ISO)
josamycin  (ISO)
lamivudine  (ISO)
lead nitrate  (EXP)
Licarin A  (ISO)
melatonin  (ISO)
methidathion  (ISO)
microcystin-LR  (EXP)
Mitotane  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nimesulide  (ISO)
okadaic acid  (ISO)
oxaloacetic acid  (ISO)
p-menthan-3-ol  (ISO)
paracetamol  (EXP)
paraquat  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
pirinixic acid  (EXP)
Propiverine  (EXP)
puerarin  (EXP)
quercetin  (ISO)
reactive oxygen species  (ISO)
resveratrol  (EXP,ISO)
SB 431542  (ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (ISO)
sodium hydrogensulfite  (EXP)
sulfur dioxide  (EXP)
T-2 toxin  (EXP)
telbivudine  (ISO)
tenofovir disoproxil fumarate  (ISO)
thapsigargin  (EXP,ISO)
thioacetamide  (EXP)
thiram  (ISO)
trans-caffeic acid  (ISO)
trichloroethene  (EXP)
tungsten  (ISO)
tunicamycin  (ISO)
tyrphostin B42  (ISO)
valproic acid  (ISO)
zalcitabine  (EXP)
zidovudine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Novel features of animal mtDNA evolution as shown by sequences of two rat cytochrome oxidase subunit II genes. Brown GG and Simpson MV, Proc Natl Acad Sci U S A 1982 May;79(10):3246-50.
2. Elevated spinal cyclooxygenase and prostaglandin release during hyperalgesia in diabetic rats. Freshwater JD, etal., Diabetes 2002 Jul;51(7):2249-55.
3. The complete nucleotide sequence of the Rattus norvegicus mitochondrial genome: cryptic signals revealed by comparative analysis between vertebrates. Gadaleta G, etal., J Mol Evol 1989 Jun;28(6):497-516.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Traumatic brain injury-induced changes in gene expression and functional activity of mitochondrial cytochrome C oxidase. Harris LK, etal., J Neurotrauma. 2001 Oct;18(10):993-1009.
6. Reactive Oxygen Species Are Involved in the Development of Gastric Cancer and Gastric Cancer-Related Depression through ABL1-Mediated Inflammation Signaling Pathway. Huang T, etal., Oxid Med Cell Longev. 2019 Jul 15;2019:5813985. doi: 10.1155/2019/5813985. eCollection 2019.
7. A third isoform of cytochrome c oxidase subunit VIII is present in mammals. Huttemann M, etal., Gene 2003 Jul 17;312:95-102.
8. Impaired expression of NADH dehydrogenase subunit 1 and PPARgamma coactivator-1 in skeletal muscle of ZDF rats: restoration by troglitazone. Jove M, etal., J Lipid Res. 2004 Jan;45(1):113-23. Epub 2003 Oct 16.
9. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
10. Mitochondrial loss, dysfunction and altered dynamics in Huntington's disease. Kim J, etal., Hum Mol Genet. 2010 Oct 15;19(20):3919-35. doi: 10.1093/hmg/ddq306. Epub 2010 Jul 21.
11. Nimesulide inhibits the growth of human esophageal carcinoma cells by inactivating the JAK2/STAT3 pathway. Liu JR, etal., Pathol Res Pract. 2015 Jun;211(6):426-34. doi: 10.1016/j.prp.2015.01.007. Epub 2015 Jan 24.
12. Adaptative decrease in expression of the mRNA for uncoupling protein and subunit II of cytochrome c oxidase in rat brown adipose tissue during pregnancy and lactation. Martin I, etal., Biochem J. 1989 Nov 1;263(3):965-8.
13. Effects of cold environment on mitochondrial genome expression in the rat: evidence for a tissue-specific increase in the liver, independent of changes in mitochondrial gene abundance. Martin I, etal., Biochem J. 1993 Nov 15;296 ( Pt 1):231-4.
14. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
15. Non-random patterns of nucleotide substitutions and codon strategy in the mammalian mitochondrial genes coding for identified and unidentified reading frames. Pepe G, etal., Biochem Int 1983 Apr;6(4):553-63.
16. Novel 1,4-benzothazines obliterate COX-2 mediated JAK-2/STAT-3 signals with potential regulation of oxidative and metabolic stress during colorectal cancer. Rai A, etal., Pharmacol Res. 2018 Jun;132:188-203. doi: 10.1016/j.phrs.2017.12.010. Epub 2017 Dec 8.
17. Application quantitative proteomics approach to identify differentially expressed proteins associated with cardiac protection mediated by cycloastragenol in acute myocardial infarction rats. Ren YS, etal., J Proteomics. 2020 Jun 30;222:103691. doi: 10.1016/j.jprot.2020.103691. Epub 2020 Feb 14.
18. GOA pipeline RGD automated data pipeline
19. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
20. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
21. Comprehensive gene review and curation RGD comprehensive gene curation
22. Cytochrome c oxidase isoform IV-2 is involved in 3-nitropropionic acid-induced toxicity in striatal astrocytes. Singh S, etal., Glia. 2009 Nov 1;57(14):1480-91. doi: 10.1002/glia.20864.
23. WY14643 improves left ventricular myocardial mitochondrial and systolic functions in obese rats under chronic persistent hypoxia via the PPARα pathway. Yan J, etal., Life Sci. 2021 Feb 1;266:118888. doi: 10.1016/j.lfs.2020.118888. Epub 2020 Dec 10.
Additional References at PubMed
PMID:16626973   PMID:16677768   PMID:17540723   PMID:17559081   PMID:17600550   PMID:17881916   PMID:17885826   PMID:17963755   PMID:18349208   PMID:18456673   PMID:21335517   PMID:21717513  
PMID:21863308   PMID:22043833   PMID:22082260   PMID:25727371   PMID:27592455   PMID:29227865   PMID:29476059   PMID:30528878   PMID:31799638   PMID:34201437   PMID:35352799   PMID:36889213  


Genomics

Comparative Map Data
Mt-co2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2MT7,006 - 7,689 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2MT7,006 - 7,689 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2MT7,006 - 7,689 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2MT7,006 - 7,689 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2MT7,006 - 7,689 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2MT7,006 - 7,689 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblMT7,006 - 7,689 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0MT7,006 - 7,689 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblMT7,006 - 7,689 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0MT7,006 - 7,689 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4MT7,006 - 7,689 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Cytogenetic MapMT NCBI
MT-CO2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38MT7,586 - 8,269 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblMT7,586 - 8,269 (+)EnsemblGRCh38hg38GRCh38
GRCh37MT7,586 - 8,269 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36MT7,587 - 8,270 (+)NCBINCBI36Build 36hg18NCBI36
mt-Co2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39MT7,013 - 7,696 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblMT7,013 - 7,696 (+)EnsemblGRCm39 Ensembl
GRCm38MT7,013 - 7,696 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblMT7,013 - 7,696 (+)EnsemblGRCm38mm10GRCm38
MGSCv37MT7,013 - 7,696 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MT-CO2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1MT7,034 - 7,717 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblMT7,034 - 7,717 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaMT7,034 - 7,717 (+)NCBIDog10K_Boxer_Tasha
MT-CO2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblMT8,203 - 8,890 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1MT8,203 - 8,890 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2MT8,203 - 8,890 (+)NCBISscrofa10.2Sscrofa10.2susScr3

Variants

.
Variants in Mt-co2
12 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:64
Count of miRNA genes:57
Interacting mature miRNAs:61
Transcripts:ENSRNOT00000043693
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 103 79 78 47 25 47 6 196 97 83 35 52 31

Sequence

Nucleotide Sequences
GenBank Nucleotide AJ428514 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY172581 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ673907 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ673911 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ673912 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ673913 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ673916 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ919759 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ919760 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ919765 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ919766 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ919767 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ919768 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ919769 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ919770 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ919771 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GU997609 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GU997610 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM152027 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM152028 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KJ530565 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KJ939360 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KJ939361 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KM114606 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KM114607 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KM114608 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KM577635 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KM657952 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KM657953 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KM820832 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KM820834 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KM820835 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KM820836 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KP099715 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KP233832 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KP241960 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MW209726 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000043693   ⟹   ENSRNOP00000046414
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblMT7,006 - 7,689 (+)Ensembl
Rnor_6.0 EnsemblMT7,006 - 7,689 (+)Ensembl
Protein Sequences
Protein RefSeqs YP_665632 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAN77597 (Get FASTA)   NCBI Sequence Viewer  
  ABG11764 (Get FASTA)   NCBI Sequence Viewer  
  ABG11816 (Get FASTA)   NCBI Sequence Viewer  
  ABG11829 (Get FASTA)   NCBI Sequence Viewer  
  ABG11842 (Get FASTA)   NCBI Sequence Viewer  
  ABG11881 (Get FASTA)   NCBI Sequence Viewer  
  ACP50283 (Get FASTA)   NCBI Sequence Viewer  
  ACP50296 (Get FASTA)   NCBI Sequence Viewer  
  ACP50361 (Get FASTA)   NCBI Sequence Viewer  
  ACP50374 (Get FASTA)   NCBI Sequence Viewer  
  ACP50387 (Get FASTA)   NCBI Sequence Viewer  
  ACP50400 (Get FASTA)   NCBI Sequence Viewer  
  ACP50413 (Get FASTA)   NCBI Sequence Viewer  
  ACP50426 (Get FASTA)   NCBI Sequence Viewer  
  ACP50439 (Get FASTA)   NCBI Sequence Viewer  
  ADE05942 (Get FASTA)   NCBI Sequence Viewer  
  ADE05955 (Get FASTA)   NCBI Sequence Viewer  
  ADG85624 (Get FASTA)   NCBI Sequence Viewer  
  ADG85637 (Get FASTA)   NCBI Sequence Viewer  
  AHZ60969 (Get FASTA)   NCBI Sequence Viewer  
  AIU45578 (Get FASTA)   NCBI Sequence Viewer  
  AIU45591 (Get FASTA)   NCBI Sequence Viewer  
  AIU45682 (Get FASTA)   NCBI Sequence Viewer  
  AIU45695 (Get FASTA)   NCBI Sequence Viewer  
  AIU45708 (Get FASTA)   NCBI Sequence Viewer  
  AIY51545 (Get FASTA)   NCBI Sequence Viewer  
  AIZ58325 (Get FASTA)   NCBI Sequence Viewer  
  AIZ58338 (Get FASTA)   NCBI Sequence Viewer  
  AJD83435 (Get FASTA)   NCBI Sequence Viewer  
  AJE61355 (Get FASTA)   NCBI Sequence Viewer  
  AJE61381 (Get FASTA)   NCBI Sequence Viewer  
  AJE61394 (Get FASTA)   NCBI Sequence Viewer  
  AJJ48380 (Get FASTA)   NCBI Sequence Viewer  
  AJK29984 (Get FASTA)   NCBI Sequence Viewer  
  AJO99996 (Get FASTA)   NCBI Sequence Viewer  
  CAD21562 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000046414.3
GenBank Protein P00406 (Get FASTA)   NCBI Sequence Viewer  
  QQL93271 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Acc Id: ENSRNOP00000046414   ⟸   ENSRNOT00000043693
Protein Domains
Cytochrome oxidase subunit II copper A binding   Cytochrome oxidase subunit II transmembrane region

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P00406-F1-model_v2 AlphaFold P00406 1-227 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621872 AgrOrtholog
BioCyc Gene G2FUF-19 BioCyc
Ensembl Genes ENSRNOG00000030371 Ensembl, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000043693.3 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.287.90 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.40.420 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro CcO_II UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CcO_II-like_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CcO_II_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Copper_CuA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cupredoxin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_c_oxidase_su2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_c_oxidase_su2_TM_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_c_oxidase_su2_TM_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:26198 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 26198 ENTREZGENE
PANTHER CYTOCHROME C OXIDASE SUBUNIT 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR22888 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam COX2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  COX2_TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mt-co2 PhenoGen
PRINTS CYCOXIDASEII UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE COX2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  COX2_CUA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  COX2_TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000030371 RatGTEx
Superfamily-SCOP SSF49503 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF81464 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A097PE04 ENTREZGENE, UniProtKB/TrEMBL
  COX2_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q37738 ENTREZGENE
  Q80WI7 ENTREZGENE
  Q8SEZ5 ENTREZGENE, UniProtKB/TrEMBL
  S5RZM8 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary Q37738 UniProtKB/Swiss-Prot
  Q80WI7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-09 Mt-co2  mitochondrially encoded cytochrome c oxidase II  mt-Co2  cytochrome c oxidase II, mitochondrial  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-11 Krt1-9  cytochrome c oxidase II, mitochondrial  mt-Co2  cytochrome c oxidase 2, mitochondrial  Name updated to reflect Human and Mouse nomenclature 625702 APPROVED
2002-08-07 mt-Co2  cytochrome c oxidase 2, mitochondrial      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_protein one of the three mitochondrial coded subunits, among the 13 subunits of each COX monomer 724423