Cct4 (chaperonin containing TCP1 subunit 4)

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Gene: Cct4 (chaperonin containing TCP1 subunit 4) Rattus norvegicus

Analyze

Symbol:

Cct4

Name:

chaperonin containing TCP1 subunit 4

RGD ID:

727937

Description:

Predicted to enable protein folding chaperone and unfolded protein binding activity. Predicted to be involved in several processes, including positive regulation of DNA biosynthetic process; positive regulation of protein localization; and positive regulation of telomerase RNA localization to Cajal body. Predicted to act upstream of or within binding activity of sperm to zona pellucida and toxin transport. Predicted to be located in several cellular components, including cell body; microtubule cytoskeleton; and nucleoplasm. Predicted to be part of chaperonin-containing T-complex and zona pellucida receptor complex. Used to study hereditary sensory neuropathy. Orthologous to human CCT4 (chaperonin containing TCP1 subunit 4); INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

CCT-delta; chaperonin containing Tcp1, subunit 4 (delta); chaperonin subunit 4 (delta); T-complex protein 1 subunit delta; TCP-1-delta

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	CCT4 (chaperonin containing TCP1 subunit 4)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Cct4 (chaperonin containing Tcp1, subunit 4 (delta))	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Cct4 (chaperonin containing TCP1 subunit 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	CCT4 (chaperonin containing TCP1 subunit 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	CCT4 (chaperonin containing TCP1 subunit 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Cct4 (chaperonin containing TCP1 subunit 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	CCT4 (chaperonin containing TCP1 subunit 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	CCT4 (chaperonin containing TCP1 subunit 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Cct4 (chaperonin containing TCP1 subunit 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Cct4 (chaperonin containing Tcp1, subunit 4 (delta))	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	CCT4 (chaperonin containing TCP1 subunit 4)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	cct4 (chaperonin containing TCP1, subunit 4 (delta))	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	CCT4	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CCT4	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	cct-4	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	14	96,991,853 - 97,004,732 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	96,991,859 - 97,005,267 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	14	101,325,100 - 101,337,974 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	14	102,567,399 - 102,580,273 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	14	99,039,002 - 99,051,876 (+)	NCBI	Rnor_WKY
Rnor_6.0	14	107,767,392 - 107,780,270 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	107,767,392 - 107,780,270 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	14	107,843,411 - 107,856,260 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	14	103,675,110 - 103,687,893 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	14	103,694,320 - 103,707,104 (+)	NCBI
Celera	14	95,973,133 - 95,985,983 (+)	NCBI		Celera
Cytogenetic Map	14	q22	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

hereditary sensory neuropathy (IMP)

schizophrenia (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane (EXP,ISO)

1,2-dimethylhydrazine (ISO)

1-chloro-2,4-dinitrobenzene (ISO)

17alpha-ethynylestradiol (EXP,ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (EXP)

2,6-dinitrotoluene (EXP)

3-chloropropane-1,2-diol (EXP)

3-isobutyl-1-methyl-7H-xanthine (ISO)

acrylamide (EXP,ISO)

all-trans-retinoic acid (ISO)

aminoglutethimide (ISO)

antirheumatic drug (ISO)

arsenite(3-) (ISO)

benzo[a]pyrene (ISO)

benzo[e]pyrene (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

caffeine (ISO)

cannabidiol (ISO)

carbon nanotube (ISO)

casticin (ISO)

CGP 52608 (ISO)

chromium(6+) (ISO)

crocidolite asbestos (ISO)

Cuprizon (ISO)

cyclosporin A (ISO)

dexamethasone (ISO)

dinophysistoxin 1 (ISO)

doxorubicin (ISO)

endosulfan (EXP)

enzyme inhibitor (ISO)

finasteride (EXP)

flutamide (EXP)

folic acid (ISO)

furan (EXP)

gentamycin (EXP)

hyaluronic acid (EXP)

hydrogen peroxide (EXP)

indirubin (ISO)

indometacin (ISO)

ivermectin (ISO)

L-serine (ISO)

methapyrilene (ISO)

nefazodone (EXP)

nimesulide (EXP)

okadaic acid (ISO)

paraquat (EXP)

pentachlorophenol (ISO)

phenethyl isothiocyanate (EXP)

PhIP (EXP)

propiconazole (ISO)

Propiverine (EXP)

resveratrol (EXP)

rotenone (EXP)

sodium arsenite (ISO)

sulindac (EXP)

tetrachloromethane (EXP,ISO)

titanium dioxide (ISO)

trimellitic anhydride (ISO)

valdecoxib (EXP)

valproic acid (ISO)

zinc sulfate (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

binding of sperm to zona pellucida (ISO)

chaperone-mediated protein folding (ISO)

positive regulation of establishment of protein localization to telomere (ISO)

positive regulation of protein localization to Cajal body (ISO)

positive regulation of telomerase activity (ISO)

positive regulation of telomerase RNA localization to Cajal body (ISO)

positive regulation of telomere maintenance via telomerase (ISO)

protein folding (IBA,IEA,ISO)

protein stabilization (ISO)

scaRNA localization to Cajal body (ISO)

toxin transport (ISO)

Cellular Component

cell body (ISO)

centrosome (ISO)

chaperonin-containing T-complex (IBA,ISO,ISS)

cilium (IEA)

cytoplasm (IEA)

cytosol (ISO)

melanosome (IEA)

microtubule (ISO)

nucleoplasm (IEA,ISO)

zona pellucida receptor complex (ISO)

Molecular Function

ATP binding (IEA)

ATP hydrolysis activity (IEA)

ATP-dependent protein folding chaperone (IEA)

protein binding (ISO)

protein folding chaperone (ISO)

unfolded protein binding (IBA,IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Normalization and subtraction: two approaches to facilitate gene discovery.	Bonaldo MF, etal., Genome Res 1996 Sep;6(9):791-806.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Hereditary sensory neuropathy is caused by a mutation in the delta subunit of the cytosolic chaperonin-containing t-complex peptide-1 (Cct4 ) gene.	Lee MJ, etal., Hum Mol Genet 2003 Aug 1;12(15):1917-25.
4.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
5.	NCBI rat LocusLink and RefSeq merged data October 15, 2003	NCBI rat LocusLink and RefSeq merged data October 15, 2003
6.	GOA pipeline	RGD automated data pipeline
7.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
8.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:7828721	PMID:7953530	PMID:15193290	PMID:15489334	PMID:16854843	PMID:20080638	PMID:20193073	PMID:20458337	PMID:21525035	PMID:21880732	PMID:22658674	PMID:23011926
PMID:23376485	PMID:23533145	PMID:23716698	PMID:24625528	PMID:25124038	PMID:25467444	PMID:26316108	PMID:29476059	PMID:32357304	PMID:33450132

Genomics

Comparative Map Data

Cct4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	14	96,991,853 - 97,004,732 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	96,991,859 - 97,005,267 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	14	101,325,100 - 101,337,974 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	14	102,567,399 - 102,580,273 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	14	99,039,002 - 99,051,876 (+)	NCBI	Rnor_WKY
Rnor_6.0	14	107,767,392 - 107,780,270 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	107,767,392 - 107,780,270 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	14	107,843,411 - 107,856,260 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	14	103,675,110 - 103,687,893 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	14	103,694,320 - 103,707,104 (+)	NCBI
Celera	14	95,973,133 - 95,985,983 (+)	NCBI		Celera
Cytogenetic Map	14	q22	NCBI

CCT4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	61,868,085 - 61,888,671 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	2	61,868,085 - 61,888,671 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	2	62,095,220 - 62,115,806 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	61,948,766 - 61,969,295 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	2	62,006,913 - 62,027,442	NCBI
Celera	2	61,940,173 - 61,960,736 (-)	NCBI		Celera
Cytogenetic Map	2	p15	NCBI
HuRef	2	61,835,217 - 61,855,722 (-)	NCBI		HuRef
CHM1_1	2	62,025,224 - 62,045,751 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	2	61,874,246 - 61,894,829 (-)	NCBI		T2T-CHM13v2.0

Cct4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	22,940,593 - 22,953,336 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	22,940,519 - 22,953,780 (+)	Ensembl		GRCm39 Ensembl
GRCm38	11	22,990,593 - 23,003,336 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	22,990,519 - 23,003,780 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	11	22,890,593 - 22,903,336 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	11	22,890,593 - 22,903,336 (+)	NCBI		MGSCv36	mm8
Celera	11	25,126,226 - 25,138,969 (+)	NCBI		Celera
Cytogenetic Map	11	A3.2	NCBI
cM Map	11	14.25	NCBI

Cct4
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955424	22,088,949 - 22,108,514 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955424	22,088,949 - 22,108,514 (+)	NCBI	ChiLan1.0	ChiLan1.0

CCT4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	2A	63,084,090 - 63,104,530 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2A	63,084,090 - 63,105,216 (-)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	2A	61,950,477 - 61,970,783 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

CCT4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	10	61,859,148 - 61,874,030 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	10	61,859,245 - 61,874,389 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	10	61,748,927 - 61,763,778 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	10	62,867,889 - 62,882,584 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	10	62,867,244 - 62,882,587 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	10	62,551,782 - 62,566,434 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	10	62,855,534 - 62,870,428 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	10	63,151,020 - 63,165,931 (-)	NCBI		UU_Cfam_GSD_1.0

Cct4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024406292	21,330,016 - 21,346,300 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936491	7,224,692 - 7,241,358 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936491	7,224,989 - 7,241,348 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CCT4
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	79,924,507 - 79,946,207 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	3	79,924,338 - 79,941,926 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	83,760,065 - 83,777,463 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CCT4
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	14	45,086,932 - 45,106,922 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	14	45,086,920 - 45,111,271 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666045	66,727,959 - 66,748,110 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Cct4
(Heterocephalus glaber - naked mole-rat)

Naked Mole-rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624833	46,076 - 62,665 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624833	46,071 - 62,665 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Cct4
54 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	28
Count of miRNA genes:	25
Interacting mature miRNAs:	26
Transcripts:	ENSRNOT00000012847
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
631523	Pia13	Pristane induced arthritis QTL 13	3.3		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	14	40793460	98037301	Rat
2300197	Scl59	Serum cholesterol level QTL 59			blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	14	55147478	100147478	Rat
9590294	Uminl4	Urine mineral level QTL 4	5.66	0.001	urine mineral amount (VT:0015086)	urine electrolyte level (CMO:0000593)	14	55624247	100624247	Rat
9589034	Epfw11	Epididymal fat weight QTL 11	6	0.001	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	14	55624247	100624247	Rat
2317879	Alcrsp27	Alcohol response QTL 27	3.3	0.63	response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	14	56631369	101631369	Rat
634328	Hc5	Hypercalciuria QTL 5	2.3		urine calcium amount (VT:0002985)	urine calcium excretion rate (CMO:0000763)	14	58184885	103184885	Rat
1582259	Gluco23	Glucose level QTL 23	3.1	0.0008	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	14	70053989	104886043	Rat
1641900	Alcrsp11	Alcohol response QTL 11			alcohol metabolism trait (VT:0015089)	blood ethanol level (CMO:0000535)	14	70053989	104886043	Rat

Markers in Region

BE118339

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	14	97,001,371 - 97,001,556 (+)	MAPPER	mRatBN7.2
Rnor_6.0	14	107,776,910 - 107,777,094	NCBI	Rnor6.0
Rnor_5.0	14	107,852,903 - 107,853,087	UniSTS	Rnor5.0
RGSC_v3.4	14	103,684,664 - 103,684,848	UniSTS	RGSC3.4
Celera	14	95,982,642 - 95,982,826	UniSTS
RH 3.4 Map	14	766.5	UniSTS
Cytogenetic Map	14	q22	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	43	57	41	19	41	8	11	74	35	41	11	8
Low
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_182814	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC109547	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY223861	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC079283	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BQ200856	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CA340557	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CB612673	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473996	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000254	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000012847 ⟹ ENSRNOP00000012847

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	14	96,991,859 - 97,005,267 (+)	Ensembl
Rnor_6.0 Ensembl	14	107,767,392 - 107,780,270 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000109669 ⟹ ENSRNOP00000078161

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	14	96,991,859 - 97,005,267 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000116685 ⟹ ENSRNOP00000086401

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	14	96,993,448 - 97,005,267 (+)	Ensembl

RefSeq Acc Id:

NM_182814 ⟹ NP_877966

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	14	96,991,853 - 97,004,732 (+)	NCBI
Rnor_6.0	14	107,767,392 - 107,780,270 (+)	NCBI
Rnor_5.0	14	107,843,411 - 107,856,260 (+)	NCBI
RGSC_v3.4	14	103,675,110 - 103,687,893 (+)	RGD
Celera	14	95,973,133 - 95,985,983 (+)	RGD

Sequence:

show sequence

TTCCGCCTTCTCTCCCGGCGTCGCTTTCTGGAAGGTTCGTGGAGGCGGCGGCCAGGGAGACCGT
TACTCCACAGCAGGCCGGAATCCGTGTCCATCGGTCCTCCTGAACCCGCGCAGACGCCATCAAA
GTCGCCATGCCGGAGAACGTAGCTTCCCGAAGCGGGCCGCCCGCAGCGGGGCCGGGCAACCGCG
GGAAAGGCGCCTACCAGGACCGCGACAAACCGGCCCAGATCCGCTTCAGCAACATTTCCGCGGC
CAAAGCGGTTGCCGATGCCATTAGAACAAGCCTTGGACCTAAAGGAATGGACAAAATGATTCAA
GACGGAAAAGGCGATGTGACCATTACCAATGATGGTGCCACCATTCTGAAACAAATGCAAGTAT
TACACCCAGCAGCCAGAATGCTGGTGGAACTGTCCAAAGCTCAAGACATAGAAGCAGGGGATGG
CACCACGTCGGTCGTCATCATTGCTGGCTCTCTCTTAGACTCCTGTACCAAGCTTCTGCAGAAA
GGTATACATCCAACCATCATTTCCGAGTCATTCCAGAAAGCTTTGGAAAAGGGTCTTGAAATCC
TTACCGACATGTCTCGGCCTGTGCAACTGAGCGACAGAGAAACCTTGTTAAATAGTGCAACCAC
TTCATTGAACTCAAAGGTTGTCTCTCAGTATTCAAGTCTGCTCTCTCCAATGAGTGTCAATGCA
GTGATGAAAGTGATCGATCCAGCCACGGCTACCAGTGTCGATCTTAGAGATATTAAAATAGTTA
AGAAGCTTGGTGGGACGATAGATGACTGTGAGCTGGTGGAAGGCCTTGTTCTCACACAGAAAGT
GGCAAATTCTGGCATAACGAGAGTTGAGAAGGCTAAGATTGGGCTTATTCAGTTTTGCTTATCT
GCTCCTAAAACAGATATGGATAATCAGATAGTAGTATCTGACTACGCCCAGATGGATCGAGTGC
TTCGAGAAGAAAGAGCCTATATTTTAAATTTGGTGAAGCAAATTAAGAAAACAGGATGTAATGT
CCTTCTCATACAGAAGTCTATTCTAAGAGATGCACTTAGTGATCTTGCGTTACATTTTCTGAAT
AAAATGAAGATTATGGTGGTTAAGGACATTGAAAGAGAAGACATTGAATTCATCTGTAAGACAA
TTGGAACCAAACCAGTGGCTCACATTGACCAGTTCACTCCTGACATGCTGGGTTCTGCTGAGTT
AGCAGAGGAAGTCAGTTTGAATGGTTCTGGAAAACTGTTCAAGATTACAGGCTGTACAAGCCCA
GGCAAAACAGTGACAATTGTCGTCCGAGGCTCTAACAAACTGGTGATTGAGGAAGCTGAGCGCT
CCATTCACGATGCTCTCTGTGTTATCCGATGCTTGGTGAAGAAGAGAGCTCTTATTGCAGGAGG
TGGTGCTCCAGAAATAGAGCTGGCCCTCAGACTGACGGAGTACTCCCGGACACTGAGTGGCATG
GAGTCCTACTGTGTTCGAGCTTTTGCAGATGCCATGGAAGTCATTCCATCTACACTGGCTGAAA
ATGCTGGCCTGAATCCCATCTCTACTGTAACAGAGCTAAGAAACCGCCATGCCCAAGGAGAAAA
AACTACAGGCATTAATGTCCGAAAGGGTGGGATCTCCAACATTCTGGAGGAAATGGTTGTCCAG
CCTCTGTTGGTGTCAGTCAGTGCGTTGACCCTAGCAACTGAAACTGTGCGGAGCATTCTGAAAA
TTGATGATGTGGTAAATACTCGATAATCTGGATGAGGCTGGCTGACTGGCACGAGTATGGAGAG
AAGTATTGTGGCTAGAGTGGAAGATGATGGCCTTGTTCCTTGTCTGGGAGCTTGCTTCTTCAGA
GTTTTTGGACATTGTCTTGCAGTTGGCATTTGTTGGGAATTGTATTGAAACAATTTAATGAAAA
TATTAAATACTTGGTTTTAAACTCCATATTTGTCATTCCAAAGCTATATTGTTTTTAATACTTT
GGGGGAAATGCCTATAGGTAAACTACAGCCCTCAAAATTTAACATTTACCTATTGATCTAACCC
CTTAGTCCTGTGTATTCTTGGTTGGTTCATCTGTGGTTGTATTTGTTTGTTGAGACATTCTA

hide sequence

Protein Sequences


Protein RefSeqs	NP_877966	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH79283	(Get FASTA)	NCBI Sequence Viewer
	AAP46161	(Get FASTA)	NCBI Sequence Viewer
	EDL97980	(Get FASTA)	NCBI Sequence Viewer
	Q7TPB1	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_877966 ⟸ NM_182814

- UniProtKB:

Q7TPB1 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MPENVASRSGPPAAGPGNRGKGAYQDRDKPAQIRFSNISAAKAVADAIRTSLGPKGMDKMIQDG
KGDVTITNDGATILKQMQVLHPAARMLVELSKAQDIEAGDGTTSVVIIAGSLLDSCTKLLQKGI
HPTIISESFQKALEKGLEILTDMSRPVQLSDRETLLNSATTSLNSKVVSQYSSLLSPMSVNAVM
KVIDPATATSVDLRDIKIVKKLGGTIDDCELVEGLVLTQKVANSGITRVEKAKIGLIQFCLSAP
KTDMDNQIVVSDYAQMDRVLREERAYILNLVKQIKKTGCNVLLIQKSILRDALSDLALHFLNKM
KIMVVKDIEREDIEFICKTIGTKPVAHIDQFTPDMLGSAELAEEVSLNGSGKLFKITGCTSPGK
TVTIVVRGSNKLVIEEAERSIHDALCVIRCLVKKRALIAGGGAPEIELALRLTEYSRTLSGMES
YCVRAFADAMEVIPSTLAENAGLNPISTVTELRNRHAQGEKTTGINVRKGGISNILEEMVVQPL
LVSVSALTLATETVRSILKIDDVVNTR

hide sequence

RefSeq Acc Id:

ENSRNOP00000012847 ⟸ ENSRNOT00000012847

RefSeq Acc Id:

ENSRNOP00000078161 ⟸ ENSRNOT00000109669

RefSeq Acc Id:

ENSRNOP00000086401 ⟸ ENSRNOT00000116685

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q7TPB1-F1-model_v2	AlphaFold	Q7TPB1	1-539	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13699519

Promoter ID:

EPDNEW_R10043

Type:

initiation region

Name:

Cct4_1

Description:

chaperonin containing TCP1 subunit 4

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	14	107,767,398 - 107,767,458	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:727937	AgrOrtholog
BioCyc Gene	G2FUF-14788	BioCyc
Ensembl Genes	ENSRNOG00000009642	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000012847	ENTREZGENE, UniProtKB/Swiss-Prot
	ENSRNOP00000078161.1	UniProtKB/TrEMBL
	ENSRNOP00000086401.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000012847	ENTREZGENE, UniProtKB/Swiss-Prot
	ENSRNOT00000109669.1	UniProtKB/TrEMBL
	ENSRNOT00000116685.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.560.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	3.30.260.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	3.50.7.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7134210	IMAGE-MGC_LOAD
InterPro	Chap_CCT_delta	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Chaperone_TCP-1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Chaperonin_TCP-1_CS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Cpn60/GroEL/TCP-1	UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
	GroEL-like_apical_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GROEL-like_equatorial_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TCP-1-like_intermed_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:29374	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:94410	IMAGE-MGC_LOAD
NCBI Gene	29374	ENTREZGENE
PANTHER	PTHR11353	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Cpn60_TCP1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Cct4	PhenoGen
PRINTS	TCOMPLEXTCP1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	TCP1_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TCP1_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TCP1_3	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF48592	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF52029	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF54849	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs	chap_CCT_delta	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A8I5YC75_RAT	UniProtKB/TrEMBL
	A0A8I6A646_RAT	UniProtKB/TrEMBL
	Q7TPB1	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-01-13	Cct4	chaperonin containing TCP1 subunit 4	Cct4	chaperonin containing Tcp1, subunit 4 (delta)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-09-29	Cct4	chaperonin containing Tcp1, subunit 4 (delta)	Cct4	chaperonin subunit 4 (delta)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2004-12-14	Cct4	chaperonin subunit 4 (delta)			Symbol and Name status set to approved	1299863	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_mutations_overexpression	1349G>A mutation causes hereditary sensory neuropathy	1299607

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar