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Gene: CSK (C-terminal Src kinase) Homo sapiens
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Symbol: CSK
Name: C-terminal Src kinase
Description: The protein encoded by this gene is involved in multiple pathways, including the regulation of Src family kinases. It plays an important role in T-cell activation through its association with the protein encoded by the protein tyrosine phosphatase, non-receptor type 22 (PTPN22) gene. This protein also phosphorylates C-terminal tyrosine residues on multiple substrates, including the protein encoded by the SRC proto-oncogene, non-receptor tyrosine kinase gene. Phosphorylation suppresses the kinase activity of the Src family tyrosine kinases. An intronic polymorphism (rs34933034) in this gene has been found to affect B-cell activation and is associated with systemic lupus erythematosus (SLE). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2017]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: C-Src kinase; c-src tyrosine kinase; CSK, non-receptor tyrosine kinase; MGC117393; protein-tyrosine kinase CYL; tyrosine-protein kinase CSK
Orthologs:
Mus musculus (house mouse) : Csk (c-src tyrosine kinase)  MGI  Alliance
Rattus norvegicus (Norway rat) : Csk (C-terminal Src kinase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Csk (C-terminal Src kinase)
Pan paniscus (bonobo/pygmy chimpanzee) : CSK (C-terminal Src kinase)
Canis lupus familiaris (dog) : CSK (C-terminal Src kinase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Csk (C-terminal Src kinase)
Sus scrofa (pig) : CSK (CSK, non-receptor tyrosine kinase)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381574,782,084 - 74,803,198 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371575,074,425 - 75,095,539 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361572,861,768 - 72,882,558 (+)NCBINCBI36hg18NCBI36
Build 341572,861,767 - 72,882,557NCBI
Celera1552,024,458 - 52,045,568 (+)NCBI
Cytogenetic Map15q24.1NCBI
HuRef1551,872,089 - 51,892,744 (+)NCBIHuRef
CHM1_11575,192,927 - 75,214,023 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Genomics

Comparative Map Data
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miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
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Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on CSK
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1318780
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-07-09
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.