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Gene: Mmut (methylmalonyl-CoA mutase) Rattus norvegicus
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Symbol: Mmut
Name: methylmalonyl-CoA mutase
Description: Predicted to have several functions, including cobalamin binding activity; methylmalonyl-CoA mutase activity; and protein homodimerization activity. Predicted to be involved in homocysteine metabolic process; positive regulation of GTPase activity; and post-embryonic development. Human ortholog(s) of this gene implicated in methylmalonic aciduria due to methylmalonyl-CoA mutase deficiency. Orthologous to human MMUT (methylmalonyl-CoA mutase); PARTICIPATES IN 3-hydroxy-3-methylglutaryl-CoA lyase deficiency pathway; 3-hydroxyisobutyric aciduria pathway; 3-methylcrotonyl CoA carboxylase 1 deficiency pathway; INTERACTS WITH (+)-schisandrin B; 5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: MODEL
Also known as: LOC301276; LOC688517; methylmalonyl CoA mutase; methylmalonyl-CoA mutase, mitochondrial; methylmalonyl-Coenzyme A mutase; Mut; rCG43751-like; similar to Methylmalonyl-CoA mutase, mitochondrial precursor (MCM) (Methylmalonyl-CoA isomerase)
Orthologs:
Homo sapiens (human) : MMUT (methylmalonyl-CoA mutase)  HGNC  Alliance
Mus musculus (house mouse) : Mmut (methylmalonyl-Coenzyme A mutase)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mmut (methylmalonyl-CoA mutase)
Pan paniscus (bonobo/pygmy chimpanzee) : MMUT (methylmalonyl-CoA mutase)
Canis lupus familiaris (dog) : MMUT (methylmalonyl-CoA mutase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mmut (methylmalonyl-CoA mutase)
Sus scrofa (pig) : MMUT (methylmalonyl-CoA mutase)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0923,323,934 - 23,352,144 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl923,323,936 - 23,352,668 (-)Ensembl
Rnor_5.0922,182,975 - 22,211,162 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4916,065,495 - 16,093,956 (-)NCBIRGSC3.4rn4RGSC3.4
Celera917,606,384 - 17,634,555 (-)NCBICelera
Cytogenetic Map9q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
 
More on Mmut
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1587662
Created: 2006-11-19
Species: Rattus norvegicus
Last Modified: 2019-11-27
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.