Acot12 (acyl-CoA thioesterase 12) - Rat Genome Database

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Gene: Acot12 (acyl-CoA thioesterase 12) Ictidomys tridecemlineatus
Analyze
Symbol: Acot12
Name: acyl-CoA thioesterase 12
RGD ID: 12452765
Description: ENCODES a protein that exhibits acetyl-CoA hydrolase activity (ortholog); identical protein binding (ortholog); INVOLVED IN acetyl-CoA metabolic process (ortholog); PARTICIPATES IN Leigh disease pathway; primary hyperoxaluria type 2 pathway; pyruvate decarboxylase deficiency pathway; ASSOCIATED WITH genetic disease (ortholog); liver cancer (ortholog); Neurodevelopmental Disorders (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); extracellular exosome (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: acetyl-coenzyme A thioesterase; acyl-coenzyme A thioesterase 12
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213181,944,364 - 181,989,976 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936469636,315 - 681,376 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936469635,663 - 681,373 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Acot12
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213181,944,364 - 181,989,976 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936469636,315 - 681,376 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936469635,663 - 681,373 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACOT12
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38581,308,609 - 81,394,134 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl581,329,996 - 81,394,179 (-)EnsemblGRCh38hg38GRCh38
GRCh37580,625,815 - 80,689,953 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36580,661,839 - 80,725,712 (-)NCBINCBI36Build 36hg18NCBI36
Build 34580,661,838 - 80,725,712NCBI
Celera576,530,237 - 76,594,485 (-)NCBICelera
Cytogenetic Map5q14.1NCBI
HuRef575,834,814 - 75,898,818 (-)NCBIHuRef
CHM1_1580,058,759 - 80,122,826 (-)NCBICHM1_1
T2T-CHM13v2.0581,793,197 - 81,878,724 (-)NCBIT2T-CHM13v2.0
Acot12
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391391,889,635 - 91,934,271 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1391,889,631 - 91,934,267 (+)EnsemblGRCm39 Ensembl
GRCm381391,741,326 - 91,786,148 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1391,741,512 - 91,786,148 (+)EnsemblGRCm38mm10GRCm38
MGSCv371391,881,126 - 91,925,753 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361392,215,760 - 92,260,387 (+)NCBIMGSCv36mm8
Celera1395,375,248 - 95,419,932 (+)NCBICelera
Cytogenetic Map13C3NCBI
cM Map1347.43NCBI
Acot12
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8224,721,648 - 24,763,686 (+)NCBIGRCr8
mRatBN7.2222,986,867 - 23,027,538 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl222,986,626 - 23,027,536 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx230,027,186 - 30,067,868 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0228,127,527 - 28,168,209 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0222,946,811 - 22,987,990 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0220,857,056 - 20,901,656 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl220,857,202 - 20,901,659 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0248,055,053 - 48,096,606 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4221,984,849 - 22,035,224 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1221,905,217 - 21,955,593 (+)NCBI
Celera219,090,138 - 19,130,693 (+)NCBICelera
Cytogenetic Map2q12NCBI
Acot12
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541828,829,144 - 28,875,486 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541828,829,316 - 28,872,629 (+)NCBIChiLan1.0ChiLan1.0
ACOT12
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2433,906,886 - 33,972,212 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1532,060,511 - 32,125,642 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0533,885,302 - 33,950,075 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1534,196,456 - 34,260,652 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl534,196,504 - 34,260,254 (+)Ensemblpanpan1.1panPan2
ACOT12
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1325,928,356 - 25,979,688 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl325,928,394 - 25,971,378 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha327,164,302 - 27,215,764 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0325,842,682 - 25,894,121 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl325,842,690 - 25,885,817 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1325,794,545 - 25,845,903 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0325,763,842 - 25,815,461 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0326,043,885 - 26,095,246 (+)NCBIUU_Cfam_GSD_1.0
ACOT12
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl289,855,162 - 89,905,111 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1289,855,159 - 89,905,105 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2291,785,951 - 91,815,862 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ACOT12
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1475,398,361 - 75,543,933 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl475,469,424 - 75,535,267 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604924,343,822 - 24,409,316 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Acot12
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247431,851,068 - 1,883,255 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247431,849,498 - 1,883,250 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSSTOT00000001412   ⟹   ENSSTOP00000001266
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_004936469636,315 - 681,376 (-)Ensembl
RefSeq Acc Id: XM_005315647   ⟹   XP_005315704
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024407213181,944,364 - 181,989,976 (+)NCBI
SpeTri2.0NW_004936469635,663 - 681,373 (-)NCBI
Sequence:
RefSeq Acc Id: XM_040272516   ⟹   XP_040128450
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024407213181,949,403 - 181,989,976 (+)NCBI
RefSeq Acc Id: XM_040272517   ⟹   XP_040128451
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024407213181,949,403 - 181,989,976 (+)NCBI
RefSeq Acc Id: XM_040272518   ⟹   XP_040128452
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024407213181,954,675 - 181,989,976 (+)NCBI
RefSeq Acc Id: XM_040272519   ⟹   XP_040128453
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024407213181,954,675 - 181,989,976 (+)NCBI
Protein Sequences
Protein RefSeqs XP_005315704 (Get FASTA)   NCBI Sequence Viewer  
  XP_040128450 (Get FASTA)   NCBI Sequence Viewer  
  XP_040128451 (Get FASTA)   NCBI Sequence Viewer  
  XP_040128452 (Get FASTA)   NCBI Sequence Viewer  
  XP_040128453 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000001266.3
GenBank Protein KAG3266425 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: XP_005315704   ⟸   XM_005315647
- Peptide Label: isoform X1
- UniProtKB: I3LYJ2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_040128451   ⟸   XM_040272517
- Peptide Label: isoform X2
RefSeq Acc Id: XP_040128450   ⟸   XM_040272516
- Peptide Label: isoform X2
RefSeq Acc Id: XP_040128452   ⟸   XM_040272518
- Peptide Label: isoform X2
RefSeq Acc Id: XP_040128453   ⟸   XM_040272519
- Peptide Label: isoform X2
RefSeq Acc Id: ENSSTOP00000001266   ⟸   ENSSTOT00000001412
Protein Domains
HotDog ACOT-type   START


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000001413 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000001412.3 UniProtKB/TrEMBL
Gene3D-CATH 3.30.530.20 UniProtKB/TrEMBL
  Hotdog Thioesterase UniProtKB/TrEMBL
InterPro Cytosol_ACT UniProtKB/TrEMBL
  HOTDOG_ACOT UniProtKB/TrEMBL
  HotDog_dom_sf UniProtKB/TrEMBL
  START-like_dom_sf UniProtKB/TrEMBL
  START_lipid-bd_dom UniProtKB/TrEMBL
  Thioestr_dom UniProtKB/TrEMBL
NCBI Gene Acot12 ENTREZGENE
PANTHER ACETYL-COENZYME A THIOESTERASE UniProtKB/TrEMBL
  PTHR11049 UniProtKB/TrEMBL
Pfam 4HBT UniProtKB/TrEMBL
  START UniProtKB/TrEMBL
PROSITE HOTDOG_ACOT UniProtKB/TrEMBL
  START UniProtKB/TrEMBL
Superfamily-SCOP Bet v1-like UniProtKB/TrEMBL
  SSF54637 UniProtKB/TrEMBL
UniProt I3LYJ2 ENTREZGENE, UniProtKB/TrEMBL