Kcnj5 (potassium inwardly-rectifying channel, subfamily J, member 5) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Kcnj5 (potassium inwardly-rectifying channel, subfamily J, member 5) Rattus norvegicus
Analyze
Symbol: Kcnj5
Name: potassium inwardly-rectifying channel, subfamily J, member 5
RGD ID: 61971
Description: Contributes to inward rectifier potassium channel activity. Predicted to be involved in cardiac conduction; potassium ion import across plasma membrane; and regulation of monoatomic ion transmembrane transport. Located in T-tubule and external side of plasma membrane. Human ortholog(s) of this gene implicated in atrial fibrillation; long QT syndrome 13; and primary hyperaldosteronism. Orthologous to human KCNJ5 (potassium inwardly rectifying channel subfamily J member 5); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,6-dinitrotoluene; alpha-hexachlorocyclohexane.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: cardiac inward rectifier; CIR; G protein-activated inward rectifier potassium channel 4; GIRK-4; GIRK4; heart KATP channel; inward rectifier K(+) channel Kir3.4; KATP-1; MGC93525; potassium channel, inwardly rectifying subfamily J member 5; potassium channel, inwardly rectifying subfamily J, member 5; potassium voltage-gated channel subfamily J member 5
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8838,981,598 - 39,011,197 (-)NCBIGRCr8
mRatBN7.2830,724,923 - 30,753,083 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl830,724,925 - 30,753,518 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx834,797,358 - 34,825,231 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0833,091,766 - 33,119,639 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0830,954,588 - 30,982,520 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0833,435,493 - 33,463,410 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl833,433,905 - 33,463,467 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0833,488,649 - 33,510,083 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4832,082,866 - 32,104,412 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1831,320,012 - 32,113,178 (-)NCBI
Celera832,183,024 - 32,204,559 (-)NCBICelera
Cytogenetic Map8q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-duloxetine hydrochloride  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,6-dinitrotoluene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
acetylcholine  (ISO)
aflatoxin B1  (ISO)
aldosterone  (ISO)
all-trans-retinoic acid  (ISO)
alpha-hexachlorocyclohexane  (EXP)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
amoxapine  (ISO)
amphetamine  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
avobenzone  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
Calcimycin  (ISO)
cantharidin  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
corticosterone  (EXP)
Cuprizon  (EXP)
dexamethasone  (ISO)
dibutyl phthalate  (ISO)
dichlorine  (EXP)
diethylstilbestrol  (ISO)
doxorubicin  (ISO)
epoxiconazole  (ISO)
ethosuximide  (EXP)
fenvalerate  (EXP)
fluoxetine  (ISO)
formaldehyde  (ISO)
genistein  (ISO)
lead diacetate  (ISO)
methamphetamine  (EXP)
mianserin  (ISO)
mirtazapine  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
nefazodone  (ISO)
ozone  (EXP,ISO)
paracetamol  (ISO)
paraquat  (EXP)
paroxetine  (ISO)
permethrin  (EXP)
phenformin  (EXP)
potassium atom  (EXP,ISO)
resveratrol  (ISO)
rotenone  (EXP)
sertraline  (ISO)
Soman  (EXP)
sunitinib  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
triclosan  (ISO)
valproic acid  (ISO)
venlafaxine hydrochloride  (ISO)
vitamin E  (ISO)
zearalenone  (ISO)
zinc atom  (EXP)
zinc sulfate  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway   (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
atenolol pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bisoprolol pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway  (ISO)
carvedilol pharmacodynamics pathway  (ISO)
diltiazem pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
ibutilide pharmacodynamics pathway  (ISO)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
sotalol pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway  (ISO)
verapamil pharmacodynamics pathway  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Cardiac strong inward rectifier potassium channels. Anumonwo JM and Lopatin AN, J Mol Cell Cardiol. 2010 Jan;48(1):45-54. doi: 10.1016/j.yjmcc.2009.08.013. Epub 2009 Aug 22.
2. Alterations in potassium channel gene expression in atria of patients with persistent and paroxysmal atrial fibrillation: differential regulation of protein and mRNA levels for K+ channels. Brundel BJ, etal., J Am Coll Cardiol. 2001 Mar 1;37(3):926-32.
3. Distribution of the muscarinic K+ channel proteins Kir3.1 and Kir3.4 in the ventricle, atrium, and sinoatrial node of heart. Dobrzynski H, etal., J Histochem Cytochem. 2001 Oct;49(10):1221-34.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Direct activation of inward rectifier potassium channels by PIP2 and its stabilization by Gbetagamma. Huang CL, etal., Nature. 1998 Feb 19;391(6669):803-6. doi: 10.1038/35882.
7. Functional characterization and localization of a cardiac-type inwardly rectifying K+ channel. Iizuka M, etal., Receptors Channels. 1995;3(4):299-315.
8. The G-protein-gated atrial K+ channel IKACh is a heteromultimer of two inwardly rectifying K(+)-channel proteins. Krapivinsky G, etal., Nature 1995 Mar 9;374(6518):135-41.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
12. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
13. GOA pipeline RGD automated data pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:7592809   PMID:12297500   PMID:12477932   PMID:15489334   PMID:15716420   PMID:17296805   PMID:19940474   PMID:20064856   PMID:20560207   PMID:21653876   PMID:22465809   PMID:24148898  
PMID:25696012   PMID:26487066  


Genomics

Comparative Map Data
Kcnj5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8838,981,598 - 39,011,197 (-)NCBIGRCr8
mRatBN7.2830,724,923 - 30,753,083 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl830,724,925 - 30,753,518 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx834,797,358 - 34,825,231 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0833,091,766 - 33,119,639 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0830,954,588 - 30,982,520 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0833,435,493 - 33,463,410 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl833,433,905 - 33,463,467 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0833,488,649 - 33,510,083 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4832,082,866 - 32,104,412 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1831,320,012 - 32,113,178 (-)NCBI
Celera832,183,024 - 32,204,559 (-)NCBICelera
Cytogenetic Map8q21NCBI
KCNJ5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811128,891,356 - 128,921,163 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11128,891,356 - 128,921,163 (+)EnsemblGRCh38hg38GRCh38
GRCh3711128,761,251 - 128,791,058 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611128,266,523 - 128,293,174 (+)NCBINCBI36Build 36hg18NCBI36
Build 3411128,266,522 - 128,293,174NCBI
Celera11125,929,625 - 125,956,261 (+)NCBICelera
Cytogenetic Map11q24.3NCBI
HuRef11124,711,137 - 124,737,786 (+)NCBIHuRef
CHM1_111128,647,771 - 128,674,425 (+)NCBICHM1_1
T2T-CHM13v2.011128,926,287 - 128,956,088 (+)NCBIT2T-CHM13v2.0
Kcnj5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39932,226,002 - 32,255,640 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl932,226,003 - 32,255,646 (-)EnsemblGRCm39 Ensembl
GRCm38932,314,706 - 32,344,380 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl932,314,707 - 32,344,350 (-)EnsemblGRCm38mm10GRCm38
MGSCv37932,122,368 - 32,151,822 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36932,064,348 - 32,093,802 (-)NCBIMGSCv36mm8
Celera929,575,909 - 29,607,555 (-)NCBICelera
Cytogenetic Map9A4NCBI
cM Map917.65NCBI
Kcnj5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541229,850,097 - 29,874,213 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541229,850,097 - 29,874,213 (+)NCBIChiLan1.0ChiLan1.0
KCNJ5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29129,573,968 - 129,607,177 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111130,681,522 - 130,714,740 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011123,705,361 - 123,735,370 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111127,602,663 - 127,637,326 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11127,606,208 - 127,634,213 (+)Ensemblpanpan1.1panPan2
KCNJ5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.155,736,544 - 5,760,705 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl55,740,176 - 5,760,866 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha55,799,513 - 5,820,774 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.055,699,117 - 5,704,382 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.155,758,951 - 5,780,195 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.055,736,878 - 5,758,109 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.055,770,917 - 5,792,183 (-)NCBIUU_Cfam_GSD_1.0
Kcnj5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947111,076,299 - 111,103,302 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365723,344,937 - 3,373,747 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365723,344,942 - 3,373,690 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCNJ5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl955,836,701 - 55,864,941 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1955,836,777 - 55,861,288 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2961,927,955 - 61,952,450 (+)NCBISscrofa10.2Sscrofa10.2susScr3
KCNJ5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11120,025,238 - 120,098,006 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1120,025,300 - 120,057,023 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660436,035,256 - 6,065,531 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kcnj5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248123,213,774 - 3,244,012 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248123,213,619 - 3,243,514 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Kcnj5
254 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:24
Count of miRNA genes:24
Interacting mature miRNAs:24
Transcripts:ENSRNOT00000041038
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357398Slep3Serum leptin concentration QTL 33.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)8971246341866876Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)83018886794457446Rat
2317030Wbc5White blood cell count QTL 53.210.005leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)8873663553736635Rat
1331804Cm30Cardiac mass QTL 303.77443heart mass (VT:0007028)heart wet weight (CMO:0000069)82824291253961020Rat
2317032Ginf2Gastrointestinal inflammation QTL 23.210.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)8470581049705810Rat
2301416Bp315Blood pressure QTL 3150.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)8767057852670578Rat
2317036Livw3Liver weight QTL 32.430.01liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)8470581049705810Rat
12880023Bw184Body weight QTL 1840.001body mass (VT:0001259)body weight (CMO:0000012)8209764047097640Rat
1354627Despr14Despair related QTL 140.0056locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)8768895552688955Rat
12880028Cm103Cardiac mass QTL 1030.02heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)8209764047097640Rat
2317051Aia18Adjuvant induced arthritis QTL 182.42joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)8873663553736635Rat
2317048Ginf1Gastrointestinal inflammation QTL 13.520.005cecum mucosa thickness (VT:0010234)enterocolitis severity score (CMO:0002138)8470581049705810Rat
12880025Cm102Cardiac mass QTL 1020.044heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)8209764047097640Rat
1558646Swd5Spike wave discharge measurement QTL 53.450.00036brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)81490675159906751Rat
1300146Rf17Renal function QTL 172.9renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)82824291273242912Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)82824291299525068Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)82720571599103503Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)81933115293965294Rat
2302278Gluco36Glucose level QTL 364.2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)82950266550095447Rat
12880044Am9Aortic mass QTL 90.007aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)8209764047097640Rat
631648Stl5Serum triglyceride level QTL 540.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)82720571554998217Rat
724514Uae15Urinary albumin excretion QTL 152.9urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)82950266570386295Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
631842Inf1Infertility severity QTL 14.10.001seminal gland mass (VT:0010524)seminal vesicle wet weight (CMO:0001603)82266233067662330Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
631271Lecl1Lens clarity QTL 10.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)81898416884531599Rat
2303564Gluco43Glucose level QTL 433blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)82613018771130187Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)82720571599103503Rat
1598824Memor4Memory QTL 42.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)8971222053356647Rat
1354595Despr4Despair related QTL 42.160.0036locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)8768895552688955Rat
2303572Insul13Insulin level QTL 132blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)82613018771130187Rat
724540Uae8Urinary albumin excretion QTL 85urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)82815732330848259Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)82720571599103503Rat
1359021Bp271Blood pressure QTL 2711.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)82664491246711092Rat
2302367Slep5Serum leptin concentration QTL 53.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)8971246341866876Rat
61373Mcs4Mammary carcinoma susceptibility QTL 41.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)81629044461290444Rat

Markers in Region
RH133266  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2830,725,022 - 30,725,228 (+)MAPPERmRatBN7.2
Rnor_6.0833,435,593 - 33,435,798NCBIRnor6.0
RH 3.4 Map8251.8UniSTS
Cytogenetic Map8q21UniSTS
AW530580  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2830,725,610 - 30,725,806 (+)MAPPERmRatBN7.2
Rnor_6.0833,436,181 - 33,436,376NCBIRnor6.0
RH 3.4 Map8251.8UniSTS
Cytogenetic Map8q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 10 49 113 91 90 59 25 59 6 217 96 93 45 53 31

Sequence


Ensembl Acc Id: ENSRNOT00000041038   ⟹   ENSRNOP00000048134
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl830,724,925 - 30,752,992 (-)Ensembl
Rnor_6.0 Ensembl833,433,905 - 33,463,467 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000110676   ⟹   ENSRNOP00000079101
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl830,724,925 - 30,753,518 (-)Ensembl
RefSeq Acc Id: NM_017297   ⟹   NP_058993
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8838,983,032 - 39,011,096 (-)NCBI
mRatBN7.2830,724,923 - 30,752,987 (-)NCBI
Rnor_6.0833,435,493 - 33,463,410 (-)NCBI
Rnor_5.0833,488,649 - 33,510,083 (-)NCBI
RGSC_v3.4832,082,866 - 32,104,412 (-)RGD
Celera832,183,024 - 32,204,559 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039080975   ⟹   XP_038936903
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8838,981,598 - 39,011,197 (-)NCBI
mRatBN7.2830,724,923 - 30,753,083 (-)NCBI
RefSeq Acc Id: XM_039080976   ⟹   XP_038936904
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8838,981,598 - 39,011,197 (-)NCBI
mRatBN7.2830,724,923 - 30,753,083 (-)NCBI
RefSeq Acc Id: XM_039080977   ⟹   XP_038936905
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8838,981,598 - 39,011,197 (-)NCBI
mRatBN7.2830,724,923 - 30,753,083 (-)NCBI
RefSeq Acc Id: XM_063265035   ⟹   XP_063121105
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8838,981,598 - 38,999,105 (-)NCBI
RefSeq Acc Id: XM_063265036   ⟹   XP_063121106
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8838,981,598 - 38,999,998 (-)NCBI
RefSeq Acc Id: NP_058993   ⟸   NM_017297
- UniProtKB: P48548 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000048134   ⟸   ENSRNOT00000041038
RefSeq Acc Id: XP_038936903   ⟸   XM_039080975
- Peptide Label: isoform X2
- UniProtKB: A0A8I6G4T8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038936904   ⟸   XM_039080976
- Peptide Label: isoform X3
- UniProtKB: P48548 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038936905   ⟸   XM_039080977
- Peptide Label: isoform X3
- UniProtKB: P48548 (UniProtKB/Swiss-Prot)
Ensembl Acc Id: ENSRNOP00000079101   ⟸   ENSRNOT00000110676
RefSeq Acc Id: XP_063121106   ⟸   XM_063265036
- Peptide Label: isoform X3
- UniProtKB: P48548 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063121105   ⟸   XM_063265035
- Peptide Label: isoform X1
Protein Domains
Inward rectifier potassium channel C-terminal   Potassium channel inwardly rectifying transmembrane

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P48548-F1-model_v2 AlphaFold P48548 1-419 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61971 AgrOrtholog
BioCyc Gene G2FUF-31237 BioCyc
Ensembl Genes ENSRNOG00000033796 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000041038 ENTREZGENE
  ENSRNOT00000041038.6 UniProtKB/Swiss-Prot
  ENSRNOT00000110676 ENTREZGENE
  ENSRNOT00000159264 ENTREZGENE
Gene3D-CATH 1.10.287.70 UniProtKB/Swiss-Prot
  2.60.40.1400 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7192366 IMAGE-MGC_LOAD
InterPro Ig_E-set UniProtKB/Swiss-Prot
  IRK_C UniProtKB/Swiss-Prot
  K_chnl_inward-rec_Kir UniProtKB/Swiss-Prot
  K_chnl_inward-rec_Kir3.4 UniProtKB/Swiss-Prot
  K_chnl_inward-rec_Kir_cyto UniProtKB/Swiss-Prot
  Kir_TM UniProtKB/Swiss-Prot
KEGG Report rno:29713 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93525 IMAGE-MGC_LOAD
NCBI Gene 29713 ENTREZGENE
PANTHER G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 4 UniProtKB/Swiss-Prot
  PTHR11767 UniProtKB/Swiss-Prot
Pfam IRK UniProtKB/Swiss-Prot
  IRK_C UniProtKB/Swiss-Prot
PharmGKB KCNJ5 RGD
PhenoGen Kcnj5 PhenoGen
PIRSF GIRK_kir UniProtKB/Swiss-Prot
PRINTS KIR34CHANNEL UniProtKB/Swiss-Prot
  KIRCHANNEL UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000033796 RatGTEx
Superfamily-SCOP SSF81296 UniProtKB/Swiss-Prot
  Voltage-gated potassium channels UniProtKB/Swiss-Prot
UniProt A0A8I6G4T8 ENTREZGENE, UniProtKB/TrEMBL
  A6JYH6_RAT UniProtKB/TrEMBL
  KCNJ5_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-07-19 Kcnj5  potassium inwardly-rectifying channel, subfamily J, member 5  Kcnj5  potassium voltage-gated channel subfamily J member 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-02-11 Kcnj5  potassium voltage-gated channel subfamily J member 5  Kcnj5  potassium channel, inwardly rectifying subfamily J, member 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-01-26 Kcnj5  potassium channel, inwardly rectifying subfamily J, member 5  Kcnj5  potassium inwardly-rectifying channel, subfamily J, member 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Kcnj5  potassium inwardly-rectifying channel, subfamily J, member 5      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_physical_interaction forms a heteromultimer with GIRK1 to create the G-protein-gated atrial K+ channel, IKACh 61646
gene_regulation channel currents were increased by G beta gamma 729061