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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2055
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Adra1a
Name: adrenoceptor alpha 1A
Acc ID: CHEBI:8364
Term: prazosin
Definition: A member of the class of piperazines that is piperazine substituted by a furan-2-ylcarbonyl group and a 4-amino-6,7-dimethoxyquinazolin-2-yl group at positions 1 and 4 respectively.
Chemical ID: MESH:D011224
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Adra1aaffects bindingEXP 6480464CTDPrazosin binds to ADRA1A proteinPMID:7536677
Adra1aincreases expressionEXP 6480464CTDPrazosin results in increased expression of ADRA1A mRNA; Prazosin results in increased expression of ADRA1A proteinPMID:11693201 PMID:11934817
Adra1amultiple interactionsEXP 6480464CTDPrazosin binds to and affects the activity of ADRA1A protein; Prazosin binds to and results in decreased activity of ADRA1A protein; Prazosin inhibits the reaction [[cirazoline results in increased activity of ADRA1A protein] which results in increased transport of Glucose]; Prazosin inhibits the reaction [Norepinephrine results in increased activity of ADRA1A protein]PMID:10416824 PMID:15550506 PMID:15951348 PMID:16545797 PMID:9639061
Adra1aaffects bindingISOADRA1A (Homo sapiens)6480464CTDADRA1A protein binds to Prazosin; Prazosin binds to ADRA1A proteinPMID:20030735 PMID:7536677 PMID:8183249 PMID:8196478
Adra1adecreases activityISOAdra1a (Mus musculus)6480464CTDPrazosin results in decreased activity of ADRA1A proteinPMID:6310690
Adra1amultiple interactionsISOADRA1A (Homo sapiens)6480464CTD1-(2-(3-methoxyphenyl)ethyl)phenoxy-3-(dimethylamino)-2-propanol inhibits the reaction [Prazosin binds to ADRA1A protein]; alfuzosin inhibits the reaction [Prazosin binds to ADRA1A protein]; Epinephrine inhibits the reaction [ADRA1A protein binds to Prazosin]; Ketanserin inhibits the reaction [Prazosin binds to ADRA1A protein]; Norepinephrine inhibits the reaction [ADRA1A protein binds to Prazosin]; Oxymetazoline inhibits the reaction [ADRA1A protein binds to Prazosin]; Oxymetazoline inhibits the reaction [Prazosin binds to ADRA1A protein]; Prazosin binds to and results in decreased activity of ADRA1A protein; Prazosin inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in decreased transport of Potassium]; sarpogrelate inhibits the reaction [Prazosin binds to ADRA1A protein]; xylometazoline inhibits the reaction [ADRA1A protein binds to Prazosin]PMID:11937776 PMID:15365637 PMID:15627480 PMID:20030735 PMID:8196478
Adra1amultiple interactionsISOAdra1a (Mus musculus)6480464CTDPrazosin binds to and results in decreased activity of ADRA1A proteinPMID:12560108
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