Dhrs4 (dehydrogenase/reductase 4) - Rat Genome Database

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Gene: Dhrs4 (dehydrogenase/reductase 4) Rattus norvegicus
Analyze
Symbol: Dhrs4
Name: dehydrogenase/reductase 4
RGD ID: 708482
Description: Predicted to enable several functions, including identical protein binding activity; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; and retinal dehydrogenase activity. Predicted to be involved in several processes, including positive regulation of reactive oxygen species metabolic process; retinal metabolic process; and steroid metabolic process. Located in peroxisome. Orthologous to several human genes including DHRS4 (dehydrogenase/reductase 4); PARTICIPATES IN retinol metabolic pathway; vitamin A deficiency pathway; INTERACTS WITH (+)-schisandrin B; 2,2',4,4'-Tetrabromodiphenyl ether; 5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: carbonyl reductase; CR; DCR-AKL; dehydrogenase/reductase (SDR family) member 4; dehydrogenase/reductase SDR family member 4; LOC266686; NADP-retinol dehydrogenase; NADPH-dependent carbonyl reductase; NADPH-dependent carbonyl reductase/NADP-retinol dehydrogenase; NADPH-dependent retinol dehydrogenase/reductase; NDRD; peroxisomal short-chain alcohol dehydrogenase; PHCR; PSCD; short chain dehydrogenase/reductase family 25C member 2
RGD Orthologs
Human
Mouse
Bonobo
Dog
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81532,924,482 - 32,948,103 (+)NCBIGRCr8
mRatBN7.21528,966,544 - 28,978,135 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1528,966,553 - 28,978,127 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1530,812,271 - 30,823,840 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01531,959,479 - 31,971,048 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01530,201,827 - 30,213,396 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01534,155,043 - 34,167,073 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1534,155,504 - 34,167,072 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01538,045,908 - 38,057,499 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41533,609,570 - 33,621,142 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11533,625,453 - 33,636,460 (+)NCBI
Celera1528,542,580 - 28,554,149 (+)NCBICelera
Cytogenetic Map15p13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinal  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (EXP)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (ISO)
benzbromarone  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
ciguatoxin CTX1B  (ISO)
clofibrate  (EXP,ISO)
clofibric acid  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
diuron  (EXP)
doxorubicin  (ISO)
elemental selenium  (ISO)
epoxiconazole  (ISO)
ethanol  (EXP)
finasteride  (EXP)
flutamide  (EXP)
gentamycin  (EXP)
hydrogen peroxide  (ISO)
indometacin  (EXP)
inulin  (ISO)
L-ethionine  (EXP)
methapyrilene  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
Muraglitazar  (EXP)
N-nitrosomorpholine  (EXP)
NADP zwitterion  (ISO)
NADP(+)  (ISO)
nefazodone  (EXP)
nimesulide  (EXP)
omeprazole  (EXP)
ozone  (ISO)
p-toluidine  (EXP)
paracetamol  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
phlorizin  (ISO)
pirinixic acid  (EXP,ISO)
resveratrol  (ISO)
selenium atom  (ISO)
sodium arsenite  (EXP,ISO)
sunitinib  (ISO)
Tesaglitazar  (EXP)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
trichloroethene  (EXP,ISO)
trovafloxacin  (ISO)
tungsten  (ISO)
valproic acid  (ISO)
vitamin E  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Identification of peroxisomal proteins by using M13 phage protein VI phage display: molecular evidence that mammalian peroxisomes contain a 2,4-dienoyl-CoA reductase. Fransen M, etal., Biochem J 1999 Jun 1;340 ( Pt 2):561-8.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
7. GOA pipeline RGD automated data pipeline
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:12680773   PMID:14651853   PMID:17230527   PMID:18334214   PMID:18571493   PMID:19056333   PMID:19442656   PMID:20178365   PMID:21525035   PMID:22227495   PMID:23036705   PMID:23376485  
PMID:25931508  


Genomics

Comparative Map Data
Dhrs4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81532,924,482 - 32,948,103 (+)NCBIGRCr8
mRatBN7.21528,966,544 - 28,978,135 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1528,966,553 - 28,978,127 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1530,812,271 - 30,823,840 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01531,959,479 - 31,971,048 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01530,201,827 - 30,213,396 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01534,155,043 - 34,167,073 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1534,155,504 - 34,167,072 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01538,045,908 - 38,057,499 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41533,609,570 - 33,621,142 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11533,625,453 - 33,636,460 (+)NCBI
Celera1528,542,580 - 28,554,149 (+)NCBICelera
Cytogenetic Map15p13NCBI
DHRS4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381423,953,770 - 23,969,279 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1423,953,734 - 23,969,279 (+)EnsemblGRCh38hg38GRCh38
GRCh371424,422,979 - 24,438,488 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361423,492,805 - 23,508,328 (+)NCBINCBI36Build 36hg18NCBI36
Build 341423,492,804 - 23,508,326NCBI
Celera144,285,601 - 4,303,126 (+)NCBICelera
Cytogenetic Map14q11.2NCBI
HuRef144,539,991 - 4,555,519 (+)NCBIHuRef
CHM1_11424,421,623 - 24,437,128 (+)NCBICHM1_1
T2T-CHM13v2.01418,154,102 - 18,169,615 (+)NCBIT2T-CHM13v2.0
Dhrs4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391455,715,880 - 55,727,797 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1455,716,215 - 55,727,797 (+)EnsemblGRCm39 Ensembl
GRCm381455,478,741 - 55,490,340 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1455,478,758 - 55,490,340 (+)EnsemblGRCm38mm10GRCm38
MGSCv371456,097,595 - 56,109,177 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361454,432,868 - 54,444,411 (+)NCBIMGSCv36mm8
Celera1453,283,670 - 53,295,252 (+)NCBICelera
Cytogenetic Map14C3NCBI
cM Map1428.19NCBI
DHRS4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21525,352,031 - 25,367,508 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11424,568,524 - 24,584,000 (+)NCBINHGRI_mPanPan1
PanPan1.11422,831,557 - 22,953,699 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1422,831,756 - 22,846,695 (+)Ensemblpanpan1.1panPan2
CPNE6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.184,046,532 - 4,058,498 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl84,046,544 - 4,084,744 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha83,968,424 - 3,980,384 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.084,157,197 - 4,169,172 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl84,157,179 - 4,169,172 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.183,847,979 - 3,859,935 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.083,909,733 - 3,921,692 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.084,171,825 - 4,183,775 (+)NCBIUU_Cfam_GSD_1.0
DHRS4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl775,242,124 - 75,255,598 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1775,242,121 - 75,255,594 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2780,512,359 - 80,525,829 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DHRS4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12924,170,090 - 24,185,509 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2924,169,818 - 24,185,634 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605922,224,518 - 22,239,925 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Dhrs4
34 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:41
Count of miRNA genes:38
Interacting mature miRNAs:40
Transcripts:ENSRNOT00000024782
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331729Rf42Renal function QTL 423.071kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)151736289773690657Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15142356671Rat
1582227Gluco30Glucose level QTL 303.60.0003blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)152803066582262678Rat
1582228Epfw3Epididymal fat weight QTL 34.10.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)152280624098288169Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)152280624098288169Rat
9589149Insul29Insulin level QTL 299.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)15134723002Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1530632945306329Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151249614165205939Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15155302115Rat
2293688Bss29Bone structure and strength QTL 295.310.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)151111114256111142Rat
8552920Pigfal8Plasma insulin-like growth factor 1 level QTL 83blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)15134723002Rat
8694361Abfw6Abdominal fat weight QTL 610.20.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)15134723002Rat
1582214Stl21Serum triglyceride level QTL 213.10.022blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)152803066582262678Rat
631273Lecl2Lens clarity QTL 20.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)151059608955596089Rat
2300167Bmd63Bone mineral density QTL 635.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
731170Pur3Proteinuria QTL 32.30.0005urine protein amount (VT:0005160)urine protein excretion rate (CMO:0000759)15141686771Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15226636846921453Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152211793367117933Rat
2300173Bmd62Bone mineral density QTL 6212.80.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)151985656646187442Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151672552880672115Rat
1582251Gluco24Glucose level QTL 243.20.0008blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)15553075650530756Rat
1354657Despr13Despair related QTL 130.0022locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)15129912054Rat
631550Bw7Body weight QTL 73.6body mass (VT:0001259)body weight (CMO:0000012)151985656634924750Rat
1582242Gluco28Glucose level QTL 283.30.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)152803066582262678Rat
1582244Bw79Body weight QTL 7940.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)152280624098288169Rat

Markers in Region
BE114851  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21528,975,446 - 28,975,617 (+)MAPPERmRatBN7.2
Rnor_6.01534,164,385 - 34,164,555NCBIRnor6.0
Rnor_5.01538,054,811 - 38,054,981UniSTSRnor5.0
RGSC_v3.41533,618,454 - 33,618,624UniSTSRGSC3.4
Celera1528,551,461 - 28,551,631UniSTS
RH 3.4 Map15260.61UniSTS
Cytogenetic Map15p13UniSTS
RH130081  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21528,977,811 - 28,977,998 (+)MAPPERmRatBN7.2
Rnor_6.01534,166,750 - 34,166,936NCBIRnor6.0
Rnor_5.01538,057,176 - 38,057,362UniSTSRnor5.0
RGSC_v3.41533,620,819 - 33,621,005UniSTSRGSC3.4
Celera1528,553,826 - 28,554,012UniSTS
RH 3.4 Map15260.81UniSTS
Cytogenetic Map15p13UniSTS
BE113024  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21528,968,298 - 28,968,515 (+)MAPPERmRatBN7.2
Rnor_6.01534,157,238 - 34,157,454NCBIRnor6.0
Rnor_5.01538,047,662 - 38,047,878UniSTSRnor5.0
RGSC_v3.41533,611,304 - 33,611,520UniSTSRGSC3.4
Celera1528,544,314 - 28,544,530UniSTS
RH 3.4 Map15260.21UniSTS
Cytogenetic Map15p13UniSTS
BE120291  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21528,970,324 - 28,970,507 (+)MAPPERmRatBN7.2
Rnor_6.01534,159,263 - 34,159,445NCBIRnor6.0
Rnor_5.01538,049,689 - 38,049,871UniSTSRnor5.0
RGSC_v3.41533,613,332 - 33,613,514UniSTSRGSC3.4
Celera1528,546,339 - 28,546,521UniSTS
RH 3.4 Map15260.81UniSTS
Cytogenetic Map15p13UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 16 41 7 10 36 35 34 11 7
Low 3 1 1 38 7 1
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000024782   ⟹   ENSRNOP00000024782
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1528,966,553 - 28,978,127 (+)Ensembl
Rnor_6.0 Ensembl1534,155,504 - 34,167,072 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000119531   ⟹   ENSRNOP00000082872
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1528,966,553 - 28,977,730 (+)Ensembl
RefSeq Acc Id: NM_153315   ⟹   NP_695227
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81532,936,534 - 32,948,103 (+)NCBI
mRatBN7.21528,966,565 - 28,978,135 (+)NCBI
Rnor_6.01534,155,504 - 34,167,073 (+)NCBI
Rnor_5.01538,045,908 - 38,057,499 (+)NCBI
RGSC_v3.41533,609,570 - 33,621,142 (+)RGD
Celera1528,542,580 - 28,554,149 (+)RGD
Sequence:
RefSeq Acc Id: XM_039093040   ⟹   XP_038948968
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81532,936,515 - 32,946,246 (+)NCBI
mRatBN7.21528,966,544 - 28,976,256 (+)NCBI
RefSeq Acc Id: XM_063274033   ⟹   XP_063130103
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81532,924,482 - 32,948,096 (+)NCBI
RefSeq Acc Id: NP_695227   ⟸   NM_153315
- UniProtKB: Q6IRD4 (UniProtKB/Swiss-Prot),   Q8VID1 (UniProtKB/Swiss-Prot),   A0A8I5ZUW8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000024782   ⟸   ENSRNOT00000024782
RefSeq Acc Id: XP_038948968   ⟸   XM_039093040
- Peptide Label: isoform X2
- UniProtKB: A0A8I5ZUW8 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000082872   ⟸   ENSRNOT00000119531
RefSeq Acc Id: XP_063130103   ⟸   XM_063274033
- Peptide Label: isoform X1
- UniProtKB: Q8VID1 (UniProtKB/Swiss-Prot),   Q6IRD4 (UniProtKB/Swiss-Prot),   A0A8I5ZUW8 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8VID1-F1-model_v2 AlphaFold Q8VID1 1-279 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:708482 AgrOrtholog
BioCyc Gene G2FUF-13725 BioCyc
Ensembl Genes ENSRNOG00000018239 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055012440 UniProtKB/Swiss-Prot
  ENSRNOG00060026632 UniProtKB/Swiss-Prot
  ENSRNOG00065032870 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000024782.5 UniProtKB/Swiss-Prot
  ENSRNOT00000119531.1 UniProtKB/TrEMBL
  ENSRNOT00055021208 UniProtKB/Swiss-Prot
  ENSRNOT00060046172 UniProtKB/Swiss-Prot
  ENSRNOT00065056513 UniProtKB/Swiss-Prot
Gene3D-CATH NAD(P)-binding Rossmann-like Domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7099044 IMAGE-MGC_LOAD
InterPro NAD(P)-bd_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sc_DH/Rdtase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SDR_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:266686 UniProtKB/Swiss-Prot
MGC_CLONE MGC:91451 IMAGE-MGC_LOAD
NCBI Gene 266686 ENTREZGENE
PANTHER DEHYDROGENASE/REDUCTASE (SDR FAMILY) MEMBER 4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR43943:SF8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam adh_short UniProtKB/TrEMBL
  adh_short_C2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Dhrs4 PhenoGen
PRINTS GDHRDH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SDRFAMILY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ADH_SHORT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000018239 RatGTEx
  ENSRNOG00055012440 RatGTEx
  ENSRNOG00060026632 RatGTEx
  ENSRNOG00065032870 RatGTEx
Superfamily-SCOP SSF51735 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZUW8 ENTREZGENE, UniProtKB/TrEMBL
  A6KGZ7_RAT UniProtKB/TrEMBL
  A6KGZ8_RAT UniProtKB/TrEMBL
  DHRS4_RAT UniProtKB/Swiss-Prot
  Q6IRD4 ENTREZGENE
  Q8VID1 ENTREZGENE
UniProt Secondary Q6IRD4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-06-01 Dhrs4  dehydrogenase/reductase 4  Dhrs4  dehydrogenase/reductase (SDR family) member 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Dhrs4  dehydrogenase/reductase (SDR family) member 4  LOC266686  carbonyl reductase  Symbol and Name updated 1299863 APPROVED