Anpep (alanyl aminopeptidase, membrane) - Rat Genome Database

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Gene: Anpep (alanyl aminopeptidase, membrane) Rattus norvegicus
Analyze
Symbol: Anpep
Name: alanyl aminopeptidase, membrane
RGD ID: 2991
Description: Enables aminopeptidase activity and peptide binding activity. Involved in metanephric proximal tubule development; peptide catabolic process; and protein processing. Located in brush border membrane. Orthologous to human ANPEP (alanyl aminopeptidase, membrane); PARTICIPATES IN angiotensin IV signaling pathway; renin-angiotensin cascade pathway; glutathione metabolic pathway; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,2,2-tetramine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: alanyl (membrane) aminopeptidase; alanyl aminopeptidase; aminopeptidase M; aminopeptidase N; AP-M; AP-N; Apm; APN; cluster of differentiation antigen 13 (CD13); kidney aminopeptidase M; kidney Zn peptidase; KZP; Lap1; leucine arylaminopeptidase 1; membrane alanine aminopeptidase; microsomal aminopeptidase; rAPN
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Mcs32
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81143,176,645 - 143,219,447 (-)NCBIGRCr8
mRatBN7.21133,767,332 - 133,810,137 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1133,767,332 - 133,785,789 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1141,676,519 - 141,695,002 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01148,845,924 - 148,864,407 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01141,763,630 - 141,782,111 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01141,561,364 - 141,604,249 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1141,561,334 - 141,604,273 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01142,522,426 - 142,565,721 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41135,600,751 - 135,619,208 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11135,679,156 - 135,697,614 (-)NCBI
Celera1125,830,648 - 125,849,086 (-)NCBICelera
RH 3.4 Map11063.2RGD
Cytogenetic Map1q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,10-phenanthroline  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP,ISO)
2,2,2-tetramine  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-bromohexadecanoic acid  (ISO)
2-palmitoylglycerol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acetylsalicylic acid  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
Aroclor 1254  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzene  (EXP,ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
buta-1,3-diene  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
chromium(6+)  (ISO)
chrysene  (ISO)
cisplatin  (ISO)
cobalt dichloride  (EXP,ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (EXP,ISO)
daidzein  (ISO)
daidzein 7-O-beta-D-glucoside  (ISO)
DDT  (EXP)
deoxynivalenol  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dicrotophos  (ISO)
diethylstilbestrol  (ISO)
diuron  (EXP)
elemental selenium  (ISO)
endosulfan  (EXP)
ethylenediaminetetraacetic acid  (ISO)
fenthion  (ISO)
flutamide  (EXP)
folic acid  (ISO)
furan  (EXP)
genistein  (ISO)
genistein 7-O-beta-D-glucoside  (ISO)
gentamycin  (EXP,ISO)
glycitein  (ISO)
glycitin  (ISO)
GW 4064  (ISO)
inulin  (ISO)
ivermectin  (ISO)
L-ascorbic acid  (ISO)
methidathion  (ISO)
methotrexate  (ISO)
methylmercury chloride  (ISO)
methylmercury(1+)  (EXP)
mifepristone  (ISO)
nefazodone  (EXP)
nickel atom  (ISO)
nickel sulfate  (ISO)
nimesulide  (EXP)
ozone  (ISO)
paracetamol  (ISO)
PD 0325901  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP,ISO)
pirimiphos-methyl  (EXP)
pirinixic acid  (ISO)
porphyrins  (ISO)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
quercetin  (ISO)
rotenone  (ISO)
selenium atom  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
simvastatin  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
sotorasib  (ISO)
streptozocin  (EXP)
succimer  (ISO)
tacrolimus hydrate  (EXP)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (ISO)
Tesaglitazar  (EXP)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
tobramycin  (EXP)
toluene  (EXP)
trametinib  (ISO)
trichloroethene  (EXP)
triphenyl phosphate  (ISO)
Triptolide  (EXP)
triptonide  (ISO)
troglitazone  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Renin-angiotensin system-regulating aminopeptidase activities are modified in the pineal gland of rats with breast cancer induced by N-methyl-nitrosourea. Carrera MP, etal., Cancer Invest. 2006 Mar;24(2):149-53.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
5. Elucidating the molecular physiopathology of acute respiratory distress syndrome in severe acute respiratory syndrome patients. Kong SL, etal., Virus Res. 2009 Nov;145(2):260-9. Epub 2009 Jul 25.
6. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
7. Targeting the renin-angiotensin system: what's new? Leckie BJ Curr Med Chem Cardiovasc Hematol Agents. 2005 Jan;3(1):23-32.
8. Molecular cloning and amino acid sequence of rat kidney aminopeptidase M: a member of a super family of zinc-metallohydrolases. Malfroy B, etal., Biochem Biophys Res Commun 1989 May 30;161(1):236-41.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Renogenic characterization and in vitro differentiation of rat amniotic fluid stem cells into renal proximal tubular- and juxtaglomerular-like cells. Minocha E, etal., In Vitro Cell Dev Biol Anim. 2019 Feb;55(2):138-147. doi: 10.1007/s11626-018-00315-2. Epub 2019 Jan 15.
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. Intrarenal aminopeptidase N inhibition restores defective angiontesin II type 2-mediated natriuresis in spontaneously hypertensive rats. Padia SH, etal., Hypertension. 2010 Feb;55(2):474-80. Epub 2009 Dec 7.
13. Insulin-regulated aminopeptidase/placental leucil Aminopeptidase (IRAP/P-lAP) and angiotensin IV-forming activities are modified in serum of rats with breast cancer induced by N-methyl-nitrosourea. Pilar Carrera M, etal., Anticancer Res. 2006 Mar-Apr;26(2A):1011-4.
14. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
15. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
16. The luminal membrane of rat thick limb expresses AT1 receptor and aminopeptidase activities. Poumarat JS, etal., Kidney Int. 2002 Aug;62(2):434-45.
17. GOA pipeline RGD automated data pipeline
18. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. Rat brain contains high levels of mannose-6-phosphorylated glycoproteins including lysosomal enzymes and palmitoyl-protein thioesterase, an enzyme implicated in infantile neuronal lipofuscinosis. Sleat DE, etal., J Biol Chem. 1996 Aug 9;271(32):19191-8.
21. Amino acid sequence deduced from a rat kidney cDNA suggests it encodes the Zn-peptidase aminopeptidase N. Watt VM and Yip CC, J Biol Chem 1989 Apr 5;264(10):5480-7.
22. Human aminopeptidase N is a receptor for human coronavirus 229E. Yeager CL, etal., Nature 1992 Jun 4;357(6377):420-2.
Additional References at PubMed
PMID:1673322   PMID:2564851   PMID:9305626   PMID:9765589   PMID:11672613   PMID:15308636   PMID:15326289   PMID:16502470   PMID:17169335   PMID:17242304   PMID:17519555   PMID:17897319  
PMID:17952634   PMID:18547641   PMID:19056867   PMID:19199708   PMID:19876009   PMID:20096929   PMID:20851150   PMID:21082674   PMID:21708977   PMID:21982785   PMID:22206666   PMID:22373413  
PMID:23376485   PMID:23533145   PMID:23894332   PMID:25461922   PMID:25645918   PMID:26449746   PMID:30531704   PMID:36765308  


Genomics

Comparative Map Data
Anpep
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81143,176,645 - 143,219,447 (-)NCBIGRCr8
mRatBN7.21133,767,332 - 133,810,137 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1133,767,332 - 133,785,789 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1141,676,519 - 141,695,002 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01148,845,924 - 148,864,407 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01141,763,630 - 141,782,111 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01141,561,364 - 141,604,249 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1141,561,334 - 141,604,273 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01142,522,426 - 142,565,721 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41135,600,751 - 135,619,208 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11135,679,156 - 135,697,614 (-)NCBI
Celera1125,830,648 - 125,849,086 (-)NCBICelera
RH 3.4 Map11063.2RGD
Cytogenetic Map1q31NCBI
ANPEP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381589,784,895 - 89,814,852 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1589,784,895 - 89,815,401 (-)EnsemblGRCh38hg38GRCh38
GRCh371590,328,126 - 90,358,084 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361588,129,130 - 88,159,076 (-)NCBINCBI36Build 36hg18NCBI36
Build 341588,129,130 - 88,150,938NCBI
Celera1566,730,914 - 66,760,859 (-)NCBICelera
Cytogenetic Map15q26.1NCBI
HuRef1566,440,812 - 66,470,613 (-)NCBIHuRef
CHM1_11590,169,132 - 90,199,097 (-)NCBICHM1_1
T2T-CHM13v2.01587,540,783 - 87,570,713 (-)NCBIT2T-CHM13v2.0
Anpep
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39779,471,551 - 79,497,958 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl779,471,551 - 79,510,807 (-)EnsemblGRCm39 Ensembl
GRCm38779,821,803 - 79,848,210 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl779,821,803 - 79,861,059 (-)EnsemblGRCm38mm10GRCm38
MGSCv37786,966,689 - 86,987,238 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36779,695,316 - 79,715,797 (-)NCBIMGSCv36mm8
Celera777,221,100 - 77,243,027 (-)NCBICelera
Cytogenetic Map7D2NCBI
cM Map745.19NCBI
Anpep
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541615,424,932 - 15,444,075 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541615,415,981 - 15,442,032 (+)NCBIChiLan1.0ChiLan1.0
ANPEP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21679,335,577 - 79,365,554 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11583,037,936 - 83,059,833 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01568,479,349 - 68,509,238 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11587,681,826 - 87,703,713 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1587,681,826 - 87,703,713 (-)Ensemblpanpan1.1panPan2
ANPEP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1352,764,418 - 52,779,516 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl352,764,418 - 52,779,746 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha355,398,319 - 55,413,377 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0353,181,131 - 53,196,208 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl353,181,130 - 53,203,507 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1352,702,917 - 52,717,931 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0352,912,916 - 52,927,956 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0353,253,252 - 53,268,352 (-)NCBIUU_Cfam_GSD_1.0
Anpep
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640130,745,212 - 130,770,994 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648315,563,528 - 15,589,601 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648315,563,540 - 15,582,521 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ANPEP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl755,351,087 - 55,373,881 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1755,351,081 - 55,373,856 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2760,240,144 - 60,262,909 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap7cen-q21NCBI
ANPEP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1298,324,094 - 8,354,491 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl298,323,797 - 8,346,581 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605938,429,007 - 38,487,801 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Anpep
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476816,838,693 - 16,856,059 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476816,840,743 - 16,856,158 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Anpep
340 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:62
Count of miRNA genes:54
Interacting mature miRNAs:61
Transcripts:ENSRNOT00000020002
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61442Strs1Sensitivity to stroke QTL 17.4cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)1121767634166767634Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
1598866Bp287Blood pressure QTL 2875.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121006655166006655Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1123350408182418476Rat
9590300Scort16Serum corticosterone level QTL 164.390.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1103111621148111621Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
631199Cm23Cardiac mass QTL 234.60.0004heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1115585465172949803Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
1598850Bp297Blood pressure QTL 2972.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121006655166006655Rat
631570Bp94Blood pressure QTL 940.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123479780142990467Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)190508614173018436Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)190508614180359386Rat
61346Rf2Renal disease susceptibility QTL 23.7urine protein amount (VT:0005160)urine protein level (CMO:0000591)199267916144267916Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1100357752183970443Rat
1300153Bp171Blood pressure QTL 1713.37arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)190664883143200202Rat
2317833Alcrsp19Alcohol response QTL 1912.40.001response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1100979852145979852Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642644214537671Rat
631202Gluco13Glucose level QTL 130.0001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1131763437159756369Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118944897199050459Rat
1300158Bp173Blood pressure QTL 1733.48arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1115540693185145286Rat
1641897Alcrsp1Alcohol response QTL 1response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1100979852145979852Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)194494440181830018Rat
2293142Bp314Blood pressure QTL 314arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192184926137184926Rat
9685799Bp375Blood pressure QTL 375arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501170611501Rat
2293140Bp313Blood pressure QTL 313arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121833674166833674Rat
9685802Bp376Blood pressure QTL 376arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1126540680171540680Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)187580395150700247Rat
61370Mcs3Mammary carcinoma susceptibility QTL 32.15mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1102268556147268556Rat
1641895Bp298Blood pressure QTL 298arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1123350408182418476Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
631496Bp97Blood pressure QTL 973.08arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1106047847151047847Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
2303591Gluco41Glucose level QTL 412blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1102168504147168504Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194494440172949803Rat
2313060Bss71Bone structure and strength QTL 712.60.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)1118944747163944747Rat
6893347Bw98Body weight QTL 980.20.53body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1102813953201278233Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
61399Tcat1Tongue tumor resistance QTL 13.3tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 5 mm (CMO:0001879)199267916144267916Rat
6893361Bw104Body weight QTL 1040.590.27body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)192948896144267916Rat
738006Anxrr14Anxiety related response QTL 1440.00035locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1130636910175636910Rat
1558645Bw55Body weight QTL 553.20.004body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1102813953201278233Rat
634348Bp138Blood pressure QTL 138arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501168883176Rat
8694370Bw154Body weight QTL 1548.910.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)1103111621148111621Rat
738028Anxrr12Anxiety related response QTL 124.90.00001locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1130636910175636910Rat
1354623Rf46Renal function QTL 463.8blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)1102813953151162766Rat
631654Bp107Blood pressure QTL 107arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501170611501Rat
631544Bp84Blood pressure QTL 845.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350408181759564Rat
631549Bp89Blood pressure QTL 895.7arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350581201284552Rat
1358189Cstrr1Cold stress response QTL 10.0001catecholamine amount (VT:0010543)urine norepinephrine level (CMO:0001629)1123350408182418476Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1102813953218753816Rat

Markers in Region
D1Rat350  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21133,786,907 - 133,787,062 (+)MAPPERmRatBN7.2
Rnor_6.01141,580,935 - 141,581,089NCBIRnor6.0
Rnor_5.01142,541,997 - 142,542,151UniSTSRnor5.0
RGSC_v3.41135,620,322 - 135,620,477RGDRGSC3.4
RGSC_v3.41135,620,323 - 135,620,477UniSTSRGSC3.4
RGSC_v3.11135,698,729 - 135,698,883RGD
Celera1125,850,075 - 125,850,229UniSTS
RH 3.4 Map11058.1RGD
RH 3.4 Map11058.1UniSTS
SHRSP x BN Map168.8399UniSTS
SHRSP x BN Map168.8399RGD
FHH x ACI Map167.73RGD
Cytogenetic Map1q31UniSTS
RH130139  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21133,767,436 - 133,767,626 (+)MAPPERmRatBN7.2
Rnor_6.01141,561,469 - 141,561,658NCBIRnor6.0
Rnor_5.01142,522,531 - 142,522,720UniSTSRnor5.0
RGSC_v3.41135,600,856 - 135,601,045UniSTSRGSC3.4
Celera1125,830,753 - 125,830,942UniSTS
RH 3.4 Map11062.9UniSTS
Cytogenetic Map1q31UniSTS
RH94699  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21133,767,385 - 133,767,584 (+)MAPPERmRatBN7.2
Rnor_6.01141,561,418 - 141,561,616NCBIRnor6.0
Rnor_5.01142,522,480 - 142,522,678UniSTSRnor5.0
RGSC_v3.41135,600,805 - 135,601,003UniSTSRGSC3.4
Celera1125,830,702 - 125,830,900UniSTS
RH 3.4 Map11063.2UniSTS
Cytogenetic Map1q31UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000020002   ⟹   ENSRNOP00000020002
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1133,767,332 - 133,785,789 (-)Ensembl
Rnor_6.0 Ensembl1141,561,457 - 141,579,871 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000092125   ⟹   ENSRNOP00000069456
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1133,767,332 - 133,785,789 (-)Ensembl
Rnor_6.0 Ensembl1141,561,334 - 141,604,273 (-)Ensembl
RefSeq Acc Id: NM_031012   ⟹   NP_112274
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81143,176,645 - 143,195,101 (-)NCBI
mRatBN7.21133,767,332 - 133,785,789 (-)NCBI
Rnor_6.01141,561,364 - 141,579,820 (-)NCBI
Rnor_5.01142,522,426 - 142,565,721 (-)NCBI
RGSC_v3.41135,600,751 - 135,619,208 (-)RGD
Celera1125,830,648 - 125,849,086 (-)RGD
Sequence:
RefSeq Acc Id: XM_006229407   ⟹   XP_006229469
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81143,176,646 - 143,200,776 (-)NCBI
mRatBN7.21133,767,333 - 133,791,462 (-)NCBI
Rnor_6.01141,561,365 - 141,585,498 (-)NCBI
Rnor_5.01142,522,426 - 142,565,721 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006229408   ⟹   XP_006229470
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81143,176,646 - 143,197,340 (-)NCBI
mRatBN7.21133,767,333 - 133,788,027 (-)NCBI
Rnor_6.01141,561,365 - 141,582,066 (-)NCBI
Rnor_5.01142,522,426 - 142,565,721 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006229409   ⟹   XP_006229471
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81143,176,646 - 143,219,447 (-)NCBI
mRatBN7.21133,767,333 - 133,810,137 (-)NCBI
Rnor_6.01141,561,365 - 141,604,249 (-)NCBI
Rnor_5.01142,522,426 - 142,565,721 (-)NCBI
Sequence:
RefSeq Acc Id: NP_112274   ⟸   NM_031012
- Peptide Label: precursor
- UniProtKB: Q9JHP4 (UniProtKB/Swiss-Prot),   P15684 (UniProtKB/Swiss-Prot),   A0A0G2JVE6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006229471   ⟸   XM_006229409
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JVE6 (UniProtKB/TrEMBL),   A6JC72 (UniProtKB/TrEMBL),   G3V7W7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006229469   ⟸   XM_006229407
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JVE6 (UniProtKB/TrEMBL),   A6JC72 (UniProtKB/TrEMBL),   G3V7W7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006229470   ⟸   XM_006229408
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JVE6 (UniProtKB/TrEMBL),   A6JC72 (UniProtKB/TrEMBL),   G3V7W7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000069456   ⟸   ENSRNOT00000092125
Ensembl Acc Id: ENSRNOP00000020002   ⟸   ENSRNOT00000020002
Protein Domains
Aminopeptidase N-like N-terminal   ERAP1-like C-terminal   Peptidase M1 membrane alanine aminopeptidase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P15684-F1-model_v2 AlphaFold P15684 1-965 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690135
Promoter ID:EPDNEW_R657
Type:multiple initiation site
Name:Anpep_1
Description:alanyl aminopeptidase, membrane
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01141,579,844 - 141,579,904EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2991 AgrOrtholog
BioCyc Gene G2FUF-58771 BioCyc
Ensembl Genes ENSRNOG00000014610 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00055008286 UniProtKB/Swiss-Prot
  ENSRNOG00060004176 UniProtKB/Swiss-Prot
  ENSRNOG00065030192 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000020002.6 UniProtKB/TrEMBL
  ENSRNOT00000092125.2 UniProtKB/TrEMBL
  ENSRNOT00055014005 UniProtKB/Swiss-Prot
  ENSRNOT00060006973 UniProtKB/Swiss-Prot
  ENSRNOT00065052113 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.390.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.25.50.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.40.1730 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.40.1910 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Aminopeptidase_N-like_N UniProtKB/Swiss-Prot
  Aminopeptidase_N-like_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aminopeptidase_N-like_N UniProtKB/TrEMBL
  ERAP1-like_C_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  M1_APN-typ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M1_aminopeptidases UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M1_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M4/M1_CTD_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:81641 UniProtKB/Swiss-Prot
NCBI Gene Anpep ENTREZGENE
PANTHER AMINOPEPTIDASE N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEASE M1 ZINC METALLOPROTEASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ERAP1_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M1_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Anpep PhenoGen
PRINTS ALADIPTASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ZINC_PROTEASE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000014610 RatGTEx
  ENSRNOG00055008286 RatGTEx
  ENSRNOG00060004176 RatGTEx
  ENSRNOG00065030192 RatGTEx
Superfamily-SCOP Metalloproteases ('zincins'), catalytic domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF63737 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JVE6 ENTREZGENE, UniProtKB/TrEMBL
  A6JC72 ENTREZGENE, UniProtKB/TrEMBL
  AMPN_RAT UniProtKB/Swiss-Prot
  G3V7W7 ENTREZGENE, UniProtKB/TrEMBL
  P15684 ENTREZGENE
  Q9JHP4 ENTREZGENE
UniProt Secondary Q9JHP4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-13 Anpep  alanyl aminopeptidase, membrane  Anpep  alanyl (membrane) aminopeptidase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Anpep  alanyl (membrane) aminopeptidase      Symbol and Name status set to approved 70586 APPROVED
2001-12-10 Anpep  alanyl (membrane) aminopeptidase      Symbol and Name updated to reflect Human and Mouse nomenclature 69665 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in large amount in kidney, lung, liver, heart and aorta 69943
gene_expression expressed in large amount in kidney, lung, liver, heart and aorta 69944
gene_function broad specificity aminopeptidase; found to cleave antigen peptides bound to major histocompatibility complex class II molecules of presenting cells 724707
gene_process plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases; may be involved in the metabolism of regulatory peptides of diverse cell types; may have a role in angiogenesis 724707
gene_process plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases 69943
gene_process plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases 69944
gene_product glycoprotein, member of the peptidase family m1 (zinc metalloprotease) 69943
gene_product glycoprotein, member of the peptidase family m1 (zinc metalloprotease) 69944
gene_protein 965 amino acids, 140 kDa 69943
gene_protein 965 amino acids, 140 kDa 69944