Pik3cg (phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma) - Rat Genome Database

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Gene: Pik3cg (phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma) Rattus norvegicus
Analyze
Symbol: Pik3cg
Name: phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
RGD ID: 1306468
Description: Enables 1-phosphatidylinositol-3-kinase activity. Involved in several processes, including hepatocyte apoptotic process; negative regulation of triglyceride catabolic process; and phosphatidylinositol phosphate biosynthetic process. Part of phosphatidylinositol 3-kinase complex. Used to study liver cirrhosis. Biomarker of diabetic retinopathy. Human ortholog(s) of this gene implicated in autistic disorder; immunodeficiency 97; and swine influenza. Orthologous to human PIK3CG (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma); PARTICIPATES IN phosphatidylinositol 3-kinase-Akt signaling pathway; eicosanoid signaling pathway; ephrin - ephrin receptor bidirectional signaling axis; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform; phosphoinositide-3-kinase, catalytic, gamma polypeptide; Pi3k
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8654,494,247 - 54,529,563 (-)NCBIGRCr8
mRatBN7.2648,766,778 - 48,802,098 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl648,766,864 - 48,802,043 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx649,076,821 - 49,111,984 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0649,391,750 - 49,426,907 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0648,836,049 - 48,871,239 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0651,465,696 - 51,501,234 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl651,465,908 - 51,498,337 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0661,106,730 - 61,142,184 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4650,441,892 - 50,476,931 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1650,447,918 - 50,480,237 (-)NCBI
Celera647,971,127 - 48,004,061 (-)NCBICelera
Cytogenetic Map6q16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,4'-trichlorobiphenyl  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-nonylphenol  (EXP)
5-aza-2'-deoxycytidine  (ISO)
acetohydrazide  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
allethrin  (EXP)
alpha-Zearalanol  (EXP)
amosite asbestos  (ISO)
amphetamine  (EXP)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
BMS-754807  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP)
calcium silicate  (ISO)
captan  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
cordycepin  (ISO)
corilagin  (EXP)
cycloheximide  (ISO)
cyhalothrin  (ISO)
deoxynivalenol  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
dioxygen  (EXP,ISO)
diquat  (ISO)
ethanol  (ISO)
folpet  (ISO)
formaldehyde  (ISO)
glycyrrhetinate  (ISO)
glycyrrhetinic acid  (ISO)
glycyrrhizinic acid  (ISO)
GSK-J4  (ISO)
hexadecanoic acid  (ISO)
hydrazine  (ISO)
IC-87114  (ISO)
idelalisib  (ISO)
isoprenaline  (ISO)
kaempferol  (EXP)
lead diacetate  (EXP)
lead(0)  (EXP)
letrozole  (EXP)
lidocaine  (EXP)
lipopolysaccharide  (ISO)
LY294002  (ISO)
metformin  (ISO)
methylmercury(1+)  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP)
nickel atom  (ISO)
nitrates  (EXP)
Nonylphenol  (EXP)
ochratoxin A  (ISO)
okadaic acid  (ISO)
PCB138  (ISO)
pioglitazone  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
silicon dioxide  (ISO)
sirolimus  (EXP,ISO)
sodium arsenite  (ISO)
tamibarotene  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
toluene 2,4-diisocyanate  (ISO)
tributylstannane  (ISO)
Tributyltin oxide  (ISO)
triphenyl phosphate  (ISO)
trovafloxacin  (ISO)
tungsten  (ISO)
valproic acid  (ISO)
wortmannin  (EXP,ISO)
xanthohumol  (ISO)
zinc dichloride  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Acylated and unacylated ghrelin attenuate isoproterenol-induced lipolysis in isolated rat visceral adipocytes through activation of phosphoinositide 3-kinase gamma and phosphodiesterase 3B. Baragli A, etal., Biochim Biophys Acta. 2011 Jun;1811(6):386-96. Epub 2011 Mar 22.
2. Class IB-phosphatidylinositol 3-kinase (PI3K) deficiency ameliorates IA-PI3K-induced systemic lupus but not T cell invasion. Barber DF, etal., J Immunol. 2006 Jan 1;176(1):589-93.
3. PI3Kgamma within a nonhematopoietic cell type negatively regulates diet-induced thermogenesis and promotes obesity and insulin resistance. Becattini B, etal., Proc Natl Acad Sci U S A. 2011 Oct 18;108(42):E854-63. Epub 2011 Sep 26.
4. A specific role of phosphatidylinositol 3-kinase gamma. A regulation of autonomic Ca(2)+ oscillations in cardiac cells. Bony C, etal., J Cell Biol. 2001 Feb 19;152(4):717-28.
5. PI3Kgamma controls leukocyte recruitment, tissue injury, and lethality in a model of graft-versus-host disease in mice. Castor MG, etal., J Leukoc Biol. 2011 Jun;89(6):955-64. Epub 2011 Mar 14.
6. Improvement of the resistance against early Mycobacterium tuberculosis-infection in the absence of PI3Kγ enzyme is associated with increase of CD4+IL-17+ cells and neutrophils. Cavalcanti-Neto MP, etal., Tuberculosis (Edinb). 2018 Dec;113:1-9. doi: 10.1016/j.tube.2018.08.009. Epub 2018 Aug 23.
7. Deletion of the phosphoinositide 3-kinase p110gamma gene attenuates murine atherosclerosis. Chang JD, etal., Proc Natl Acad Sci U S A. 2007 May 8;104(19):8077-82. Epub 2007 May 2.
8. S100B-mediated protection against the pro-apoptotic effects of ethanol on fetal rhombencephalic neurons. Druse MJ, etal., Brain Res. 2007 May 30;1150:46-54. Epub 2007 Mar 13.
9. Inhibitor of PI3Kgamma ameliorates TNBS-induced colitis in mice by affecting the functional activity of CD4+CD25+FoxP3+ regulatory T cells. Dutra RC, etal., Br J Pharmacol. 2011 May;163(2):358-74. doi: 10.1111/j.1476-5381.2011.01226.x.
10. Key role of phosphoinositide 3-kinase class IB in pancreatic cancer. Edling CE, etal., Clin Cancer Res. 2010 Oct 15;16(20):4928-37. doi: 10.1158/1078-0432.CCR-10-1210. Epub 2010 Sep 28.
11. Phosphoinositide 3-Kinase {gamma} Inhibition Plays a Crucial Role in Early Steps of Inflammation by Blocking Neutrophil Recruitment. Ferrandi C, etal., J Pharmacol Exp Ther. 2007 Sep;322(3):923-30. Epub 2007 May 25.
12. Phosphatidyl Inositol 3 Kinase-Gamma Balances Antiviral and Inflammatory Responses During Influenza A H1N1 Infection: From Murine Model to Genetic Association in Patients. Garcia CC, etal., Front Immunol. 2018 May 15;9:975. doi: 10.3389/fimmu.2018.00975. eCollection 2018.
13. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
14. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
15. Phosphatidylinositol 3-kinase gamma inhibition ameliorates inflammation and tumor growth in a model of colitis-associated cancer. Gonzalez-Garcia A, etal., Gastroenterology. 2010 Apr;138(4):1374-83. Epub 2009 Dec 11.
16. Loss of phosphoinositide 3-kinase gamma decreases migration and activation of phagocytes but not T cell activation in antigen-induced arthritis. Gruen M, etal., BMC Musculoskelet Disord. 2010 Apr 7;11:63.
17. Activation of PI3Kγ/Akt pathway mediates bone cancer pain in rats. Guan X, etal., J Neurochem. 2015 Aug;134(3):590-600. doi: 10.1111/jnc.13139. Epub 2015 Jun 4.
18. PI3Kgamma protects from myocardial ischemia and reperfusion injury through a kinase-independent pathway. Haubner BJ, etal., PLoS One. 2010 Feb 22;5(2):e9350.
19. Phosphatidylinositol-3-kinase p110gamma contributes to bile salt-induced apoptosis in primary rat hepatocytes and human hepatoma cells. Hohenester S, etal., J Hepatol. 2010 Nov;53(5):918-26. Epub 2010 Jul 17.
20. Effect of miR-182 on hepatic fibrosis induced by Schistosomiasis japonica by targeting FOXO1 through PI3K/AKT signaling pathway. Huang Y, etal., J Cell Physiol. 2018 Oct;233(10):6693-6704. doi: 10.1002/jcp.26469. Epub 2018 Apr 25.
21. Prolactin-stimulated transepithelial calcium transport in duodenum and Caco-2 monolayer are mediated by the phosphoinositide 3-kinase pathway. Jantarajit W, etal., Am J Physiol Endocrinol Metab. 2007 Jul;293(1):E372-84. Epub 2007 May 8.
22. Phosphatidylinositol-3-kinase gamma plays a central role in blood-brain barrier dysfunction in acute experimental stroke. Jin R, etal., Stroke. 2011 Jul;42(7):2033-44. Epub 2011 May 5.
23. Platelet-derived growth factor-BB-mediated activation of Akt suppresses smooth muscle-specific gene expression through inhibition of mitogen-activated protein kinase and redistribution of serum response factor. Kaplan-Albuquerque N, etal., J Biol Chem. 2003 Oct 10;278(41):39830-8. Epub 2003 Jul 25.
24. PI3K-gamma inhibition ameliorates acute lung injury through regulation of IkappaBalpha/NF-kappaB pathway and innate immune responses. Kim DI, etal., J Clin Immunol. 2012 Apr;32(2):340-51. Epub 2011 Dec 24.
25. Loss of insulin-mediated vasoprotection: early effect of diabetes on pericyte-containing microvessels of the retina. Kobayashi T and Puro DG, Invest Ophthalmol Vis Sci. 2007 May;48(5):2350-5.
26. Phosphatidylinositol 3-Kinase γ is required for the development of experimental cerebral malaria. Lacerda-Queiroz N, etal., PLoS One. 2015 Mar 16;10(3):e0119633. doi: 10.1371/journal.pone.0119633. eCollection 2015.
27. Lack of phosphoinositide 3-kinase-gamma attenuates ventilator-induced lung injury. Lionetti V, etal., Crit Care Med. 2006 Jan;34(1):134-41.
28. Repression of microRNA-21 inhibits retinal vascular endothelial cell growth and angiogenesis via PTEN dependent-PI3K/Akt/VEGF signaling pathway in diabetic retinopathy. Lu JM, etal., Exp Eye Res. 2020 Jan;190:107886. doi: 10.1016/j.exer.2019.107886. Epub 2019 Nov 21.
29. PI3Kγ mediates kaposi's sarcoma-associated herpesvirus vGPCR-induced sarcomagenesis. Martin D, etal., Cancer Cell. 2011 Jun 14;19(6):805-13. doi: 10.1016/j.ccr.2011.05.005.
30. Phosphoinositide-3 kinase gamma activity contributes to sepsis and organ damage by altering neutrophil recruitment. Martin EL, etal., Am J Respir Crit Care Med. 2010 Sep 15;182(6):762-73. Epub 2010 May 27.
31. Importance of phosphoinositide 3-kinase gamma in the host defense against pneumococcal infection. Maus UA, etal., Am J Respir Crit Care Med. 2007 May 1;175(9):958-66. doi: 10.1164/rccm.200610-1533OC. Epub 2007 Feb 22.
32. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
33. Novel roles of local insulin-like growth factor-1 activation in gastric ulcer healing: promotes actin polymerization, cell proliferation, re-epithelialization, and induces cyclooxygenase-2 in a phosphatidylinositol 3-kinase-dependent manner. Nguyen T, etal., Am J Pathol. 2007 Apr;170(4):1219-28.
34. Involvement of phosphoinositide 3-kinase gamma in the neuro-inflammatory response and cognitive impairments induced by beta-amyloid 1-40 peptide in mice. Passos GF, etal., Brain Behav Immun. 2010 Mar;24(3):493-501. Epub 2009 Dec 16.
35. Targeted inhibition of beta-adrenergic receptor kinase-1-associated phosphoinositide-3 kinase activity preserves beta-adrenergic receptor signaling and prolongs survival in heart failure induced by calsequestrin overexpression. Perrino C, etal., J Am Coll Cardiol. 2005 Jun 7;45(11):1862-70.
36. Insulin granule recruitment and exocytosis is dependent on p110gamma in insulinoma and human beta-cells. Pigeau GM, etal., Diabetes. 2009 Sep;58(9):2084-92. Epub 2009 Jun 23.
37. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
38. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
39. Role of PI3Kdelta and PI3Kgamma in inflammatory arthritis and tissue localization of neutrophils. Randis TM, etal., Eur J Immunol. 2008 May;38(5):1215-24.
40. GOA pipeline RGD automated data pipeline
41. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
42. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
43. Comprehensive gene review and curation RGD comprehensive gene curation
44. Absence of PI3Kgamma leads to increased leukocyte apoptosis and diminished severity of experimental autoimmune encephalomyelitis. Rodrigues DH, etal., J Neuroimmunol. 2010 May;222(1-2):90-4. Epub 2010 Mar 19.
45. Frontline Science: Coincidental null mutation of Csf2rα in a colony of PI3Kγ-/- mice causes alveolar macrophage deficiency and fatal respiratory viral infection. Schneider C, etal., J Leukoc Biol. 2017 Feb;101(2):367-376. doi: 10.1189/jlb.4HI0316-157R. Epub 2016 Jul 28.
46. Association of INPP1, PIK3CG, and TSC2 gene variants with autistic disorder: implications for phosphatidylinositol signalling in autism. Serajee FJ, etal., J Med Genet. 2003 Nov;40(11):e119.
47. Canonical PI3Kγ signaling in myeloid cells restricts Trypanosoma cruzi infection and dampens chagasic myocarditis. Silva MC, etal., Nat Commun. 2018 Apr 17;9(1):1513. doi: 10.1038/s41467-018-03986-3.
48. Involvement of phosphoinositide 3-kinase gamma in angiogenesis and healing of experimental myocardial infarction in mice. Siragusa M, etal., Circ Res. 2010 Mar 5;106(4):757-68. Epub 2010 Jan 7.
49. [The antagonistic effect of PI3K-gamma inhibitor AS605240 on cardiac hypertrophy and cardiac fibrosis induced by isoproterenol in rats]. Song LF, etal., Sichuan Da Xue Xue Bao Yi Xue Ban. 2011 Jul;42(4):471-4.
50. Phosphatidylinositol 3-kinase-γ signaling promotes Campylobacter jejuni-induced colitis through neutrophil recruitment in mice. Sun X, etal., J Immunol. 2013 Jan 1;190(1):357-65. doi: 10.4049/jimmunol.1201825. Epub 2012 Nov 23.
51. Essential role of phosphoinositide 3-kinase gamma in eosinophil chemotaxis within acute pulmonary inflammation. Thomas M, etal., Immunology. 2009 Mar;126(3):413-22. Epub 2008 Aug 27.
52. Cardioprotection induced by olprinone, a phosphodiesterase III inhibitor, involves phosphatidylinositol-3-OH kinase-Akt and a mitochondrial permeability transition pore during early reperfusion. Tosaka S, etal., J Anesth. 2007;21(2):176-80. Epub 2007 May 30.
53. The absence of functional PI3Kgamma prevents leukocyte recruitment and ameliorates DSS-induced colitis in mice. van Dop WA, etal., Immunol Lett. 2010 Jun 15;131(1):33-9. doi: 10.1016/j.imlet.2010.03.008. Epub 2010 Mar 27.
54. CDK2 regulation through PI3K and CDK4 is necessary for cell cycle progression of primary rat hepatocytes. Wierod L, etal., Cell Prolif. 2007 Aug;40(4):475-87.
55. The alarmin cytokine, high mobility group box 1, is produced by viable cardiomyocytes and mediates the lipopolysaccharide-induced myocardial dysfunction via a TLR4/phosphatidylinositol 3-kinase gamma pathway. Xu H, etal., J Immunol. 2010 Feb 1;184(3):1492-8. doi: 10.4049/jimmunol.0902660. Epub 2009 Dec 18.
56. The PI3K/Akt pathway mediates the nongenomic cardioprotective effects of estrogen following trauma-hemorrhage. Yu HP, etal., Ann Surg. 2007 Jun;245(6):971-7.
57. Tissue kallikrein reverses insulin resistance and attenuates nephropathy in diabetic rats by activation of phosphatidylinositol 3-kinase/protein kinase B and adenosine 5'-monophosphate-activated protein kinase signaling pathways. Yuan G, etal., Endocrinology. 2007 May;148(5):2016-26. Epub 2007 Feb 1.
58. Involvement of phosphoinositide 3-kinases in neutrophil activation and the development of acute lung injury. Yum HK, etal., J Immunol. 2001 Dec 1;167(11):6601-8. doi: 10.4049/jimmunol.167.11.6601.
59. Stimulatory effect of puerarin on bone formation through activation of PI3K/Akt pathway in rat calvaria osteoblasts. Zhang Y, etal., Planta Med. 2007 Apr;73(4):341-7. Epub 2007 Apr 18.
Additional References at PubMed
PMID:11416136   PMID:12507995   PMID:12538627   PMID:14762792   PMID:15192701   PMID:15385964   PMID:15845362   PMID:16130182   PMID:16343426   PMID:16414349   PMID:16762504   PMID:16989733  
PMID:17016676   PMID:17555093   PMID:17630321   PMID:17885802   PMID:17893321   PMID:17942284   PMID:18071753   PMID:18163378   PMID:18163380   PMID:18269915   PMID:18299886   PMID:18410228  
PMID:18461448   PMID:18512147   PMID:18616564   PMID:18635661   PMID:18663086   PMID:18785877   PMID:18791856   PMID:19015400   PMID:19060913   PMID:19255141   PMID:19279233   PMID:19381068  
PMID:19531027   PMID:19698760   PMID:19709371   PMID:19804812   PMID:19896516   PMID:19946888   PMID:19997978   PMID:20093365   PMID:20333648   PMID:20371878   PMID:20383584   PMID:20404059  
PMID:20562859   PMID:20665543   PMID:20821260   PMID:20870746   PMID:20953735   PMID:20967511   PMID:21042752   PMID:21182226   PMID:21219473   PMID:21498085   PMID:21683721   PMID:21822733  
PMID:21984198   PMID:22166507   PMID:22251375   PMID:22316281   PMID:22447946   PMID:22490886   PMID:22553040   PMID:22702339   PMID:22967108   PMID:23008439   PMID:23142719   PMID:23271286  
PMID:23524565   PMID:23524571   PMID:23548598   PMID:23824069   PMID:24312696   PMID:24361011   PMID:24742749   PMID:24950409   PMID:25004887   PMID:25044177   PMID:25048263   PMID:25073791  
PMID:25201632   PMID:25327288   PMID:25644171   PMID:26093674   PMID:26546817   PMID:26616056   PMID:26818151   PMID:27059137   PMID:27539497   PMID:27725163   PMID:27821807   PMID:28129651  
PMID:28464602   PMID:29288664   PMID:29737948   PMID:37157936   PMID:38063101   PMID:38063104  


Genomics

Comparative Map Data
Pik3cg
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8654,494,247 - 54,529,563 (-)NCBIGRCr8
mRatBN7.2648,766,778 - 48,802,098 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl648,766,864 - 48,802,043 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx649,076,821 - 49,111,984 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0649,391,750 - 49,426,907 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0648,836,049 - 48,871,239 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0651,465,696 - 51,501,234 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl651,465,908 - 51,498,337 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0661,106,730 - 61,142,184 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4650,441,892 - 50,476,931 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1650,447,918 - 50,480,237 (-)NCBI
Celera647,971,127 - 48,004,061 (-)NCBICelera
Cytogenetic Map6q16NCBI
PIK3CG
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387106,865,282 - 106,908,980 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7106,865,278 - 106,908,980 (+)EnsemblGRCh38hg38GRCh38
GRCh377106,505,727 - 106,549,425 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367106,293,160 - 106,334,828 (+)NCBINCBI36Build 36hg18NCBI36
Build 347106,099,874 - 106,141,543NCBI
Celera7101,311,222 - 101,352,879 (+)NCBICelera
Cytogenetic Map7q22.3NCBI
HuRef7100,864,687 - 100,906,376 (+)NCBIHuRef
CHM1_17106,439,450 - 106,481,120 (+)NCBICHM1_1
T2T-CHM13v2.07108,181,318 - 108,225,014 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27105,867,019 - 105,908,676 (+)NCBI
Pik3cg
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391232,223,128 - 32,258,675 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1232,223,472 - 32,258,658 (-)EnsemblGRCm39 Ensembl
GRCm381232,173,397 - 32,208,677 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1232,173,473 - 32,208,659 (-)EnsemblGRCm38mm10GRCm38
MGSCv371232,858,262 - 32,893,514 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361232,760,883 - 32,793,717 (-)NCBIMGSCv36mm8
Celera1233,627,107 - 33,665,676 (-)NCBICelera
Cytogenetic Map12A3NCBI
cM Map1213.74NCBI
Pik3cg
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541011,402,520 - 11,437,422 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541011,402,476 - 11,433,335 (+)NCBIChiLan1.0ChiLan1.0
PIK3CG
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26143,705,405 - 143,748,878 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17191,975,373 - 192,018,845 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0798,841,974 - 98,885,446 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17111,569,947 - 111,611,614 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7111,570,148 - 111,611,614 (+)Ensemblpanpan1.1panPan2
PIK3CG
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11813,576,966 - 13,611,748 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1813,570,999 - 13,611,141 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1813,224,877 - 13,259,686 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01813,848,210 - 13,882,893 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1813,847,825 - 13,882,854 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11813,664,384 - 13,696,319 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01813,582,574 - 13,617,381 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01813,862,587 - 13,897,681 (-)NCBIUU_Cfam_GSD_1.0
Pik3cg
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511855,959,678 - 55,990,585 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647917,084,920 - 17,112,258 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647917,084,006 - 17,112,264 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PIK3CG
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9106,698,207 - 106,745,099 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19106,698,200 - 106,748,217 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29117,537,774 - 117,572,944 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PIK3CG
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12175,781,812 - 75,823,404 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2175,784,648 - 75,825,496 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604228,038,017 - 28,081,732 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pik3cg
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473922,737,270 - 22,772,589 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473922,737,376 - 22,772,696 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pik3cg
230 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:70
Count of miRNA genes:35
Interacting mature miRNAs:35
Transcripts:ENSRNOT00000012487, ENSRNOT00000045589
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9590290Uminl2Urine mineral level QTL 23.960.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)63878398983783989Rat
8693632Alc27Alcohol consumption QTL 272.20.791drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)63432335751121479Rat
634318Bw118Body weight QTL 1183.55abdominal fat pad mass (VT:1000711)abdominal fat pad weight (CMO:0000088)63330954957730294Rat
10401812Kidm54Kidney mass QTL 54kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)61436878859368788Rat
634307Bp141Blood pressure QTL 1414arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)63523041780230417Rat
2292589Emca10Estrogen-induced mammary cancer QTL 100.048mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)61653614061536140Rat
634330Pia16Pristane induced arthritis QTL 163.9joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)645790088104200226Rat
10401800Kidm49Kidney mass QTL 49kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)61436878859368788Rat
1300164Rf15Renal function QTL 153.12renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6507449754641141Rat
1331779Rf38Renal function QTL 382.876kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)63207442872227641Rat
1354632Scl29Serum cholesterol level QTL 293.74blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)63509870971636405Rat
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)610894415110548006Rat
2293839Kiddil2Kidney dilation QTL 24.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62086642281133036Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)615107216107351382Rat
9590140Scort4Serum corticosterone level QTL 414.490.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)63878398983783989Rat
9590306Scort18Serum corticosterone level QTL 182.880.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)63878398983783989Rat
1578665Bss16Bone structure and strength QTL 164.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)61173566972593685Rat
2293841Kiddil4Kidney dilation QTL 44.4kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62086642281133036Rat
1641898Colcr4Colorectal carcinoma resistance QTL43.710.0007intestine integrity trait (VT:0010554)well differentiated malignant colorectal tumor surface area measurement (CMO:0002077)62033877762613667Rat
1578668Bmd14Bone mineral density QTL 143.8femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)61173566972593685Rat
6893340Cm77Cardiac mass QTL 770.260.57heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)63330954981132889Rat
70199Coreg1Compensatory renal growth QTL 111.8kidney mass (VT:0002707)compensatory renal growth score (CMO:0001894)63569161857730540Rat
2301972Bp325Blood pressure QTL 3254.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6172227641Rat
1354664Slep2Serum leptin concentration QTL 24.49blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)61653614071636405Rat
1300143Rf14Renal function QTL 142.92renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)63443413777102317Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000012487   ⟹   ENSRNOP00000012487
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl648,766,864 - 48,802,043 (-)Ensembl
Rnor_6.0 Ensembl651,465,908 - 51,498,337 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000103315   ⟹   ENSRNOP00000093926
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl648,770,218 - 48,802,043 (-)Ensembl
RefSeq Acc Id: NM_001371300   ⟹   NP_001358229
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8654,494,334 - 54,529,509 (-)NCBI
mRatBN7.2648,766,864 - 48,802,043 (-)NCBI
RefSeq Acc Id: XM_003750140   ⟹   XP_003750188
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8654,494,247 - 54,529,440 (-)NCBI
mRatBN7.2648,766,778 - 48,801,948 (-)NCBI
Rnor_6.0651,465,696 - 51,501,233 (-)NCBI
Rnor_5.0661,106,730 - 61,142,184 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006240003   ⟹   XP_006240065
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8654,494,247 - 54,529,563 (-)NCBI
mRatBN7.2648,766,778 - 48,802,098 (-)NCBI
Rnor_6.0651,465,696 - 51,501,233 (-)NCBI
Rnor_5.0661,106,730 - 61,142,184 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006240004   ⟹   XP_006240066
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8654,494,247 - 54,529,334 (-)NCBI
mRatBN7.2648,766,778 - 48,801,948 (-)NCBI
Rnor_6.0651,465,696 - 51,501,233 (-)NCBI
Rnor_5.0661,106,730 - 61,142,184 (-)NCBI
Sequence:
RefSeq Acc Id: XP_003750188   ⟸   XM_003750140
- Peptide Label: isoform X1
- UniProtKB: D3ZFJ0 (UniProtKB/TrEMBL),   A0A8I6AKZ7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006240065   ⟸   XM_006240003
- Peptide Label: isoform X1
- UniProtKB: D3ZFJ0 (UniProtKB/TrEMBL),   A0A8I6AKZ7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006240066   ⟸   XM_006240004
- Peptide Label: isoform X1
- UniProtKB: D3ZFJ0 (UniProtKB/TrEMBL),   A0A8I6AKZ7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000012487   ⟸   ENSRNOT00000012487
RefSeq Acc Id: NP_001358229   ⟸   NM_001371300
- UniProtKB: D3ZFJ0 (UniProtKB/TrEMBL),   A0A8I6AKZ7 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000093926   ⟸   ENSRNOT00000103315
Protein Domains
C2 PI3K-type   PI3K-ABD   PI3K-RBD   PI3K/PI4K catalytic   PIK helical

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZFJ0-F1-model_v2 AlphaFold D3ZFJ0 1-1102 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306468 AgrOrtholog
BioCyc Gene G2FUF-37898 BioCyc
BioCyc Pathway PWY-6352 [3-phosphoinositide biosynthesis] BioCyc
BioCyc Pathway Image PWY-6352 BioCyc
Ensembl Genes ENSRNOG00000009385 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000012487 ENTREZGENE
  ENSRNOT00000012487.6 UniProtKB/TrEMBL
  ENSRNOT00000103315.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.1070.11 UniProtKB/TrEMBL
  1.25.40.70 UniProtKB/TrEMBL
  2.60.40.150 UniProtKB/TrEMBL
  3.10.20.770 UniProtKB/TrEMBL
  Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4 UniProtKB/TrEMBL
InterPro ARM-type_fold UniProtKB/TrEMBL
  C2_domain_sf UniProtKB/TrEMBL
  Kinase-like_dom UniProtKB/TrEMBL
  PI3/4_kinase_cat_dom UniProtKB/TrEMBL
  PI3/4_kinase_cat_sf UniProtKB/TrEMBL
  PI3/4_kinase_CS UniProtKB/TrEMBL
  PI3K_accessory_sf UniProtKB/TrEMBL
  PI3K_adapt-bd_dom UniProtKB/TrEMBL
  PI3K_C2 UniProtKB/TrEMBL
  PI3K_ras-bd UniProtKB/TrEMBL
  PI_Kinase UniProtKB/TrEMBL
  PIK3CG_ABD UniProtKB/TrEMBL
  PInositide-3_kin_accessory_dom UniProtKB/TrEMBL
  Ubiquitin-rel_dom UniProtKB/TrEMBL
NCBI Gene 298947 ENTREZGENE
PANTHER PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM UniProtKB/TrEMBL
  PI_Kinase UniProtKB/TrEMBL
Pfam PI3_PI4_kinase UniProtKB/TrEMBL
  PI3K_C2 UniProtKB/TrEMBL
  PI3K_rbd UniProtKB/TrEMBL
  PI3Ka UniProtKB/TrEMBL
  PIK3CG_ABD UniProtKB/TrEMBL
PhenoGen Pik3cg PhenoGen
PROSITE PI3_4_KINASE_1 UniProtKB/TrEMBL
  PI3_4_KINASE_2 UniProtKB/TrEMBL
  PI3_4_KINASE_3 UniProtKB/TrEMBL
  PI3K_ABD UniProtKB/TrEMBL
  PI3K_C2 UniProtKB/TrEMBL
  PI3K_RBD UniProtKB/TrEMBL
  PIK_HELICAL UniProtKB/TrEMBL
RatGTEx ENSRNOG00000009385 RatGTEx
SMART PI3K_C2 UniProtKB/TrEMBL
  PI3K_rbd UniProtKB/TrEMBL
  PI3Ka UniProtKB/TrEMBL
  PI3Kc UniProtKB/TrEMBL
Superfamily-SCOP ARM-type_fold UniProtKB/TrEMBL
  Kinase_like UniProtKB/TrEMBL
  SSF49562 UniProtKB/TrEMBL
  SSF54236 UniProtKB/TrEMBL
UniProt A0A8I6AKZ7 ENTREZGENE, UniProtKB/TrEMBL
  D3ZFJ0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-10-10 Pik3cg  phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma  Pik3cg  phosphoinositide-3-kinase, catalytic, gamma polypeptide  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Pik3cg  phosphoinositide-3-kinase, catalytic, gamma polypeptide   Pik3cg_predicted  phosphoinositide-3-kinase, catalytic, gamma polypeptide (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Pik3cg_predicted  phosphoinositide-3-kinase, catalytic, gamma polypeptide (predicted)      Symbol and Name status set to approved 70820 APPROVED