Hnrnpm (heterogeneous nuclear ribonucleoprotein M) - Rat Genome Database
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Gene: Hnrnpm (heterogeneous nuclear ribonucleoprotein M) Rattus norvegicus
Analyze
Symbol: Hnrnpm
Name: heterogeneous nuclear ribonucleoprotein M
RGD ID: 620369
Description: Exhibits calcium-dependent protein binding activity and protein antigen binding activity. Involved in several processes, including cellular response to carcinoembryonic antigen; cellular response to lipopolysaccharide; and positive regulation of protein import. Localizes to cell surface. Orthologous to human HNRNPM (heterogeneous nuclear ribonucleoprotein M); PARTICIPATES IN spliceosome pathway; INTERACTS WITH (+)-schisandrin B; 2,6-dinitrotoluene; 7,12-dimethyltetraphene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: hnRNP M; Hnrpm; Hnrpm4; M4 protein; MGC109545
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0718,516,253 - 18,554,536 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl718,516,512 - 18,554,227 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0718,693,853 - 18,731,993 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4716,150,060 - 16,188,054 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1716,150,062 - 16,188,046 (-)NCBI
Celera713,337,407 - 13,375,335 (-)NCBICelera
Cytogenetic Map7q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:9731529   PMID:10947964   PMID:11984006   PMID:11991638   PMID:12477932   PMID:15489334   PMID:16128803   PMID:19946888   PMID:22082260   PMID:22658674   PMID:22681889   PMID:23533145  
PMID:23658023   PMID:23979707   PMID:24625528   PMID:29476059   PMID:30053369  


Genomics

Comparative Map Data
Hnrnpm
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0718,516,253 - 18,554,536 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl718,516,512 - 18,554,227 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0718,693,853 - 18,731,993 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4716,150,060 - 16,188,054 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1716,150,062 - 16,188,046 (-)NCBI
Celera713,337,407 - 13,375,335 (-)NCBICelera
Cytogenetic Map7q13NCBI
HNRNPM
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl198,444,767 - 8,489,114 (+)EnsemblGRCh38hg38GRCh38
GRCh38198,444,575 - 8,489,114 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37198,509,460 - 8,554,002 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36198,415,803 - 8,459,998 (+)NCBINCBI36hg18NCBI36
Build 34198,415,650 - 8,459,994NCBI
Celera198,367,796 - 8,411,661 (+)NCBI
Cytogenetic Map19p13.2NCBI
HuRef198,165,461 - 8,209,438 (+)NCBIHuRef
CHM1_1198,509,135 - 8,553,070 (+)NCBICHM1_1
Hnrnpm
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391733,865,207 - 33,904,432 (-)NCBIGRCm39mm39
GRCm381733,646,233 - 33,685,458 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1733,646,233 - 33,686,860 (-)EnsemblGRCm38mm10GRCm38
MGSCv371733,783,178 - 33,822,403 (-)NCBIGRCm37mm9NCBIm37
MGSCv361733,252,927 - 33,292,090 (-)NCBImm8
Celera1736,401,579 - 36,440,923 (-)NCBICelera
Cytogenetic Map17B1NCBI
Hnrnpm
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_004955563933,824 - 975,064 (-)NCBIChiLan1.0ChiLan1.0
HNRNPM
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1198,579,206 - 8,624,029 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl198,579,211 - 8,624,029 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0197,731,828 - 7,776,101 (+)NCBIMhudiblu_PPA_v0panPan3
HNRNPM
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2052,993,824 - 53,034,606 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12052,993,934 - 53,034,608 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Hnrnpm
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365885,241,276 - 5,283,952 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HNRNPM
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl270,813,745 - 70,872,858 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1270,813,745 - 70,858,903 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2271,180,163 - 71,225,248 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HNRNPM
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl67,796,045 - 7,839,244 (+)Ensembl
ChlSab1.167,795,996 - 7,839,506 (+)NCBI
Hnrnpm
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248281,199,048 - 1,250,887 (+)NCBI

Position Markers
RH132782  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0718,554,423 - 18,554,631NCBIRnor6.0
Rnor_5.0718,732,023 - 18,732,231UniSTSRnor5.0
RGSC_v3.4716,188,229 - 16,188,437UniSTSRGSC3.4
Celera713,375,510 - 13,375,718UniSTS
Cytogenetic Map7q12UniSTS
RH143889  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0718,525,154 - 18,525,372NCBIRnor6.0
Rnor_5.0718,702,754 - 18,702,972UniSTSRnor5.0
RGSC_v3.4716,158,960 - 16,159,178UniSTSRGSC3.4
Celera713,346,241 - 13,346,459UniSTS
Cytogenetic Map7q12UniSTS
RH 3.4 Map769.0UniSTS
RH143934  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0718,517,421 - 18,517,577NCBIRnor6.0
Rnor_5.0718,695,021 - 18,695,177UniSTSRnor5.0
RGSC_v3.4716,151,228 - 16,151,384UniSTSRGSC3.4
Celera713,338,575 - 13,338,731UniSTS
Cytogenetic Map7q12UniSTS
RH144620  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0718,543,262 - 18,543,446NCBIRnor6.0
Rnor_5.0718,720,862 - 18,721,046UniSTSRnor5.0
RGSC_v3.4716,177,068 - 16,177,252UniSTSRGSC3.4
Celera713,364,349 - 13,364,533UniSTS
Cytogenetic Map7q12UniSTS
RH 3.4 Map796.3UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7134147172Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7134828535Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7134828535Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7137009673Rat
2317047Wbc4White blood cell count QTL 40.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)7138119654Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)7265313832258115Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)72920071124838025Rat
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7591147750911477Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7595196950951969Rat
10755438Coatc9Coat color QTL 90coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7975804554758045Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)71164710256647102Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)71232846767193263Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)712328467106995532Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)71268785067801690Rat
10755440Coatc10Coat color QTL 100coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)71395217958952179Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)71444568559445685Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:376
Count of miRNA genes:135
Interacting mature miRNAs:144
Transcripts:ENSRNOT00000011047, ENSRNOT00000036172, ENSRNOT00000059985
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000011047   ⟹   ENSRNOP00000011047
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl718,516,512 - 18,554,227 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000036172   ⟹   ENSRNOP00000032108
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl718,516,512 - 18,554,227 (-)Ensembl
RefSeq Acc Id: NM_001109911   ⟹   NP_001103381
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0718,516,253 - 18,554,248 (-)NCBI
Rnor_5.0718,693,853 - 18,731,993 (-)NCBI
RGSC_v3.4716,150,060 - 16,188,054 (-)RGD
Celera713,337,407 - 13,375,335 (-)RGD
Sequence:
RefSeq Acc Id: NM_053876   ⟹   NP_446328
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0718,516,253 - 18,554,248 (-)NCBI
Rnor_5.0718,693,853 - 18,731,993 (-)NCBI
RGSC_v3.4716,150,060 - 16,188,054 (-)RGD
Celera713,337,407 - 13,375,335 (-)RGD
Sequence:
RefSeq Acc Id: XM_006241116   ⟹   XP_006241178
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0718,516,674 - 18,554,536 (-)NCBI
Rnor_5.0718,693,853 - 18,731,993 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008765198   ⟹   XP_008763420
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0718,516,253 - 18,547,572 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_446328   ⟸   NM_053876
- Peptide Label: isoform b
- UniProtKB: Q62826 (UniProtKB/Swiss-Prot),   F1LV13 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001103381   ⟸   NM_001109911
- Peptide Label: isoform a
- UniProtKB: Q62826 (UniProtKB/Swiss-Prot),   F1M3D3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006241178   ⟸   XM_006241116
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_008763420   ⟸   XM_008765198
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSRNOP00000032108   ⟸   ENSRNOT00000036172
RefSeq Acc Id: ENSRNOP00000011047   ⟸   ENSRNOT00000011047
Protein Domains
RRM

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695082
Promoter ID:EPDNEW_R5607
Type:initiation region
Name:Hnrnpm_1
Description:heterogeneous nuclear ribonucleoprotein M
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0718,554,248 - 18,554,308EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Damaging Variants


Assembly: Rnor_5.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
7 18713065 18713066 A C snv KFRS3B/Kyo (KyushuU), F344/Jcl (KyushuU), IS-Tlk/Kyo (KyushuU), BDIX/NemOda (KyushuU), NIG-III/Hok (KyushuU)
7 18713091 18713092 C A snv KFRS3B/Kyo (KyushuU), BDIX/NemOda (KyushuU), IS-Tlk/Kyo (KyushuU), NIG-III/Hok (KyushuU), ZF (KyushuU), F344/Jcl (KyushuU), DOB/Oda (KyushuU)
7 18713093 18713094 A C snv IS-Tlk/Kyo (KyushuU), NIG-III/Hok (KyushuU), ZF (KyushuU), KFRS3B/Kyo (KyushuU), DOB/Oda (KyushuU), BDIX/NemOda (KyushuU), F344/Jcl (KyushuU)
7 18713108 18713109 C A snv ZF (KyushuU), KFRS3B/Kyo (KyushuU), HWY/Slc (KyushuU), IS-Tlk/Kyo (KyushuU), IS/Kyo (KyushuU), NIG-III/Hok (KyushuU), DOB/Oda (KyushuU), RCS/Kyo (KyushuU), F344/Jcl (KyushuU), BDIX/NemOda (KyushuU)
7 18713109 18713110 C A snv DOB/Oda (KyushuU), F344/Jcl (KyushuU), IS/Kyo (KyushuU), KFRS3B/Kyo (KyushuU), ZF (KyushuU), IS-Tlk/Kyo (KyushuU), NIG-III/Hok (KyushuU), BDIX/NemOda (KyushuU)


Assembly: Rnor_6.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
7 18535465 18535466 A C snv COP/CrCrl (MCW & UW), ACI/EurMcwi (MCW), SS/JrHsdMcwi (MCW)
7 18535491 18535492 C A snv COP/CrCrl (MCW & UW), CDR, CDS
7 18535493 18535494 A C snv COP/CrCrl (MCW & UW), CDS, CDR
7 18535508 18535509 C A snv CDR, CDS, ACI/EurMcwi (MCW), COP/CrCrl (MCW & UW)
7 18535509 18535510 C A snv CDS, CDR, COP/CrCrl (MCW & UW), ACI/EurMcwi (MCW)
7 18539208 18539209 A G snv F344/NRrrc (MCW), WN/N (MCW)


Assembly: RGSC_v3.4

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
7 16169314 16169315 C A snv LE/Stm (KNAW)
7 16169315 16169316 C A snv LE/Stm (KNAW)
7 16173014 16173015 A G snv F344/NRrrc (KNAW), WN/N (KNAW)


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620369 AgrOrtholog
Ensembl Genes ENSRNOG00000007921 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000011047 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000032108 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000011047 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000036172 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 3.30.70.330 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7325202 IMAGE-MGC_LOAD
InterPro HnRNP_M UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HnRNP_M_PY-NLS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  hnRNPM_RRM3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nucleotide-bd_a/b_plait_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RBD_domain_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RRM_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:116655 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:109545 IMAGE-MGC_LOAD
NCBI Gene 116655 ENTREZGENE
PANTHER PTHR23003:SF6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam HnRNP_M UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RRM_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Hnrnpm PhenoGen
PROSITE RRM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART RRM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF54928 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Rn.10156 ENTREZGENE
UniProt F1LV13 ENTREZGENE, UniProtKB/TrEMBL
  F1M3D3 ENTREZGENE, UniProtKB/TrEMBL
  HNRPM_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q5M815 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-07-13 Hnrnpm  heterogeneous nuclear ribonucleoprotein M  Hnrpm  heterogeneous nuclear ribonucleoprotein M  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Hnrpm  heterogeneous nuclear ribonucleoprotein M      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Hnrpm  heterogeneous nuclear ribonucleoprotein M      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_domains contains 3 putative RNA-binding domains, an arginine/methionine/glutamine-rich C terminus and 3 potential membrane spanning regions 632922
gene_protein a 78-kDa membrane protein 632922
gene_transcript 2.4-kilobase transcript 632922