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Gene: Cdkn2d (cyclin dependent kinase inhibitor 2D) Rattus norvegicus

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Symbol:

Cdkn2d

Name:

cyclin dependent kinase inhibitor 2D

RGD ID:

1593190

Description:

Predicted to enable cyclin-dependent protein serine/threonine kinase inhibitor activity and protein kinase binding activity. Predicted to be involved in several processes, including autophagic cell death; negative regulation of G1/S transition of mitotic cell cycle; and negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage. Predicted to act upstream of or within negative regulation of cell cycle G1/S phase transition and sensory perception of sound. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of cyclin D2-CDK4 complex. Predicted to be active in nucleus. Orthologous to human CDKN2D (cyclin dependent kinase inhibitor 2D); PARTICIPATES IN G1/S transition pathway; cell cycle pathway, mitotic; INTERACTS WITH 1,2-dimethylhydrazine; 1,3-dinitrobenzene; bisphenol A.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

cyclin-dependent kinase 4 inhibitor D; MGC109660; MGC73010; similar to cyclin-dependent kinase inhibitor 2D

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	28,108,036 - 28,110,809 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	8	28,108,044 - 28,110,809 (-)	Ensembl				GRCr8
mRatBN7.2	8	19,831,874 - 19,834,640 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	19,831,866 - 19,834,674 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	8	23,851,704 - 23,854,497 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	22,149,553 - 22,152,346 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	20,061,563 - 20,064,328 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Celera	8	21,223,465 - 21,226,230 (-)	NCBI		Celera
Cytogenetic Map	8	q13	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

familial hypercholesterolemia (ISO)

immunodeficiency 35 (ISO)

Stomach Neoplasms (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-alpha-phellandrene (ISO)

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (EXP)

1,3-dinitrobenzene (EXP)

1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (ISO)

17beta-estradiol (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2-hydroxypropanoic acid (ISO)

3,3'-diindolylmethane (ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxynon-2-enal (ISO)

5-aza-2'-deoxycytidine (ISO)

all-trans-retinoic acid (ISO)

alpha-phellandrene (ISO)

antirheumatic drug (ISO)

aristolochic acid A (ISO)

arsane (ISO)

arsenic atom (ISO)

arsenous acid (ISO)

avobenzone (ISO)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

calciol (ISO)

calcitriol (ISO)

calycosin (ISO)

CGP 52608 (ISO)

chromium(6+) (ISO)

cisplatin (ISO)

copper atom (ISO)

copper(0) (ISO)

copper(II) sulfate (ISO)

cumene (ISO)

curcumin (EXP)

cyclophosphamide (ISO)

cyclosporin A (ISO)

cypermethrin (EXP)

dexamethasone (ISO)

diarsenic trioxide (ISO)

dibutyl phthalate (ISO)

diethylstilbestrol (ISO)

dioxygen (ISO)

dorsomorphin (ISO)

ethylparaben (ISO)

formaldehyde (ISO)

hydrogen peroxide (ISO)

indometacin (ISO)

iron atom (ISO)

iron(0) (ISO)

lead(0) (ISO)

levonorgestrel (ISO)

Licochalcone B (ISO)

lipopolysaccharide (ISO)

LY294002 (ISO)

methyl methanesulfonate (ISO)

methylseleninic acid (ISO)

mono(2-ethylhexyl) phthalate (ISO)

monobenzyl phthalate (ISO)

monoethyl phthalate (ISO)

monosodium L-glutamate (EXP)

N-methyl-4-phenylpyridinium (ISO)

N-nitrosodiethylamine (ISO)

NCX-4040 (ISO)

nickel sulfate (ISO)

okadaic acid (ISO)

p-menthan-3-ol (ISO)

paracetamol (ISO)

perfluorohexanesulfonic acid (ISO)

perfluorononanoic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

phenobarbital (ISO)

phenylmercury acetate (ISO)

potassium chromate (ISO)

potassium dichromate (ISO)

pyrazinecarboxamide (EXP)

rac-lactic acid (ISO)

reactive oxygen species (ISO)

rotenone (ISO)

SB 431542 (ISO)

silicon dioxide (ISO)

silver atom (ISO)

silver(0) (ISO)

simvastatin (ISO)

sodium arsenite (ISO)

sunitinib (ISO)

testosterone (ISO)

testosterone undecanoate (ISO)

tetrachloromethane (ISO)

thiram (ISO)

titanium dioxide (ISO)

trichloroethene (ISO)

triphenyl phosphate (ISO)

triptonide (ISO)

trovafloxacin (ISO)

tungsten (ISO)

urethane (ISO)

valproic acid (ISO)

vancomycin (ISO)

vorinostat (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

autophagic cell death (IEA,ISO)

DNA synthesis involved in DNA repair (IEA,ISO)

negative regulation of cell cycle G1/S phase transition (IEA,ISO)

negative regulation of cell growth (IEA,ISO)

negative regulation of cell population proliferation (IEA,ISO)

negative regulation of G1/S transition of mitotic cell cycle (IEA,ISO)

negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage (IEA,ISO)

regulation of cell cycle G1/S phase transition (IEA)

regulation of G1/S transition of mitotic cell cycle (IEA,ISO)

response to retinoic acid (IEA,ISO)

response to UV (IEA,ISO)

response to vitamin D (IEA,ISO)

sensory perception of sound (IEA,ISO)

Cellular Component

cyclin D2-CDK4 complex (IEA,ISO)

cytoplasm (IEA,ISO)

cytosol (IEA,ISO)

nucleoplasm (IEA,ISO)

nucleus (IBA,IEA,ISO)

Molecular Function

cyclin-dependent protein serine/threonine kinase inhibitor activity (IBA,IEA,ISO)

protein binding (ISO)

protein kinase binding (IEA,ISO)

protein kinase inhibitor activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

cell cycle pathway, mitotic (IEA)

G1/S transition pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
2.	GOA pipeline	RGD automated data pipeline

Additional References at PubMed

PMID:12477932	PMID:26722409

Genomics

Comparative Map Data

Cdkn2d
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	28,108,036 - 28,110,809 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	8	28,108,044 - 28,110,809 (-)	Ensembl				GRCr8
mRatBN7.2	8	19,831,874 - 19,834,640 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	19,831,866 - 19,834,674 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	8	23,851,704 - 23,854,497 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	22,149,553 - 22,152,346 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	20,061,563 - 20,064,328 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Celera	8	21,223,465 - 21,226,230 (-)	NCBI		Celera
Cytogenetic Map	8	q13	NCBI

CDKN2D
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	19	10,566,460 - 10,568,979 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	19	10,566,460 - 10,569,059 (-)	Ensembl			hg38	GRCh38
GRCh37	19	10,677,136 - 10,679,655 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	10,538,138 - 10,540,655 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	19	10,538,138 - 10,540,655	NCBI
Celera	19	10,571,882 - 10,574,399 (-)	NCBI		Celera
Cytogenetic Map	19	p13.2	NCBI
HuRef	19	10,255,057 - 10,257,571 (-)	NCBI		HuRef
CHM1_1	19	10,677,886 - 10,680,400 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	19	10,692,920 - 10,695,436 (-)	NCBI		T2T-CHM13v2.0

Cdkn2d
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	21,199,759 - 21,202,553 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	9	21,199,706 - 21,202,703 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	9	21,288,459 - 21,291,421 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	21,288,410 - 21,291,407 (-)	Ensembl			mm10	GRCm38
MGSCv37	9	21,092,907 - 21,095,653 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	9	21,038,865 - 21,041,421 (-)	NCBI		MGSCv36	mm8
Celera	9	18,557,588 - 18,560,334 (-)	NCBI		Celera
Cytogenetic Map	9	A3	NCBI
cM Map	9	7.76	NCBI

Cdkn2d
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955495	1,755,878 - 1,757,037 (-)	Ensembl
ChiLan1.0	NW_004955495	1,755,280 - 1,759,125 (-)	NCBI	ChiLan1.0	ChiLan1.0

CDKN2D
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	20	15,484,899 - 15,487,580 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	19	14,483,496 - 14,486,148 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	19	10,118,302 - 10,120,957 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	19	10,780,683 - 10,782,829 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2

CDKN2D
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	20	50,607,382 - 50,609,929 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	20	50,607,674 - 50,609,482 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	20	50,479,638 - 50,482,207 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	20	51,130,501 - 51,133,072 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	20	51,130,778 - 51,133,070 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	20	50,337,348 - 50,339,917 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	20	50,765,427 - 50,767,996 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	20	51,006,476 - 51,009,047 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Cdkn2d
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	209,511,523 - 209,514,098 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936659	840,519 - 843,117 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936659	840,602 - 843,078 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CDKN2D
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	69,337,432 - 69,339,933 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	2	69,337,428 - 69,339,998 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	69,723,120 - 69,725,688 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CDKN2D
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	9,579,648 - 9,582,249 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	6	9,579,470 - 9,582,101 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666074	10,408,971 - 10,411,618 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Cdkn2d
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624828	2,634,654 - 2,636,701 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624828	2,634,347 - 2,637,123 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Variants

Variants in Cdkn2d
17 total Variants

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1357398	Slep3	Serum leptin concentration QTL 3	3.43		blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	8	17994105	50763951	Rat
2317030	Wbc5	White blood cell count QTL 5	3.21	0.005	leukocyte quantity (VT:0000217)	white blood cell count (CMO:0000027)	8	16994642	61994642	Rat
12880044	Am9	Aortic mass QTL 9		0.007	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	8	10382540	55382540	Rat
2317032	Ginf2	Gastrointestinal inflammation QTL 2	3.21	0.005	liver integrity trait (VT:0010547)	liver granuloma severity score (CMO:0002157)	8	12964165	57964165	Rat
2301416	Bp315	Blood pressure QTL 315		0.008	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	15952279	60952279	Rat
2317036	Livw3	Liver weight QTL 3	2.43	0.01	liver mass (VT:0003402)	liver weight to body weight ratio (CMO:0000633)	8	12964165	57964165	Rat
1598824	Memor4	Memory QTL 4	2.5		exploratory behavior trait (VT:0010471)	total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)	8	17993862	62252873	Rat
12880023	Bw184	Body weight QTL 184		0.001	body mass (VT:0001259)	body weight (CMO:0000012)	8	10382540	55382540	Rat
9590084	Insglur5	Insulin/glucose ratio QTL 5	18.54	0.001	blood insulin amount (VT:0001560)	calculated plasma insulin level (CMO:0002170)	8	1	32882639	Rat
12880028	Cm103	Cardiac mass QTL 103		0.02	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	8	10382540	55382540	Rat
2317051	Aia18	Adjuvant induced arthritis QTL 18	2.42		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	8	16994642	61994642	Rat
2317048	Ginf1	Gastrointestinal inflammation QTL 1	3.52	0.005	cecum mucosa thickness (VT:0010234)	enterocolitis severity score (CMO:0002138)	8	12964165	57964165	Rat
2302367	Slep5	Serum leptin concentration QTL 5	3.43		blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	8	17994105	50763951	Rat
12880025	Cm102	Cardiac mass QTL 102		0.044	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	8	10382540	55382540	Rat

Markers in Region

RH143781

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Celera	8	21,223,565 - 21,223,808	UniSTS
RH 3.4 Map	8	181.3	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	hemolymphoid system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	sensory system	visual system
7	1	18	52	67	138	95	11	51	36	32	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001009719	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063265956	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC063185	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC088350	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473993	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000008	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000095108 ⟹ ENSRNOP00000077513

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	8	28,108,044 - 28,110,809 (-)	Ensembl
mRatBN7.2 Ensembl	8	19,831,866 - 19,834,674 (-)	Ensembl

RefSeq Acc Id:

NM_001009719 ⟹ NP_001009719

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	28,108,044 - 28,110,809 (-)	NCBI
mRatBN7.2	8	19,831,874 - 19,834,640 (-)	NCBI
Celera	8	21,223,465 - 21,226,230 (-)	RGD

Sequence:

show sequence

GGGGGCCTGCCAGAGCGAGGGTCGTACAGGCAGAAGGCGCCGGGTCTGCGGCCGGGGAATAACC
ATAGAGTTTGCCTTGGTGGCACCGCAACCCCTGAGAACCGAAATCTGATCCAGCCCTTGCTGGT
CCCCAGCCCTGACCTGAATTGGGCTTGGGGCTGGGTGGGTTTCACAGACCACCGGTAGCCACTA
TGCTTCTGGAAGAAGTCAGCGTCGGCGACCGGTTGAGTGGCGCAGCGGCCCGTGGCGACGTGCA
AGAGGTGCGCCGCCTTCTGCACCGGGAGCTGGTGCATCCTGACGCCCTGAACCGCTTTGGCAAG
ACGGCCTTGCAGGTCATGATGTTTGGAAGTCCAGCAGTTGCTCTGGAACTCCTGAAGCAAGGCG
CCAGCCCCAACGTCCAAGATGCCTCTGGTACCAGTCCAGTGCATGATGCCGCGCGCACTGGGTT
CCTGGACACCCTGAAGGTTCTGGTGGAGCATGGTGCTGACGTCAACACCCTGGACAGCACCGGG
TCTCTCCCCATCCACCTGGCCATCCGAGAGGGCCATAGCTCTGTGGTCAGCTTCCTAGCTCCTG
AATCTGATCTCCATCACAAGGACGCCTCAGGCCTCACTCCCCTGGAGTTGGCTCGGCAGAGAGG
GGCTCAGAACCTCATGGACATTCTGCAGTCGCACATGATGATCCCAATGTGACCCGGGCCACAG
TCTCCCACCTTGCTGGGTTACTTGTCAACAAAGGAGGAAAGAAACTTTCTCTTTTCACTCCTGT
CCATTGAAGAAGGGAGTGGGAGGAGCAGTTTGTGGTTTGTTGGTGTTGATTTCTTGAGTGTGTG
TGTTTGGGGGTTGTTTCTCATTTGTTTTTCTCACCCCTTTTTGGTGTGTTGGACAAAGAAGGGG
CTTCTACAGGCACCAGCCACCTAAACGGTTCAGTTTCCTCTGCACTGGGGCTGCACAGAAGACC
TCAGGGCAGGGGCTTAAAGCTCTAGCCTCAAGTGAGGTCATCACCTCCTGGGCTCCTGGGAGCT
GGTGACCTTGGTGCTCAGAGAGCCCTGAAGTGTGAGCCATCTACTTTGGTCATGGGAGGGGGAG
GGGAAACATTTAAAATCAGTTAAAAGGATAACATGAGTTTTTTGTTTTTTTTTTTTTTCATGGA
AGGTTTCCAGTTTTGTTGTACAGTTTGAAATATATATATTTATTGCTTTATGAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_063265956 ⟹ XP_063122026

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	28,108,036 - 28,110,339 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001009719	(Get FASTA)	NCBI Sequence Viewer
	XP_063122026	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH63185	(Get FASTA)	NCBI Sequence Viewer
	AAH88350	(Get FASTA)	NCBI Sequence Viewer
	EDL78306	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000077513
	ENSRNOP00000077513.1

RefSeq Acc Id:	NP_001009719 ⟸ NM_001009719
- UniProtKB:	Q6P4Z7 (UniProtKB/TrEMBL), A0A8I5Y1N2 (UniProtKB/TrEMBL)
- Sequence:	show sequence MLLEEVSVGDRLSGAAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMFGSPAVALELLKQG ASPNVQDASGTSPVHDAARTGFLDTLKVLVEHGADVNTLDSTGSLPIHLAIREGHSSVVSFLAP ESDLHHKDASGLTPLELARQRGAQNLMDILQSHMMIPM hide sequence

Ensembl Acc Id:

ENSRNOP00000077513 ⟸ ENSRNOT00000095108

RefSeq Acc Id:	XP_063122026 ⟸ XM_063265956
- Peptide Label:	isoform X1

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1593190	AgrOrtholog
BioCyc Gene	G2FUF-31426	BioCyc
Ensembl Genes	ENSRNOG00000064248	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000095108	ENTREZGENE
	ENSRNOT00000095108.1	UniProtKB/TrEMBL
Gene3D-CATH	1.25.40.20	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:6889848	IMAGE-MGC_LOAD
	IMAGE:7368483	IMAGE-MGC_LOAD
InterPro	Ank_Repeat/CDKN_Inhibitor	UniProtKB/TrEMBL
	Ankyrin_rpt	UniProtKB/TrEMBL
	Ankyrin_rpt-contain_sf	UniProtKB/TrEMBL
KEGG Report	rno:494444	UniProtKB/TrEMBL
MGC_CLONE	MGC:109660	IMAGE-MGC_LOAD
	MGC:73010	IMAGE-MGC_LOAD
NCBI Gene	494444	ENTREZGENE
PANTHER	ANK_REP_REGION DOMAIN-CONTAINING PROTEIN	UniProtKB/TrEMBL
	CYCLIN-DEPENDENT KINASE 4 INHIBITOR D	UniProtKB/TrEMBL
Pfam	Ank	UniProtKB/TrEMBL
	Ank_2	UniProtKB/TrEMBL
PhenoGen	Cdkn2d	PhenoGen
PROSITE	ANK_REP_REGION	UniProtKB/TrEMBL
	ANK_REPEAT	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000064248	RatGTEx
SMART	ANK	UniProtKB/TrEMBL
Superfamily-SCOP	ANK	UniProtKB/TrEMBL
UniProt	A0A8I5Y1N2	ENTREZGENE, UniProtKB/TrEMBL
	Q6P4Z7	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2021-01-28	Cdkn2d	cyclin dependent kinase inhibitor 2D	Cdkn2d	similar to cyclin-dependent kinase inhibitor 2D	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-11-20	Cdkn2d	similar to cyclin-dependent kinase inhibitor 2D			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - KEGG (archival)