Csk (C-terminal Src kinase) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Csk (C-terminal Src kinase) Rattus norvegicus
Analyze
Symbol: Csk
Name: C-terminal Src kinase
RGD ID: 1308800
Description: Enables enzyme binding activity; proline-rich region binding activity; and protein tyrosine kinase activity. Involved in several processes, including negative regulation of bone resorption; negative regulation of interleukin-6 production; and regulation of signal transduction. Located in cytoplasm. Biomarker of hepatocellular carcinoma. Orthologous to human CSK (C-terminal Src kinase); PARTICIPATES IN platelet-derived growth factor signaling pathway; chemokine mediated signaling pathway; neurotrophic factor signaling pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dibromophenyl 2,4,5-tribromophenyl ether.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: C-SRC kinase; c-src tyrosine kinase; CSK, non-receptor tyrosine kinase; LOC315707; MGC112926; protein-tyrosine kinase (CSK); tyrosine-protein kinase CSK
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8866,925,650 - 66,944,861 (-)NCBIGRCr8
mRatBN7.2858,029,748 - 58,048,742 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl858,029,749 - 58,048,292 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx863,562,597 - 63,567,220 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0861,840,172 - 61,844,795 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0859,704,719 - 59,709,342 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0862,405,714 - 62,424,707 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl862,405,715 - 62,424,303 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0862,183,286 - 62,208,785 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4861,381,336 - 61,386,013 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1861,400,389 - 61,405,067 (-)NCBI
Celera857,495,667 - 57,500,290 (-)NCBICelera
Cytogenetic Map8q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
(R)-adrenaline  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
3',5'-cyclic AMP  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
arachidonic acid  (ISO)
aristolochic acid A  (ISO)
atrazine  (ISO)
beauvericin  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bosutinib  (EXP)
butan-1-ol  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
chlorpyrifos  (ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
copper(II) chloride  (ISO)
cyclophosphamide  (ISO)
dexamethasone  (ISO)
Dibutyl phosphate  (ISO)
dicrotophos  (ISO)
diethylstilbestrol  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
enzyme inhibitor  (ISO)
ethanol  (ISO)
formaldehyde  (ISO)
geldanamycin  (ISO)
gentamycin  (EXP)
isobutanol  (ISO)
isoprenaline  (ISO)
ivermectin  (ISO)
leflunomide  (EXP)
methyl methanesulfonate  (ISO)
N-nitrosodiethylamine  (EXP)
nitrofen  (EXP)
ozone  (ISO)
perfluorododecanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
phenethyl caffeate  (EXP)
phosgene  (ISO)
ponatinib  (ISO)
potassium dichromate  (ISO)
progesterone  (ISO)
pyrazoles  (ISO)
pyrimidines  (ISO)
rac-lactic acid  (ISO)
saracatinib  (ISO)
selenium atom  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
Soman  (EXP)
sulindac  (EXP,ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
terbutaline  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
valproic acid  (ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cell-cell junction  (ISO)
cytoplasm  (IDA,IEA)
plasma membrane  (IBA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Recombinant Csk expressed in Escherichia coli is autophosphorylated on tyrosine residue(s). Bougeret C, etal., Oncogene. 1993 May;8(5):1241-7.
2. Fer kinase/FerT and adherens junction dynamics in the testis: an in vitro and in vivo study. Chen YM, etal., Biol Reprod. 2003 Aug;69(2):656-72. Epub 2003 Apr 16.
3. Association of inhibitory tyrosine protein kinase p50csk with protein tyrosine phosphatase PEP in T cells and other hemopoietic cells. Cloutier JF and Veillette A, EMBO J. 1996 Sep 16;15(18):4909-18.
4. Integrins direct Src family kinases to regulate distinct phases of oligodendrocyte development. Colognato H, etal., J Cell Biol. 2004 Oct 25;167(2):365-75.
5. CSK negatively regulates nerve growth factor induced neural differentiation and augments AKT kinase activity. Dey N, etal., Exp Cell Res. 2005 Jul 1;307(1):1-14.
6. Functional modification of a murine macrophage cell line, J744A.1, transfected with rat csk genes. Dondog EA Hokkaido Igaku Zasshi. 2000 May;75(3):197-208.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. Roles of C-terminal Src kinase in the initiation and the termination of the high affinity IgE receptor-mediated signaling. Honda Z, etal., J Biol Chem. 1997 Oct 10;272(41):25753-60.
10. Regulation of Src family kinases in the developing rat brain: correlation with their regulator kinase, Csk. Inomata M, etal., J Biochem. 1994 Aug;116(2):386-92.
11. Down-regulation of the tumor suppressor gene C-terminal Src kinase: an early event during premalignant colonic epithelial hyperproliferation. Kunte DP, etal., FEBS Lett. 2005 Jul 4;579(17):3497-502.
12. Protein kinases and adherens junction dynamics in the seminiferous epithelium of the rat testis. Lee NP and Cheng CY, J Cell Physiol. 2005 Feb;202(2):344-60.
13. Adrenomedullin inhibits angiotensin II-induced oxidative stress via Csk-mediated inhibition of Src activity. Liu J, etal., Am J Physiol Heart Circ Physiol. 2007 Apr;292(4):H1714-21. Epub 2006 Oct 27.
14. Reduced C-terminal Src kinase (Csk) activities in hepatocellular carcinoma. Masaki T, etal., Hepatology. 1999 Feb;29(2):379-84.
15. Cardiomyocyte apoptosis triggered by RAFTK/pyk2 via Src kinase is antagonized by paxillin. Melendez J, etal., J Biol Chem. 2004 Dec 17;279(51):53516-23. Epub 2004 Aug 22.
16. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
17. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
18. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
19. GOA pipeline RGD automated data pipeline
20. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
21. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
22. Mammalian Pragmin regulates Src family kinases via the Glu-Pro-Ile-Tyr-Ala (EPIYA) motif that is exploited by bacterial effectors. Safari F, etal., Proc Natl Acad Sci U S A. 2011 Sep 6;108(36):14938-43. doi: 10.1073/pnas.1107740108. Epub 2011 Aug 22.
23. A functional polymorphism of Ptpn22 is associated with type 1 diabetes in the BioBreeding rat. Sarmiento J, etal., J Immunol. 2015 Jan 15;194(2):615-29. doi: 10.4049/jimmunol.1302689. Epub 2014 Dec 12.
24. C-terminal Src kinase-mediated EPIYA phosphorylation of Pragmin creates a feed-forward C-terminal Src kinase activation loop that promotes cell motility. Senda Y, etal., Cancer Sci. 2016 Jul;107(7):972-80. doi: 10.1111/cas.12962. Epub 2016 Jun 13.
25. Suppression of arthritic bone destruction by adenovirus-mediated csk gene transfer to synoviocytes and osteoclasts. Takayanagi H, etal., J Clin Invest. 1999 Jul;104(2):137-46.
26. C-terminal SRC kinase controls acute inflammation and granulocyte adhesion. Thomas RM, etal., Immunity. 2004 Feb;20(2):181-91.
27. SH2 domain-mediated interaction of inhibitory protein tyrosine kinase Csk with protein tyrosine phosphatase-HSCF. Wang B, etal., Mol Cell Biol. 2001 Feb;21(4):1077-88.
Additional References at PubMed
PMID:1709258   PMID:1722201   PMID:10790433   PMID:10801129   PMID:11884384   PMID:12477932   PMID:14613929   PMID:15861137   PMID:16203139   PMID:16511561   PMID:16982692   PMID:17911601  
PMID:18086565   PMID:18258597   PMID:19056867   PMID:19888460   PMID:20605918   PMID:21699177   PMID:23548896   PMID:27225249   PMID:27391443  


Genomics

Comparative Map Data
Csk
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8866,925,650 - 66,944,861 (-)NCBIGRCr8
mRatBN7.2858,029,748 - 58,048,742 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl858,029,749 - 58,048,292 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx863,562,597 - 63,567,220 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0861,840,172 - 61,844,795 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0859,704,719 - 59,709,342 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0862,405,714 - 62,424,707 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl862,405,715 - 62,424,303 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0862,183,286 - 62,208,785 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4861,381,336 - 61,386,013 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1861,400,389 - 61,405,067 (-)NCBI
Celera857,495,667 - 57,500,290 (-)NCBICelera
Cytogenetic Map8q24NCBI
CSK
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381574,782,080 - 74,803,197 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1574,782,080 - 74,803,197 (+)EnsemblGRCh38hg38GRCh38
GRCh371575,074,421 - 75,095,538 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361572,861,768 - 72,882,558 (+)NCBINCBI36Build 36hg18NCBI36
Build 341572,861,767 - 72,882,557NCBI
Celera1552,024,458 - 52,045,568 (+)NCBICelera
Cytogenetic Map15q24.1NCBI
HuRef1551,872,089 - 51,892,744 (+)NCBIHuRef
CHM1_11575,192,927 - 75,214,023 (+)NCBICHM1_1
T2T-CHM13v2.01572,651,992 - 72,673,091 (+)NCBIT2T-CHM13v2.0
Csk
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39957,533,929 - 57,560,758 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl957,533,929 - 57,560,914 (-)EnsemblGRCm39 Ensembl
GRCm38957,626,646 - 57,653,631 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl957,626,646 - 57,653,631 (-)EnsemblGRCm38mm10GRCm38
MGSCv37957,474,453 - 57,492,987 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36957,424,783 - 57,443,317 (-)NCBIMGSCv36mm8
Celera954,862,569 - 54,881,336 (-)NCBICelera
Cytogenetic Map9BNCBI
cM Map931.18NCBI
Csk
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554503,127,561 - 3,144,550 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554503,127,561 - 3,144,550 (-)NCBIChiLan1.0ChiLan1.0
CSK
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21664,010,025 - 64,030,936 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11568,173,681 - 68,194,308 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01553,724,814 - 53,745,710 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11573,342,703 - 73,363,476 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1573,342,703 - 73,363,476 (+)Ensemblpanpan1.1panPan2
CSK
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13037,851,269 - 37,870,382 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3037,852,046 - 37,870,378 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3037,784,125 - 37,802,413 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03038,056,541 - 38,074,206 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3038,056,497 - 38,074,435 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13038,009,325 - 38,027,610 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03038,055,644 - 38,073,934 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03038,291,119 - 38,309,429 (+)NCBIUU_Cfam_GSD_1.0
Csk
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640115,909,712 - 115,929,808 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647133,757,772 - 33,778,933 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647133,757,778 - 33,777,871 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CSK
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl758,736,531 - 58,755,260 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1758,736,473 - 58,755,034 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2763,425,071 - 63,443,632 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CSK
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1268,667,657 - 8,688,850 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl268,667,655 - 8,688,824 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666048132,942,200 - 132,963,400 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Csk
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462489424,203 - 29,668 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462489412,621 - 29,400 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Csk
83 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:106
Count of miRNA genes:94
Interacting mature miRNAs:99
Transcripts:ENSRNOT00000026358
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298065Scl16Serum cholesterol level QTL 163.8blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)83085640475856404Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)830848154101699754Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)84186687686866876Rat
11556286Cm81Cardiac mass QTL 810.01heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)83084815461290444Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84269268490165460Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)830848154101699754Rat
1582222Epfw2Epididymal fat weight QTL 23.20.0005epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)83173772976737729Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83558203280582032Rat
4889938Bss89Bone structure and strength QTL 893.8tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)85009524982460899Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)830848154101699754Rat
1300146Rf17Renal function QTL 172.9renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)82824291273242912Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83084815482460899Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)82824291299525068Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)82720571599103503Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)81933115293965294Rat
724514Uae15Urinary albumin excretion QTL 152.9urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)82950266570386295Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83084815461290444Rat
737824Hcar10Hepatocarcinoma resistance QTL 102.9liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)84071306682925667Rat
631842Inf1Infertility severity QTL 14.10.001seminal gland mass (VT:0010524)seminal vesicle wet weight (CMO:0001603)82266233067662330Rat
1331769Rf39Renal function QTL 393.871urine output (VT:0003620)timed urine volume (CMO:0000260)84186687675097878Rat
1359033Bp273Blood pressure QTL 273arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815461290444Rat
1358906Bp253Blood pressure QTL 25340.0004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)84071306693965294Rat
61358Bp39Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83555193880551938Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)82720571599103503Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)846531639119088626Rat
1331744Bp217Blood pressure QTL 2173.398arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815458482492Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)830848259105647037Rat
1582254Kidm31Kidney mass QTL 313kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)85423764485365202Rat
10402857Bp380Blood pressure QTL 3800.95arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)85396876598968765Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)82720571599103503Rat
631216Stl9Serum triglyceride level QTL 94.710.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)84186701070386132Rat
1582243Bw66Body weight QTL 663.40.0048body mass (VT:0001259)body weight (CMO:0000012)85423764485365202Rat
5684973Bss100Bone structure and strength QTL 1004.7tibia area (VT:1000281)tibia area measurement (CMO:0001382)85009524982460899Rat
61373Mcs4Mammary carcinoma susceptibility QTL 41.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)81629044461290444Rat
1300177Cm2Cardiac mass QTL 23.65heart mass (VT:0007028)heart weight (CMO:0000017)854259986100382532Rat
2313057Bss76Bone structure and strength QTL 7630.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)83084815482460899Rat
12879878Bw183Body weight QTL 1830.001body mass (VT:0001259)body weight (CMO:0000012)84329616998968765Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)83018886794457446Rat
12879879Cm99Cardiac mass QTL 990.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)84329616998968765Rat
2313067Bss77Bone structure and strength QTL 773.10.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)83084815482460899Rat
12879880Cm100Cardiac mass QTL 1000.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)84329616998968765Rat
12879881Cm101Cardiac mass QTL 1010.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)84329616998968765Rat
12879882Am8Aortic mass QTL 80.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)84329616998968765Rat
12879883Kidm65Kidney mass QTL 650.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)84329616998968765Rat
1358912Bw51Body weight QTL 512.95body mass (VT:0001259)body weight (CMO:0000012)851351728107062046Rat
2313086Bss60Bone structure and strength QTL 604.10.0001tibia length (VT:0004357)tibia length (CMO:0000450)85009524982460899Rat
1558646Swd5Spike wave discharge measurement QTL 53.450.00036brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)81490675159906751Rat
2293697Bmd39Bone mineral density QTL 39femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)85404374498968765Rat
1331837Bw23Body weight QTL 234.190.00007body mass (VT:0001259)body weight (CMO:0000012)84653172299083736Rat
1331838Niddm61Non-insulin dependent diabetes mellitus QTL 613.530.0004blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83646953599083736Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
631271Lecl1Lens clarity QTL 10.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)81898416884531599Rat
2303564Gluco43Glucose level QTL 433blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)82613018771130187Rat
2303570Gluco48Glucose level QTL 482blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)84980583194805831Rat
2313046Bss78Bone structure and strength QTL 783.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)83084815482460899Rat
2303572Insul13Insulin level QTL 132blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)82613018771130187Rat
631664Hcar3Hepatocarcinoma resistance QTL 32.90.0005liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)85423764499103503Rat
2301402Bp316Blood pressure QTL 3160.005arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)85396876598968765Rat

Markers in Region
AW212630  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2858,029,812 - 58,029,924 (+)MAPPERmRatBN7.2
Rnor_6.0862,405,779 - 62,405,890NCBIRnor6.0
Rnor_5.0862,183,351 - 62,183,462UniSTSRnor5.0
RGSC_v3.4861,381,401 - 61,381,512UniSTSRGSC3.4
Celera857,495,732 - 57,495,843UniSTS
Cytogenetic Map8q24UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000026358   ⟹   ENSRNOP00000026358
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl858,029,749 - 58,034,372 (-)Ensembl
Rnor_6.0 Ensembl862,405,715 - 62,410,338 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000091223   ⟹   ENSRNOP00000068638
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl858,029,754 - 58,048,292 (-)Ensembl
Rnor_6.0 Ensembl862,405,984 - 62,424,303 (-)Ensembl
RefSeq Acc Id: NM_001030039   ⟹   NP_001025210
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8866,925,650 - 66,930,274 (-)NCBI
mRatBN7.2858,029,748 - 58,034,372 (-)NCBI
Rnor_6.0862,405,714 - 62,410,338 (-)NCBI
Rnor_5.0862,183,286 - 62,208,785 (-)NCBI
RGSC_v3.4861,381,336 - 61,386,013 (-)RGD
Celera857,495,667 - 57,500,290 (-)RGD
Sequence:
RefSeq Acc Id: XM_006243163   ⟹   XP_006243225
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8866,925,650 - 66,944,861 (-)NCBI
mRatBN7.2858,029,748 - 58,048,742 (-)NCBI
Rnor_6.0862,405,714 - 62,424,707 (-)NCBI
Rnor_5.0862,183,286 - 62,208,785 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006243164   ⟹   XP_006243226
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8866,925,650 - 66,943,854 (-)NCBI
mRatBN7.2858,029,748 - 58,047,954 (-)NCBI
Rnor_6.0862,405,714 - 62,423,964 (-)NCBI
Rnor_5.0862,183,286 - 62,208,785 (-)NCBI
Sequence:
RefSeq Acc Id: NP_001025210   ⟸   NM_001030039
- UniProtKB: Q4G003 (UniProtKB/Swiss-Prot),   P32577 (UniProtKB/Swiss-Prot),   A6J4X1 (UniProtKB/TrEMBL),   A0A8L2QZY0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006243225   ⟸   XM_006243163
- Peptide Label: isoform X1
- UniProtKB: Q4G003 (UniProtKB/Swiss-Prot),   P32577 (UniProtKB/Swiss-Prot),   A6J4X1 (UniProtKB/TrEMBL),   A0A8L2QZY0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006243226   ⟸   XM_006243164
- Peptide Label: isoform X1
- UniProtKB: Q4G003 (UniProtKB/Swiss-Prot),   P32577 (UniProtKB/Swiss-Prot),   A6J4X1 (UniProtKB/TrEMBL),   A0A8L2QZY0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000026358   ⟸   ENSRNOT00000026358
Ensembl Acc Id: ENSRNOP00000068638   ⟸   ENSRNOT00000091223
Protein Domains
Protein kinase   SH2   SH3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P32577-F1-model_v2 AlphaFold P32577 1-450 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696021
Promoter ID:EPDNEW_R6541
Type:initiation region
Name:Csk_1
Description:C-terminal Src kinase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0862,424,254 - 62,424,314EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308800 AgrOrtholog
BioCyc Gene G2FUF-30300 BioCyc
Ensembl Genes ENSRNOG00000019374 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055029546 UniProtKB/Swiss-Prot
  ENSRNOG00060021015 UniProtKB/Swiss-Prot
  ENSRNOG00065017300 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000026358.7 UniProtKB/Swiss-Prot
  ENSRNOT00000091223.2 UniProtKB/TrEMBL
  ENSRNOT00055051204 UniProtKB/Swiss-Prot
  ENSRNOT00060036569 UniProtKB/Swiss-Prot
  ENSRNOT00065028855 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.505.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 Domains UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7380519 IMAGE-MGC_LOAD
InterPro Csk-like_SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Non-receptor_tyrosine_kinases UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:315707 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:112926 IMAGE-MGC_LOAD
NCBI Gene 315707 ENTREZGENE
PANTHER TYROSINE-PROTEIN KINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYROSINE-PROTEIN KINASE CSK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PK_Tyr_Ser-Thr UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
  SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Csk PhenoGen
PRINTS SH2DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYRKINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000019374 RatGTEx
  ENSRNOG00055029546 RatGTEx
  ENSRNOG00060021015 RatGTEx
  ENSRNOG00065017300 RatGTEx
SMART SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TyrKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50044 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF55550 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8L2QZY0 ENTREZGENE, UniProtKB/TrEMBL
  A6J4X1 ENTREZGENE, UniProtKB/TrEMBL
  CSK_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q4G003 ENTREZGENE
UniProt Secondary Q4G003 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-05-18 Csk  C-terminal Src kinase  Csk  CSK, non-receptor tyrosine kinase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2017-03-02 Csk  CSK, non-receptor tyrosine kinase  Csk  c-src tyrosine kinase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Csk  c-src tyrosine kinase  Csk_predicted  c-src tyrosine kinase (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Csk_predicted  c-src tyrosine kinase (predicted)      Symbol and Name status set to approved 70820 APPROVED