CSK (C-terminal Src kinase) - Rat Genome Database

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Gene: CSK (C-terminal Src kinase) Sus scrofa
Analyze
Symbol: CSK
Name: C-terminal Src kinase
RGD ID: 13965077
Description: ENCODES a protein that exhibits proline-rich region binding (ortholog); protein phosphatase binding (ortholog); protein tyrosine kinase activity (ortholog); INVOLVED IN adherens junction organization (ortholog); cellular response to peptide hormone stimulus (ortholog); negative regulation of bone resorption (ortholog); PARTICIPATES IN platelet-derived growth factor signaling pathway; ASSOCIATED WITH Bardet-Biedl syndrome (ortholog); Bloom syndrome (ortholog); colorectal cancer (ortholog); FOUND IN cell-cell junction (inferred); cytoplasm (inferred); plasma membrane (inferred)
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: c-src tyrosine kinase; CSK, non-receptor tyrosine kinase; tyrosine-protein kinase CSK
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl758,736,531 - 58,755,260 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1758,736,473 - 58,755,034 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2763,425,071 - 63,443,632 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:14681463   PMID:17145712   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
CSK
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl758,736,531 - 58,755,260 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1758,736,473 - 58,755,034 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2763,425,071 - 63,443,632 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CSK
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381574,782,080 - 74,803,197 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1574,782,080 - 74,803,197 (+)EnsemblGRCh38hg38GRCh38
GRCh371575,074,421 - 75,095,538 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361572,861,768 - 72,882,558 (+)NCBINCBI36Build 36hg18NCBI36
Build 341572,861,767 - 72,882,557NCBI
Celera1552,024,458 - 52,045,568 (+)NCBICelera
Cytogenetic Map15q24.1NCBI
HuRef1551,872,089 - 51,892,744 (+)NCBIHuRef
CHM1_11575,192,927 - 75,214,023 (+)NCBICHM1_1
T2T-CHM13v2.01572,651,992 - 72,673,091 (+)NCBIT2T-CHM13v2.0
Csk
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39957,533,929 - 57,560,758 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl957,533,929 - 57,560,914 (-)EnsemblGRCm39 Ensembl
GRCm38957,626,646 - 57,653,631 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl957,626,646 - 57,653,631 (-)EnsemblGRCm38mm10GRCm38
MGSCv37957,474,453 - 57,492,987 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36957,424,783 - 57,443,317 (-)NCBIMGSCv36mm8
Celera954,862,569 - 54,881,336 (-)NCBICelera
Cytogenetic Map9BNCBI
cM Map931.18NCBI
Csk
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8866,925,650 - 66,944,861 (-)NCBIGRCr8
mRatBN7.2858,029,748 - 58,048,742 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl858,029,749 - 58,048,292 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx863,562,597 - 63,567,220 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0861,840,172 - 61,844,795 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0859,704,719 - 59,709,342 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0862,405,714 - 62,424,707 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl862,405,715 - 62,424,303 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0862,183,286 - 62,208,785 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4861,381,336 - 61,386,013 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1861,400,389 - 61,405,067 (-)NCBI
Celera857,495,667 - 57,500,290 (-)NCBICelera
Cytogenetic Map8q24NCBI
Csk
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554503,127,561 - 3,144,550 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554503,127,561 - 3,144,550 (-)NCBIChiLan1.0ChiLan1.0
CSK
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21664,010,025 - 64,030,936 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11568,173,681 - 68,194,308 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01553,724,814 - 53,745,710 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11573,342,703 - 73,363,476 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1573,342,703 - 73,363,476 (+)Ensemblpanpan1.1panPan2
CSK
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13037,851,269 - 37,870,382 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3037,852,046 - 37,870,378 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3037,784,125 - 37,802,413 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03038,056,541 - 38,074,206 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3038,056,497 - 38,074,435 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13038,009,325 - 38,027,610 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03038,055,644 - 38,073,934 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03038,291,119 - 38,309,429 (+)NCBIUU_Cfam_GSD_1.0
Csk
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640115,909,712 - 115,929,808 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647133,757,772 - 33,778,933 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647133,757,778 - 33,777,871 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CSK
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1268,667,657 - 8,688,850 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl268,667,655 - 8,688,824 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666048132,942,200 - 132,963,400 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Csk
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462489424,203 - 29,668 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462489412,621 - 29,400 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in CSK
385 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 5 2 5 3
Low 5 2 3 2 23 2 3
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000002128   ⟹   ENSSSCP00000002078
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl758,736,531 - 58,755,235 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000047150   ⟹   ENSSSCP00000032790
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl758,736,533 - 58,755,260 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000053105   ⟹   ENSSSCP00000042225
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl758,736,533 - 58,755,260 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000097140   ⟹   ENSSSCP00000076274
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl758,736,797 - 58,755,255 (-)Ensembl
RefSeq Acc Id: NM_001190173   ⟹   NP_001177102
RefSeq Status: VALIDATED
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1758,736,473 - 58,755,034 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021098027   ⟹   XP_020953686
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1758,736,522 - 58,754,791 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_001177102   ⟸   NM_001190173
- UniProtKB: A0A287BRU6 (UniProtKB/TrEMBL),   A0A8D1YSL8 (UniProtKB/TrEMBL),   A0A8D0YU43 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020953686   ⟸   XM_021098027
- Peptide Label: isoform X1
- UniProtKB: A0A8D1RUK3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000002078   ⟸   ENSSSCT00000002128
RefSeq Acc Id: ENSSSCP00000042225   ⟸   ENSSSCT00000053105
RefSeq Acc Id: ENSSSCP00000032790   ⟸   ENSSSCT00000047150
RefSeq Acc Id: ENSSSCP00000076274   ⟸   ENSSSCT00000097140
Protein Domains
Protein kinase   SH2   SH3


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000001900 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00025059893 UniProtKB/TrEMBL
  ENSSSCG00030016677 UniProtKB/TrEMBL
  ENSSSCG00035016175 UniProtKB/TrEMBL
  ENSSSCG00040040101 UniProtKB/TrEMBL
  ENSSSCG00045032099 UniProtKB/TrEMBL
  ENSSSCG00050024737 UniProtKB/TrEMBL
  ENSSSCG00055024167 UniProtKB/TrEMBL
  ENSSSCG00060075461 UniProtKB/TrEMBL
  ENSSSCG00065042024 UniProtKB/TrEMBL
  ENSSSCG00070010956 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000002128.5 UniProtKB/TrEMBL
  ENSSSCT00000047150.3 UniProtKB/TrEMBL
  ENSSSCT00000053105.3 UniProtKB/TrEMBL
  ENSSSCT00000097140 ENTREZGENE
  ENSSSCT00000097140.1 UniProtKB/TrEMBL
  ENSSSCT00025082024.1 UniProtKB/TrEMBL
  ENSSSCT00025082210.1 UniProtKB/TrEMBL
  ENSSSCT00030023079.1 UniProtKB/TrEMBL
  ENSSSCT00030023081.1 UniProtKB/TrEMBL
  ENSSSCT00030023088.1 UniProtKB/TrEMBL
  ENSSSCT00030023095.1 UniProtKB/TrEMBL
  ENSSSCT00035020652.1 UniProtKB/TrEMBL
  ENSSSCT00035020661.1 UniProtKB/TrEMBL
  ENSSSCT00035020669.1 UniProtKB/TrEMBL
  ENSSSCT00035020681.1 UniProtKB/TrEMBL
  ENSSSCT00040053712.1 UniProtKB/TrEMBL
  ENSSSCT00040053991.1 UniProtKB/TrEMBL
  ENSSSCT00040054222.1 UniProtKB/TrEMBL
  ENSSSCT00045054876.1 UniProtKB/TrEMBL
  ENSSSCT00045054975.1 UniProtKB/TrEMBL
  ENSSSCT00045055207.1 UniProtKB/TrEMBL
  ENSSSCT00050033299.1 UniProtKB/TrEMBL
  ENSSSCT00050033333.1 UniProtKB/TrEMBL
  ENSSSCT00050033347.1 UniProtKB/TrEMBL
  ENSSSCT00055047713.1 UniProtKB/TrEMBL
  ENSSSCT00055047857.1 UniProtKB/TrEMBL
  ENSSSCT00055047981.1 UniProtKB/TrEMBL
  ENSSSCT00060104712.1 UniProtKB/TrEMBL
  ENSSSCT00060104745.1 UniProtKB/TrEMBL
  ENSSSCT00060104778.1 UniProtKB/TrEMBL
  ENSSSCT00060104812.1 UniProtKB/TrEMBL
  ENSSSCT00065057467.1 UniProtKB/TrEMBL
  ENSSSCT00065057475.1 UniProtKB/TrEMBL
  ENSSSCT00065057481.1 UniProtKB/TrEMBL
  ENSSSCT00070021330.1 UniProtKB/TrEMBL
  ENSSSCT00070021366.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.505.10 UniProtKB/TrEMBL
  SH3 Domains UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Csk-like_SH2 UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/TrEMBL
  SH3_domain UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/TrEMBL
  Tyr_kinase_cat_dom UniProtKB/TrEMBL
KEGG Report ssc:100154110 UniProtKB/TrEMBL
NCBI Gene CSK ENTREZGENE
PANTHER TYROSINE-PROTEIN KINASE UniProtKB/TrEMBL
  TYROSINE-PROTEIN KINASE CSK UniProtKB/TrEMBL
Pfam Pkinase_Tyr UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH3_1 UniProtKB/TrEMBL
PRINTS SH2DOMAIN UniProtKB/TrEMBL
  TYRKINASE UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
SMART SH2 UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
  TyrKc UniProtKB/TrEMBL
Superfamily-SCOP SSF50044 UniProtKB/TrEMBL
  SSF55550 UniProtKB/TrEMBL
  SSF56112 UniProtKB/TrEMBL
UniProt A0A286ZMV7_PIG UniProtKB/TrEMBL
  A0A287AEI0_PIG UniProtKB/TrEMBL
  A0A287BRU6 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1TL91_PIG UniProtKB/TrEMBL
  A0A8D0UWX1_PIG UniProtKB/TrEMBL
  A0A8D0YU43 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1LVV6_PIG UniProtKB/TrEMBL
  A0A8D1RUK3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1WX46_PIG UniProtKB/TrEMBL
  A0A8D1YPU3_PIG UniProtKB/TrEMBL
  A0A8D1YSL8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1YVE3_PIG UniProtKB/TrEMBL
  A0A8W4FAC0_PIG UniProtKB/TrEMBL
  F1SJ27_PIG UniProtKB/TrEMBL
VGNC ID VGNC:87037 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-03-04 CSK  C-terminal Src kinase  CSK  CSK, non-receptor tyrosine kinase  Symbol and/or name change 5135510 APPROVED