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Gene: Adra1a (adrenoceptor alpha 1A) Rattus norvegicus
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Symbol: Adra1a
Name: adrenoceptor alpha 1A
Description: Exhibits alpha1-adrenergic receptor activity. Involved in several processes, including modulation of chemical synaptic transmission; positive regulation of blood circulation; and regulation of intracellular signal transduction. Localizes to several cellular components, including Z disc; dopaminergic synapse; and integral component of synaptic membrane. Used to study bladder neck obstruction. Biomarker of hypertension and polycystic ovary syndrome. Human ortholog(s) of this gene implicated in Alzheimer's disease and hypertension. Orthologous to human ADRA1A (adrenoceptor alpha 1A); PARTICIPATES IN alfentanil pharmacodynamics pathway; bupivacaine pharmacodynamics pathway; buprenorphine pharmacodynamics pathway; INTERACTS WITH (6aR,9R)-N-[(2S)-1-hydroxybutan-2-yl]-4,7-dimethyl-6,6a,8,9-tetrahydroindolo[4,3-fg]quinoline-9-carboxamide; (R)-adrenaline; (R)-noradrenaline.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: Adra1c; adrenergic alpha 1c receptor; adrenergic receptor alpha 1c; adrenergic receptor alpha 1c subtype; adrenergic receptor, alpha 1a; adrenergic receptor, alpha 1c; adrenergic, alpha-1A-, receptor; alpha 1A-adrenoceptor; alpha 1A-adrenoreceptor; alpha 1C-adrenergic receptor; alpha-1A adrenergic receptor; alpha-1A adrenoceptor; alpha-1A adrenoreceptor; alpha-1C adrenergic receptor
Orthologs:
Homo sapiens (human) : ADRA1A (adrenoceptor alpha 1A)  HGNC  Alliance
Mus musculus (house mouse) : Adra1a (adrenergic receptor, alpha 1a)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Adra1a (adrenoceptor alpha 1A)
Pan paniscus (bonobo/pygmy chimpanzee) : ADRA1A (adrenoceptor alpha 1A)
Canis lupus familiaris (dog) : ADRA1A (adrenoceptor alpha 1A)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Adra1a (adrenoceptor alpha 1A)
Sus scrofa (pig) : ADRA1A (adrenoceptor alpha 1A)
Chlorocebus sabaeus (African green monkey) : ADRA1A (adrenoceptor alpha 1A)
Heterocephalus glaber (naked mole-rat) : Adra1a (adrenoceptor alpha 1A)
more info ...
Allele / Splice: Adra1am1Mcwi  
Genetic Models: FHH-Adra1am1Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01543,296,997 - 43,398,314 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1543,298,794 - 43,392,451 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01548,197,628 - 48,297,316 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41546,173,429 - 46,263,198 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11546,189,187 - 46,279,387 (+)NCBI
Celera1540,502,534 - 40,590,531 (+)NCBICelera
Cytogenetic Map15p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Adra1a
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2055
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-07-21
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.