RGD Reference Report - The biphasic change of cytosolic acetyl-CoA hydrolase in rat liver during 3'-methyl-4-dimethylaminoazobenzene hepatocarcinogenesis. - Rat Genome Database

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The biphasic change of cytosolic acetyl-CoA hydrolase in rat liver during 3'-methyl-4-dimethylaminoazobenzene hepatocarcinogenesis.

Authors: Ebisuno, S  Isohashi, F  Nakanishi, Y  Higashi, T  Sakamoto, Y 
Citation: Ebisuno S, etal., Jpn J Cancer Res. 1989 Feb;80(2):132-5.
RGD ID: 13831129
Pubmed: PMID:2566591   (View Abstract at PubMed)
PMCID: PMC5917701   (View Article at PubMed Central)

When Donryu male albino rats were given diet containing 0.06% 3'-methyl-4-dimethyl-aminoazobenzene (3'-Me-DAB) for 20 weeks, the activity of cytosolic acetyl-CoA hydrolase in their livers decreased to about one-third the initial level in week 2, returned to the control level in week 7, and then decreased again to about one-tenth of the control in week 20. These changes in enzyme activity were parallel with changes in the amount of enzyme protein determined by ELISA. In 3'-Me-DAB-resistant rats, however, the enzyme activity and enzyme protein remained within the normal range during administration of 3'-Me-DAB-containing diet for 20 weeks and no tumors were detectable macroscopically. Interestingly, the biphasic change in this enzyme activity was inversely associated with the well known change of gamma-glutamyltranspeptidase activity during azo-dye-induced hepatocarcinogenesis.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
liver cancer  ISOAcot12 (Rattus norvegicus)13831129; 13831129 RGD 
liver cancer  IDA 13831129 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Acot12  (acyl-CoA thioesterase 12)

Genes (Mus musculus)
Acot12  (acyl-CoA thioesterase 12)

Genes (Homo sapiens)
ACOT12  (acyl-CoA thioesterase 12)


Additional Information