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Gene: Enpp1 (ectonucleotide pyrophosphatase/phosphodiesterase 1) Rattus norvegicus
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Symbol: Enpp1
Name: ectonucleotide pyrophosphatase/phosphodiesterase 1
Description: Exhibits phosphodiesterase I activity. Involved in several processes, including brain development; cellular response to cAMP; and cellular response to mechanical stimulus. Localizes to several cellular components, including the dendrite; neuronal cell body; and synapse. Biomarker of aortic valve disease 1. Human ortholog(s) of this gene implicated in several diseases, including arterial calcification of infancy; end stage renal failure; obesity; ossification of the posterior longitudinal ligament of spine; and type 2 diabetes mellitus. Orthologous to human ENPP1 (ectonucleotide pyrophosphatase/phosphodiesterase 1); PARTICIPATES IN insulin signaling pathway; niacin metabolic pathway; pantothenic acid metabolic pathway; INTERACTS WITH 17beta-estradiol; 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: E-NPP 1; ectonucleotide pyrophosphatase/phosphodiesterase family member 1; Npps; Pc1; phosphodiesterase I/nucleotide pyrophosphatase 1; plasma-cell membrane glycoprotein PC-1
Orthologs:
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0121,748,201 - 21,813,205 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl121,748,261 - 21,813,371 (+)Ensembl
Rnor_5.0123,228,262 - 23,292,896 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4121,223,678 - 21,287,411 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1121,223,940 - 21,288,766 (+)NCBI
Celera119,451,097 - 19,514,516 (+)NCBICelera
Cytogenetic Map1p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
 
More on Enpp1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 628825
Created: 2003-02-27
Species: Rattus norvegicus
Last Modified: 2019-11-27
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.