ACAT2 (acetyl-CoA acetyltransferase 2) - Rat Genome Database

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Gene: ACAT2 (acetyl-CoA acetyltransferase 2) Sus scrofa
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Symbol: ACAT2
Name: acetyl-CoA acetyltransferase 2
RGD ID: 13962094
Description: ENCODES a protein that exhibits acetyl-CoA C-acetyltransferase activity (ortholog); INVOLVED IN bile acid signaling pathway (ortholog); brain development (ortholog); cellular response to fatty acid (ortholog); PARTICIPATES IN alendronate pharmacodynamics pathway; bile acid signaling pathway; cholesterol biosynthetic pathway; ASSOCIATED WITH arteriosclerosis (ortholog); beta-ketothiolase deficiency (ortholog); coronary artery disease (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: acetyl-CoA acetyltransferase, cytosolic; Acetyl-Coenzyme A acetyltransferase 2; sterol O-acyltransferase 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl17,598,735 - 7,612,811 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.117,600,616 - 7,612,861 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.219,399,574 - 9,411,820 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:14681463   PMID:17145712   PMID:25050817  


Genomics

Comparative Map Data
ACAT2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl17,598,735 - 7,612,811 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.117,600,616 - 7,612,861 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.219,399,574 - 9,411,820 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ACAT2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl6159,762,045 - 159,779,112 (+)EnsemblGRCh38hg38GRCh38
GRCh386159,762,045 - 159,779,112 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh376160,183,077 - 160,200,144 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366160,102,979 - 160,120,077 (+)NCBINCBI36hg18NCBI36
Build 346160,153,495 - 160,170,496NCBI
Celera6160,829,071 - 160,846,164 (+)NCBI
Cytogenetic Map6q25.3NCBI
HuRef6157,652,350 - 157,670,330 (+)NCBIHuRef
CHM1_16160,445,318 - 160,462,435 (+)NCBICHM1_1
Acat2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391713,161,929 - 13,179,612 (-)NCBIGRCm39mm39
GRCm39 Ensembl1713,161,777 - 13,179,634 (-)Ensembl
GRCm381712,943,042 - 12,960,725 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1712,942,890 - 12,960,747 (-)EnsemblGRCm38mm10GRCm38
MGSCv371713,135,908 - 13,153,591 (-)NCBIGRCm37mm9NCBIm37
MGSCv361712,785,822 - 12,803,643 (-)NCBImm8
Celera1712,974,572 - 12,992,259 (-)NCBICelera
Cytogenetic Map17A1NCBI
cM Map178.73NCBI
Acat2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2147,695,833 - 47,713,879 (+)NCBI
Rnor_6.0 Ensembl147,972,399 - 47,992,653 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0147,972,399 - 47,992,654 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0151,757,961 - 51,776,935 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4141,922,020 - 41,940,074 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1141,924,964 - 41,943,018 (+)NCBI
Celera143,380,977 - 43,399,019 (+)NCBICelera
Cytogenetic Map1q11NCBI
Acat2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543921,122,923 - 21,142,480 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543921,123,886 - 21,142,562 (-)NCBIChiLan1.0ChiLan1.0
ACAT2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.16162,656,497 - 162,673,606 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6162,656,497 - 162,673,606 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v06157,644,894 - 157,661,965 (+)NCBIMhudiblu_PPA_v0panPan3
ACAT2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1149,011,665 - 49,029,368 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl149,011,706 - 49,029,327 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha149,853,633 - 49,871,344 (+)NCBI
ROS_Cfam_1.0149,196,147 - 49,214,069 (+)NCBI
UMICH_Zoey_3.1149,078,510 - 49,096,406 (+)NCBI
UNSW_CanFamBas_1.0148,949,606 - 48,967,503 (+)NCBI
UU_Cfam_GSD_1.0149,564,773 - 49,582,676 (+)NCBI
Acat2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946144,003,888 - 144,021,848 (+)NCBI
SpeTri2.0NW_00493648911,255,871 - 11,273,848 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACAT2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11387,363,527 - 87,378,002 (+)NCBI
Acat2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248553,177,402 - 3,199,634 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 9 1
Low 10 4 3 5 2 14 2 2 3
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000004477   ⟹   ENSSSCP00000004375
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl17,600,625 - 7,612,335 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000039899   ⟹   ENSSSCP00000043380
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl17,600,618 - 7,612,810 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000044125   ⟹   ENSSSCP00000047700
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl17,598,735 - 7,612,290 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000079409   ⟹   ENSSSCP00000063447
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl17,603,993 - 7,612,811 (-)Ensembl
RefSeq Acc Id: XM_001928345   ⟹   XP_001928380
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.117,600,616 - 7,612,861 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_001928380 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein JAG69757 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_001928380   ⟸   XM_001928345
- UniProtKB: A0A287AHQ0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000043380   ⟸   ENSSSCT00000039899
RefSeq Acc Id: ENSSSCP00000047700   ⟸   ENSSSCT00000044125
RefSeq Acc Id: ENSSSCP00000063447   ⟸   ENSSSCT00000079409
RefSeq Acc Id: ENSSSCP00000004375   ⟸   ENSSSCT00000004477
Protein Domains
Thiolase_C   Thiolase_N


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000004049 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070026920 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000004375 UniProtKB/TrEMBL
  ENSSSCP00000043380 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000047700 UniProtKB/TrEMBL
  ENSSSCP00000063447 UniProtKB/TrEMBL
  ENSSSCP00070045757 UniProtKB/TrEMBL
  ENSSSCP00070045758 UniProtKB/TrEMBL
  ENSSSCP00070045759 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000004477 UniProtKB/TrEMBL
  ENSSSCT00000039899 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000044125 UniProtKB/TrEMBL
  ENSSSCT00000079409 UniProtKB/TrEMBL
  ENSSSCT00070053985 UniProtKB/TrEMBL
  ENSSSCT00070053986 UniProtKB/TrEMBL
  ENSSSCT00070053987 UniProtKB/TrEMBL
Gene3D-CATH 3.40.47.10 UniProtKB/TrEMBL
InterPro Thiolase UniProtKB/TrEMBL
  Thiolase-like UniProtKB/TrEMBL
  Thiolase_AS UniProtKB/TrEMBL
  Thiolase_C UniProtKB/TrEMBL
  Thiolase_CS UniProtKB/TrEMBL
  Thiolase_N UniProtKB/TrEMBL
KEGG Report ssc:100152303 UniProtKB/TrEMBL
NCBI Gene ACAT2 ENTREZGENE
Pfam Thiolase_C UniProtKB/TrEMBL
  Thiolase_N UniProtKB/TrEMBL
PIRSF Ac-CoA_Ac_transf UniProtKB/TrEMBL
PROSITE THIOLASE_2 UniProtKB/TrEMBL
  THIOLASE_3 UniProtKB/TrEMBL
Superfamily-SCOP SSF53901 UniProtKB/TrEMBL
TIGRFAMs AcCoA-C-Actrans UniProtKB/TrEMBL
UniProt A0A287AHQ0 ENTREZGENE, UniProtKB/TrEMBL
  A0A287AV07_PIG UniProtKB/TrEMBL
  A0A4X1VUR0_PIG UniProtKB/TrEMBL
  A0A4X1VV60_PIG UniProtKB/TrEMBL
  A0A4X1VWU7_PIG UniProtKB/TrEMBL
  A0A5G2QFE1_PIG UniProtKB/TrEMBL
  F1SB62_PIG UniProtKB/TrEMBL
VGNC ID VGNC:85005 ENTREZGENE