RGD Reference Report - Noradrenaline contracts rat retinal arterioles via stimulation of alpha(1A)- and alpha(1D)-adrenoceptors. - Rat Genome Database

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Noradrenaline contracts rat retinal arterioles via stimulation of alpha(1A)- and alpha(1D)-adrenoceptors.

Authors: Mori, A  Hanada, M  Sakamoto, K  Nakahara, T  Ishii, K 
Citation: Mori A, etal., Eur J Pharmacol. 2011 Dec 30;673(1-3):65-9. Epub 2011 Oct 21.
RGD ID: 5688308
Pubmed: PMID:22040923   (View Abstract at PubMed)
DOI: DOI:10.1016/j.ejphar.2011.10.012   (Journal Full-text)

The aim of this study was to characterize the alpha-adrenoceptor subtype(s) involved in the noradrenaline-induced contraction of retinal arterioles in rats. In vivo ocular fundus images were captured with a digital camera equipped with a special objective lens. By measuring changes in diameter of retinal arterioles in the fundus images, retinal vascular response was assessed. The systemic blood pressure and heart rate in the animals were also continuously recorded. Following blockade of beta/beta-adrenoceptors with propranolol, noradrenaline (0.03-3 mug/kg/min, i.v.) decreased the diameter of retinal arterioles and increased the mean blood pressure in a dose-dependent manner. The highest dose (3 mug/kg/min, i.v.) of noradrenaline caused a small increase in heart rate. The alpha(1A)-adrenoceptor antagonist RS100329 (0.1 mg/kg, i.v.) and the alpha(1D)-adrenoceptor antagonist BMY 7378 (1 mg/kg, i.v.) significantly prevented noradrenaline-induced contraction of retinal arterioles and pressor responses whereas the alpha(1B)-adrenoceptor antagonist L-765314 (1 mg/kg, i.v.) did not. The alpha(1A)-adrenoceptor agonist, A 61603 (0.03-0.3 mug/kg/min, i.v.), also caused contractile responses of retinal arterioles and pressor responses. These responses were almost completely prevented by RS100329 (0.1 mg/kg, i.v.), but not by BMY 7378 (1 mg/kg, i.v.). These results suggest that the contractile effects of noradrenaline on retinal arterioles and peripheral resistance vessels are, at least in part, mediated by stimulation of alpha(1A)- and alpha(1D)-adrenoceptors. Furthermore, it is likely that the alpha-adrenoceptor subtype(s) involved in rat vascular responses are similar in both retinal and peripheral circulation.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Adra1aRatpositive regulation of heart rate  IMP  RGD 
Adra1aRatpositive regulation of systemic arterial blood pressure  IMP  RGD 
Adra1aRatpositive regulation of vasoconstriction  IMP  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Adra1a  (adrenoceptor alpha 1A)


Additional Information