Lmnb2 (lamin B2) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Lmnb2 (lamin B2) Rattus norvegicus
Analyze
Symbol: Lmnb2
Name: lamin B2
RGD ID: 1563803
Description: Predicted to enable identical protein binding activity. Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in several processes, including heterochromatin formation; nucleus organization; and protein localization to nuclear envelope. Predicted to be located in lamin filament and nuclear membrane. Predicted to be active in nuclear envelope and nuclear lamina. Human ortholog(s) of this gene implicated in partial lipodystrophy; primary autosomal recessive microcephaly; and progressive myoclonus epilepsy 9. Orthologous to human LMNB2 (lamin B2); INTERACTS WITH 6-propyl-2-thiouracil; acetamide; acrylamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: lamin-B2; LOC299625; RGD1563803; similar to Lmnb2 protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.278,792,628 - 8,808,665 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl78,789,314 - 8,808,665 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx711,676,600 - 11,692,579 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0713,552,108 - 13,568,087 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0711,418,629 - 11,434,610 (+)NCBIRnor_WKY
Rnor_6.0711,657,870 - 11,676,936 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl711,660,934 - 11,675,472 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0711,828,299 - 11,844,456 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4710,303,626 - 10,326,068 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera76,976,982 - 6,993,012 (+)NCBICelera
Cytogenetic Map7q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,6-tribromophenol  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4-nitrophenol  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (EXP)
AM-251  (ISO)
aminoglutethimide  (ISO)
amphetamine  (EXP)
arsenite(3-)  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
beta-carotene  (ISO)
bisphenol A  (EXP,ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
carbon nanotube  (ISO)
cerium trichloride  (ISO)
ciguatoxin CTX1B  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
coumestrol  (ISO)
CU-O LINKAGE  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
dioxygen  (ISO)
Enterolactone  (ISO)
fenthion  (ISO)
flavone  (ISO)
genistein  (ISO)
indometacin  (ISO)
ivermectin  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
methidathion  (ISO)
methylmercury chloride  (ISO)
methylseleninic acid  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nickel atom  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraoxon  (ISO)
poly(vinylpyrrolidone)  (EXP)
raloxifene  (ISO)
resveratrol  (ISO)
silver atom  (EXP)
silver(0)  (EXP)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP)
sunitinib  (ISO)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloroethene  (ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
trichloroethene  (EXP)
trimellitic anhydride  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8032679   PMID:16364897   PMID:20457914   PMID:21842415   PMID:22349700   PMID:25002582  


Genomics

Comparative Map Data
Lmnb2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.278,792,628 - 8,808,665 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl78,789,314 - 8,808,665 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx711,676,600 - 11,692,579 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0713,552,108 - 13,568,087 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0711,418,629 - 11,434,610 (+)NCBIRnor_WKY
Rnor_6.0711,657,870 - 11,676,936 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl711,660,934 - 11,675,472 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0711,828,299 - 11,844,456 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4710,303,626 - 10,326,068 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera76,976,982 - 6,993,012 (+)NCBICelera
Cytogenetic Map7q11NCBI
LMNB2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38192,428,166 - 2,456,959 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl192,427,638 - 2,456,959 (-)EnsemblGRCh38hg38GRCh38
GRCh37192,428,164 - 2,456,957 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36192,379,164 - 2,407,958 (-)NCBINCBI36Build 36hg18NCBI36
Build 34192,379,164 - 2,407,958NCBI
Celera192,365,655 - 2,394,449 (-)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef192,200,214 - 2,228,845 (-)NCBIHuRef
CHM1_1192,427,662 - 2,456,465 (-)NCBICHM1_1
T2T-CHM13v2.0192,403,957 - 2,432,750 (-)NCBIT2T-CHM13v2.0
Lmnb2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391080,737,197 - 80,754,079 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1080,737,037 - 80,754,079 (-)EnsemblGRCm39 Ensembl
GRCm381080,901,363 - 80,918,245 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1080,901,203 - 80,918,245 (-)EnsemblGRCm38mm10GRCm38
MGSCv371080,364,108 - 80,380,990 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361080,304,492 - 80,321,334 (-)NCBIMGSCv36mm8
Celera1081,920,184 - 81,937,066 (-)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
Lmnb2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554954,828,638 - 4,851,928 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554954,826,653 - 4,851,984 (-)NCBIChiLan1.0ChiLan1.0
LMNB2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1192,406,296 - 2,430,568 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl192,406,296 - 2,430,568 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0191,440,462 - 1,469,601 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
LMNB2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12056,652,183 - 56,663,476 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2056,652,750 - 56,670,278 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2056,441,797 - 56,459,358 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02057,379,149 - 57,396,719 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2057,376,730 - 57,399,644 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12056,431,395 - 56,448,956 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02056,916,504 - 56,934,153 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02057,116,796 - 57,134,399 (+)NCBIUU_Cfam_GSD_1.0
Lmnb2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118216,369,489 - 216,386,878 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365881,448,277 - 1,465,376 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049365881,448,195 - 1,465,332 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LMNB2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl276,125,927 - 76,146,558 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1276,125,932 - 76,146,564 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2276,677,404 - 76,698,027 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LMNB2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.162,207,096 - 2,234,258 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl62,209,989 - 2,234,215 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660816,428,694 - 6,452,779 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lmnb2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248285,633,191 - 5,648,240 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248285,630,328 - 5,648,231 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Lmnb2
25 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:751
Count of miRNA genes:256
Interacting mature miRNAs:324
Transcripts:ENSRNOT00000022336, ENSRNOT00000075183
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7127829089Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7131962314Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7131962314Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134000259Rat
2317047Wbc4White blood cell count QTL 40.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)7135342956Rat
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7144782185Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7144822433Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)766427026029351Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
10755438Coatc9Coat color QTL 90coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7352928048529280Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7532901950329019Rat
10755440Coatc10Coat color QTL 100coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7749649952496499Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7757398552573985Rat

Markers in Region
RH140520  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.278,808,435 - 8,808,575 (+)MAPPERmRatBN7.2
Rnor_6.0711,676,707 - 11,676,846NCBIRnor6.0
Rnor_5.0711,844,227 - 11,844,366UniSTSRnor5.0
RGSC_v3.4710,319,326 - 10,319,465UniSTSRGSC3.4
Celera76,992,783 - 6,992,922UniSTS
Cytogenetic Map7q11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 26 25 18 15 18 1 1 60 20 37 1
Low 17 32 23 4 23 7 10 14 15 4 11 7
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000022336   ⟹   ENSRNOP00000022336
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl78,792,628 - 8,808,665 (+)Ensembl
Rnor_6.0 Ensembl711,660,934 - 11,675,472 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000094689   ⟹   ENSRNOP00000079276
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl78,792,628 - 8,808,665 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000109213   ⟹   ENSRNOP00000086789
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl78,789,314 - 8,808,665 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000114820   ⟹   ENSRNOP00000080459
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl78,802,878 - 8,808,665 (+)Ensembl
RefSeq Acc Id: NM_001305235   ⟹   NP_001292164
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.278,792,628 - 8,808,665 (+)NCBI
Rnor_6.0711,660,902 - 11,676,936 (+)NCBI
Celera76,976,982 - 6,993,012 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006241035   ⟹   XP_006241097
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.278,802,413 - 8,808,665 (+)NCBI
Rnor_6.0711,670,624 - 11,675,342 (+)NCBI
Rnor_5.0711,828,299 - 11,844,456 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001292164 (Get FASTA)   NCBI Sequence Viewer  
  XP_006241097 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL89210 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_006241097   ⟸   XM_006241035
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZPN1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001292164   ⟸   NM_001305235
- UniProtKB: D3ZLC1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000022336   ⟸   ENSRNOT00000022336
RefSeq Acc Id: ENSRNOP00000080459   ⟸   ENSRNOT00000114820
RefSeq Acc Id: ENSRNOP00000079276   ⟸   ENSRNOT00000094689
RefSeq Acc Id: ENSRNOP00000086789   ⟸   ENSRNOT00000109213
Protein Domains
IF rod   LTD

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZLC1-F1-model_v2 AlphaFold D3ZLC1 1-616 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695008
Promoter ID:EPDNEW_R5521
Type:single initiation site
Name:Lmnb2_1
Description:lamin B2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0711,660,929 - 11,660,989EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1563803 AgrOrtholog
BioCyc Gene G2FUF-34979 BioCyc
Ensembl Genes ENSRNOG00000025742 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000022336 ENTREZGENE
  ENSRNOP00000022336.6 UniProtKB/TrEMBL
  ENSRNOP00000079276.1 UniProtKB/TrEMBL
  ENSRNOP00000080459 ENTREZGENE
  ENSRNOP00000080459.1 UniProtKB/TrEMBL
  ENSRNOP00000086789.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000022336 ENTREZGENE
  ENSRNOT00000022336.9 UniProtKB/TrEMBL
  ENSRNOT00000094689.1 UniProtKB/TrEMBL
  ENSRNOT00000109213.1 UniProtKB/TrEMBL
  ENSRNOT00000114820 ENTREZGENE
  ENSRNOT00000114820.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.1260 UniProtKB/TrEMBL
InterPro IF_rod_dom UniProtKB/TrEMBL
  Lamin_tail_dom UniProtKB/TrEMBL
  Lamin_tail_dom_sf UniProtKB/TrEMBL
KEGG Report rno:299625 UniProtKB/TrEMBL
NCBI Gene 299625 ENTREZGENE
Pfam Filament UniProtKB/TrEMBL
  LTD UniProtKB/TrEMBL
PhenoGen Lmnb2 PhenoGen
PROSITE IF_ROD_2 UniProtKB/TrEMBL
  LTD UniProtKB/TrEMBL
SMART Filament UniProtKB/TrEMBL
Superfamily-SCOP SSF74853 UniProtKB/TrEMBL
UniProt A0A8I5ZMS1_RAT UniProtKB/TrEMBL
  A0A8I5ZPN1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A308_RAT UniProtKB/TrEMBL
  D3ZLC1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-06 Lmnb2  lamin B2  RGD1563803_predicted  similar to Lmnb2 protein (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1563803_predicted  similar to Lmnb2 protein (predicted)  LOC299625  similar to Lmnb2 protein  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC299625  similar to Lmnb2 protein      Symbol and Name status set to provisional 70820 PROVISIONAL