Adra1a (adrenoceptor alpha 1A) - Rat Genome Database

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Gene: Adra1a (adrenoceptor alpha 1A) Rattus norvegicus
Symbol: Adra1a
Name: adrenoceptor alpha 1A
RGD ID: 2055
Description: Enables alpha1-adrenergic receptor activity. Involved in several processes, including calcium ion transport into cytosol; positive regulation of cell communication; and regulation of blood circulation. Acts upstream of or within negative regulation of Rho protein signal transduction. Located in T-tubule and Z disc. Is active in several cellular components, including GABA-ergic synapse; dopaminergic synapse; and synaptic membrane. Used to study bladder neck obstruction. Biomarker of hypertension and polycystic ovary syndrome. Human ortholog(s) of this gene implicated in Alzheimer's disease; heroin dependence; and hypertension. Orthologous to human ADRA1A (adrenoceptor alpha 1A); PARTICIPATES IN alfentanil pharmacodynamics pathway; bupivacaine pharmacodynamics pathway; buprenorphine pharmacodynamics pathway; INTERACTS WITH (6aR,9R)-N-[(2S)-1-hydroxybutan-2-yl]-4,7-dimethyl-6,6a,8,9-tetrahydroindolo[4,3-fg]quinoline-9-carboxamide; (R)-adrenaline; (R)-noradrenaline.
Type: protein-coding
Previously known as: Adra1c; adrenergic alpha 1c receptor; adrenergic receptor alpha 1c; adrenergic receptor alpha 1c subtype; adrenergic receptor, alpha 1a; adrenergic receptor, alpha 1c; adrenergic, alpha-1A-, receptor; alpha 1A-adrenoceptor; alpha 1A-adrenoreceptor; alpha 1C-adrenergic receptor; alpha-1A adrenergic receptor; alpha-1A adrenoceptor; alpha-1A adrenoreceptor; alpha-1C adrenergic receptor
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Adra1am1Mcwi  
Genetic Models: FHH-Adra1am1Mcwi
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21540,830,125 - 40,935,902 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1540,832,534 - 40,927,500 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1542,698,261 - 42,788,014 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01543,848,472 - 43,938,221 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01542,292,849 - 42,382,617 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01543,296,997 - 43,398,314 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1543,298,794 - 43,392,451 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01548,197,628 - 48,297,316 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41546,173,429 - 46,263,198 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11546,189,187 - 46,279,387 (+)NCBI
Celera1540,502,534 - 40,590,531 (+)NCBICelera
Cytogenetic Map15p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
(6aR,9R)-N-[(2S)-1-hydroxybutan-2-yl]-4,7-dimethyl-6,6a,8,9-tetrahydroindolo[4,3-fg]quinoline-9-carboxamide  (EXP)
(R)-adrenaline  (EXP,ISO)
(R)-noradrenaline  (EXP,ISO)
(R,R)-tramadol  (EXP)
1,2-dimethylhydrazine  (ISO)
1-(5-isoquinolinesulfonyl)-2-methylpiperazine  (EXP)
1D-myo-inositol 1,4,5-trisphosphate  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-(1-naphthalenylmethyl)-4,5-dihydro-1H-imidazole  (EXP)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
2-phenylethylamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
5-(2-methylpiperazine-1-sulfonyl)isoquinoline  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (EXP)
alfuzosin  (EXP,ISO)
ammonium acetate  (EXP)
ammonium chloride  (EXP)
arsenite(3-)  (ISO)
barium(0)  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
buspirone  (EXP)
butanal  (ISO)
calcium atom  (EXP,ISO)
calcium(0)  (EXP,ISO)
carbon nanotube  (ISO)
carvedilol  (EXP,ISO)
chlorpromazine  (EXP)
chlorpyrifos  (EXP)
clozapine  (EXP)
colforsin daropate hydrochloride  (ISO)
cyclosporin A  (ISO)
D-glucose  (EXP)
diazinon  (EXP)
dibutyl phthalate  (EXP)
dichloroacetic acid  (ISO)
dioxygen  (EXP)
doxazosin  (EXP,ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
epoxiconazole  (ISO)
ethanol  (EXP)
ferroheme b  (ISO)
fipronil  (ISO)
glucose  (EXP)
GR 127935  (EXP)
granisetron  (EXP)
heme b  (ISO)
indoramin  (EXP,ISO)
ketanserin  (EXP,ISO)
KT 5720  (ISO)
lisuride  (EXP)
LY294002  (EXP)
methapyrilene  (ISO)
methiothepin  (EXP)
methysergide  (EXP)
monosodium L-glutamate  (ISO)
N,N-diethyl-m-toluamide  (ISO)
Niguldipine  (ISO)
O-methyleugenol  (ISO)
oxymetazoline  (EXP,ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
Phenoxybenzamine  (EXP)
phentolamine  (ISO)
phenylephrine  (EXP,ISO)
phenylpropanolamine  (ISO)
phorbol 13-acetate 12-myristate  (EXP)
pirinixic acid  (ISO)
potassium atom  (EXP,ISO)
prazosin  (EXP,ISO)
quinidine  (ISO)
raloxifene  (EXP)
sarpogrelate  (ISO)
silicon dioxide  (ISO)
silodosin  (ISO)
sodium arsenite  (ISO)
spiperone  (EXP)
streptozocin  (EXP)
synephrine  (ISO)
tamsulosin  (EXP,ISO)
terazosin  (EXP,ISO)
testosterone  (EXP)
titanium dioxide  (ISO)
tramadol  (EXP)
trichloroethene  (EXP)
troglitazone  (ISO)
trovafloxacin  (ISO)
U-73122  (EXP)
valproic acid  (EXP)
verapamil  (ISO)
Xylometazoline  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of phospholipase C activity  (IDA)
adenylate cyclase-activating adrenergic receptor signaling pathway  (IBA,IEA)
adult heart development  (IEA,ISO)
calcium ion transport into cytosol  (IMP)
cell growth involved in cardiac muscle cell development  (IEA,ISO)
cell-cell signaling  (IBA)
MAPK cascade  (IEA,ISO)
negative regulation of autophagy  (IEA,ISO)
negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure  (IEA,ISO)
negative regulation of Rho protein signal transduction  (IMP)
neuron-glial cell signaling  (IEA,ISO)
norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure  (IEA,ISO)
organ growth  (ISO)
phospholipase C-activating G protein-coupled receptor signaling pathway  (IBA,IEA,ISO)
pilomotor reflex  (IEA,ISO)
positive regulation of action potential  (IMP)
positive regulation of cardiac muscle contraction  (IMP)
positive regulation of cardiac muscle hypertrophy  (IEA,ISO)
positive regulation of cytosolic calcium ion concentration  (IBA,IEA,IMP)
positive regulation of ERK1 and ERK2 cascade  (IMP)
positive regulation of heart rate  (IMP)
positive regulation of heart rate by epinephrine-norepinephrine  (IBA,IEA,ISO)
positive regulation of MAPK cascade  (IBA,IEA,ISO,ISS)
positive regulation of protein kinase C signaling  (IDA,IMP)
positive regulation of smooth muscle contraction  (IEA,IMP,ISO)
positive regulation of synaptic transmission, GABAergic  (IDA)
positive regulation of systemic arterial blood pressure  (IMP)
positive regulation of the force of heart contraction by epinephrine-norepinephrine  (IEA,ISO)
positive regulation of vasoconstriction  (IBA,IDA,IEA,IMP)
presynaptic modulation of chemical synaptic transmission  (EXP,IDA)
regulation of blood pressure  (ISO)
regulation of cardiac muscle contraction  (IEA)
response to cocaine  (ISO)
response to hormone  (IMP)
response to xenobiotic stimulus  (IMP)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
alfentanil pharmacodynamics pathway  (ISO)
bupivacaine pharmacodynamics pathway  (ISO)
buprenorphine pharmacodynamics pathway  (ISO)
calcium/calcium-mediated signaling pathway  (IEA)
carvedilol pharmacodynamics pathway  (ISO)
chloroprocaine pharmacodynamics pathway  (ISO)
citalopram pharmacodynamics pathway  (ISO)
cocaine pharmacodynamics pathway  (ISO)
codeine and morphine pharmacodynamics pathway  (ISO)
desipramine pharmacodynamics pathway  (ISO)
diphenoxylate pharmacodynamics pathway  (ISO)
escitalopram pharmacodynamics pathway  (ISO)
ethylmorphine pharmacodynamics pathway  (ISO)
fentanyl pharmacodynamics pathway  (ISO)
fluoxetine pharmacodynamics pathway  (ISO)
G protein mediated signaling pathway via Galphaq family  (ISS)
heroin pharmacodynamics pathway  (ISO)
hydrocodone pharmacodynamics pathway  (ISO)
hydromorphone pharmacodynamics pathway  (ISO)
imipramine pharmacodynamics pathway  (ISO)
levacetylmethadol pharmacodynamics pathway  (ISO)
levobupivacaine phgarmacodynamics pathway  (ISO)
levorphanol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
mepivacaine pharmacodynamics pathway  (ISO)
methadone pharmacodynamics pathway  (ISO)
nalbuphine pharmacodynamics pathway  (ISO)
naloxone pharmacodynamics pathway  (ISO)
naltrexone pharmacodynamics pathway  (ISO)
nicotine pharmacodynamics pathway  (ISO)
oxybuprocaine pharmacodynamics pathway  (ISO)
oxycodone pharmacodynamics pathway  (ISO)
oxymorphone pharmacodynamics pathway  (ISO)
pentazocine pharmacodynamics pathway  (ISO)
prilocaine pharmacodynamics pathway  (ISO)
procaine pharmacodynamics pathway  (ISO)
remifentanil pharmacodynamics pathway  (ISO)
ropivacaine pharmacodynamics pathway  (ISO)
tramadol pharmacodynamics pathway  (ISO)


References - curated
# Reference Title Reference Citation
1. Vascular alpha1-adrenoceptors in isolated perfused rat kidney: influence of ageing. Awe SO and Adeagbo AS, Auton Autacoid Pharmacol. 2007 Jan;27(1):19-26.
2. Stress impairs alpha(1A) adrenoceptor-mediated noradrenergic facilitation of GABAergic transmission in the basolateral amygdala. Braga MF, etal., Neuropsychopharmacology. 2004 Jan;29(1):45-58.
3. Identification of alpha1-adrenoceptor subtypes involved in contraction of young CD rat epididymal vas deferens. Buccioni M, etal., Eur J Pharmacol. 2009 Jan 14;602(2-3):388-94. Epub 2008 Nov 14.
4. Opposite effects of alpha 1- and beta-adrenoceptor stimulation on both glutamate- and gamma-aminobutyric acid-mediated spontaneous transmission in cultured rat hippocampal neurons. Croce A, etal., J Neurosci Res. 2003 Feb 15;71(4):516-25. doi: 10.1002/jnr.10516.
5. Association study of Catechol-o-methyltransferase and Alpha-1-adrenergic receptor gene polymorphisms with multiple phenotypes of heroin use disorder. Deji C, etal., Neurosci Lett. 2021 Mar 23;748:135677. doi: 10.1016/j.neulet.2021.135677. Epub 2021 Feb 9.
6. alpha(1A)- and alpha(1B)-adrenergic receptors differentially modulate antidepressant-like behavior in the mouse. Doze VA, etal., Brain Res. 2009 Aug 18;1285:148-57. Epub 2009 Jun 18.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. Captopril therapy decreases both expression and function of alpha-adrenoceptors in pre- hypertensive rat aorta. Godinez-Hernandez D, etal., Auton Autacoid Pharmacol. 2006 Jan;26(1):21-9.
10. Cell surface expression of alpha1D-adrenergic receptors is controlled by heterodimerization with alpha1B-adrenergic receptors. Hague C, etal., J Biol Chem. 2004 Apr 9;279(15):15541-9. Epub 2004 Jan 21.
11. Alpha-1A adrenoceptors modulate potentiation of spinal nociceptive pathways in the rat spinal cord in vitro. Hedo G and Lopez-Garcia JA, Neuropharmacology. 2001 Dec;41(7):862-9.
12. Alpha1A-adrenergic receptors are functionally expressed by a subpopulation of cornu ammonis 1 interneurons in rat hippocampus. Hillman KL, etal., J Pharmacol Exp Ther. 2007 Jun;321(3):1062-8. Epub 2007 Mar 2.
13. Enhancement of methoxamine-induced contractile responses of rat ventricular muscle in streptozotocin-induced diabetes is associated with alpha1A adrenoceptor upregulation. Kamata K, etal., Acta Physiol (Oxf). 2006 Nov-Dec;188(3-4):173-83.
14. Altered adrenergic receptor signaling following traumatic brain injury contributes to working memory dysfunction. Kobori N, etal., Neuroscience. 2011 Jan 13;172:293-302. Epub 2010 Oct 23.
15. The rat homologue of the bovine alpha 1c-adrenergic receptor shows the pharmacological properties of the classical alpha 1A subtype. Laz TM, etal., Mol Pharmacol 1994 Sep;46(3):414-22.
16. Alpha1-adrenoceptors involvement in painful diabetic neuropathy: a role in allodynia. Lee YH, etal., Neuroreport. 2000 May 15;11(7):1417-20.
17. Receptor subtype involved in alpha 1-adrenergic receptor-mediated Ca2+ signaling in cardiomyocytes. Luo DL, etal., Acta Pharmacol Sin. 2007 Jul;28(7):968-74.
18. Ovarian expression of alpha (1)- and beta (2)-adrenoceptors and p75 neurotrophin receptors in rats with steroid-induced polycystic ovaries. Manni L, etal., Auton Neurosci. 2005 Mar 31;118(1-2):79-87.
19. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
20. a-1 Adrenergic receptors are localized on presynaptic elements in the nucleus accumbens and regulate mesolimbic dopamine transmission. Mitrano DA, etal., Neuropsychopharmacology. 2012 Aug;37(9):2161-72. doi: 10.1038/npp.2012.68. Epub 2012 May 16.
21. Noradrenaline contracts rat retinal arterioles via stimulation of alpha(1A)- and alpha(1D)-adrenoceptors. Mori A, etal., Eur J Pharmacol. 2011 Dec 30;673(1-3):65-9. Epub 2011 Oct 21.
22. Repeated imipramine and electroconvulsive shock increase alpha 1A-adrenoceptor mRNA level in rat prefrontal cortex. Nalepa I, etal., Eur J Pharmacol 2002 May 31;444(3):151-9.
23. Interaction of alpha1-adrenoceptor subtypes with different G proteins induces opposite effects on cardiac L-type Ca2+ channel. O-Uchi J, etal., Circ Res. 2008 Jun 6;102(11):1378-88. Epub 2008 May 8.
24. MURC, a muscle-restricted coiled-coil protein that modulates the Rho/ROCK pathway, induces cardiac dysfunction and conduction disturbance. Ogata T, etal., Mol Cell Biol. 2008 May;28(10):3424-36. doi: 10.1128/MCB.02186-07. Epub 2008 Mar 10.
25. Evaluation of the structural variation among light chain variable domains. Padlan EA Mol Immunol. 1979 May;16(5):287-96.
26. Alpha 1 adrenergic receptor control of renal blood vessels during aging. Passmore JC, etal., Can J Physiol Pharmacol. 2005 Apr;83(4):335-42.
27. Alpha1-adrenergic receptors: new insights and directions. Piascik MT and Perez DM, J Pharmacol Exp Ther. 2001 Aug;298(2):403-10.
28. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
29. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
30. GOA pipeline RGD automated data pipeline
31. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
32. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
33. Comprehensive gene review and curation RGD comprehensive gene curation
34. Alpha1-adrenoceptors in the rat cerebral cortex: new insights into the characterization of alpha1L- and alpha1D-adrenoceptors. Segura V, etal., Eur J Pharmacol. 2010 Sep 1;641(1):41-8. Epub 2010 May 23.
35. Cloning of the rat alpha 1C-adrenergic receptor from cardiac myocytes. alpha 1C, alpha 1B, and alpha 1D mRNAs are present in cardiac myocytes but not in cardiac fibroblasts. Stewart AF, etal., Circ Res 1994 Oct;75(4):796-802.
36. A selective alpha1A-adrenoceptor antagonist inhibits detrusor overactivity in a rat model of benign prostatic hyperplasia. Tatemichi S, etal., J Urol. 2006 Sep;176(3):1236-41.
37. Heteromerization of chemokine (C-X-C motif) receptor 4 with α1A/B-adrenergic receptors controls α1-adrenergic receptor function. Tripathi A, etal., Proc Natl Acad Sci U S A. 2015 Mar 31;112(13):E1659-68. doi: 10.1073/pnas.1417564112. Epub 2015 Mar 16.
38. Evidence that NAN-190-induced hypotension involves vascular alpha1-adrenoceptor antagonism in the rat. Villalobos-Molina R, etal., Eur J Pharmacol. 2002 Nov 22;455(1):59-64.
39. Age-dependent regulation of depression-like behaviors through modulation of adrenergic receptor alphaA subtype expression revealed by the analysis of interleukin-1 receptor antagonist knockout mice. Wakabayashi C, etal., Neuroscience. 2011 Sep 29;192:475-84. Epub 2011 Jun 17.
40. Potential relevance of alpha(1)-adrenergic receptor autoantibodies in refractory hypertension. Wenzel K, etal., PLoS One. 2008;3(11):e3742. Epub 2008 Nov 17.
41. Alpha1-adrenoceptor antagonists improve bladder storage function through reduction of afferent activity in rats with bladder outlet obstruction. Yazaki J, etal., Neurourol Urodyn. 2011 Mar;30(3):461-7. doi: 10.1002/nau.20984. Epub 2010 Sep 30.
42. Role of supraspinal and spinal alpha1-adrenergic receptor subtypes in micturition reflex in conscious rats. Yoshizumi M, etal., Am J Physiol Renal Physiol. 2010 Oct;299(4):F785-91. Epub 2010 Jul 28.
43. [Role of alpha-adrenergic receptors in vascular hyperreactivity in rats with high level spinal injury]. Zou Z, etal., Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2006 Mar;18(3):176-9.
Additional References at PubMed
PMID:7693016   PMID:8185565   PMID:9590558   PMID:9630362   PMID:10493741   PMID:12093905   PMID:12184796   PMID:12471020   PMID:12595294   PMID:12724349   PMID:12782680   PMID:12784082  
PMID:12837924   PMID:15140898   PMID:15496483   PMID:15550506   PMID:15690361   PMID:15964981   PMID:16037404   PMID:16308429   PMID:16517124   PMID:17512257   PMID:17537920   PMID:17671986  
PMID:18204069   PMID:18246093   PMID:18255226   PMID:18257746   PMID:18297111   PMID:18314882   PMID:18351393   PMID:18430422   PMID:18480291   PMID:18997438   PMID:19068224   PMID:19201164  
PMID:19302553   PMID:19685172   PMID:19686710   PMID:19844130   PMID:20739228   PMID:20977469   PMID:21182905   PMID:21335239   PMID:21373947   PMID:21535246   PMID:21546445   PMID:21958220  
PMID:22076634   PMID:22120526   PMID:22302710   PMID:22307672   PMID:22358083   PMID:22504059   PMID:22506532   PMID:22542873   PMID:23071607   PMID:23195622   PMID:23916734   PMID:24404141  
PMID:24526581   PMID:24567387   PMID:24939293   PMID:24950619   PMID:25032954   PMID:25630693   PMID:25857252   PMID:26189024   PMID:26277396   PMID:26593425   PMID:26676573   PMID:26700590  
PMID:27994061   PMID:28276515   PMID:28569366   PMID:29329779   PMID:29685886   PMID:30520144   PMID:33025031   PMID:33166680   PMID:34062902   PMID:34204888  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21540,830,125 - 40,935,902 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1540,832,534 - 40,927,500 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1542,698,261 - 42,788,014 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01543,848,472 - 43,938,221 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01542,292,849 - 42,382,617 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01543,296,997 - 43,398,314 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1543,298,794 - 43,392,451 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01548,197,628 - 48,297,316 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41546,173,429 - 46,263,198 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11546,189,187 - 46,279,387 (+)NCBI
Celera1540,502,534 - 40,590,531 (+)NCBICelera
Cytogenetic Map15p12NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38826,748,150 - 26,867,379 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl826,748,150 - 26,867,278 (-)EnsemblGRCh38hg38GRCh38
GRCh37826,605,667 - 26,724,795 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36826,661,584 - 26,778,839 (-)NCBINCBI36Build 36hg18NCBI36
Build 34826,679,287 - 26,778,603NCBI
Celera825,568,607 - 25,685,865 (-)NCBICelera
Cytogenetic Map8p21.2NCBI
HuRef825,150,527 - 25,267,740 (-)NCBIHuRef
CHM1_1826,807,550 - 26,924,814 (-)NCBICHM1_1
T2T-CHM13v2.0827,024,936 - 27,144,213 (-)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391466,872,705 - 67,009,549 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1466,872,700 - 67,008,617 (+)EnsemblGRCm39 Ensembl
GRCm381466,635,251 - 66,771,240 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1466,635,251 - 66,771,168 (+)EnsemblGRCm38mm10GRCm38
MGSCv371467,254,095 - 67,352,166 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361465,589,368 - 65,687,439 (+)NCBIMGSCv36mm8
Celera1464,381,891 - 64,479,506 (+)NCBICelera
Cytogenetic Map14D1NCBI
cM Map1434.6NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495540349,399,127 - 49,485,934 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540349,394,173 - 49,485,881 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1820,997,925 - 21,112,427 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0825,947,996 - 26,138,022 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1822,930,296 - 23,043,595 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl822,853,677 - 23,044,388 (-)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.12530,690,959 - 30,801,484 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2530,693,571 - 30,801,486 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2531,281,657 - 31,383,233 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02530,890,909 - 31,000,565 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2530,890,925 - 31,010,689 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12530,825,262 - 30,929,065 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02530,697,626 - 30,799,475 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02530,864,630 - 30,965,891 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_0244049438,896,700 - 8,984,131 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936757150,496 - 237,710 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936757149,366 - 237,710 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl1410,626,293 - 10,733,068 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11410,623,391 - 10,733,378 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21411,811,795 - 11,910,037 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1824,884,187 - 24,985,824 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl824,885,741 - 24,983,125 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605217,173,567 - 17,274,934 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_00462475821,569,908 - 21,665,244 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475821,557,161 - 21,665,432 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Adra1a
605 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:72
Count of miRNA genes:55
Interacting mature miRNAs:70
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
731170Pur3Proteinuria QTL 32.30.0005urine protein amount (VT:0005160)urine protein excretion rate (CMO:0000759)15141686771Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15142356671Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15155302115Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1530632945306329Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15226636846921453Rat
1582251Gluco24Glucose level QTL 243.20.0008blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)15553075650530756Rat
631273Lecl2Lens clarity QTL 20.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)151059608955596089Rat
2300167Bmd63Bone mineral density QTL 635.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2300173Bmd62Bone mineral density QTL 6212.80.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2293688Bss29Bone structure and strength QTL 295.310.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)151111114256111142Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151249614165205939Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151672552880672115Rat
1331729Rf42Renal function QTL 423.071kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)151736289773690657Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)151985656646187442Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152211793367117933Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)152280624098288169Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)152280624098288169Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)152280624098288169Rat
1582214Stl21Serum triglyceride level QTL 213.10.022blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)152803066582262678Rat
1582227Gluco30Glucose level QTL 303.60.0003blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)152803066582262678Rat
1582228Epfw3Epididymal fat weight QTL 34.10.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
1582242Gluco28Glucose level QTL 283.30.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)152803066582262678Rat
1582244Bw79Body weight QTL 7940.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
2293691Bmd37Bone mineral density QTL 376.60.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)153361105871477291Rat
2293686Bmd36Bone mineral density QTL 367.40.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)153361105871477291Rat
1598828Glom14Glomerulus QTL 142.5kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)153405413979054139Rat
7411725Strs7Sensitivity to stroke QTL 73.8cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)154028990149308583Rat
2306968Anxrr23Anxiety related response QTL 234.83reflex trait (VT:0001961)amplitude of the acoustic startle response (CMO:0001520)154063126846187442Rat
1300144Rf23Renal function QTL 233.61renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)154063126898288169Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21540,887,820 - 40,888,072 (+)MAPPERmRatBN7.2
Rnor_6.01543,358,016 - 43,358,267NCBIRnor6.0
Rnor_5.01548,237,671 - 48,237,922UniSTSRnor5.0
RGSC_v3.41546,228,079 - 46,228,331RGDRGSC3.4
RGSC_v3.41546,228,080 - 46,228,331UniSTSRGSC3.4
RGSC_v3.11546,243,860 - 46,244,111RGD
Celera1540,557,512 - 40,557,767UniSTS
RH 3.4 Map15311.0UniSTS
RH 3.4 Map15311.0RGD
RH 2.0 Map15297.6RGD
Cytogenetic Map15p12UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21540,832,162 - 40,832,668 (+)MAPPERmRatBN7.2
Rnor_6.01543,298,993 - 43,299,498NCBIRnor6.0
Rnor_5.01548,294,911 - 48,295,416UniSTSRnor5.0
RGSC_v3.41546,173,037 - 46,173,542UniSTSRGSC3.4
Celera1540,502,142 - 40,502,647UniSTS
Cytogenetic Map15p12UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21540,832,878 - 40,832,954 (+)MAPPERmRatBN7.2
Rnor_6.01543,299,709 - 43,299,784NCBIRnor6.0
Rnor_5.01548,294,625 - 48,294,700UniSTSRnor5.0
RGSC_v3.41546,173,753 - 46,173,828UniSTSRGSC3.4
Celera1540,502,858 - 40,502,933UniSTS
Cytogenetic Map15p12UniSTS

Genetic Models
This gene Adra1a is modified in the following models/strains:


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 15 1 1 6
Low 14 13 13 8 10 74 23 23 5 8
Below cutoff 2 8 11 9 5 9 1 8 17


RefSeq Acc Id: ENSRNOT00000012736   ⟹   ENSRNOP00000012736
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1540,832,534 - 40,927,500 (+)Ensembl
Rnor_6.0 Ensembl1543,298,794 - 43,392,451 (+)Ensembl
RefSeq Acc Id: NM_017191   ⟹   NP_058887
Rat AssemblyChrPosition (strand)Source
mRatBN7.21540,832,555 - 40,922,324 (+)NCBI
Rnor_6.01543,299,385 - 43,392,431 (+)NCBI
Rnor_5.01548,197,628 - 48,297,316 (-)NCBI
RGSC_v3.41546,173,429 - 46,263,198 (+)RGD
Celera1540,502,534 - 40,590,531 (+)RGD
RefSeq Acc Id: XM_006252107   ⟹   XP_006252169
Rat AssemblyChrPosition (strand)Source
mRatBN7.21540,830,125 - 40,935,902 (+)NCBI
Rnor_6.01543,296,997 - 43,398,314 (+)NCBI
Rnor_5.01548,197,628 - 48,297,316 (-)NCBI
RefSeq Acc Id: XM_006252109   ⟹   XP_006252171
Rat AssemblyChrPosition (strand)Source
mRatBN7.21540,830,125 - 40,935,902 (+)NCBI
Rnor_6.01543,296,997 - 43,398,314 (+)NCBI
Rnor_5.01548,197,628 - 48,297,316 (-)NCBI
RefSeq Acc Id: XM_006252110   ⟹   XP_006252172
Rat AssemblyChrPosition (strand)Source
mRatBN7.21540,830,127 - 40,935,902 (+)NCBI
Rnor_6.01543,297,009 - 43,398,314 (+)NCBI
Rnor_5.01548,197,628 - 48,297,316 (-)NCBI
RefSeq Acc Id: XM_039093212   ⟹   XP_038949140
Rat AssemblyChrPosition (strand)Source
mRatBN7.21540,830,125 - 40,935,902 (+)NCBI
RefSeq Acc Id: XM_039093213   ⟹   XP_038949141
Rat AssemblyChrPosition (strand)Source
mRatBN7.21540,830,125 - 40,935,902 (+)NCBI
RefSeq Acc Id: NP_058887   ⟸   NM_017191
- UniProtKB: P43140 (UniProtKB/Swiss-Prot),   A6K6N1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006252171   ⟸   XM_006252109
- Peptide Label: isoform X3
- UniProtKB: A0A8L2Q6V0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006252169   ⟸   XM_006252107
- Peptide Label: isoform X1
- UniProtKB: P43140 (UniProtKB/Swiss-Prot),   A6K6N1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006252172   ⟸   XM_006252110
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: ENSRNOP00000012736   ⟸   ENSRNOT00000012736
RefSeq Acc Id: XP_038949140   ⟸   XM_039093212
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038949141   ⟸   XM_039093213
- Peptide Label: isoform X4
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P43140-F1-model_v2 AlphaFold P43140 1-466 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2055 AgrOrtholog
BioCyc Gene G2FUF-13323 BioCyc
Ensembl Genes ENSRNOG00000009522 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000012736 ENTREZGENE
  ENSRNOT00000012736.4 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ADR_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ADRA1A_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29412 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Adra1a PhenoGen
  ADRENRGCA1AR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000009522 RatGTEx
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-07-13 Adra1a  adrenoceptor alpha 1A  Adra1a  adrenergic, alpha-1A-, receptor  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-18 Adra1a  adrenergic, alpha-1A-, receptor  Adra1a  adrenergic receptor, alpha 1a  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Adra1a  adrenergic receptor, alpha 1a      Symbol and Name status set to approved 70586 APPROVED
2001-06-22 Adra1c  Adrenergic , alpha 1c, receptor      Symbol and Name withdrawn 67952 WITHDRAWN
2001-06-22 Adra1a  Adrenergic receptor, alpha 1a      Symbol and Name updated to reflect Human and Mouse nomenclature 67952 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease may mediate effects of repeated imipramine and electroconvulsive shock antidepressant therapies 631767
gene_drugs increased receptor density in prefrontal cortex and hippocampus is observed in response to anti-depressants treatments of repeated imipramine and electroconvulsive shock 631767
gene_expression expressed in heart 631766
gene_expression expressed in adult and neonatal cardiac myocytes 631766
gene_expression is not expressed in cardiac fibroblasts 631766
gene_expression expressed in brain prefrontal cortex and hippocampus 631767
gene_expression mRNA detected in vas deferans, heart, kidney, and hippocampus 69745
gene_function binds adrenergic compounds and analogs and activates phospholipase C 69745
gene_process mediates signal transduction through activation of phospholipase C 69745