Coq3 (coenzyme Q3 methyltransferase)

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Gene: Coq3 (coenzyme Q3 methyltransferase) Rattus norvegicus

Analyze

Symbol:

Coq3

Name:

coenzyme Q3 methyltransferase

RGD ID:

2380

Description:

Enables hexaprenyldihydroxybenzoate methyltransferase activity. Involved in methylation and regulation of ubiquinone biosynthetic process. Located in mitochondrion. Orthologous to human COQ3 (coenzyme Q3, methyltransferase); PARTICIPATES IN ubiquinone biosynthetic pathway; INTERACTS WITH 1,2,4-trimethylbenzene; 17alpha-ethynylestradiol; 2,4-dinitrotoluene.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

2-polyprenyl-6-hydroxyphenol methylase; 2-polyprenyl-6-hydroxyphenyl methylase; 3,4-dihydroxy-5-hexaprenylbenzoate methyltransferase; 3-demethylubiquinol 3-O-methyltransferase; 3-demethylubiquinone-9 3-methyltransferase; coenzyme Q (ubiquinone); coenzyme q (ubiquinone) biosynthetic enzyme 3; coenzyme Q3 homolog, methyltransferase; coenzyme Q3 homolog, methyltransferase (S. cerevisiae); coenzyme Q3 homolog, methyltransferase (yeast); DHHB methyltransferase; DHHB-MT; DHHB-MTase; dihydroxyhexaprenylbenzoate methyltransferase; hexaprenyldihydroxybenzoate methyltransferase; hexaprenyldihydroxybenzoate methyltransferase, mitochondrial; MGC156658; polyprenyldihydroxybenzoate methyltransferase; ubiquinone biosynthesis O-methyltransferase, mitochondrial

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	COQ3 (coenzyme Q3, methyltransferase)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Coq3 (coenzyme Q3 methyltransferase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Coq3 (coenzyme Q3, methyltransferase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	COQ3 (coenzyme Q3, methyltransferase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	COQ3 (coenzyme Q3, methyltransferase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Coq3 (coenzyme Q3, methyltransferase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	COQ3 (coenzyme Q3, methyltransferase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	COQ3 (coenzyme Q3, methyltransferase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Coq3 (coenzyme Q3, methyltransferase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	COQ3 (coenzyme Q3, methyltransferase)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Coq3 (coenzyme Q3 methyltransferase)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	coq3 (coenzyme Q3 methyltransferase)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG9249	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	COQ3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	coq-3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	5	35,429,567 - 35,460,613 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	35,429,574 - 35,460,607 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	37,568,779 - 37,585,044 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	5	39,161,507 - 39,177,768 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	5	39,101,017 - 39,117,278 (+)	NCBI	Rnor_WKY
Rnor_6.0	5	36,024,673 - 36,056,664 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	36,024,649 - 36,056,669 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	40,693,937 - 40,710,202 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	36,640,718 - 36,656,981 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	5	36,640,896 - 36,657,160 (-)	NCBI
Celera	5	34,458,047 - 34,473,986 (+)	NCBI		Celera
Cytogenetic Map	5	q21	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,1-dichloroethene (ISO)

1,2,4-trimethylbenzene (EXP)

17alpha-ethynylestradiol (EXP)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,4-dinitrotoluene (EXP)

2,6-dinitrotoluene (EXP)

2-hydroxypropanoic acid (ISO)

3-chloropropane-1,2-diol (EXP)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole (EXP)

6-propyl-2-thiouracil (EXP)

acrylamide (ISO)

amiodarone (EXP,ISO)

ammonium chloride (EXP)

aristolochic acid A (ISO)

arsenite(3-) (ISO)

atrazine (ISO)

benzbromarone (EXP)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

cadmium atom (ISO)

cadmium dichloride (EXP,ISO)

cadmium sulfate (ISO)

calcitriol (ISO)

carbonyl cyanide p-trifluoromethoxyphenylhydrazone (ISO)

cisplatin (ISO)

clofibrate (EXP)

copper(II) sulfate (ISO)

cyclosporin A (ISO)

dibutyl phthalate (ISO)

dicrotophos (ISO)

dioxygen (ISO)

diuron (EXP)

endosulfan (EXP)

ethanol (ISO)

finasteride (EXP)

flutamide (EXP)

folic acid (ISO)

gentamycin (EXP)

isobutanol (ISO)

L-ethionine (EXP)

N-nitrosodiethylamine (EXP)

okadaic acid (ISO)

omeprazole (EXP)

oxaliplatin (EXP)

ozone (ISO)

paracetamol (EXP,ISO)

phenobarbital (EXP)

pirinixic acid (EXP,ISO)

quercetin (ISO)

quercitrin (ISO)

rac-lactic acid (ISO)

sunitinib (ISO)

testosterone (ISO)

tetrachloromethane (EXP)

thapsigargin (ISO)

thioacetamide (EXP)

tolcapone (EXP)

topotecan (EXP)

tunicamycin (ISO)

urethane (ISO)

valproic acid (ISO)

vinclozolin (EXP)

vorinostat (ISO)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

glycerol metabolic process (ISO)

methylation (IDA)

regulation of ubiquinone biosynthetic process (IGI)

ubiquinone biosynthetic process (IBA,IEA,ISO)

Cellular Component

extrinsic component of mitochondrial inner membrane (IEA)

mitochondrial inner membrane (ISO)

mitochondrion (IBA,IDA,ISO)

ubiquinone biosynthesis complex (ISO)

Molecular Function

2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity (IEA)

3-demethylubiquinone-9 3-O-methyltransferase activity (IEA)

hexaprenyldihydroxybenzoate methyltransferase activity (IBA,IMP)

methyltransferase activity (IBA)

O-methyltransferase activity (ISO)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

ubiquinone biosynthetic pathway (IEA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Cloning of a rat cDNA encoding dihydroxypolyprenylbenzoate methyltransferase by functional complementation of a Saccharomyces cerevisiae mutant deficient in ubiquinone biosynthesis.	Marbois BN, etal., Gene 1994 Jan 28;138(1-2):213-7.
4.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
5.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
6.	SMPDB Annotation Import Pipeline	Pipeline to import SMPDB annotations from SMPDB into RGD
7.	Yeast and rat Coq3 and Escherichia coli UbiG polypeptides catalyze both O-methyltransferase steps in coenzyme Q biosynthesis.	Poon WW, etal., J Biol Chem. 1999 Jul 30;274(31):21665-72.
8.	GOA pipeline	RGD automated data pipeline
9.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
11.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
12.	Tentative Sequence Identification Numbers	Tentative Sequence Data IDs. TIGR Gene Index, Rat Data

Additional References at PubMed

PMID:10777520	PMID:15489334	PMID:18614015	PMID:26316108

Genomics

Comparative Map Data

Coq3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	5	35,429,567 - 35,460,613 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	35,429,574 - 35,460,607 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	37,568,779 - 37,585,044 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	5	39,161,507 - 39,177,768 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	5	39,101,017 - 39,117,278 (+)	NCBI	Rnor_WKY
Rnor_6.0	5	36,024,673 - 36,056,664 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	36,024,649 - 36,056,669 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	40,693,937 - 40,710,202 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	36,640,718 - 36,656,981 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	5	36,640,896 - 36,657,160 (-)	NCBI
Celera	5	34,458,047 - 34,473,986 (+)	NCBI		Celera
Cytogenetic Map	5	q21	NCBI

COQ3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	6	99,369,401 - 99,394,195 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	6	99,369,401 - 99,394,195 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	6	99,817,277 - 99,842,071 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	6	99,924,069 - 99,948,803 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	6	99,924,072 - 99,948,801	NCBI
Celera	6	100,461,523 - 100,486,230 (-)	NCBI		Celera
Cytogenetic Map	6	q16.2	NCBI
HuRef	6	97,257,764 - 97,282,457 (-)	NCBI		HuRef
CHM1_1	6	100,080,413 - 100,105,111 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	6	100,543,769 - 100,568,541 (-)	NCBI		T2T-CHM13v2.0

Coq3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	21,879,646 - 21,912,163 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	21,879,673 - 21,912,162 (+)	Ensembl		GRCm39 Ensembl
GRCm38	4	21,879,646 - 21,912,163 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	21,879,673 - 21,912,162 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	4	21,806,822 - 21,839,273 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	4	21,970,510 - 22,002,961 (+)	NCBI		MGSCv36	mm8
Celera	4	21,624,381 - 21,656,627 (+)	NCBI		Celera
Cytogenetic Map	4	A3	NCBI
cM Map	4	9.11	NCBI

Coq3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955411	25,243,684 - 25,268,225 (-)	NCBI	ChiLan1.0	ChiLan1.0

COQ3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	6	101,092,782 - 101,117,481 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	6	101,092,782 - 101,117,485 (-)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	6	97,210,293 - 97,235,234 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

COQ3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	12	57,589,993 - 57,606,486 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	12	57,590,662 - 57,606,447 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	12	57,346,528 - 57,364,340 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	12	58,411,990 - 58,428,072 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	12	58,409,953 - 58,428,040 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UNSW_CanFamBas_1.0	12	57,615,466 - 57,631,408 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	12	57,860,596 - 57,876,612 (-)	NCBI		UU_Cfam_GSD_1.0

Coq3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404946	92,526,750 - 92,547,673 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936651	979,053 - 1,000,871 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936651	983,397 - 1,000,669 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

COQ3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	66,232,181 - 66,346,575 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	1	66,321,288 - 66,347,088 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

COQ3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	13	74,477,313 - 74,501,841 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666040	46,810,795 - 46,836,136 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Coq3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624810	5,613,750 - 5,670,544 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624810	5,613,716 - 5,666,379 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Coq3
186 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	139
Count of miRNA genes:	113
Interacting mature miRNAs:	127
Transcripts:	ENSRNOT00000013384
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1331756	Rf34	Renal function QTL 34	4.16275		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	5	1	90450412	Rat
70212	Niddm25	Non-insulin dependent diabetes mellitus QTL 25	3.54		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	5	1	131345958	Rat
1331771	Rf35	Renal function QTL 35	4.36965		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	5	729470	86724018	Rat
1576314	Eutr1	Estrogen induced uterine response QTL 1			uterus integrity trait (VT:0010575)	pyometritis severity score (CMO:0002009)	5	2138965	166875058	Rat
8662454	Vetf3	Vascular elastic tissue fragility QTL 3	27.4		artery integrity trait (VT:0010639)	number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)	5	2282226	69540447	Rat
1300117	Hrtrt8	Heart rate QTL 8	3.49		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	5	3844018	47869213	Rat
61462	Niddm10	Non-insulin dependent diabetes mellitus QTL 10	3.9	0.001	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	5	5112159	47171491	Rat
2293666	Bmd38	Bone mineral density QTL 38	4.4		femur size trait (VT:1000369)	femoral neck cortical cross-sectional area (CMO:0001702)	5	8948228	53948228	Rat
7394712	Emca13	Estrogen-induced mammary cancer QTL 13			mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	9823266	99753708	Rat
1641903	Alcrsp3	Alcohol response QTL 3			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	5	12689285	57689285	Rat
634305	Mamtr1	Mammary tumor resistance QTL 1		0.0001	mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	12789751	113558310	Rat
1600358	Mamtr5	Mammary tumor resistance QTL 5			mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	18873947	63873947	Rat
1358353	Srcrtb2	Stress Responsive Cort Basal QTL 2	3.48	0.003	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	5	18873947	74251464	Rat
8552954	Pigfal14	Plasma insulin-like growth factor 1 level QTL 14	9		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	5	21226744	66226744	Rat
1549901	Neudeg2	Neurodegradation QTL 2	4	0	nervous system integrity trait (VT:0010566)	mononuclear cell count (CMO:0002119)	5	24838710	44045280	Rat
1578767	Stresp17	Stress response QTL 17	4.3	0.01	blood aldosterone amount (VT:0005346)	plasma aldosterone level (CMO:0000551)	5	27955440	72955440	Rat
1578776	Stresp18	Stress response QTL 18	2.9		thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	5	27955440	72955440	Rat
6903292	Stl28	Serum triglyceride level QTL 28	2.6	0.0073	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	5	28515489	73515489	Rat
6903306	Scl35	Serum cholesterol QTL 35	2.6	0.0073	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	28515489	73515489	Rat
2290448	Scl54	Serum cholesterol level QTL 54	2.93		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	31663789	131345958	Rat
1598807	Glom12	Glomerulus QTL 12	2.7		kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	5	33215665	78215665	Rat
1298067	Scl15	Serum cholesterol level QTL 15	4.8	0.001	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	33215665	78215665	Rat
1302786	Kidm8	Kidney mass QTL 8	28.15		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	5	33215665	78215665	Rat
1576317	Eutr2	Estrogen induced uterine response QTL 2		0.01	uterus integrity trait (VT:0010575)	pyometritis severity score (CMO:0002009)	5	34730116	104251008	Rat
2316959	Gluco59	Glucose level QTL 59	4.7		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	5	34944474	113558310	Rat
1641922	Alcrsp8	Alcohol response QTL 8			alcohol metabolism trait (VT:0015089)	blood ethanol level (CMO:0000535)	5	35189153	68564008	Rat
1641912	Alcrsp18	Alcohol response QTL 18			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	5	35189153	141643988	Rat

Markers in Region

RH131083

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	35,460,312 - 35,460,508 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	36,056,364 - 36,056,559	NCBI	Rnor6.0
Rnor_5.0	5	40,709,908 - 40,710,103	UniSTS	Rnor5.0
RGSC_v3.4	5	36,640,815 - 36,641,010	UniSTS	RGSC3.4
Celera	5	34,473,692 - 34,473,887	UniSTS
RH 3.4 Map	5	199.8	UniSTS
Cytogenetic Map	5	q21	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	43	57	41	19	41	8	11	74	35	41	10	8
Low												1
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_019187	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017593201	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039109358	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC081811	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC098666	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC126094	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473962	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ216025	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ230994	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000161	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	L20427	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000013384 ⟹ ENSRNOP00000013384

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	5	35,429,574 - 35,460,607 (+)	Ensembl
Rnor_6.0 Ensembl	5	36,024,649 - 36,056,669 (+)	Ensembl

RefSeq Acc Id:

NM_019187 ⟹ NP_062060

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	5	35,444,340 - 35,460,607 (+)	NCBI
Rnor_6.0	5	36,040,393 - 36,056,658 (+)	NCBI
Rnor_5.0	5	40,693,937 - 40,710,202 (+)	NCBI
RGSC_v3.4	5	36,640,718 - 36,656,981 (-)	RGD
Celera	5	34,458,047 - 34,473,986 (+)	RGD

Sequence:

show sequence

CATTAAAATGTGGCTTAGATCTTACAGGATAACGTTTTCCTGTTTGACCAGACTAAAAACTTAC
AGGTCCTCTTGGAAGAAATTATACAGTACTTCACAAACAGTTGACAGCAAGGAGGTCAAAACCT
TCCAGGCCCTGGCTCACTCATGGTGGGATGAGCAAGGGAAGTTTGCGCCTCTTCATTCTATGAA
TGACCTACGGGTGCCGTTCATTAGAGACAATCTTTTGAAAACAAGTACTAATCATGATCCAGGA
AAGCCTTTATCTGGGATGAAGATTCTCGACGTTGGCTGTGGCGGTGGGTTATTAACTGAACCTC
TAGGGAGACTGGGAGCTTCAGTTGTTGGAATCGATCCTGTGGCTGAAAACATTAAGATAGCACA
GCACCATAAATCATTTGATCCAGTCCTGGATAAGAGGATACAGTACCGAGTGTGCTCCCTGGAG
GAGACCTTGAATGAGAATGCAGAGTGTTTTGATGCTGTCGTGGCTTCTGAAGTGGTCGAGCATG
TGAACAACCTTGAAATGTTCATACAGTGCTGCTATCAAGTATTGAAACCTGGTGGCTCTTTATT
CATTACTACAGTGAACAAAACACAGCTGTCCTATGTCTTGGGAATTGTTTTCTCAGAGCAAATT
GCAGGCATTGTTCCAAAAGGCACTCATACGTGGGAGAAGTTTGTTTCACCTGAAAAGCTAGAAA
GCATCTTGGAACCAAATGGTCTGTCAGTTGAAACTGTGGCAGGAATGGTCTATAACCCTTTCTC
AGGTTACTGGCATTGGACTGAAAATACCAGCCTTAACTATGCAGCCCATGCTGTGAGAGCCAGG
GCTCAGGAACACCTGGAGCCTGCTGAGTCTGCTTGAAAGGGGGAAGCAGAAGCACCCCATGCCA
AAGTCTCCGGCAGCCCAAGTGTGCACGAGGGGCAGAGAAAATGAGAAAGCTCTGAGGACAGCAG
TAAATATGCTTGAAGTTGTGTTGTTTACAAATCCAAACATCTTACTCCTTTTCGGGAGGGATTC
TGAAGAACAAAAGGTCAATAAAAATATCTAAATC

hide sequence

RefSeq Acc Id:

XM_017593201 ⟹ XP_017448690

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	5	35,429,567 - 35,460,613 (+)	NCBI
Rnor_6.0	5	36,024,673 - 36,056,664 (+)	NCBI

Sequence:

show sequence

GTTGTGAGGAGGGACCGGAAAAGGAGTAGGATTCTGGTCGCGATGTGGAGAGGTGGAAGGCTGA
GCTCTCGTGGGGTTCGTTTCCTAGAAACACTTGGGTTTGCGTGCCCCAGCGCGGTAGCCGAGCC
TCCTCGTGTAACTTCATGGACCGCTTTCTCAGGGAACCAGCTCACTAGGAATCTACAGATTAAG
CCATGGGAATTTAGTGGACACAGGACCATGTGGCTTAGATCTTACAGGATAACGTTTTCCTGTT
TGACCAGACTAAAAACTTACAGGTCCTCTTGGAAGAAATTATACAGTACTTCACAAACAGTTGA
CAGCAAGGAGGTCAAAACCTTCCAGGCCCTGGCTCACTCATGGTGGGATGAGCAAGGGAAGTTT
GCGCCTCTTCATTCTATGAATGACCTACGGGTGCCGTTCATTAGAGACAATCTTTTGAAAACAA
GTACTAATCATGATCCAGGAAAGCCTTTATCTGGGATGAAGATTCTCGACGTTGGCTGTGGCGG
TGGGTTATTAACTGAACCTCTAGGGAGACTGGGAGCTTCAGTTGTTGGAATCGATCCTGTGGCT
GAAAACATTAAGATAGCACAGCACCATAAATCATTTGATCCAGTCCTGGATAAGAGGATACAGT
ACCGAGTGTGCTCCCTGGAGGAGACCTTGAATGAGAATGCAGAGTGTTTTGATGCTGTCGTGGC
TTCTGAAGTTGTCGAGCATGTGAACAACCTTGAAATGTTCATACAGTGCTGCTATCAAGTATTG
AAACCTGGTGGCTCTTTATTCATTACTACAGTGAACAAAACACAGCTGTCCTATGTCTTGGGAA
TTGTTTTCTCAGAGCAAATTGCAGGCATTGTTCCAAAAGGCACTCATACGTGGGAGAAGTTTGT
TTCACCTGAAAAGCTAGAAAGCATCTTGGAACCAAATGGTCTGTCAGTTGAAACTGTGGCAGGA
ATGGTCTATAACCCTTTCTCAGGTTACTGGCATTGGACTGAAAATACCAGCCTTAACTATGCAG
CCCATGCTGTGAGAGCCAGGGCTCAGGAACACCTGGAGCCTGCTGAGTCTGCTTGAAAGGGGGA
AGCAGAAGCACCCCATGCCAAAGTCTCCGGCAGCCCAAGTGTGCACGAGGGGCAGAGAAAATGA
GAAAGCTCTGAGGACAGCAGTAAATATGCTTGAAGTTGTGTTGTTTACAAATCCAAACATCTTA
CTCCTTTTCGGGAGGGATTCTGAAGAACAAAAGGTCAATAAAAATATCTAAATCAATGGA

hide sequence

RefSeq Acc Id:

XM_039109358 ⟹ XP_038965286

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	5	35,429,579 - 35,460,613 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_062060	(Get FASTA)	NCBI Sequence Viewer
	XP_017448690	(Get FASTA)	NCBI Sequence Viewer
	XP_038965286	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAC37643	(Get FASTA)	NCBI Sequence Viewer
	AAH81811	(Get FASTA)	NCBI Sequence Viewer
	AAH98666	(Get FASTA)	NCBI Sequence Viewer
	AAI26095	(Get FASTA)	NCBI Sequence Viewer
	EDL98525	(Get FASTA)	NCBI Sequence Viewer
	Q63159	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_062060 ⟸ NM_019187

- UniProtKB:

Q63159 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MWLRSYRITFSCLTRLKTYRSSWKKLYSTSQTVDSKEVKTFQALAHSWWDEQGKFAPLHSMNDL
RVPFIRDNLLKTSTNHDPGKPLSGMKILDVGCGGGLLTEPLGRLGASVVGIDPVAENIKIAQHH
KSFDPVLDKRIQYRVCSLEETLNENAECFDAVVASEVVEHVNNLEMFIQCCYQVLKPGGSLFIT
TVNKTQLSYVLGIVFSEQIAGIVPKGTHTWEKFVSPEKLESILEPNGLSVETVAGMVYNPFSGY
WHWTENTSLNYAAHAVRARAQEHLEPAESA

hide sequence

RefSeq Acc Id:	XP_017448690 ⟸ XM_017593201
- Peptide Label:	isoform X1
- UniProtKB:	Q642D7 (UniProtKB/Swiss-Prot), Q63159 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MWRGGRLSSRGVRFLETLGFACPSAVAEPPRVTSWTAFSGNQLTRNLQIKPWEFSGHRTMWLRS YRITFSCLTRLKTYRSSWKKLYSTSQTVDSKEVKTFQALAHSWWDEQGKFAPLHSMNDLRVPFI RDNLLKTSTNHDPGKPLSGMKILDVGCGGGLLTEPLGRLGASVVGIDPVAENIKIAQHHKSFDP VLDKRIQYRVCSLEETLNENAECFDAVVASEVVEHVNNLEMFIQCCYQVLKPGGSLFITTVNKT QLSYVLGIVFSEQIAGIVPKGTHTWEKFVSPEKLESILEPNGLSVETVAGMVYNPFSGYWHWTE NTSLNYAAHAVRARAQEHLEPAESA hide sequence

RefSeq Acc Id:

ENSRNOP00000013384 ⟸ ENSRNOT00000013384

RefSeq Acc Id:	XP_038965286 ⟸ XM_039109358
- Peptide Label:	isoform X2

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q63159-F1-model_v2	AlphaFold	Q63159	1-345	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13693598

Promoter ID:

EPDNEW_R4123

Type:

multiple initiation site

Name:

Coq3_1

Description:

coenzyme Q3 methyltransferase

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	5	36,024,700 - 36,024,760	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:2380	AgrOrtholog
BioCyc Gene	G2FUF-41810	BioCyc
Ensembl Genes	ENSRNOG00000009974	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein	ENSRNOP00000013384	ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000013384	ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH	3.40.50.150	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7191748	IMAGE-MGC_LOAD
	IMAGE:7323432	IMAGE-MGC_LOAD
	IMAGE:8370738	IMAGE-MGC_LOAD
InterPro	SAM-dependent_MTases	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	UbiG_MeTrfase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:29309	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:112616	IMAGE-MGC_LOAD
	MGC:156658	IMAGE-MGC_LOAD
	MGC:93489	IMAGE-MGC_LOAD
NCBI Gene	29309	ENTREZGENE
PhenoGen	Coq3	PhenoGen
Superfamily-SCOP	SSF53335	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR	TC217815
TIGRFAMs	UbiG	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	COQ3_RAT	UniProtKB/Swiss-Prot
	Q4G082_RAT	UniProtKB/TrEMBL
	Q63159	ENTREZGENE
	Q642D7	ENTREZGENE
UniProt Secondary	A0JN24	UniProtKB/Swiss-Prot
	Q642D7	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2013-09-16	Coq3	coenzyme Q3 methyltransferase	Coq3	coenzyme Q3 homolog, methyltransferase (S. cerevisiae)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-10-15	Coq3	coenzyme Q3 homolog, methyltransferase (S. cerevisiae)	Coq3	coenzyme Q3 homolog, methyltransferase (yeast)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2004-09-10	Coq3	coenzyme Q3 homolog, methyltransferase (yeast)		coenzyme q (ubiquinone) biosynthetic enzyme 3	Name updated	1299863	APPROVED
2002-06-10	Coq3	coenzyme q (ubiquinone) biosynthetic enzyme 3			Name updated	70584	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_function	putative 3,4-dihydroxy-5-polyprenylbenzoate-MTase	69814
gene_function	catalyzes the fourth step in biosynthesis of ubiquinone (coenzyme Q) from p-hydroxybenzoic acid in functional complementation assay in S. cerevisiae	69814
gene_process	may participate in synthesis of ubiquinone	69814

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

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Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)