CSK (C-terminal Src kinase) - Rat Genome Database

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Gene: CSK (C-terminal Src kinase) Sus scrofa
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Symbol: CSK
Name: C-terminal Src kinase
RGD ID: 13965077
Description: ENCODES a protein that exhibits proline-rich region binding (ortholog); protein phosphatase binding (ortholog); protein tyrosine kinase activity (ortholog); INVOLVED IN adherens junction organization (ortholog); brain development (ortholog); cellular response to peptide hormone stimulus (ortholog); PARTICIPATES IN platelet-derived growth factor signaling pathway; ASSOCIATED WITH Bloom syndrome (ortholog); colon cancer (ortholog); dermatitis (ortholog); FOUND IN cytoplasm (ortholog); membrane raft (ortholog)
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: c-src tyrosine kinase; CSK, non-receptor tyrosine kinase; tyrosine-protein kinase CSK
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl758,736,529 - 58,755,260 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1758,736,473 - 58,755,034 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2763,425,071 - 63,443,632 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:14681463   PMID:17145712  


Genomics

Comparative Map Data
CSK
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl758,736,529 - 58,755,260 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1758,736,473 - 58,755,034 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2763,425,071 - 63,443,632 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CSK
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1574,782,080 - 74,803,197 (+)EnsemblGRCh38hg38GRCh38
GRCh381574,782,080 - 74,803,197 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371575,074,421 - 75,095,538 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361572,861,768 - 72,882,558 (+)NCBINCBI36hg18NCBI36
Build 341572,861,767 - 72,882,557NCBI
Celera1552,024,458 - 52,045,568 (+)NCBI
Cytogenetic Map15q24.1NCBI
HuRef1551,872,089 - 51,892,744 (+)NCBIHuRef
CHM1_11575,192,927 - 75,214,023 (+)NCBICHM1_1
Csk
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39957,533,929 - 57,560,914 (-)NCBIGRCm39mm39
GRCm39 Ensembl957,533,929 - 57,560,914 (-)Ensembl
GRCm38957,626,646 - 57,653,631 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl957,626,646 - 57,653,631 (-)EnsemblGRCm38mm10GRCm38
MGSCv37957,474,453 - 57,492,987 (-)NCBIGRCm37mm9NCBIm37
MGSCv36957,424,783 - 57,443,317 (-)NCBImm8
Celera954,862,569 - 54,881,336 (-)NCBICelera
Cytogenetic Map9BNCBI
cM Map931.18NCBI
Csk
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2858,029,748 - 58,048,742 (-)NCBImRatBN7.2
Rnor_6.0 Ensembl862,405,715 - 62,424,303 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0862,405,714 - 62,424,707 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0862,183,286 - 62,208,785 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4861,381,336 - 61,386,013 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1861,400,389 - 61,405,067 (-)NCBI
Celera857,495,667 - 57,500,290 (-)NCBICelera
Cytogenetic Map8q24NCBI
Csk
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554503,127,561 - 3,144,550 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554503,127,561 - 3,144,550 (-)NCBIChiLan1.0ChiLan1.0
CSK
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11573,342,703 - 73,363,476 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1573,342,703 - 73,363,476 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01553,724,814 - 53,745,710 (+)NCBIMhudiblu_PPA_v0panPan3
CSK
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13037,851,269 - 37,870,382 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3037,852,046 - 37,870,378 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3037,784,125 - 37,802,413 (+)NCBI
ROS_Cfam_1.03038,056,541 - 38,074,206 (+)NCBI
UMICH_Zoey_3.13038,009,325 - 38,027,610 (+)NCBI
UNSW_CanFamBas_1.03038,055,644 - 38,073,934 (+)NCBI
UU_Cfam_GSD_1.03038,291,119 - 38,309,429 (+)NCBI
Csk
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640115,909,712 - 115,929,808 (+)NCBI
SpeTri2.0NW_00493647133,757,778 - 33,777,871 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CSK
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1268,667,657 - 8,688,850 (-)NCBI
ChlSab1.1 Ensembl268,667,655 - 8,688,824 (-)Ensembl
Vero_WHO_p1.0NW_023666048132,942,200 - 132,963,400 (+)NCBI
Csk
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462489412,621 - 29,400 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 5 2 5 3
Low 5 2 3 2 23 2 3
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000002128   ⟹   ENSSSCP00000002078
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl758,736,531 - 58,755,235 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000047150   ⟹   ENSSSCP00000032790
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl758,736,529 - 58,755,260 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000053105   ⟹   ENSSSCP00000042225
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl758,736,529 - 58,755,260 (-)Ensembl
RefSeq Acc Id: NM_001190173   ⟹   NP_001177102
RefSeq Status: VALIDATED
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1758,736,473 - 58,755,034 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021098027   ⟹   XP_020953686
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1758,736,522 - 58,754,791 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001177102 (Get FASTA)   NCBI Sequence Viewer  
  XP_020953686 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001177102   ⟸   NM_001190173
- UniProtKB: A0A287BRU6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020953686   ⟸   XM_021098027
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSSSCP00000002078   ⟸   ENSSSCT00000002128
RefSeq Acc Id: ENSSSCP00000042225   ⟸   ENSSSCT00000053105
RefSeq Acc Id: ENSSSCP00000032790   ⟸   ENSSSCT00000047150
Protein Domains
Protein kinase   SH2   SH3


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000001900 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000002078 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000032790 UniProtKB/TrEMBL
  ENSSSCP00000042225 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000002128 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000047150 UniProtKB/TrEMBL
  ENSSSCT00000053105 UniProtKB/TrEMBL
Gene3D-CATH 3.30.505.10 UniProtKB/TrEMBL
InterPro Csk-like_SH2 UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/TrEMBL
  SH3_domain UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/TrEMBL
  Tyr_kinase_cat_dom UniProtKB/TrEMBL
KEGG Report ssc:100154110 UniProtKB/TrEMBL
NCBI Gene CSK ENTREZGENE
Pfam Pkinase_Tyr UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH3_1 UniProtKB/TrEMBL
PRINTS SH2DOMAIN UniProtKB/TrEMBL
  TYRKINASE UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
SMART SH2 UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
  TyrKc UniProtKB/TrEMBL
Superfamily-SCOP SSF50044 UniProtKB/TrEMBL
  SSF55550 UniProtKB/TrEMBL
  SSF56112 UniProtKB/TrEMBL
UniProt A0A286ZMV7_PIG UniProtKB/TrEMBL
  A0A287AEI0_PIG UniProtKB/TrEMBL
  A0A287BRU6 ENTREZGENE, UniProtKB/TrEMBL
  F1SJ27_PIG UniProtKB/TrEMBL
VGNC ID VGNC:87037 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-03-04 CSK  C-terminal Src kinase  CSK  CSK, non-receptor tyrosine kinase  Symbol and/or name change 5135510 APPROVED