Pik3cg (phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma) - Rat Genome Database

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Gene: Pik3cg (phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma) Rattus norvegicus
Analyze
Symbol: Pik3cg
Name: phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
RGD ID: 1306468
Description: Enables 1-phosphatidylinositol-3-kinase activity. Involved in several processes, including hepatocyte apoptotic process; negative regulation of triglyceride catabolic process; and phosphatidylinositol phosphate biosynthetic process. Part of phosphatidylinositol 3-kinase complex. Used to study liver cirrhosis. Biomarker of diabetic retinopathy. Human ortholog(s) of this gene implicated in autistic disorder and swine influenza. Orthologous to human PIK3CG (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma); PARTICIPATES IN phosphatidylinositol 3-kinase-Akt signaling pathway; eicosanoid signaling pathway; ephrin - ephrin receptor bidirectional signaling axis; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol; 4-nonylphenol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform; phosphoinositide-3-kinase, catalytic, gamma polypeptide; Pi3k
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2648,766,778 - 48,802,098 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl648,766,864 - 48,802,043 (-)Ensembl
Rnor_6.0651,465,696 - 51,501,234 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl651,465,908 - 51,498,337 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0661,106,730 - 61,142,184 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4650,441,892 - 50,476,931 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1650,447,918 - 50,480,237 (-)NCBI
Celera647,971,127 - 48,004,061 (-)NCBICelera
Cytogenetic Map6q16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
4,4'-sulfonyldiphenol  (EXP)
4-nonylphenol  (EXP)
5-aza-2'-deoxycytidine  (ISO)
acetohydrazide  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amosite asbestos  (ISO)
amphetamine  (EXP)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP)
bisphenol F  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP)
calcium silicate  (ISO)
captan  (ISO)
carbon nanotube  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
cycloheximide  (ISO)
cyhalothrin  (ISO)
deoxynivalenol  (ISO)
diarsenic trioxide  (ISO)
dioxygen  (ISO)
ethanol  (ISO)
folpet  (ISO)
formaldehyde  (ISO)
glycyrrhetinate  (ISO)
glycyrrhetinic acid  (ISO)
glycyrrhizinic acid  (ISO)
hydrazine  (ISO)
IC-87114  (ISO)
idelalisib  (ISO)
isoprenaline  (ISO)
letrozole  (EXP)
lipopolysaccharide  (ISO)
LY294002  (ISO)
metformin  (ISO)
methylmercury(1+)  (ISO)
nickel atom  (ISO)
nitrates  (EXP)
Nonylphenol  (EXP)
ochratoxin A  (ISO)
PCB138  (ISO)
pioglitazone  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
silicon dioxide  (ISO)
sirolimus  (ISO)
sodium arsenite  (ISO)
tamibarotene  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
toluene 2,4-diisocyanate  (ISO)
tributylstannane  (ISO)
Tributyltin oxide  (ISO)
tungsten  (ISO)
valproic acid  (ISO)
wortmannin  (EXP,ISO)
xanthohumol  (ISO)
zinc dichloride  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
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5. Castor MG, etal., J Leukoc Biol. 2011 Jun;89(6):955-64. Epub 2011 Mar 14.
6. Cavalcanti-Neto MP, etal., Tuberculosis (Edinb). 2018 Dec;113:1-9. doi: 10.1016/j.tube.2018.08.009. Epub 2018 Aug 23.
7. Chang JD, etal., Proc Natl Acad Sci U S A. 2007 May 8;104(19):8077-82. Epub 2007 May 2.
8. Druse MJ, etal., Brain Res. 2007 May 30;1150:46-54. Epub 2007 Mar 13.
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12. Garcia CC, etal., Front Immunol. 2018 May 15;9:975. doi: 10.3389/fimmu.2018.00975. eCollection 2018.
13. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
14. GOA data from the GO Consortium
15. Gonzalez-Garcia A, etal., Gastroenterology. 2010 Apr;138(4):1374-83. Epub 2009 Dec 11.
16. Gruen M, etal., BMC Musculoskelet Disord. 2010 Apr 7;11:63.
17. Guan X, etal., J Neurochem. 2015 Aug;134(3):590-600. doi: 10.1111/jnc.13139. Epub 2015 Jun 4.
18. Haubner BJ, etal., PLoS One. 2010 Feb 22;5(2):e9350.
19. Hohenester S, etal., J Hepatol. 2010 Nov;53(5):918-26. Epub 2010 Jul 17.
20. Huang Y, etal., J Cell Physiol. 2018 Oct;233(10):6693-6704. doi: 10.1002/jcp.26469. Epub 2018 Apr 25.
21. Jantarajit W, etal., Am J Physiol Endocrinol Metab. 2007 Jul;293(1):E372-84. Epub 2007 May 8.
22. Jin R, etal., Stroke. 2011 Jul;42(7):2033-44. Epub 2011 May 5.
23. Kaplan-Albuquerque N, etal., J Biol Chem. 2003 Oct 10;278(41):39830-8. Epub 2003 Jul 25.
24. Kim DI, etal., J Clin Immunol. 2012 Apr;32(2):340-51. Epub 2011 Dec 24.
25. Kobayashi T and Puro DG, Invest Ophthalmol Vis Sci. 2007 May;48(5):2350-5.
26. Lacerda-Queiroz N, etal., PLoS One. 2015 Mar 16;10(3):e0119633. doi: 10.1371/journal.pone.0119633. eCollection 2015.
27. Lionetti V, etal., Crit Care Med. 2006 Jan;34(1):134-41.
28. Lu JM, etal., Exp Eye Res. 2020 Jan;190:107886. doi: 10.1016/j.exer.2019.107886. Epub 2019 Nov 21.
29. Martin D, etal., Cancer Cell. 2011 Jun 14;19(6):805-13. doi: 10.1016/j.ccr.2011.05.005.
30. Martin EL, etal., Am J Respir Crit Care Med. 2010 Sep 15;182(6):762-73. Epub 2010 May 27.
31. Maus UA, etal., Am J Respir Crit Care Med. 2007 May 1;175(9):958-66. doi: 10.1164/rccm.200610-1533OC. Epub 2007 Feb 22.
32. MGD data from the GO Consortium
33. Nguyen T, etal., Am J Pathol. 2007 Apr;170(4):1219-28.
34. Passos GF, etal., Brain Behav Immun. 2010 Mar;24(3):493-501. Epub 2009 Dec 16.
35. Perrino C, etal., J Am Coll Cardiol. 2005 Jun 7;45(11):1862-70.
36. Pigeau GM, etal., Diabetes. 2009 Sep;58(9):2084-92. Epub 2009 Jun 23.
37. Pipeline to import Pathway Interaction Database annotations from NCI into RGD
38. Pipeline to import SMPDB annotations from SMPDB into RGD
39. Randis TM, etal., Eur J Immunol. 2008 May;38(5):1215-24.
40. RGD automated data pipeline
41. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
42. RGD automated import pipeline for gene-chemical interactions
43. RGD comprehensive gene curation
44. Rodrigues DH, etal., J Neuroimmunol. 2010 May;222(1-2):90-4. Epub 2010 Mar 19.
45. Schneider C, etal., J Leukoc Biol. 2017 Feb;101(2):367-376. doi: 10.1189/jlb.4HI0316-157R. Epub 2016 Jul 28.
46. Serajee FJ, etal., J Med Genet. 2003 Nov;40(11):e119.
47. Silva MC, etal., Nat Commun. 2018 Apr 17;9(1):1513. doi: 10.1038/s41467-018-03986-3.
48. Siragusa M, etal., Circ Res. 2010 Mar 5;106(4):757-68. Epub 2010 Jan 7.
49. Song LF, etal., Sichuan Da Xue Xue Bao Yi Xue Ban. 2011 Jul;42(4):471-4.
50. Sun X, etal., J Immunol. 2013 Jan 1;190(1):357-65. doi: 10.4049/jimmunol.1201825. Epub 2012 Nov 23.
51. Thomas M, etal., Immunology. 2009 Mar;126(3):413-22. Epub 2008 Aug 27.
52. Tosaka S, etal., J Anesth. 2007;21(2):176-80. Epub 2007 May 30.
53. van Dop WA, etal., Immunol Lett. 2010 Jun 15;131(1):33-9. doi: 10.1016/j.imlet.2010.03.008. Epub 2010 Mar 27.
54. Wierod L, etal., Cell Prolif. 2007 Aug;40(4):475-87.
55. Xu H, etal., J Immunol. 2010 Feb 1;184(3):1492-8. doi: 10.4049/jimmunol.0902660. Epub 2009 Dec 18.
56. Yu HP, etal., Ann Surg. 2007 Jun;245(6):971-7.
57. Yuan G, etal., Endocrinology. 2007 May;148(5):2016-26. Epub 2007 Feb 1.
58. Yum HK, etal., J Immunol. 2001 Dec 1;167(11):6601-8. doi: 10.4049/jimmunol.167.11.6601.
59. Zhang Y, etal., Planta Med. 2007 Apr;73(4):341-7. Epub 2007 Apr 18.
Additional References at PubMed
PMID:11416136   PMID:12507995   PMID:12538627   PMID:14762792   PMID:15192701   PMID:15385964   PMID:15845362   PMID:16130182   PMID:16343426   PMID:16414349   PMID:16762504   PMID:16989733  
PMID:17016676   PMID:17555093   PMID:17630321   PMID:17885802   PMID:17893321   PMID:17942284   PMID:18071753   PMID:18163378   PMID:18163380   PMID:18269915   PMID:18299886   PMID:18410228  
PMID:18461448   PMID:18512147   PMID:18616564   PMID:18635661   PMID:18663086   PMID:18785877   PMID:18791856   PMID:19015400   PMID:19060913   PMID:19255141   PMID:19279233   PMID:19381068  
PMID:19531027   PMID:19698760   PMID:19709371   PMID:19804812   PMID:19896516   PMID:19946888   PMID:19997978   PMID:20093365   PMID:20333648   PMID:20371878   PMID:20383584   PMID:20404059  
PMID:20562859   PMID:20665543   PMID:20821260   PMID:20870746   PMID:20953735   PMID:20967511   PMID:21042752   PMID:21182226   PMID:21219473   PMID:21498085   PMID:21683721   PMID:21822733  
PMID:21984198   PMID:22166507   PMID:22251375   PMID:22316281   PMID:22447946   PMID:22490886   PMID:22553040   PMID:22702339   PMID:22967108   PMID:23008439   PMID:23142719   PMID:23271286  
PMID:23524565   PMID:23524571   PMID:23548598   PMID:23704876   PMID:23824069   PMID:24312696   PMID:24361011   PMID:24742749   PMID:24950409   PMID:25004887   PMID:25044177   PMID:25048263  
PMID:25073791   PMID:25201632   PMID:25327288   PMID:25644171   PMID:26093674   PMID:26546817   PMID:26616056   PMID:26818151   PMID:27059137   PMID:27539497   PMID:27725163   PMID:27821807  
PMID:28129651   PMID:28464602   PMID:29288664   PMID:29737948  


Genomics

Comparative Map Data
Pik3cg
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2648,766,778 - 48,802,098 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl648,766,864 - 48,802,043 (-)Ensembl
Rnor_6.0651,465,696 - 51,501,234 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl651,465,908 - 51,498,337 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0661,106,730 - 61,142,184 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4650,441,892 - 50,476,931 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1650,447,918 - 50,480,237 (-)NCBI
Celera647,971,127 - 48,004,061 (-)NCBICelera
Cytogenetic Map6q16NCBI
PIK3CG
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387106,865,282 - 106,908,980 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl7106,865,278 - 106,908,980 (+)EnsemblGRCh38hg38GRCh38
GRCh377106,505,727 - 106,549,425 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367106,293,160 - 106,334,828 (+)NCBINCBI36hg18NCBI36
Build 347106,099,874 - 106,141,543NCBI
Celera7101,311,222 - 101,352,879 (+)NCBI
Cytogenetic Map7q22.3NCBI
HuRef7100,864,687 - 100,906,376 (+)NCBIHuRef
CHM1_17106,439,450 - 106,481,120 (+)NCBICHM1_1
T2T-CHM13v2.07108,181,318 - 108,225,014 (+)NCBI
CRA_TCAGchr7v27105,867,019 - 105,908,676 (+)NCBI
Pik3cg
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391232,223,128 - 32,258,675 (-)NCBIGRCm39mm39
GRCm39 Ensembl1232,223,472 - 32,258,658 (-)Ensembl
GRCm381232,173,397 - 32,208,677 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1232,173,473 - 32,208,659 (-)EnsemblGRCm38mm10GRCm38
MGSCv371232,858,262 - 32,893,514 (-)NCBIGRCm37mm9NCBIm37
MGSCv361232,760,883 - 32,793,717 (-)NCBImm8
Celera1233,627,107 - 33,665,676 (-)NCBICelera
Cytogenetic Map12A3NCBI
Pik3cg
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541011,402,520 - 11,437,422 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541011,402,476 - 11,433,335 (+)NCBIChiLan1.0ChiLan1.0
PIK3CG
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.17111,569,947 - 111,611,614 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7111,570,148 - 111,611,614 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0798,841,974 - 98,885,446 (+)NCBIMhudiblu_PPA_v0panPan3
PIK3CG
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11813,576,966 - 13,611,748 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1813,570,999 - 13,611,141 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1813,224,877 - 13,259,686 (-)NCBI
ROS_Cfam_1.01813,848,210 - 13,882,893 (-)NCBI
ROS_Cfam_1.0 Ensembl1813,847,825 - 13,882,854 (-)Ensembl
UMICH_Zoey_3.11813,664,384 - 13,696,319 (-)NCBI
UNSW_CanFamBas_1.01813,582,574 - 13,617,381 (-)NCBI
UU_Cfam_GSD_1.01813,862,587 - 13,897,681 (-)NCBI
Pik3cg
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511855,959,678 - 55,990,585 (-)NCBI
SpeTri2.0NW_00493647917,084,006 - 17,112,264 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PIK3CG
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9106,698,207 - 106,745,099 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19106,698,200 - 106,748,217 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29117,537,774 - 117,572,944 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PIK3CG
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12175,781,812 - 75,823,404 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl2175,784,648 - 75,825,496 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604228,038,017 - 28,081,732 (-)NCBIVero_WHO_p1.0
Pik3cg
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473922,737,270 - 22,772,589 (-)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_00462473922,737,376 - 22,772,696 (-)NCBIHetGla_female_1.0hetGla2


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2301972Bp325Blood pressure QTL 3254.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6172227641Rat
1300164Rf15Renal function QTL 153.12renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6507449754641141Rat
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)610894415110548006Rat
1578665Bss16Bone structure and strength QTL 164.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)61173566972593685Rat
1578668Bmd14Bone mineral density QTL 143.8femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)61173566972593685Rat
10401812Kidm54Kidney mass QTL 54kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)61436878859368788Rat
10401800Kidm49Kidney mass QTL 49kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)61436878859368788Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)615107216107351382Rat
2292589Emca10Estrogen-induced mammary cancer QTL 100.048mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)61653614061536140Rat
1354664Slep2Serum leptin concentration QTL 24.49blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)61653614071636405Rat
1641898Colcr4Colorectal carcinoma resistance QTL43.710.0007intestine integrity trait (VT:0010554)well differentiated malignant colorectal tumor surface area measurement (CMO:0002077)62033877762613667Rat
2293839Kiddil2Kidney dilation QTL 24.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62086642281133036Rat
2293841Kiddil4Kidney dilation QTL 44.4kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62086642281133036Rat
1331779Rf38Renal function QTL 382.876kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)63207442872227641Rat
634318Bw118Body weight QTL 1183.55abdominal fat pad mass (VT:1000711)abdominal fat pad weight (CMO:0000088)63330954957730294Rat
6893340Cm77Cardiac mass QTL 770.260.57heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)63330954981132889Rat
1300143Rf14Renal function QTL 142.92renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)63443413777102317Rat
1354632Scl29Serum cholesterol level QTL 293.74blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)63509870971636405Rat
634307Bp141Blood pressure QTL 1414arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)63523041780230417Rat
70199Coreg1Compensatory renal growth QTL 111.8kidney mass (VT:0002707)compensatory renal growth score (CMO:0001894)63569161857730540Rat
9590290Uminl2Urine mineral level QTL 23.960.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)63878398983783989Rat
9590306Scort18Serum corticosterone level QTL 182.880.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)63878398983783989Rat
9590140Scort4Serum corticosterone level QTL 414.490.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)63878398983783989Rat
634330Pia16Pristane induced arthritis QTL 163.9joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)645790088104200226Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:70
Count of miRNA genes:35
Interacting mature miRNAs:35
Transcripts:ENSRNOT00000012487, ENSRNOT00000045589
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 8 19 2 7
Low 1 43 48 40 40 8 9 74 35 37 4 8
Below cutoff 1 1 1 2 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000012487   ⟹   ENSRNOP00000012487
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl648,766,864 - 48,802,043 (-)Ensembl
Rnor_6.0 Ensembl651,465,908 - 51,498,337 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000103315   ⟹   ENSRNOP00000093926
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl648,770,218 - 48,802,043 (-)Ensembl
RefSeq Acc Id: NM_001371300   ⟹   NP_001358229
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2648,766,864 - 48,802,043 (-)NCBI
RefSeq Acc Id: XM_003750140   ⟹   XP_003750188
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2648,766,778 - 48,801,948 (-)NCBI
Rnor_6.0651,465,696 - 51,501,233 (-)NCBI
Rnor_5.0661,106,730 - 61,142,184 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006240003   ⟹   XP_006240065
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2648,766,778 - 48,802,098 (-)NCBI
Rnor_6.0651,465,696 - 51,501,233 (-)NCBI
Rnor_5.0661,106,730 - 61,142,184 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006240004   ⟹   XP_006240066
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2648,766,778 - 48,801,948 (-)NCBI
Rnor_6.0651,465,696 - 51,501,233 (-)NCBI
Rnor_5.0661,106,730 - 61,142,184 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_003750188   ⟸   XM_003750140
- Peptide Label: isoform X1
- UniProtKB: D3ZFJ0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006240065   ⟸   XM_006240003
- Peptide Label: isoform X1
- UniProtKB: D3ZFJ0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006240066   ⟸   XM_006240004
- Peptide Label: isoform X1
- UniProtKB: D3ZFJ0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000012487   ⟸   ENSRNOT00000012487
RefSeq Acc Id: NP_001358229   ⟸   NM_001371300
RefSeq Acc Id: ENSRNOP00000093926   ⟸   ENSRNOT00000103315
Protein Domains
C2 PI3K-type   PI3K-ABD   PI3K-RBD   PI3K/PI4K   PIK helical

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZFJ0-F1-model_v2 AlphaFold D3ZFJ0 1-1102 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (MRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306468 AgrOrtholog
BioCyc Gene G2FUF-37898 BioCyc
BioCyc Pathway PWY-6352 [3-phosphoinositide biosynthesis] BioCyc
Ensembl Genes ENSRNOG00000009385 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000012487 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000012487 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 1.10.1070.11 UniProtKB/TrEMBL
  1.25.40.70 UniProtKB/TrEMBL
  2.60.40.150 UniProtKB/TrEMBL
InterPro ARM-type_fold UniProtKB/TrEMBL
  C2_domain_sf UniProtKB/TrEMBL
  Kinase-like_dom UniProtKB/TrEMBL
  PI3/4_kinase_cat_dom UniProtKB/TrEMBL
  PI3/4_kinase_cat_sf UniProtKB/TrEMBL
  PI3/4_kinase_CS UniProtKB/TrEMBL
  PI3K_accessory_sf UniProtKB/TrEMBL
  PI3K_adapt-bd_dom UniProtKB/TrEMBL
  PI3K_C2 UniProtKB/TrEMBL
  PI3K_ras-bd UniProtKB/TrEMBL
  PI_Kinase UniProtKB/TrEMBL
  PIK3CG_ABD UniProtKB/TrEMBL
  PInositide-3_kin_accessory_dom UniProtKB/TrEMBL
  Ubiquitin-rel_dom UniProtKB/TrEMBL
NCBI Gene 298947 ENTREZGENE
PANTHER PI_Kinase UniProtKB/TrEMBL
Pfam PI3_PI4_kinase UniProtKB/TrEMBL
  PI3K_C2 UniProtKB/TrEMBL
  PI3K_rbd UniProtKB/TrEMBL
  PI3Ka UniProtKB/TrEMBL
  PIK3CG_ABD UniProtKB/TrEMBL
PhenoGen Pik3cg PhenoGen
PROSITE PI3_4_KINASE_1 UniProtKB/TrEMBL
  PI3_4_KINASE_2 UniProtKB/TrEMBL
  PI3_4_KINASE_3 UniProtKB/TrEMBL
  PI3K_ABD UniProtKB/TrEMBL
  PI3K_C2 UniProtKB/TrEMBL
  PI3K_RBD UniProtKB/TrEMBL
  PIK_HELICAL UniProtKB/TrEMBL
SMART PI3K_C2 UniProtKB/TrEMBL
  PI3K_rbd UniProtKB/TrEMBL
  PI3Ka UniProtKB/TrEMBL
  PI3Kc UniProtKB/TrEMBL
Superfamily-SCOP ARM-type_fold UniProtKB/TrEMBL
  Kinase_like UniProtKB/TrEMBL
  SSF49562 UniProtKB/TrEMBL
  SSF54236 UniProtKB/TrEMBL
UniProt D3ZFJ0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-10-10 Pik3cg  phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma  Pik3cg  phosphoinositide-3-kinase, catalytic, gamma polypeptide  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Pik3cg  phosphoinositide-3-kinase, catalytic, gamma polypeptide   Pik3cg_predicted  phosphoinositide-3-kinase, catalytic, gamma polypeptide (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Pik3cg_predicted  phosphoinositide-3-kinase, catalytic, gamma polypeptide (predicted)      Symbol and Name status set to approved 70820 APPROVED