Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: CSK (C-terminal Src kinase) Homo sapiens
Symbol: CSK
Name: C-terminal Src kinase
Description: The protein encoded by this gene is involved in multiple pathways, including the regulation of Src family kinases. It plays an important role in T-cell activation through its association with the protein encoded by the protein tyrosine phosphatase, non-receptor type 22 (PTPN22) gene. This protein also phosphorylates C-terminal tyrosine residues on multiple substrates, including the protein encoded by the SRC proto-oncogene, non-receptor tyrosine kinase gene. Phosphorylation suppresses the kinase activity of the Src family tyrosine kinases. An intronic polymorphism (rs34933034) in this gene has been found to affect B-cell activation and is associated with systemic lupus erythematosus (SLE). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2017]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: C-Src kinase; c-src tyrosine kinase; CSK, non-receptor tyrosine kinase; MGC117393; protein-tyrosine kinase CYL; tyrosine-protein kinase CSK
Mus musculus (house mouse) : Csk (c-src tyrosine kinase)  MGI  Alliance
Rattus norvegicus (Norway rat) : Csk (C-terminal Src kinase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Csk (C-terminal Src kinase)
Pan paniscus (bonobo/pygmy chimpanzee) : CSK (C-terminal Src kinase)
Canis lupus familiaris (dog) : CSK (C-terminal Src kinase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Csk (C-terminal Src kinase)
Sus scrofa (pig) : CSK (CSK, non-receptor tyrosine kinase)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381574,782,084 - 74,803,198 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371575,074,425 - 75,095,539 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361572,861,768 - 72,882,558 (+)NCBINCBI36hg18NCBI36
Build 341572,861,767 - 72,882,557NCBI
Celera1552,024,458 - 52,045,568 (+)NCBI
Cytogenetic Map15q24.1NCBI
HuRef1551,872,089 - 51,892,744 (+)NCBIHuRef
CHM1_11575,192,927 - 75,214,023 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on CSK
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1318780
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-07-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.