Adra1a (adrenoceptor alpha 1A) - Rat Genome Database

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Gene: Adra1a (adrenoceptor alpha 1A) Chinchilla lanigera
Analyze
Symbol: Adra1a
Name: adrenoceptor alpha 1A
RGD ID: 9059825
Description: ENCODES a protein that exhibits alpha1-adrenergic receptor activity (ortholog); protein heterodimerization activity (ortholog); INVOLVED IN response to cocaine; adrenergic receptor signaling pathway (ortholog); adult heart development (ortholog); PARTICIPATES IN alfentanil pharmacodynamics pathway; bupivacaine pharmacodynamics pathway; buprenorphine pharmacodynamics pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); bladder neck obstruction (ortholog); Brain Injuries (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); dopaminergic synapse (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Alpha 1-adrenergic receptor ; alpha-1A adrenergic receptor
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540349,399,127 - 49,485,934 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540349,394,173 - 49,485,881 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adrenergic receptor signaling pathway  (ISO)
adult heart development  (ISO)
cell growth involved in cardiac muscle cell development  (ISO)
MAPK cascade  (ISO)
negative regulation of autophagy  (ISO)
negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure  (ISO)
negative regulation of Rho protein signal transduction  (ISO)
neuron-glial cell signaling  (ISO)
norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure  (ISO)
organ growth  (ISO)
phospholipase C-activating adrenergic receptor signaling pathway  (ISO)
phospholipase C-activating G protein-coupled receptor signaling pathway  (ISO)
pilomotor reflex  (ISO)
positive regulation of action potential  (ISO)
positive regulation of cardiac muscle contraction  (ISO)
positive regulation of cardiac muscle hypertrophy  (ISO)
positive regulation of cytosolic calcium ion concentration  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of heart rate  (ISO)
positive regulation of heart rate by epinephrine-norepinephrine  (ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of phospholipase C/protein kinase C signal transduction  (ISO)
positive regulation of smooth muscle contraction  (ISO)
positive regulation of synaptic transmission, GABAergic  (ISO)
positive regulation of systemic arterial blood pressure  (ISO)
positive regulation of the force of heart contraction by epinephrine-norepinephrine  (ISO)
positive regulation of vasoconstriction  (ISO)
presynaptic modulation of chemical synaptic transmission  (ISO)
regulation of blood pressure  (ISO)
response to cocaine  (IMP)
response to hormone  (ISO)
response to xenobiotic stimulus  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
alfentanil pharmacodynamics pathway  (ISO)
bupivacaine pharmacodynamics pathway  (ISO)
buprenorphine pharmacodynamics pathway  (ISO)
carvedilol pharmacodynamics pathway  (ISO)
chloroprocaine pharmacodynamics pathway  (ISO)
citalopram pharmacodynamics pathway  (ISO)
cocaine pharmacodynamics pathway  (ISO)
codeine and morphine pharmacodynamics pathway  (ISO)
desipramine pharmacodynamics pathway  (ISO)
diphenoxylate pharmacodynamics pathway  (ISO)
escitalopram pharmacodynamics pathway  (ISO)
ethylmorphine pharmacodynamics pathway  (ISO)
fentanyl pharmacodynamics pathway  (ISO)
fluoxetine pharmacodynamics pathway  (ISO)
G protein mediated signaling pathway via Galphaq family  (ISO)
heroin pharmacodynamics pathway  (ISO)
hydrocodone pharmacodynamics pathway  (ISO)
hydromorphone pharmacodynamics pathway  (ISO)
imipramine pharmacodynamics pathway  (ISO)
levacetylmethadol pharmacodynamics pathway  (ISO)
levobupivacaine phgarmacodynamics pathway  (ISO)
levorphanol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
mepivacaine pharmacodynamics pathway  (ISO)
methadone pharmacodynamics pathway  (ISO)
nalbuphine pharmacodynamics pathway  (ISO)
naloxone pharmacodynamics pathway  (ISO)
naltrexone pharmacodynamics pathway  (ISO)
nicotine pharmacodynamics pathway  (ISO)
oxybuprocaine pharmacodynamics pathway  (ISO)
oxycodone pharmacodynamics pathway  (ISO)
oxymorphone pharmacodynamics pathway  (ISO)
pentazocine pharmacodynamics pathway  (ISO)
prilocaine pharmacodynamics pathway  (ISO)
procaine pharmacodynamics pathway  (ISO)
remifentanil pharmacodynamics pathway  (ISO)
ropivacaine pharmacodynamics pathway  (ISO)
tramadol pharmacodynamics pathway  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
2. Alpha 1-adrenergic receptor antagonist blocks acute cocaine action on the compound action potential of the auditory nerve in the chinchilla. Shivapuja BG, etal., Drug Alcohol Depend. 1995 Nov;40(1):43-8.
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Adra1a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540349,399,127 - 49,485,934 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540349,394,173 - 49,485,881 (-)NCBIChiLan1.0ChiLan1.0
ADRA1A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38826,748,150 - 26,867,379 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl826,748,150 - 26,867,278 (-)EnsemblGRCh38hg38GRCh38
GRCh37826,605,667 - 26,724,795 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36826,661,584 - 26,778,839 (-)NCBINCBI36Build 36hg18NCBI36
Build 34826,679,287 - 26,778,603NCBI
Celera825,568,607 - 25,685,865 (-)NCBICelera
Cytogenetic Map8p21.2NCBI
HuRef825,150,527 - 25,267,740 (-)NCBIHuRef
CHM1_1826,807,550 - 26,924,814 (-)NCBICHM1_1
T2T-CHM13v2.0827,024,936 - 27,144,213 (-)NCBIT2T-CHM13v2.0
Adra1a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391466,872,705 - 67,009,549 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1466,872,700 - 67,008,617 (+)EnsemblGRCm39 Ensembl
GRCm381466,635,251 - 66,771,240 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1466,635,251 - 66,771,168 (+)EnsemblGRCm38mm10GRCm38
MGSCv371467,254,095 - 67,352,166 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361465,589,368 - 65,687,439 (+)NCBIMGSCv36mm8
Celera1464,381,891 - 64,479,506 (+)NCBICelera
Cytogenetic Map14D1NCBI
cM Map1434.6NCBI
Adra1a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81545,005,648 - 45,111,416 (+)NCBIGRCr8
mRatBN7.21540,830,125 - 40,935,902 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1540,832,534 - 40,927,500 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1542,698,261 - 42,788,014 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01543,848,472 - 43,938,221 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01542,292,849 - 42,382,617 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01543,296,997 - 43,398,314 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1543,298,794 - 43,392,451 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01548,197,628 - 48,297,316 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41546,173,429 - 46,263,198 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11546,189,187 - 46,279,387 (+)NCBI
Celera1540,502,534 - 40,590,531 (+)NCBICelera
Cytogenetic Map15p12NCBI
ADRA1A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2745,208,441 - 45,398,224 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1820,997,925 - 21,112,427 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0825,947,996 - 26,138,022 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1822,930,296 - 23,043,595 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl822,853,677 - 23,044,388 (-)Ensemblpanpan1.1panPan2
ADRA1A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12530,690,959 - 30,801,484 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2530,693,571 - 30,801,486 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2531,281,657 - 31,383,233 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02530,890,909 - 31,000,565 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2530,890,925 - 31,010,689 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12530,825,262 - 30,929,065 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02530,697,626 - 30,799,475 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02530,864,630 - 30,965,891 (+)NCBIUU_Cfam_GSD_1.0
Adra1a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049438,896,700 - 8,984,131 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936757150,496 - 237,710 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936757149,366 - 237,710 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADRA1A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1410,626,293 - 10,733,068 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11410,623,391 - 10,733,378 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21411,811,795 - 11,910,037 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ADRA1A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1824,884,187 - 24,985,824 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl824,885,741 - 24,983,125 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605217,173,567 - 17,274,934 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Adra1a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475821,569,908 - 21,665,244 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475821,557,161 - 21,665,432 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSCLAT00000021652   ⟹   ENSCLAP00000021449
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495540349,399,127 - 49,485,934 (-)Ensembl
Ensembl Acc Id: ENSCLAT00000021653   ⟹   ENSCLAP00000021450
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495540349,403,423 - 49,485,934 (-)Ensembl
RefSeq Acc Id: XM_013514140   ⟹   XP_013369594
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495540349,394,173 - 49,485,881 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013514141   ⟹   XP_013369595
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495540349,394,173 - 49,485,347 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013514144   ⟹   XP_013369598
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495540349,426,840 - 49,485,347 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_013369594 (Get FASTA)   NCBI Sequence Viewer  
  XP_013369595 (Get FASTA)   NCBI Sequence Viewer  
  XP_013369598 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000021449
  ENSCLAP00000021449.1
  ENSCLAP00000021450
  ENSCLAP00000021450.1
RefSeq Acc Id: XP_013369594   ⟸   XM_013514140
- Peptide Label: isoform X1
- UniProtKB: A0A8C2YT61 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013369595   ⟸   XM_013514141
- Peptide Label: isoform X2
- UniProtKB: A0A8C2YT60 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013369598   ⟸   XM_013514144
- Peptide Label: isoform X3
- Sequence:
Ensembl Acc Id: ENSCLAP00000021450   ⟸   ENSCLAT00000021653
Ensembl Acc Id: ENSCLAP00000021449   ⟸   ENSCLAT00000021652
Protein Domains
G-protein coupled receptors family 1 profile


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000014689 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000021652 ENTREZGENE
  ENSCLAT00000021652.1 UniProtKB/TrEMBL
  ENSCLAT00000021653 ENTREZGENE
  ENSCLAT00000021653.1 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro ADR_fam UniProtKB/TrEMBL
  ADRA1A_rcpt UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/TrEMBL
NCBI Gene Adra1a ENTREZGENE
PANTHER ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR UniProtKB/TrEMBL
  ALPHA-1A ADRENERGIC RECEPTOR UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/TrEMBL
PRINTS ADRENERGICR UniProtKB/TrEMBL
  ADRENRGCA1AR UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
SMART 7TM_GPCR_Srsx UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/TrEMBL
UniProt A0A8C2YT60 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C2YT61 ENTREZGENE, UniProtKB/TrEMBL