Gpr18 (G protein-coupled receptor 18)

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Gene: Gpr18 (G protein-coupled receptor 18) Rattus norvegicus

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Symbol:

Gpr18

Name:

G protein-coupled receptor 18

RGD ID:

1304889

Description:

Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to act upstream of or within T cell differentiation; negative regulation of leukocyte chemotaxis; and negative regulation of tumor necrosis factor production. Predicted to be located in cytoplasmic vesicle membrane. Predicted to be active in plasma membrane. Orthologous to human GPR18 (G protein-coupled receptor 18); INTERACTS WITH 1,2-dimethylhydrazine; acetamide; alpha-Zearalanol.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

G protein-coupled receptor 18 (predicted); G-protein coupled receptor 18; Gpr18_predicted; LOC306191; LOC679957; MGC156838; N-arachidonyl glycine receptor; NAGly receptor; similar to G protein-coupled receptor 18

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	GPR18 (G protein-coupled receptor 18)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Gpr18 (G protein-coupled receptor 18)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Gpr18 (G protein-coupled receptor 18)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	GPR18 (G protein-coupled receptor 18)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	GPR18 (G protein-coupled receptor 18)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Gpr18 (G protein-coupled receptor 18)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	GPR18 (G protein-coupled receptor 18)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	GPR18 (G protein-coupled receptor 18)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Gpr18 (G protein-coupled receptor 18)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	GPR20 (G protein-coupled receptor 20)	HGNC	PhylomeDB
Alliance orthologs ³
Mus musculus (house mouse):	Gpr18 (G protein-coupled receptor 18)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	GPR18 (G protein-coupled receptor 18)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	gpr18 (G protein-coupled receptor 18)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	gpr18	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	15	105,404,062 - 105,407,812 (-)	NCBI		GRCr8
mRatBN7.2	15	98,997,427 - 99,001,177 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	15	98,997,259 - 99,001,470 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	15	102,931,135 - 102,934,869 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	15	104,023,208 - 104,026,937 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	15	100,951,028 - 100,954,757 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	15	108,323,157 - 108,326,907 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	15	108,323,179 - 108,326,907 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	15	111,710,713 - 111,714,463 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	15	107,014,823 - 107,018,573 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	15	97,769,869 - 97,773,606 (-)	NCBI		Celera
Cytogenetic Map	15	q25	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Anal Atresia, Hypospadias, and Penoscrotal Inversion (ISO)

holoprosencephaly (ISO)

holoprosencephaly 5 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (EXP,ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2-hydroxypropanoic acid (ISO)

4,4'-diaminodiphenylmethane (ISO)

acetamide (EXP)

all-trans-retinoic acid (ISO)

alpha-Zearalanol (EXP)

antirheumatic drug (ISO)

arsenous acid (ISO)

beauvericin (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP)

buta-1,3-diene (ISO)

CGP 52608 (ISO)

chloroprene (ISO)

chlorpyrifos (ISO)

Cuprizon (EXP)

cyclophosphamide (ISO)

diarsenic trioxide (ISO)

Dibutyl phosphate (ISO)

dimethylarsinic acid (ISO)

enniatin (ISO)

ethyl methanesulfonate (ISO)

formaldehyde (ISO)

gamma-hexachlorocyclohexane (ISO)

glycidol (EXP)

lipopolysaccharide (ISO)

manganese atom (EXP)

manganese(0) (EXP)

manganese(II) chloride (EXP)

methyl methanesulfonate (ISO)

methylarsonic acid (ISO)

Muraglitazar (EXP)

nickel atom (ISO)

ochratoxin A (ISO)

ozone (ISO)

Phenelzine (ISO)

pirinixic acid (ISO)

rac-lactic acid (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

sirolimus (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

Tesaglitazar (EXP)

trichloroethene (EXP)

triphenyl phosphate (ISO)

troglitazone (EXP)

valproic acid (EXP,ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

CD8-positive, alpha-beta intraepithelial T cell differentiation (ISO)

CD8-positive, gamma-delta intraepithelial T cell differentiation (ISO)

negative regulation of leukocyte chemotaxis (ISO)

negative regulation of tumor necrosis factor production (ISO)

phospholipase C-activating G protein-coupled receptor signaling pathway (IBA)

positive regulation of Rho protein signal transduction (IBA)

Cellular Component

cytoplasmic vesicle membrane (IEA)

plasma membrane (IBA)

Molecular Function

G protein-coupled receptor activity (IBA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	GOA pipeline	RGD automated data pipeline
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12477932	PMID:15489334	PMID:24431468	PMID:25348153	PMID:32197469	PMID:32949767

Genomics

Comparative Map Data

Gpr18
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	15	105,404,062 - 105,407,812 (-)	NCBI		GRCr8
mRatBN7.2	15	98,997,427 - 99,001,177 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	15	98,997,259 - 99,001,470 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	15	102,931,135 - 102,934,869 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	15	104,023,208 - 104,026,937 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	15	100,951,028 - 100,954,757 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	15	108,323,157 - 108,326,907 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	15	108,323,179 - 108,326,907 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	15	111,710,713 - 111,714,463 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	15	107,014,823 - 107,018,573 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	15	97,769,869 - 97,773,606 (-)	NCBI		Celera
Cytogenetic Map	15	q25	NCBI

GPR18
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	13	99,254,739 - 99,258,379 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	13	99,254,732 - 99,261,744 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	13	99,906,993 - 99,910,633 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	13	98,704,968 - 98,708,683 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	13	98,704,972 - 98,708,629	NCBI
Celera	13	80,750,537 - 80,754,253 (-)	NCBI		Celera
Cytogenetic Map	13	q32.3	NCBI
HuRef	13	80,501,358 - 80,505,073 (-)	NCBI		HuRef
CHM1_1	13	99,877,156 - 99,880,871 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	13	98,464,982 - 98,489,443 (-)	NCBI		T2T-CHM13v2.0

Gpr18
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	14	122,148,846 - 122,153,300 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	14	122,148,665 - 122,153,193 (-)	Ensembl		GRCm39 Ensembl
GRCm38	14	121,911,434 - 121,915,888 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	14	121,911,253 - 121,915,781 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	14	122,310,656 - 122,314,996 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	14	121,046,614 - 121,050,954 (-)	NCBI		MGSCv36	mm8
Celera	14	120,472,856 - 120,477,195 (-)	NCBI		Celera
Cytogenetic Map	14	E5	NCBI
cM Map	14	65.86	NCBI

Gpr18
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955404	11,293,897 - 11,321,072 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955404	11,293,897 - 11,321,072 (+)	NCBI	ChiLan1.0	ChiLan1.0

GPR18
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	14	100,778,706 - 100,816,860 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	13	99,445,859 - 99,454,370 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	13	80,423,534 - 80,427,604 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	13	99,562,425 - 99,566,292 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	13	99,562,589 - 99,563,584 (-)	Ensembl	panpan1.1		panPan2

GPR18
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	22	49,288,226 - 49,294,567 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	22	49,288,343 - 49,289,338 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	22	49,069,390 - 49,076,594 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	22	49,729,137 - 49,736,486 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	22	49,729,269 - 49,730,264 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	22	49,380,774 - 49,387,977 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	22	49,414,634 - 49,421,920 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	22	49,451,114 - 49,458,263 (-)	NCBI		UU_Cfam_GSD_1.0

Gpr18
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	184,709,977 - 184,714,884 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936472	11,240,880 - 11,241,875 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936472	11,240,287 - 11,242,157 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

GPR18
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	11	68,187,327 - 68,191,269 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	11	68,187,402 - 68,191,622 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	11	75,421,543 - 75,425,432 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

GPR18
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	3	77,911,752 - 77,919,717 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	3	77,911,915 - 77,912,910 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666046	34,407,270 - 34,412,540 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Gpr18
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624793	11,781,250 - 11,785,952 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Gpr18
5 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	74
Count of miRNA genes:	61
Interacting mature miRNAs:	64
Transcripts:	ENSRNOT00000016848
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
731177	Uae26	Urinary albumin excretion QTL 26	2.4	0.025	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	15	67588667	101769107	Rat
1549844	Bss7	Bone structure and strength QTL 7	6.4		femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	15	75788062	101769107	Rat
2300326	Plaw1	Placental weight QTL 1	15	0.005	placenta mass (VT:0004257)	placenta wet weight (CMO:0002088)	15	68327165	100062518	Rat
1358354	Srcrt5	Stress Responsive Cort QTL 5	3.38		blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	15	98150001	99043291	Rat
1641889	Colcr6	Colorectal carcinoma resistance QTL 6	2.9	0.0126	intestine integrity trait (VT:0010554)	benign colorectal tumor surface area measurement (CMO:0001799)	15	73690518	99794247	Rat
70155	Gcs1	Gastric cancer susceptibility QTL1	3.8		stomach morphology trait (VT:0000470)	stomach tumor susceptibility score (CMO:0002043)	15	76306099	101769107	Rat
2317055	Aia10	Adjuvant induced arthritis QTL 10	3.41		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	15	75788062	101769107	Rat
631655	Bp126	Blood pressure QTL 126	4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	15	58156477	101769107	Rat

Markers in Region

AI408540

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	15	98,997,469 - 98,997,640 (+)	MAPPER	mRatBN7.2
Rnor_6.0	15	108,323,200 - 108,323,370	NCBI	Rnor6.0
Rnor_5.0	15	111,710,756 - 111,710,926	UniSTS	Rnor5.0
RGSC_v3.4	15	107,014,866 - 107,015,036	UniSTS	RGSC3.4
Celera	15	97,769,912 - 97,770,082	UniSTS
RH 3.4 Map	15	708.8	UniSTS
Cytogenetic Map	15	q25	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	29	62	85	84	53	25	53	6	178	75	42	33	45	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001079710	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC128782	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473951	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000015	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000016848 ⟹ ENSRNOP00000016848

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	15	98,997,259 - 99,001,470 (-)	Ensembl
Rnor_6.0 Ensembl	15	108,323,179 - 108,326,907 (-)	Ensembl

RefSeq Acc Id:

NM_001079710 ⟹ NP_001073178

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	15	105,404,062 - 105,407,812 (-)	NCBI
mRatBN7.2	15	98,997,427 - 99,001,177 (-)	NCBI
Rnor_6.0	15	108,323,157 - 108,326,907 (-)	NCBI
Rnor_5.0	15	111,710,713 - 111,714,463 (-)	NCBI
RGSC_v3.4	15	107,014,823 - 107,018,573 (-)	RGD
Celera	15	97,769,869 - 97,773,606 (-)	RGD

Sequence:

show sequence

AAAGGGCAGAGCAGTGCTCAGAGCCCAGCAGACCAGCCCCGCCATCGGTACTACATCTCAGCAA
CCCTCCAACAGGACCAGCCGCAGAGGCAAAGGAAAACAATTCAAAGACACTATCTGCCTAACAC
AGGCAGGCCACTGCACACTCTTTCCAGCACCTCGCAGACAGCCCTTTGACGGACAGGAGTTTCT
ACGTACCATGGGGACCAGCCTGCTGTAAGATGGCCATCCCGAGCAATCGCGACCAGCTTGCTCT
TTCCAATGGTTCACACCCAGAGGAATACAAAATCGCAGCCCTGGTCTTCTACAGCTGCATCTTC
CTGATTGGGCTGCTTGTTAATGTCACTGCCCTATGGGTTTTCAGCTGTACGACCAAGAAAAGAA
CCACCGTAACCATCTACATGATGAACGTCGCACTGCTGGACTTAGTATTTATACTGAGTCTACC
CTTTCGGATGTTTTACTATGCAAAAGGCGAGTGGCCATTTGGAGACTACTTCTGCCACATTCTT
GGGGCCCTGGTGGTGTTTTACCCAAGCCTTGCTCTGTGGCTTCTTGCTCTCATTAGTGCTGACA
GATACATGGCCATAGTACAGCCGAAATACGCCAAGGAACTCAAGAACACTGGCAAGGCGGTGCT
CGCGTGTGTGGGGGTCTGGATAATGACCCTGACCACCACTGTCCCTCTGCTACTGCTCGATGAA
GACCCAGATAAGGCCTCCTCCCCGGCCACCTGCCTGAAGATCTCCGACATCATCCACTTAAAAG
CTGTCAATGTGCTTAACTTCACGCGACTCATATTTTTCTTCCTGATCCCTCTGTTCATCATGAT
CGGGTGCTACGTGGTCATCATTCACAGCCTCCTCCGCGGGCAGACGTCTAAGCTGAAGCCCAAG
GTCAAGGAGAAGTCCATACGGATCATCGTCACGCTCCTGCTGCAGGTGCTTGCCTGCTTCGTGC
CCTTCCACATCTGTTTTGCTCTCCTGATGCTACAGGGGGAGGAGAACAGCTACAGCCCCTGGGG
AGCCTTCACCACCTTCCTCATGAACCTCAGCACGTGTCTCGACGTCGTTCTCTACTACATTGTT
TCCAAACAGTTCCAGGCTCGAGTCATCAGTGTCATGCTGTACCGCAATTACCTTCGCAGTGTGC
GCAGAAAAAGTGTCCGGTCAGGCAGTCTACGGTCACTTAGCAACATGAACAGTGAAATGCTTTG
AGTCAGAGCAAGCTGACTGTCTTCAATCTCTTTAAAATTCTTTTTCTATCTACTCTCAGGTGAA
CCAGCATTCAATATTATCCAGTCCCTGCTCTAATAAAGAGAAATAATAATAAAAAAAAAAAAAA
AAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001073178	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	A1A5S3	(Get FASTA)	NCBI Sequence Viewer
	AAI28783	(Get FASTA)	NCBI Sequence Viewer
	EDM02571	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000016848.2
	ENSRNOP00055003493
	ENSRNOP00060011246
	ENSRNOP00065009057

RefSeq Acc Id:

NP_001073178 ⟸ NM_001079710

- UniProtKB:

A1A5S3 (UniProtKB/Swiss-Prot), A6HUK8 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAIPSNRDQLALSNGSHPEEYKIAALVFYSCIFLIGLLVNVTALWVFSCTTKKRTTVTIYMMNV
ALLDLVFILSLPFRMFYYAKGEWPFGDYFCHILGALVVFYPSLALWLLALISADRYMAIVQPKY
AKELKNTGKAVLACVGVWIMTLTTTVPLLLLDEDPDKASSPATCLKISDIIHLKAVNVLNFTRL
IFFFLIPLFIMIGCYVVIIHSLLRGQTSKLKPKVKEKSIRIIVTLLLQVLACFVPFHICFALLM
LQGEENSYSPWGAFTTFLMNLSTCLDVVLYYIVSKQFQARVISVMLYRNYLRSVRRKSVRSGSL
RSLSNMNSEML

hide sequence

Ensembl Acc Id:

ENSRNOP00000016848 ⟸ ENSRNOT00000016848

Protein Domains

G-protein coupled receptors family 1 profile

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-A1A5S3-F1-model_v2	AlphaFold	A1A5S3	1-331	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13699880

Promoter ID:

EPDNEW_R10404

Type:

multiple initiation site

Name:

Gpr18_1

Description:

G protein-coupled receptor 18

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	15	108,326,898 - 108,326,958	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1304889	AgrOrtholog
BioCyc Gene	G2FUF-12365	BioCyc
Ensembl Genes	ENSRNOG00000012628	Ensembl, UniProtKB/Swiss-Prot
	ENSRNOG00055003033	UniProtKB/Swiss-Prot
	ENSRNOG00060008733	UniProtKB/Swiss-Prot
	ENSRNOG00065007873	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000016848.5	UniProtKB/Swiss-Prot
	ENSRNOT00055004722	UniProtKB/Swiss-Prot
	ENSRNOT00060014590	UniProtKB/Swiss-Prot
	ENSRNOT00065012357	UniProtKB/Swiss-Prot
Gene3D-CATH	Rhodopsin 7-helix transmembrane proteins	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7375738	IMAGE-MGC_LOAD
InterPro	GPCR_Rhodpsn	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GPCR_Rhodpsn_7TM	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GPR18	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:679957	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE	MGC:156838	IMAGE-MGC_LOAD
NCBI Gene	Gpr18	ENTREZGENE
PANTHER	G-PROTEIN COUPLED RECEPTOR	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	N-ARACHIDONYL GLYCINE RECEPTOR	UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
Pfam	7tm_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Gpr18	PhenoGen
PRINTS	GPCRRHODOPSN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	P2YPURNOCPTR	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	G_PROTEIN_RECEP_F1_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	G_PROTEIN_RECEP_F1_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000012628	RatGTEx
	ENSRNOG00055003033	RatGTEx
	ENSRNOG00060008733	RatGTEx
	ENSRNOG00065007873	RatGTEx
Superfamily-SCOP	Family A G protein-coupled receptor-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A1A5S3	ENTREZGENE
	A6HUK8	ENTREZGENE, UniProtKB/TrEMBL
	GPR18_RAT	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-01-09	Gpr18	G protein-coupled receptor 18	LOC686964	similar to G protein-coupled receptor 18	Data merged from RGD:1591257	1643240	APPROVED
2007-01-25	Gpr18	G protein-coupled receptor 18	Gpr18_predicted	G protein-coupled receptor 18 (predicted)	Symbol and Name updated	1299863	APPROVED
2007-01-25	Gpr18_predicted	G protein-coupled receptor 18 (predicted)	LOC679957	similar to G protein-coupled receptor 18	Data merged from RGD:1598113	737654	APPROVED
2006-11-20	LOC679957	similar to G protein-coupled receptor 18			Symbol and Name status set to provisional	70820	PROVISIONAL
2006-11-20	LOC686964	similar to G protein-coupled receptor 18			Symbol and Name status set to provisional	70820	PROVISIONAL
2005-01-12	Gpr18_predicted	G protein-coupled receptor 18 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar