Acot12 (acyl-CoA thioesterase 12) - Rat Genome Database

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Gene: Acot12 (acyl-CoA thioesterase 12) Rattus norvegicus
Analyze
Symbol: Acot12
Name: acyl-CoA thioesterase 12
RGD ID: 619752
Description: Enables acetyl-CoA hydrolase activity and identical protein binding activity. Involved in acyl-CoA metabolic process. Located in cytosol. Used to study liver cancer. Orthologous to human ACOT12 (acyl-CoA thioesterase 12); PARTICIPATES IN Leigh disease pathway; primary hyperoxaluria type 2 pathway; pyruvate decarboxylase deficiency pathway; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: acetyl-coenzyme A thioesterase; acyl-CoA thioester hydrolase 12; acyl-coenzyme A thioesterase 12; Cach; CACH-1; cytoplasmic acetyl-CoA hydrolase; cytoplasmic acetyl-CoA hydrolase 1; cytosolic acetyl-CoA hydrolase; rACH; rCACH-1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2222,986,867 - 23,027,538 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl222,986,626 - 23,027,536 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx230,027,186 - 30,067,868 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0228,127,527 - 28,168,209 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0222,946,811 - 22,987,990 (+)NCBIRnor_WKY
Rnor_6.0220,857,056 - 20,901,656 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl220,857,202 - 20,901,659 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0248,055,053 - 48,096,606 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4221,984,849 - 22,035,224 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1221,905,217 - 21,955,593 (+)NCBI
Celera219,090,138 - 19,130,693 (+)NCBICelera
Cytogenetic Map2q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (IBA,IDA,IEA,ISO)
intercellular bridge  (IEA,ISO)
nucleoplasm  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. The biphasic change of cytosolic acetyl-CoA hydrolase in rat liver during 3'-methyl-4-dimethylaminoazobenzene hepatocarcinogenesis. Ebisuno S, etal., Jpn J Cancer Res. 1989 Feb;80(2):132-5.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Molecular cloning and functional expression of rat liver cytosolic acetyl-CoA hydrolase. Suematsu N, etal., Eur J Biochem 2001 May;268(9):2700-9.
12. On the regulation of cold-labile cytosolic and of mitochondrial acetyl-CoA hydrolase in rat liver. Söling HD and Rescher C, Eur J Biochem. 1985 Feb 15;147(1):111-7.
Additional References at PubMed
PMID:12545200   PMID:16103133   PMID:16476568   PMID:23709691  


Genomics

Comparative Map Data
Acot12
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2222,986,867 - 23,027,538 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl222,986,626 - 23,027,536 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx230,027,186 - 30,067,868 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0228,127,527 - 28,168,209 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0222,946,811 - 22,987,990 (+)NCBIRnor_WKY
Rnor_6.0220,857,056 - 20,901,656 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl220,857,202 - 20,901,659 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0248,055,053 - 48,096,606 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4221,984,849 - 22,035,224 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1221,905,217 - 21,955,593 (+)NCBI
Celera219,090,138 - 19,130,693 (+)NCBICelera
Cytogenetic Map2q12NCBI
ACOT12
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38581,308,609 - 81,394,134 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl581,329,996 - 81,394,179 (-)EnsemblGRCh38hg38GRCh38
GRCh37580,625,815 - 80,689,953 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36580,661,839 - 80,725,712 (-)NCBINCBI36Build 36hg18NCBI36
Build 34580,661,838 - 80,725,712NCBI
Celera576,530,237 - 76,594,485 (-)NCBICelera
Cytogenetic Map5q14.1NCBI
HuRef575,834,814 - 75,898,818 (-)NCBIHuRef
CHM1_1580,058,759 - 80,122,826 (-)NCBICHM1_1
T2T-CHM13v2.0581,814,586 - 81,878,724 (-)NCBIT2T-CHM13v2.0
Acot12
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391391,889,445 - 91,934,267 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1391,889,631 - 91,934,267 (+)EnsemblGRCm39 Ensembl
GRCm381391,741,326 - 91,786,148 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1391,741,512 - 91,786,148 (+)EnsemblGRCm38mm10GRCm38
MGSCv371391,881,126 - 91,925,753 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361392,215,760 - 92,260,387 (+)NCBIMGSCv36mm8
Celera1395,375,248 - 95,419,932 (+)NCBICelera
Cytogenetic Map13C3NCBI
Acot12
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541828,829,144 - 28,875,486 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541828,829,316 - 28,872,629 (+)NCBIChiLan1.0ChiLan1.0
ACOT12
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1534,196,456 - 34,260,652 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl534,196,504 - 34,260,254 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0533,885,302 - 33,950,075 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
ACOT12
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1325,928,356 - 25,979,688 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl325,928,394 - 25,971,378 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha327,164,302 - 27,215,764 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0325,842,682 - 25,894,121 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl325,842,690 - 25,885,817 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1325,794,545 - 25,845,903 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0325,763,842 - 25,815,461 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0326,043,885 - 26,095,246 (+)NCBIUU_Cfam_GSD_1.0
Acot12
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213181,944,364 - 181,989,976 (+)NCBIHiC_Itri_2
SpeTri2.0NW_004936469635,663 - 681,373 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACOT12
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl289,855,162 - 89,905,111 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1289,855,159 - 89,905,105 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2291,785,951 - 91,815,862 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ACOT12
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1475,398,361 - 75,543,933 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl475,469,424 - 75,535,267 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604924,343,822 - 24,409,316 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Acot12
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247431,851,068 - 1,883,255 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247431,849,498 - 1,883,250 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631682Bp115Blood pressure QTL 1154.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2137410502Rat
738010Lnnr3Liver neoplastic nodule remodeling QTL 32.94liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)2141244106Rat
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)25873687102844969Rat
61368Mcs1Mammary carcinoma susceptibility QTL 14.4mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)2788777223319447Rat
1600379Mcs18Mammary carcinoma susceptibility QTL 182.6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)2788777242804738Rat
738012Anxrr3Anxiety related response QTL 33.8exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)2902351954023519Rat
10755430Coatc6Coat color QTL 60.02576coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)21159110056591100Rat
1578664Bmd9Bone mineral QTL density 95femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)21185206249003364Rat
731184Mamtr4Mammary tumor resistance QTL 40.0003mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)21649174061491740Rat
1357990Ael1Aortic elastin QTL 13.10.00091aorta elastin amount (VT:0003905)aortic elastin21907682564076825Rat
731167Glom4Glomerulus QTL 42.40.0082kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)22030467265304672Rat
2300168Bmd47Bone mineral density QTL 476.60.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)22066244865662448Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:39
Count of miRNA genes:39
Interacting mature miRNAs:39
Transcripts:ENSRNOT00000021675
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 23 23 23 5
Low 2 10 8 8 1 20 2 1
Below cutoff 1 10 19 6 16 6 6 6 15 10 22 10 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000078919   ⟹   ENSRNOP00000075534
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl222,986,626 - 23,027,536 (+)Ensembl
Rnor_6.0 Ensembl220,857,202 - 20,901,659 (+)Ensembl
RefSeq Acc Id: NM_130747   ⟹   NP_570103
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2222,986,867 - 23,027,538 (+)NCBI
Rnor_6.0220,857,428 - 20,898,981 (+)NCBI
Rnor_5.0248,055,053 - 48,096,606 (-)NCBI
RGSC_v3.4221,984,849 - 22,035,224 (+)RGD
Celera219,090,138 - 19,130,693 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_570103 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAB39852 (Get FASTA)   NCBI Sequence Viewer  
  EDM10006 (Get FASTA)   NCBI Sequence Viewer  
  Q99NB7 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_570103   ⟸   NM_130747
- UniProtKB: Q99NB7 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000075534   ⟸   ENSRNOT00000078919
Protein Domains
HotDog ACOT-type   START

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q99NB7-F1-model_v2 AlphaFold Q99NB7 1-556 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (mRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619752 AgrOrtholog
BioCyc Gene G2FUF-54878 BioCyc
Ensembl Genes ENSRNOG00000061414 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000075534 ENTREZGENE
  ENSRNOP00000075534.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000078919 ENTREZGENE
  ENSRNOT00000078919.2 UniProtKB/TrEMBL
Gene3D-CATH 3.30.530.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cytosol_ACT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HOTDOG_ACOT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HotDog_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  START-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  START_lipid-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thioestr_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:170570 UniProtKB/Swiss-Prot
NCBI Gene 170570 ENTREZGENE
PANTHER PTHR11049 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 4HBT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  START UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Acot12 PhenoGen
PROSITE HOTDOG_ACOT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  START UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART START UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF54637 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2KAU8_RAT UniProtKB/TrEMBL
  ACO12_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Acot12  acyl-CoA thioesterase 12  Cach  cytosolic acetyl-CoA hydrolase  Symbol and Name updated 1299863 APPROVED
2005-01-20 Cach  cytosolic acetyl-CoA hydrolase  rACH  cytoplasmic acetyl-CoA hydrolase  Symbol and Name updated 1299863 APPROVED
2002-08-07 rACH  cytoplasmic acetyl-CoA hydrolase      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_protein 556 amino-acid residues and 62,017 Da 633789