Acat2 (acetyl-CoA acetyltransferase 2) - Rat Genome Database

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Gene: Acat2 (acetyl-CoA acetyltransferase 2) Rattus norvegicus
Analyze
Symbol: Acat2
Name: acetyl-CoA acetyltransferase 2
RGD ID: 1359366
Description: Enables acetyl-CoA C-acetyltransferase activity. Involved in several processes, including cellular response to fatty acid; ketone body catabolic process; and liver development. Predicted to be located in cytoplasm. Predicted to be active in mitochondrion. Biomarker of premature menopause. Human ortholog(s) of this gene implicated in coronary artery disease. Orthologous to human ACAT2 (acetyl-CoA acetyltransferase 2); PARTICIPATES IN alendronate pharmacodynamics pathway; cholesterol biosynthetic pathway; cholesterol ester storage disease pathway; INTERACTS WITH 1-(3-(trifluoromethyl)phenyl)piperazine; 1-benzylpiperazine; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Ab2-076; Acat3; acetyl-CoA acetyltransferase, cytosolic; acetyl-Coenzyme A acetyltransferase 2; acetyl-Coenzyme A acetyltransferase 3; cytosolic acetoacetyl-CoA thiolase; LOC678796; MGC95138; similar to acetyl CoA transferase-like; similar to acetyl-Coenzyme A acetyltransferase 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8150,100,840 - 50,118,886 (+)NCBIGRCr8
mRatBN7.2147,695,833 - 47,713,879 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl147,695,788 - 47,752,821 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx148,244,680 - 48,262,723 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0154,232,698 - 54,250,748 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0148,320,196 - 48,338,239 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0147,972,399 - 47,992,654 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl147,972,399 - 47,992,653 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0151,757,961 - 51,776,935 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4141,922,020 - 41,940,074 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1141,924,964 - 41,943,018 (+)NCBI
Celera143,380,977 - 43,399,019 (+)NCBICelera
Cytogenetic Map1q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (ISO)
1-(3-(trifluoromethyl)phenyl)piperazine  (EXP)
1-benzylpiperazine  (EXP)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime  (ISO)
8-Br-cAMP  (ISO)
acetamide  (EXP)
acrylamide  (EXP,ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
alpha-hexachlorocyclohexane  (EXP)
amiodarone  (EXP)
ampicillin  (EXP)
Archazolid B  (ISO)
arsenous acid  (ISO)
avobenzone  (ISO)
azathioprine  (ISO)
azoxystrobin  (ISO)
beauvericin  (ISO)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bromobenzene  (EXP)
butyric acid  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
captan  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (EXP,ISO)
cisplatin  (ISO)
clozapine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
cyclosporin A  (ISO)
cyproconazole  (EXP)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
dicrotophos  (ISO)
diuron  (EXP)
endosulfan  (EXP)
enniatin  (ISO)
Enterolactone  (ISO)
entinostat  (ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (EXP)
ethanol  (ISO)
farnesol  (ISO)
fenvalerate  (EXP)
flutamide  (EXP)
folic acid  (ISO)
folpet  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
gentamycin  (EXP)
glycyrrhetinate  (ISO)
glycyrrhetinic acid  (ISO)
glycyrrhizinic acid  (ISO)
GW 4064  (ISO)
hyaluronic acid  (EXP)
hydralazine  (ISO)
hydrogen peroxide  (EXP,ISO)
hydrogen sulfide  (ISO)
indometacin  (EXP)
inulin  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
ketamine  (EXP)
lead diacetate  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
menadione  (ISO)
metformin  (EXP)
methapyrilene  (EXP)
methylazoxymethanol  (ISO)
metronidazole  (EXP)
microcystin-LR  (ISO)
N-nitrosodiethylamine  (EXP)
neomycin  (EXP)
nickel atom  (ISO)
O-methyleugenol  (ISO)
octocrylene  (ISO)
oleic acid  (ISO)
paracetamol  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenethyl isothiocyanate  (ISO)
phenobarbital  (EXP,ISO)
phenylephrine  (EXP)
picoxystrobin  (ISO)
pioglitazone  (ISO)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
progesterone  (ISO)
propiconazole  (ISO)
quercetin  (ISO)
quercetin 3-O-beta-D-glucofuranoside  (ISO)
quercetin 3-O-beta-D-glucopyranoside  (ISO)
quinolin-8-ol  (ISO)
rotenone  (EXP,ISO)
sarin  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
T-2 toxin  (EXP)
tamoxifen  (ISO)
tebuconazole  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
thapsigargin  (EXP,ISO)
thioacetamide  (EXP,ISO)
thiram  (ISO)
tolcapone  (EXP)
topotecan  (ISO)
trichloroethene  (EXP)
triphenyl phosphate  (EXP)
triptonide  (ISO)
troglitazone  (EXP)
tunicamycin  (ISO)
uranium atom  (ISO)
urethane  (ISO)
valdecoxib  (EXP)
valproic acid  (EXP,ISO)
vancomycin  (EXP)
vincaleukoblastine  (ISO)
zearalenone  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Identification, purification and characterization of an acetoacetyl-CoA thiolase from rat liver peroxisomes. Antonenkov VD, etal., Eur J Biochem. 2000 May;267(10):2981-90.
2. Liver-specific inhibition of acyl-coenzyme a:cholesterol acyltransferase 2 with antisense oligonucleotides limits atherosclerosis development in apolipoprotein B100-only low-density lipoprotein receptor-/- mice. Bell TA 3rd, etal., Arterioscler Thromb Vasc Biol. 2006 Aug;26(8):1814-20. Epub 2006 May 4.
3. The influence of chylomicron remnants on cholesteryl ester metabolism in cultured rat hepatocytes: comparison of the effects of particles enriched in n-3 or n-6 polyunsaturated fatty acids. Botham KM, etal., Biochim Biophys Acta. 2001 Dec 30;1534(2-3):96-109.
4. The effects of dietary n-3 polyunsaturated fatty acids delivered in chylomicron remnants on the transcription of genes regulating synthesis and secretion of very-low-density lipoprotein by the liver: modulation by cellular oxidative state. Botham KM, etal., Exp Biol Med (Maywood). 2003 Feb;228(2):143-51.
5. Resistance to diet-induced hypercholesterolemia and gallstone formation in ACAT2-deficient mice. Buhman KK, etal., Nat Med 2000 Dec;6(12):1341-7.
6. Impaired VLDL assembly: a novel mechanism contributing to hepatic lipid accumulation following ovariectomy and high-fat/high-cholesterol diets? Côté I, etal., Br J Nutr. 2014 Nov 28;112(10):1592-600. doi: 10.1017/S0007114514002517. Epub 2014 Sep 29.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Acyl-CoA: cholesterol acyltransferase-2 gene polymorphisms and their association with plasma lipids and coronary artery disease risks. He X, etal., Hum Genet. 2005 Dec;118(3-4):393-403. Epub 2005 Sep 30.
9. ACAT2 contributes cholesteryl esters to newly secreted VLDL, whereas LCAT adds cholesteryl ester to LDL in mice. Lee RG, etal., J Lipid Res 2005 Jun;46(6):1205-12. Epub 2005 Apr 1.
10. Dual action of neutral sphingomyelinase on rat hepatocytes: activation of cholesteryl ester metabolism and biliary cholesterol secretion and inhibition of VLDL secretion. Liza M, etal., Lipids. 2003 Jan;38(1):53-63.
11. The course of ketosis and the activity of key enzymes of ketogenesis and ketone-body utilization during development of the postnatal rat. Lockwood EA and Bailey E, Biochem J. 1971 Aug;124(1):249-54.
12. Evidence for substantial effect modification by gender in a large-scale genetic association study of the metabolic syndrome among coronary heart disease patients. McCarthy JJ, etal., Hum Genet. 2003 Dec;114(1):87-98. Epub 2003 Oct 14.
13. The acetoacetyl-coenzyme A thiolases of rat brain and their relative activities during postnatal development. Middleton B Biochem J. 1973 Apr;132(4):731-7.
14. Cerebral ketone body metabolism. Morris AA J Inherit Metab Dis. 2005;28(2):109-21.
15. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
16. Activities of enzymes of ketone-body utilization in brain and other tissues of suckling rats. Page MA, etal., Biochem J. 1971 Jan;121(1):49-53.
17. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
18. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
19. GOA pipeline RGD automated data pipeline
20. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
21. Comprehensive gene review and curation RGD comprehensive gene curation
22. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
23. Defects of cholesterol biosynthesis. Waterham HR FEBS Lett. 2006 Oct 9;580(23):5442-9. Epub 2006 Jul 20.
Additional References at PubMed
PMID:7911016   PMID:15489334   PMID:18614015   PMID:23533145   PMID:27809850   PMID:31647302  


Genomics

Comparative Map Data
Acat2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8150,100,840 - 50,118,886 (+)NCBIGRCr8
mRatBN7.2147,695,833 - 47,713,879 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl147,695,788 - 47,752,821 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx148,244,680 - 48,262,723 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0154,232,698 - 54,250,748 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0148,320,196 - 48,338,239 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0147,972,399 - 47,992,654 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl147,972,399 - 47,992,653 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0151,757,961 - 51,776,935 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4141,922,020 - 41,940,074 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1141,924,964 - 41,943,018 (+)NCBI
Celera143,380,977 - 43,399,019 (+)NCBICelera
Cytogenetic Map1q11NCBI
ACAT2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386159,762,045 - 159,779,112 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6159,762,045 - 159,779,112 (+)EnsemblGRCh38hg38GRCh38
GRCh376160,183,077 - 160,200,144 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366160,102,979 - 160,120,077 (+)NCBINCBI36Build 36hg18NCBI36
Build 346160,153,495 - 160,170,496NCBI
Celera6160,829,071 - 160,846,164 (+)NCBICelera
Cytogenetic Map6q25.3NCBI
HuRef6157,652,350 - 157,670,330 (+)NCBIHuRef
CHM1_16160,445,318 - 160,462,378 (+)NCBICHM1_1
T2T-CHM13v2.06161,007,676 - 161,024,729 (+)NCBIT2T-CHM13v2.0
Acat2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391713,161,929 - 13,179,612 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1713,161,777 - 13,179,634 (-)EnsemblGRCm39 Ensembl
GRCm381712,943,042 - 12,960,725 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1712,942,890 - 12,960,747 (-)EnsemblGRCm38mm10GRCm38
MGSCv371713,135,908 - 13,153,591 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361712,785,822 - 12,803,643 (-)NCBIMGSCv36mm8
Celera1712,974,572 - 12,992,259 (-)NCBICelera
Cytogenetic Map17A1NCBI
cM Map178.73NCBI
Acat2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543921,122,923 - 21,142,480 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543921,123,886 - 21,142,562 (-)NCBIChiLan1.0ChiLan1.0
ACAT2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25179,860,401 - 179,877,462 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16177,765,362 - 177,782,416 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06157,644,894 - 157,661,965 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16162,656,497 - 162,673,606 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6162,656,497 - 162,673,606 (+)Ensemblpanpan1.1panPan2
ACAT2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1149,011,665 - 49,029,368 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl149,011,706 - 49,029,327 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha149,853,633 - 49,871,344 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0149,196,147 - 49,214,069 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl149,196,175 - 49,214,050 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1149,078,510 - 49,096,406 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0148,949,606 - 48,967,503 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0149,564,773 - 49,582,676 (+)NCBIUU_Cfam_GSD_1.0
Acat2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946144,003,888 - 144,021,848 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648911,255,871 - 11,283,216 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648911,255,871 - 11,273,848 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACAT2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl17,598,735 - 7,612,866 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.117,600,616 - 7,612,861 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.219,399,574 - 9,411,820 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ACAT2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11387,363,527 - 87,378,002 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604059,762,875 - 59,777,018 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Acat2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248553,176,171 - 3,199,705 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248553,177,402 - 3,199,634 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Acat2
237 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:217
Count of miRNA genes:151
Interacting mature miRNAs:170
Transcripts:ENSRNOT00000033408
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331732Srn4Serum renin concentration QTL 44.467renin activity (VT:0005581)plasma renin activity level (CMO:0000116)13523959878430678Rat
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
1357397Bw41Body weight QTL 414.190.0001body mass (VT:0001259)body weight (CMO:0000012)12234064749361612Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
1331792Rf29Renal function QTL 294.589urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)13523959878430678Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)11148131282174945Rat
8552900Pigfal1Plasma insulin-like growth factor 1 level QTL 17.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)13483685879836858Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
1354643Foco2Food consumption QTL 27.170.0001eating behavior trait (VT:0001431)food intake rate (CMO:0000427)13344984878449848Rat
2302059Pia36Pristane induced arthritis QTL 363.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)14333300288333002Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
7421626Bp360Blood pressure QTL 3600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1439328949393289Rat
1357400Bw62Body weight QTL624.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)12234064767340647Rat
1357401Bw43Body weight QTL 433.75body mass (VT:0001259)body weight (CMO:0000012)12234064749361612Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
631494Bp95Blood pressure QTL 95400.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)11620621049268520Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)11148131282174945Rat
5684998Bss101Bone structure and strength QTL 1013.6tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)11543162149361612Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
5684999Bss102Bone structure and strength QTL 1025.57e-07tibia strength trait (VT:1000284)tibia stiffness (CMO:0001735)11543162149361612Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
1300167Hrtrt2Heart rate QTL 24.35heart pumping trait (VT:2000009)heart rate (CMO:0000002)11148131275088344Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)11148131282174945Rat
1331778Rf28Renal function QTL 284.66urine potassium amount (VT:0010539)urine potassium excretion rate (CMO:0000761)14580314078430678Rat
1578756Iddm22Insulin dependent diabetes mellitus QTL 222.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)11183518156835181Rat
631508Sald1Serum aldosterone level QTL 13.7blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)1985600154856001Rat
1331785Rf27Renal function QTL 274.643urine sodium amount (VT:0006274)urine sodium level (CMO:0000129)12887978078430678Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13273727390665040Rat
724520Bp145Blood pressure QTL 1452.10.0024arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12078482865784828Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)11148131282174945Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)143284731118944897Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
9589820Insglur3Insulin/glucose ratio QTL 310.750.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)13483685879836858Rat
738020Pia8Pristane induced arthritis QTL 84.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1165833076Rat
1354599Bw29Body weight QTL 293.460.001body mass (VT:0001259)body weight (CMO:0000012)13344984878449848Rat
2302038Pia31Pristane induced arthritis QTL 315.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)11099206555992065Rat
8552948Pigfal11Plasma insulin-like growth factor 1 level QTL 114.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)13483685879836858Rat
634353Rends2Renal damage susceptibility QTL 20.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)11933357156983283Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat

Markers in Region
D1Rat332  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2147,772,213 - 47,772,342 (-)MAPPERmRatBN7.2
mRatBN7.2147,746,929 - 47,747,057 (-)MAPPERmRatBN7.2
Rnor_6.0154,424,371 - 54,424,496NCBIRnor6.0
Rnor_5.0155,644,514 - 55,644,639UniSTSRnor5.0
RGSC_v3.1141,941,176 - 41,941,281RGD
Celera143,397,178 - 43,397,283UniSTS
SHRSP x BN Map124.95UniSTS
SHRSP x BN Map124.95RGD
Cytogenetic Map1q11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 22 47 31 19 31 74 31 36 11
Low 21 10 10 10 8 11 4 5 8
Below cutoff

Sequence


Ensembl Acc Id: ENSRNOT00000033408   ⟹   ENSRNOP00000059561
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl147,695,788 - 47,713,873 (+)Ensembl
Rnor_6.0 Ensembl147,972,399 - 47,992,653 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000076951   ⟹   ENSRNOP00000068312
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl147,695,788 - 47,752,821 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000077707   ⟹   ENSRNOP00000069035
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl147,972,425 - 47,991,846 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000111916   ⟹   ENSRNOP00000085078
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl147,695,788 - 47,730,867 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000114086   ⟹   ENSRNOP00000083545
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl147,695,810 - 47,724,428 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000117522   ⟹   ENSRNOP00000087001
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl147,695,810 - 47,724,428 (+)Ensembl
RefSeq Acc Id: NM_001006995   ⟹   NP_001006996
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8150,100,840 - 50,118,886 (+)NCBI
mRatBN7.2147,695,833 - 47,713,879 (+)NCBI
Rnor_6.0147,972,399 - 47,992,654 (+)NCBI
Rnor_5.0151,757,961 - 51,776,935 (-)NCBI
RGSC_v3.4141,922,020 - 41,940,074 (+)RGD
Celera143,380,977 - 43,399,019 (+)RGD
Sequence:
RefSeq Acc Id: NP_001006996   ⟸   NM_001006995
- UniProtKB: Q5XI22 (UniProtKB/Swiss-Prot),   A6KP31 (UniProtKB/TrEMBL),   F1LS48 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000059561   ⟸   ENSRNOT00000033408
Ensembl Acc Id: ENSRNOP00000069035   ⟸   ENSRNOT00000077707
Ensembl Acc Id: ENSRNOP00000068312   ⟸   ENSRNOT00000076951
Ensembl Acc Id: ENSRNOP00000085078   ⟸   ENSRNOT00000111916
Ensembl Acc Id: ENSRNOP00000087001   ⟸   ENSRNOT00000117522
Ensembl Acc Id: ENSRNOP00000083545   ⟸   ENSRNOT00000114086
Protein Domains
DUF1725   Thiolase C-terminal   Thiolase N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5XI22-F1-model_v2 AlphaFold Q5XI22 1-397 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689614
Promoter ID:EPDNEW_R138
Type:multiple initiation site
Name:Acat2_1
Description:acetyl-CoA acetyltransferase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0147,972,376 - 47,972,436EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1359366 AgrOrtholog
BioCyc Gene G2FUF-61592 BioCyc
Ensembl Genes ENSRNOG00000019189 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055027430 UniProtKB/Swiss-Prot
  ENSRNOG00060009480 UniProtKB/Swiss-Prot
  ENSRNOG00065028948 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000033408.6 UniProtKB/TrEMBL
  ENSRNOT00000076951.3 UniProtKB/TrEMBL
  ENSRNOT00000111916.1 UniProtKB/TrEMBL
  ENSRNOT00000114086.1 UniProtKB/Swiss-Prot
  ENSRNOT00000117522.1 UniProtKB/TrEMBL
  ENSRNOT00055047495 UniProtKB/Swiss-Prot
  ENSRNOT00060016014 UniProtKB/Swiss-Prot
  ENSRNOT00065050009 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.47.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7128564 IMAGE-MGC_LOAD
InterPro DUF1725 UniProtKB/TrEMBL
  Thiolase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thiolase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thiolase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thiolase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thiolase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thiolase_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:308100 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:95138 IMAGE-MGC_LOAD
NCBI Gene 308100 ENTREZGENE
PANTHER ACETYL-COA ACETYLTRANSFERASE, CYTOSOLIC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ACETYL-COA C-ACYLTRANSFERASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam DUF1725 UniProtKB/TrEMBL
  Thiolase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thiolase_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB ACAT2 RGD
PhenoGen Acat2 PhenoGen
PIRSF Ac-CoA_Ac_transf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE THIOLASE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  THIOLASE_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000019189 RatGTEx
  ENSRNOG00055027430 RatGTEx
  ENSRNOG00060009480 RatGTEx
  ENSRNOG00065028948 RatGTEx
Superfamily-SCOP SSF53901 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A096MJY8_RAT UniProtKB/TrEMBL
  A0A8I6A0J1_RAT UniProtKB/TrEMBL
  A0A8I6AFP7_RAT UniProtKB/TrEMBL
  A6KP31 ENTREZGENE, UniProtKB/TrEMBL
  F1LS48 ENTREZGENE, UniProtKB/TrEMBL
  Q5XI22 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Acat2  acetyl-CoA acetyltransferase 2  LOC678796  similar to acetyl-Coenzyme A acetyltransferase 2  Data merged from RGD:1596891 737654 PROVISIONAL
2013-03-08 Acat2  acetyl-CoA acetyltransferase 2  Acat2  acetyl-Coenzyme A acetyltransferase 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-03-07 Acat2  acetyl-Coenzyme A acetyltransferase 2  Acat3  acetyl-Coenzyme A acetyltransferase 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC678796  similar to acetyl-Coenzyme A acetyltransferase 2      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-03-30 Acat2  acetyl-Coenzyme A acetyltransferase 2  MGC95138  similar to acetyl CoA transferase-like  Symbol and Name updated 1299863 APPROVED
2005-07-29 MGC95138  similar to acetyl CoA transferase-like      Symbol and Name status set to provisional 70820 PROVISIONAL