Cdkn2d (cyclin dependent kinase inhibitor 2D) - Rat Genome Database

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Gene: Cdkn2d (cyclin dependent kinase inhibitor 2D) Rattus norvegicus
Analyze
Symbol: Cdkn2d
Name: cyclin dependent kinase inhibitor 2D
RGD ID: 1593190
Description: ENCODES a protein that exhibits cyclin-dependent protein serine/threonine kinase inhibitor activity (ortholog); protein kinase binding (ortholog); INVOLVED IN autophagic cell death (ortholog); DNA synthesis involved in DNA repair (ortholog); G1/S transition of mitotic cell cycle (ortholog); PARTICIPATES IN G1/S transition pathway; cell cycle pathway, mitotic; ASSOCIATED WITH Stomach Neoplasms (ortholog); FOUND IN cyclin D2-CDK4 complex (ortholog); cytoplasm (ortholog); cytosol (ortholog); INTERACTS WITH 1,2-dimethylhydrazine; 1,3-dinitrobenzene; bisphenol A
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: cyclin-dependent kinase 4 inhibitor D; MGC109660; MGC73010; similar to cyclin-dependent kinase inhibitor 2D
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2819,831,874 - 19,834,640 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl819,831,866 - 19,834,674 (-)Ensembl
Celera821,223,465 - 21,226,230 (-)NCBICelera
Cytogenetic Map8 NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (EXP)
1,3-dinitrobenzene  (EXP)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-hydroxypropanoic acid  (ISO)
3,3'-diindolylmethane  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
5-aza-2'-deoxycytidine  (ISO)
all-trans-retinoic acid  (ISO)
antirheumatic drug  (ISO)
aristolochic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
avobenzone  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
cadmium dichloride  (ISO)
calciol  (ISO)
calcitriol  (ISO)
calycosin  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cumene  (ISO)
curcumin  (EXP)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
cypermethrin  (EXP)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
diethylstilbestrol  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
formaldehyde  (ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
iron atom  (ISO)
iron(0)  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
levonorgestrel  (ISO)
Licochalcone B  (ISO)
lipopolysaccharide  (ISO)
LY294002  (ISO)
methyl methanesulfonate  (ISO)
methylseleninic acid  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monobenzyl phthalate  (ISO)
monoethyl phthalate  (ISO)
monosodium L-glutamate  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (ISO)
nickel sulfate  (ISO)
p-menthan-3-ol  (ISO)
paracetamol  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
pyrazinecarboxamide  (EXP)
rac-lactic acid  (ISO)
reactive oxygen species  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
testosterone  (ISO)
testosterone undecanoate  (ISO)
tetrachloromethane  (ISO)
trichloroethene  (ISO)
triptonide  (ISO)
tungsten  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vorinostat  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
1. Pipeline to import KEGG annotations from KEGG into RGD
2. RGD automated data pipeline
Additional References at PubMed
PMID:12477932   PMID:26722409  


Genomics

Comparative Map Data
Cdkn2d
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2819,831,874 - 19,834,640 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl819,831,866 - 19,834,674 (-)Ensembl
Celera821,223,465 - 21,226,230 (-)NCBICelera
Cytogenetic Map8 NCBI
CDKN2D
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1910,566,460 - 10,569,059 (-)EnsemblGRCh38hg38GRCh38
GRCh381910,566,460 - 10,568,979 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371910,677,136 - 10,679,655 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361910,538,138 - 10,540,655 (-)NCBINCBI36hg18NCBI36
Build 341910,538,138 - 10,540,655NCBI
Celera1910,571,882 - 10,574,399 (-)NCBI
Cytogenetic Map19p13.2NCBI
HuRef1910,255,057 - 10,257,571 (-)NCBIHuRef
CHM1_11910,677,886 - 10,680,400 (-)NCBICHM1_1
Cdkn2d
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39921,199,755 - 21,202,717 (-)NCBIGRCm39mm39
GRCm39 Ensembl921,199,706 - 21,202,703 (-)Ensembl
GRCm38921,288,459 - 21,291,421 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl921,288,410 - 21,291,407 (-)EnsemblGRCm38mm10GRCm38
MGSCv37921,092,907 - 21,095,653 (-)NCBIGRCm37mm9NCBIm37
MGSCv36921,038,865 - 21,041,421 (-)NCBImm8
Celera918,557,588 - 18,560,334 (-)NCBICelera
Cytogenetic Map9A3NCBI
Cdkn2d
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554951,755,878 - 1,757,037 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554951,755,280 - 1,759,125 (-)NCBIChiLan1.0ChiLan1.0
CDKN2D
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11910,780,683 - 10,782,829 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v01910,118,302 - 10,120,957 (-)NCBIMhudiblu_PPA_v0panPan3
CDKN2D
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12050,607,382 - 50,609,929 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2050,607,674 - 50,609,482 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2050,479,638 - 50,482,207 (+)NCBI
ROS_Cfam_1.02051,130,501 - 51,133,072 (+)NCBI
UMICH_Zoey_3.12050,337,348 - 50,339,917 (+)NCBI
UNSW_CanFamBas_1.02050,765,427 - 50,767,996 (+)NCBI
UU_Cfam_GSD_1.02051,006,476 - 51,009,047 (+)NCBI
Cdkn2d
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118209,511,523 - 209,514,098 (+)NCBI
SpeTri2.0NW_004936659840,602 - 843,078 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CDKN2D
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl269,337,855 - 69,339,999 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1269,337,428 - 69,339,998 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2269,723,120 - 69,725,688 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CDKN2D
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.169,579,648 - 9,582,249 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl69,579,470 - 9,582,101 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607410,408,971 - 10,411,618 (+)NCBIVero_WHO_p1.0
Cdkn2d
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248282,634,347 - 2,637,123 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
RH143781  
Rat AssemblyChrPosition (strand)SourceJBrowse
Celera821,223,565 - 21,223,808UniSTS
RH 3.4 Map8181.3UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9590084Insglur5Insulin/glucose ratio QTL 518.540.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)8124597739Rat
2317882Alcrsp24Alcohol response QTL 243.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)8125902202Rat
12880023Bw184Body weight QTL 1840.001body mass (VT:0001259)body weight (CMO:0000012)8209764047097640Rat
12880025Cm102Cardiac mass QTL 1020.044heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)8209764047097640Rat
12880028Cm103Cardiac mass QTL 1030.02heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)8209764047097640Rat
12880044Am9Aortic mass QTL 90.007aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)8209764047097640Rat
2317032Ginf2Gastrointestinal inflammation QTL 23.210.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)8470581049705810Rat
2317036Livw3Liver weight QTL 32.430.01liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)8470581049705810Rat
2317048Ginf1Gastrointestinal inflammation QTL 13.520.005cecum mucosa thickness (VT:0010234)enterocolitis severity score (CMO:0002138)8470581049705810Rat
2301416Bp315Blood pressure QTL 3150.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)8767057852670578Rat
1354595Despr4Despair related QTL 42.160.0036locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)8768895552688955Rat
1354627Despr14Despair related QTL 140.0056locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)8768895552688955Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
2317030Wbc5White blood cell count QTL 53.210.005leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)8873663553736635Rat
2317051Aia18Adjuvant induced arthritis QTL 182.42joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)8873663553736635Rat
1598824Memor4Memory QTL 42.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)8971222053356647Rat
1357398Slep3Serum leptin concentration QTL 33.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)8971246341866876Rat
2302367Slep5Serum leptin concentration QTL 53.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)8971246341866876Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
1558646Swd5Spike wave discharge measurement QTL 53.450.00036brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)81490675159906751Rat
61373Mcs4Mammary carcinoma susceptibility QTL 41.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)81629044461290444Rat
631271Lecl1Lens clarity QTL 10.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)81898416884531599Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)81933115293965294Rat


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000095108   ⟹   ENSRNOP00000077513
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl819,831,866 - 19,834,674 (-)Ensembl
RefSeq Acc Id: NM_001009719   ⟹   NP_001009719
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2819,831,874 - 19,834,640 (-)NCBI
Celera821,223,465 - 21,226,230 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001009719 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH63185 (Get FASTA)   NCBI Sequence Viewer  
  AAH88350 (Get FASTA)   NCBI Sequence Viewer  
  EDL78306 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001009719   ⟸   NM_001009719
- UniProtKB: Q6P4Z7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000077513   ⟸   ENSRNOT00000095108
Protein Domains
ANK_REP_REGION

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSRNOG00000064248 Ensembl
Gene3D-CATH 1.25.40.20 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:6889848 IMAGE-MGC_LOAD
  IMAGE:7368483 IMAGE-MGC_LOAD
InterPro Ankyrin_rpt UniProtKB/TrEMBL
  Ankyrin_rpt-contain_dom UniProtKB/TrEMBL
  Ankyrin_rpt-contain_sf UniProtKB/TrEMBL
KEGG Report rno:494444 UniProtKB/TrEMBL
MGC_CLONE MGC:109660 IMAGE-MGC_LOAD
  MGC:73010 IMAGE-MGC_LOAD
NCBI Gene 494444 ENTREZGENE
PhenoGen Cdkn2d PhenoGen
PROSITE ANK_REP_REGION UniProtKB/TrEMBL
  ANK_REPEAT UniProtKB/TrEMBL
SMART ANK UniProtKB/TrEMBL
Superfamily-SCOP ANK UniProtKB/TrEMBL
UniProt Q6P4Z7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-01-28 Cdkn2d  cyclin dependent kinase inhibitor 2D  Cdkn2d  similar to cyclin-dependent kinase inhibitor 2D  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 Cdkn2d  similar to cyclin-dependent kinase inhibitor 2D      Symbol and Name status set to provisional 70820 PROVISIONAL