RGD Reference Report - Down-regulation of the tumor suppressor gene C-terminal Src kinase: an early event during premalignant colonic epithelial hyperproliferation. - Rat Genome Database

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Down-regulation of the tumor suppressor gene C-terminal Src kinase: an early event during premalignant colonic epithelial hyperproliferation.

Authors: Kunte, DP  Wali, RK  Koetsier, JL  Hart, J  Kostjukova, MN  Kilimnik, AY  Pyatkin, IG  Strelnikova, SR  Roy, HK 
Citation: Kunte DP, etal., FEBS Lett. 2005 Jul 4;579(17):3497-502.
RGD ID: 5134365
Pubmed: PMID:15961079   (View Abstract at PubMed)
DOI: DOI:10.1016/j.febslet.2005.05.030   (Journal Full-text)

Hyperproliferation of the premalignant epithelium is critical for colonic carcinogenesis; however the mechanisms remain largely unexplored. We report herein that prior to occurrence of neoplastic lesions in the azoxymethane-rat model of colon carcinogenesis; the tumor suppressor gene C-terminal Src kinase (Csk) was down-regulated with a concomitant increase in Src activity. Furthermore, pharmacological or genetic (RNA interference) inhibition of Csk resulted in increased proliferation in colon cancer cell lines through the mitogen-activated protein kinase dependent pathway. Thus, we demonstrate, for the first time, that Csk suppression is an important early event in colorectal cancer pathogenesis.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Hyperplasia  ISOCsk (Rattus norvegicus)5134365; 5134365mRNA and protein:decreased expression:large intestine mucosaRGD 
Hyperplasia  IEP 5134365mRNA and protein:decreased expression:large intestine mucosaRGD 

Objects Annotated

Genes (Rattus norvegicus)
Csk  (C-terminal Src kinase)

Genes (Mus musculus)
Csk  (c-src tyrosine kinase)

Genes (Homo sapiens)
CSK  (C-terminal Src kinase)


Additional Information