Enpp1 (ectonucleotide pyrophosphatase/phosphodiesterase 1) - Rat Genome Database

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Gene: Enpp1 (ectonucleotide pyrophosphatase/phosphodiesterase 1) Rattus norvegicus
Symbol: Enpp1
Name: ectonucleotide pyrophosphatase/phosphodiesterase 1
RGD ID: 628825
Description: Enables phosphodiesterase I activity. Involved in several processes, including brain development; cellular response to cAMP; and cellular response to mechanical stimulus. Located in dendrite; neuronal cell body; and plasma membrane. Biomarker of aortic valve disease 1. Human ortholog(s) of this gene implicated in several diseases, including arterial calcification of infancy; end stage renal disease; obesity; ossification of the posterior longitudinal ligament of spine; and type 2 diabetes mellitus. Orthologous to human ENPP1 (ectonucleotide pyrophosphatase/phosphodiesterase 1); PARTICIPATES IN insulin signaling pathway; niacin metabolic pathway; pantothenic acid metabolic pathway; INTERACTS WITH 17beta-estradiol; 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: E-NPP 1; ectonucleotide pyrophosphatase/phosphodiesterase family member 1; Npps; Pc1; phosphodiesterase I/nucleotide pyrophosphatase 1; plasma-cell membrane glycoprotein PC-1
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr8122,518,051 - 22,583,044 (+)NCBIGRCr8
mRatBN7.2120,698,746 - 20,763,741 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl120,698,764 - 20,763,715 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx120,475,435 - 20,539,162 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0126,475,432 - 26,539,171 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0120,675,339 - 20,739,097 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0121,748,201 - 21,813,205 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl121,748,261 - 21,813,371 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0123,228,262 - 23,292,896 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4121,223,678 - 21,287,411 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1121,223,940 - 21,288,766 (+)NCBI
Celera119,451,097 - 19,514,516 (+)NCBICelera
Cytogenetic Map1p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-palmitoylglycerol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (EXP,ISO)
allopurinol  (EXP)
alloxanthine  (EXP)
amiodarone  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
atrazine  (EXP)
benzbromarone  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
buta-1,3-diene  (ISO)
butanal  (ISO)
caffeine  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chromium atom  (ISO)
clofibrate  (EXP)
cobalt dichloride  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
Cuprizon  (EXP)
cyclosporin A  (ISO)
decabromodiphenyl ether  (ISO)
dexamethasone  (ISO)
dibutyl phthalate  (EXP)
diclofenac  (ISO)
dipyridamole  (EXP)
dorsomorphin  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
fipronil  (EXP)
flavonoids  (EXP)
folic acid  (ISO)
folpet  (ISO)
genistein  (ISO)
glycerol 2-phosphate  (ISO)
glyphosate  (EXP)
hydroquinone O-beta-D-glucopyranoside  (ISO)
indometacin  (EXP,ISO)
inulin  (ISO)
isoprenaline  (EXP)
L-ethionine  (EXP)
leflunomide  (ISO)
levamisole  (ISO)
maneb  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
methamphetamine  (ISO)
methidathion  (ISO)
methotrexate  (ISO)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (ISO)
nefazodone  (EXP)
nickel atom  (ISO)
nickel sulfate  (ISO)
nitroprusside  (EXP)
omeprazole  (EXP)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
parathion  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
pirinixic acid  (EXP,ISO)
potassium dichromate  (ISO)
progesterone  (ISO)
quercetin  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium chloride  (EXP)
sotorasib  (ISO)
sunitinib  (ISO)
tauroursodeoxycholic acid  (EXP)
testosterone  (ISO)
testosterone enanthate  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
topotecan  (EXP)
trametinib  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
valproic acid  (ISO)
venlafaxine hydrochloride  (EXP)
vinclozolin  (EXP)
vorinostat  (ISO)
warfarin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
3'-phosphoadenosine 5'-phosphosulfate metabolic process  (ISO)
adipose tissue development  (ISO)
adult locomotory behavior  (ISO)
adult walking behavior  (ISO)
aorta development  (ISO)
apoptotic process involved in development  (ISO)
artery development  (ISO)
articular cartilage development  (ISO)
ATP metabolic process  (IBA,IEA,ISO,ISS)
axon regeneration  (ISO)
B-1 B cell homeostasis  (ISO)
biomineral tissue development  (ISO)
bone development  (ISO)
bone growth  (ISO)
bone mineralization  (ISO)
bone mineralization involved in bone maturation  (ISO)
bone remodeling  (ISO)
bone resorption  (ISO)
bone trabecula formation  (ISO)
calcium ion homeostasis  (ISO)
cartilage development  (ISO)
cell morphogenesis  (ISO)
cell population proliferation  (ISO)
cellular homeostasis  (ISO)
cellular response to acidic pH  (IEP)
cellular response to cAMP  (IEP)
cellular response to insulin stimulus  (ISO)
cellular response to mechanical stimulus  (IEP)
cellular response to sodium phosphate  (ISO)
cellular response to transforming growth factor beta stimulus  (IEP)
cementum mineralization  (ISO)
central nervous system myelination  (ISO)
cerebellum development  (IEP)
cerebral cortex development  (IEP)
collagen-activated signaling pathway  (ISO)
defense response to protozoan  (ISO)
determination of adult lifespan  (ISO)
diphosphate metabolic process  (ISO)
endochondral bone morphogenesis  (ISO)
endochondral ossification  (ISO)
establishment of localization in cell  (ISO)
fat cell differentiation  (ISO)
fat pad development  (ISO)
fatty acid metabolic process  (ISO)
fibroblast growth factor receptor signaling pathway  (ISO)
gene expression  (ISO)
generation of precursor metabolites and energy  (ISO)
glucose homeostasis  (ISO)
glucose import  (ISO)
glycolytic process  (ISO)
heart development  (ISO)
hematopoietic stem cell migration to bone marrow  (ISO)
hippocampus development  (IEP)
hormone metabolic process  (ISO)
immune response  (IEA)
inflammatory response to antigenic stimulus  (ISO)
inhibition of non-skeletal tissue mineralization  (ISO)
inorganic diphosphate transport  (IBA,IEA,ISO)
intracellular phosphate ion homeostasis  (ISO)
kidney development  (ISO)
leukocyte activation involved in inflammatory response  (ISO)
ligamentous ossification  (ISO)
liver development  (IEP)
long-term synaptic potentiation  (ISO)
macrophage differentiation  (ISO)
magnesium ion homeostasis  (ISO)
melanocyte differentiation  (ISO,ISS)
microglia differentiation  (ISO)
microglial cell migration  (ISO)
middle ear morphogenesis  (ISO)
mitochondrion organization  (ISO)
morphogenesis of an epithelium  (ISO)
mRNA transcription by RNA polymerase II  (ISO)
mucus secretion  (ISO)
multicellular organism growth  (ISO)
muscle cell cellular homeostasis  (ISO)
negative regulation of bone mineralization  (ISO,ISS)
negative regulation of cell growth  (ISO)
negative regulation of fat cell differentiation  (IBA,IEA,ISO)
negative regulation of glucose import  (ISO)
negative regulation of glycogen biosynthetic process  (ISO)
negative regulation of insulin receptor signaling pathway  (ISO)
negative regulation of ossification  (ISO)
negative regulation of protein autophosphorylation  (ISO)
neuron apoptotic process  (ISO)
nucleoside triphosphate catabolic process  (IBA,IEA,ISO)
odontogenesis  (ISO)
olfactory bulb development  (IEP)
oligodendrocyte apoptotic process  (ISO)
organic phosphonate metabolic process  (ISO)
ossification  (ISO)
osteoblast differentiation  (ISO)
osteoclast differentiation  (ISO)
phosphate ion homeostasis  (ISO)
phosphate-containing compound metabolic process  (ISO)
plasma cell differentiation  (ISO)
post-embryonic forelimb morphogenesis  (ISO)
regulation of bone mineralization  (IBA,IEA)
response to ATP  (ISO)
response to dietary excess  (ISO)
response to Gram-positive bacterium  (ISO)
response to inorganic substance  (ISO)
response to insulin  (ISO)
response to magnesium ion  (ISO)
response to mechanical stimulus  (IEP)
response to platelet-derived growth factor  (ISO)
response to sodium phosphate  (ISO)
response to vitamin B6  (ISO)
response to wounding  (ISO)
sensory perception of mechanical stimulus  (ISO)
sensory perception of sound  (ISO)
sensory perception of temperature stimulus  (ISO)
sequestering of triglyceride  (ISO)
skin development  (ISO)
smoothened signaling pathway  (ISO)
spinal cord development  (ISO)
striatum development  (IEP)
T cell differentiation  (ISO)
tooth mineralization  (ISO)
vascular associated smooth muscle cell migration  (ISO)
vascular associated smooth muscle cell proliferation  (ISO)
vasculogenesis  (ISO)
vesicle-mediated transport  (IEA)
vitamin D3 metabolic process  (ISO)
Wnt signaling pathway  (ISO)

Cellular Component


References - curated
# Reference Title Reference Citation
1. The expression of ecto-nucleotide pyrophosphatase/phosphodiesterase 1 (E-NPP1) is correlated with astrocytic tumor grade. Aerts I, etal., Clin Neurol Neurosurg. 2011 Apr;113(3):224-9. doi: 10.1016/j.clineuro.2010.11.018. Epub 2010 Dec 30.
2. Cyclic AMP-dependent down regulation of ecto-nucleotide pyrophosphatase/phosphodiesterase 1 (NPP1) in rat C6 glioma. Aerts I, etal., Eur J Pharmacol. 2011 Mar 1;654(1):1-9. doi: 10.1016/j.ejphar.2010.11.031. Epub 2010 Dec 16.
3. Biochemical analysis of ecto-nucleotide pyrophosphatase phosphodiesterase activity in brain membranes indicates involvement of NPP1 isoenzyme in extracellular hydrolysis of diadenosine polyphosphates in central nervous system. Asensio AC, etal., Neurochem Int. 2007 Mar;50(4):581-90. Epub 2006 Dec 21.
4. The ENPP1 Q121 variant predicts major cardiovascular events in high-risk individuals: evidence for interaction with obesity in diabetic patients. Bacci S, etal., Diabetes. 2011 Mar;60(3):1000-7. Epub 2011 Jan 31.
5. Structural basis of allotypes of ecto-nucleotide pyrophosphatase/phosphodiesterase (plasma cell membrane glycoprotein PC-1) in the mouse and rat, and analysis of allele-specific xenogeneic antibodies. Banakh I, etal., Eur J Immunogenet 2002 Aug;29(4):307-13.
6. Immunolocalization of ecto-nucleotide pyrophosphatase/phosphodiesterase 1 (NPP1) in the rat forebrain. Bjelobaba I, etal., Brain Res. 2006 Nov 20;1120(1):54-63. Epub 2006 Oct 16.
7. Generalized arterial calcification of infancy: different clinical courses in two affected siblings. Cheng KS, etal., Am J Med Genet A. 2005 Jul 15;136(2):210-3.
8. Expression mapping of ectonucleotide pyrophosphatase/phosphodiesterase 1-3 (E-NPP1-3) in different brain structures during rat development. Cognato Gde P, etal., Int J Dev Neurosci. 2008 Oct;26(6):593-8. doi: 10.1016/j.ijdevneu.2008.05.001. Epub 2008 May 9.
9. Inhibition of ectonucleotidase with ARL67156 prevents the development of calcific aortic valve disease in warfarin-treated rats. Côté N, etal., Eur J Pharmacol. 2012 Aug 15;689(1-3):139-46. doi: 10.1016/j.ejphar.2012.05.016. Epub 2012 May 31.
10. Genetic mapping and exome sequencing identify 2 mutations associated with stroke protection in pediatric patients with sickle cell anemia. Flanagan JM, etal., Blood. 2013 Apr 18;121(16):3237-45. doi: 10.1182/blood-2012-10-464156. Epub 2013 Feb 19.
11. Phosphodiesterase-Ialpha/autotaxin: a counteradhesive protein expressed by oligodendrocytes during onset of myelination. Fox MA, etal., Mol Cell Neurosci 2003 Jul;23(3):507-19.
12. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
13. Expression of membrane-bound NPP-type ecto-phosphodiesterases in rat podocytes cultured at normal and high glucose concentrations. Jankowski M, etal., Biochem Biophys Res Commun. 2011 Dec 9;416(1-2):64-9. doi: 10.1016/j.bbrc.2011.10.144. Epub 2011 Nov 6.
14. Chondrogenesis mediated by PPi depletion promotes spontaneous aortic calcification in NPP1-/- mice. Johnson K, etal., Arterioscler Thromb Vasc Biol. 2005 Apr;25(4):686-91. Epub 2004 Dec 29.
15. Association of the distal region of the ectonucleotide pyrophosphatase/phosphodiesterase 1 gene with type 2 diabetes in an African-American population enriched for nephropathy. Keene KL, etal., Diabetes. 2008 Apr;57(4):1057-62. Epub 2008 Jan 9.
16. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
17. Enpp1: a potential facilitator of breast cancer bone metastasis. Lau WM, etal., PLoS One. 2013 Jul 5;8(7):e66752. doi: 10.1371/journal.pone.0066752. Print 2013.
18. Autosomal-recessive hypophosphatemic rickets is associated with an inactivation mutation in the ENPP1 gene. Levy-Litan V, etal., Am J Hum Genet. 2010 Feb 12;86(2):273-8. Epub 2010 Feb 4.
19. Mutant Enpp1asj mice as a model for generalized arterial calcification of infancy. Li Q, etal., Dis Model Mech. 2013 Sep;6(5):1227-35. doi: 10.1242/dmm.012765. Epub 2013 Jun 20.
20. Loss-of-function ENPP1 mutations cause both generalized arterial calcification of infancy and autosomal-recessive hypophosphatemic rickets. Lorenz-Depiereux B, etal., Am J Hum Genet. 2010 Feb 12;86(2):267-72. Epub 2010 Feb 4.
21. Variants of ENPP1 are associated with childhood and adult obesity and increase the risk of glucose intolerance and type 2 diabetes. Meyre D, etal., Nat Genet. 2005 Aug;37(8):863-7. Epub 2005 Jul 17.
22. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
23. Association of the human NPPS gene with ossification of the posterior longitudinal ligament of the spine (OPLL). Nakamura I, etal., Hum Genet. 1999 Jun;104(6):492-7.
24. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
25. Acidosis is a key regulator of osteoblast ecto-nucleotidase pyrophosphatase/phosphodiesterase 1 (NPP1) expression and activity. Orriss IR, etal., J Cell Physiol. 2015 Dec;230(12):3049-56. doi: 10.1002/jcp.25041.
26. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
27. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
28. A polymorphism (K121Q) of the human glycoprotein PC-1 gene coding region is strongly associated with insulin resistance. Pizzuti A, etal., Diabetes. 1999 Sep;48(9):1881-4.
29. UBXD4, a UBX-containing protein, regulates the cell surface number and stability of alpha3-containing nicotinic acetylcholine receptors. Rezvani K, etal., J Neurosci. 2009 May 27;29(21):6883-96. doi: 10.1523/JNEUROSCI.4723-08.2009.
30. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
31. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
32. Comprehensive gene review and curation RGD comprehensive gene curation
33. Hypophosphatemia, hyperphosphaturia, and bisphosphonate treatment are associated with survival beyond infancy in generalized arterial calcification of infancy. Rutsch F, etal., Circ Cardiovasc Genet. 2008 Dec;1(2):133-40.
34. Mutations in ENPP1 are associated with 'idiopathic' infantile arterial calcification. Rutsch F, etal., Nat Genet 2003 Aug;34(4):379-81.
35. No correlation of plasma cell 1 overexpression with insulin resistance in diabetic rats and 3T3-L1 adipocytes. Sakoda H, etal., Diabetes 1999 Jul;48(7):1365-71.
36. Insulin resistance and left ventricular hypertrophy in end-stage renal disease: association between the ENPP1 gene and left ventricular concentric remodelling. Spoto B, etal., Nephrol Dial Transplant. 2012 Feb;27(2):661-6. Epub 2011 May 19.
37. Differential regulation of the expression of nucleotide pyrophosphatases/phosphodiesterases in rat liver. Stefan C, etal., Biochim Biophys Acta. 1999 May 6;1450(1):45-52.
38. The extent of ossification of posterior longitudinal ligament of the spine associated with nucleotide pyrophosphatase gene and leptin receptor gene polymorphisms. Tahara M, etal., Spine (Phila Pa 1976). 2005 Apr 15;30(8):877-80; discussion 881.
39. Association and interaction analyses of genetic variants in ADIPOQ, ENPP1, GHSR, PPARgamma and TCF7L2 genes for diabetic nephropathy in a Taiwanese population with type 2 diabetes. Wu LS, etal., Nephrol Dial Transplant. 2009 Nov;24(11):3360-6. Epub 2009 Jun 8.
40. Expression of ectonucleotide pyrophosphatase-1 in end-plate chondrocytes with transforming growth factor beta 1 siRNA interference by cyclic mechanical tension. Xu HG, etal., Chin Med J (Engl). 2013 Oct;126(20):3886-90.
41. Regulation of insulin receptor function. Youngren JF Cell Mol Life Sci. 2007 Apr;64(7-8):873-91.
42. Unilateral anterior crossbite induces aberrant mineral deposition in degenerative temporomandibular cartilage in rats. Zhang M, etal., Osteoarthritis Cartilage. 2016 May;24(5):921-31. doi: 10.1016/j.joca.2015.12.009. Epub 2015 Dec 31.
Additional References at PubMed
PMID:1647027   PMID:3104326   PMID:7830796   PMID:8223581   PMID:9662402   PMID:10024383   PMID:10513816   PMID:11159191   PMID:11289049   PMID:12746903   PMID:17849011   PMID:17897319  
PMID:18162317   PMID:19931660   PMID:21418901   PMID:21674130   PMID:22285541   PMID:22510396   PMID:23027977   PMID:23041369   PMID:23420746   PMID:25344812   PMID:25479107   PMID:27467858  
PMID:28964717   PMID:30111653   PMID:30356045   PMID:37814911  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr8122,518,051 - 22,583,044 (+)NCBIGRCr8
mRatBN7.2120,698,746 - 20,763,741 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl120,698,764 - 20,763,715 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx120,475,435 - 20,539,162 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0126,475,432 - 26,539,171 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0120,675,339 - 20,739,097 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0121,748,201 - 21,813,205 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl121,748,261 - 21,813,371 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0123,228,262 - 23,292,896 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4121,223,678 - 21,287,411 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1121,223,940 - 21,288,766 (+)NCBI
Celera119,451,097 - 19,514,516 (+)NCBICelera
Cytogenetic Map1p12NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh386131,808,020 - 131,895,155 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6131,808,016 - 131,895,155 (+)EnsemblGRCh38hg38GRCh38
GRCh376132,129,160 - 132,216,295 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366132,170,853 - 132,254,043 (+)NCBINCBI36Build 36hg18NCBI36
Build 346132,170,852 - 132,254,043NCBI
Celera6132,876,272 - 132,963,416 (+)NCBICelera
Cytogenetic Map6q23.2NCBI
HuRef6129,704,724 - 129,791,900 (+)NCBIHuRef
CHM1_16132,392,926 - 132,480,050 (+)NCBICHM1_1
T2T-CHM13v2.06133,002,962 - 133,090,181 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391024,513,812 - 24,588,057 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1024,513,812 - 24,588,057 (-)EnsemblGRCm39 Ensembl
GRCm381024,637,914 - 24,712,159 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1024,637,914 - 24,712,159 (-)EnsemblGRCm38mm10GRCm38
MGSCv371024,361,217 - 24,431,908 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361024,330,827 - 24,401,518 (-)NCBIMGSCv36mm8
Celera1025,583,320 - 25,641,223 (-)NCBICelera
Cytogenetic Map10A4NCBI
cM Map1012.26NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495543612,415,737 - 12,480,359 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543612,416,147 - 12,477,214 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1-v25151,797,817 - 151,882,874 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16149,704,715 - 149,789,744 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06129,591,858 - 129,673,000 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16133,698,904 - 133,783,644 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6133,698,640 - 133,783,644 (+)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.11251,985 - 322,081 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1252,103 - 322,718 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha11,243,885 - 1,317,644 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0144,146 - 117,941 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl148,283 - 118,098 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1193,290 - 167,054 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0138,450 - 112,214 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01209,085 - 282,880 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_024404946120,195,622 - 120,237,836 (+)NCBIHiC_Itri_2
SpeTri2.0NW_004937067194,375 - 246,607 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl131,722,721 - 31,796,595 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1131,724,290 - 31,796,594 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2135,240,330 - 35,281,377 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.11341,670,416 - 41,755,549 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604013,807,051 - 13,921,708 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046247535,917,689 - 5,982,308 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247535,918,005 - 5,983,480 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Enpp1
839 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:84
Count of miRNA genes:75
Interacting mature miRNAs:80
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354647Despr8Despair related QTL 80.0000341locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1124744506Rat
2298546Neuinf4Neuroinflammation QTL 45.1nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1128736750Rat
2313053Bss51Bone structure and strength QTL 513.80.0001tibia length (VT:0004357)tibia length (CMO:0000450)1132356093Rat
2313070Bss52Bone structure and strength QTL 524.40.0001body length (VT:0001256)body length (CMO:0000013)1132356093Rat
2313090Bmd69Bone mineral density QTL 694.40.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)1132356093Rat
738020Pia8Pristane induced arthritis QTL 84.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1165833076Rat
1578650Bmd6Bone mineral density QTL 612.2femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)150910843284926Rat
1578651Bmd7Bone mineral density QTL 714.2femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)150910843284926Rat
1578669Bss9Bone structure and strength QTL 96.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)150910843284926Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
1600360Mcs16Mammary carcinoma susceptibility QTL 162.4mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1224439043433040Rat
7421626Bp360Blood pressure QTL 3600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1439328949393289Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
4889451Eae29Experimental allergic encephalomyelitis QTL 295.51nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1592587724697545Rat
631508Sald1Serum aldosterone level QTL 13.7blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)1985600154856001Rat
2302038Pia31Pristane induced arthritis QTL 315.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)11099206555992065Rat
1300167Hrtrt2Heart rate QTL 24.35heart pumping trait (VT:2000009)heart rate (CMO:0000002)11148131275088344Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)11148131282174945Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)11148131282174945Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)11148131282174945Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)11148131282174945Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2317755Glom22Glomerulus QTL 223.8urine protein amount (VT:0005160)urine protein level (CMO:0000591)11148148232355910Rat
1578756Iddm22Insulin dependent diabetes mellitus QTL 222.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)11183518156835181Rat
5684998Bss101Bone structure and strength QTL 1013.6tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)11543162149361612Rat
5684999Bss102Bone structure and strength QTL 1025.50.00000072tibia strength trait (VT:1000284)tibia stiffness (CMO:0001735)11543162149361612Rat
631494Bp95Blood pressure QTL 95400.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)11620621049268520Rat
634353Rends2Renal damage susceptibility QTL 20.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)11933357156983283Rat
1558642Prcr2Prostate cancer resistance QTL 24.3prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)12076315844095856Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2120,704,398 - 20,704,605 (+)MAPPERmRatBN7.2
Rnor_6.0121,753,867 - 21,754,073NCBIRnor6.0
Rnor_5.0123,233,912 - 23,234,118UniSTSRnor5.0
RGSC_v3.4121,229,308 - 21,229,515RGDRGSC3.4
RGSC_v3.4121,229,309 - 21,229,515UniSTSRGSC3.4
RGSC_v3.1121,230,688 - 21,230,894RGD
Celera119,456,728 - 19,456,934UniSTS
RH 3.4 Map1199.8RGD
RH 3.4 Map1199.8UniSTS
RH 2.0 Map1126.9RGD
FHH x ACI Map118.0099RGD
Cytogenetic Map1p12UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2120,761,085 - 20,761,237 (+)MAPPERmRatBN7.2
Rnor_6.0121,810,550 - 21,810,701NCBIRnor6.0
Rnor_5.0123,290,241 - 23,290,392UniSTSRnor5.0
RGSC_v3.4121,285,992 - 21,286,143UniSTSRGSC3.4
Celera119,513,099 - 19,513,248UniSTS
Cytogenetic Map1p12UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 3 21 20 20 9 20 4 29 25 11
Low 22 37 21 10 21 8 11 70 6 16 8
Below cutoff


RefSeq Acc Id: ENSRNOT00000019519   ⟹   ENSRNOP00000019519
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl120,698,764 - 20,763,715 (+)Ensembl
Rnor_6.0 Ensembl121,748,261 - 21,813,371 (+)Ensembl
RefSeq Acc Id: NM_053535   ⟹   NP_445987
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
GRCr8122,518,069 - 22,583,044 (+)NCBI
mRatBN7.2120,698,764 - 20,763,741 (+)NCBI
Rnor_6.0121,748,236 - 21,811,969 (+)NCBI
Rnor_5.0123,228,262 - 23,292,896 (+)NCBI
RGSC_v3.4121,223,678 - 21,287,411 (+)RGD
Celera119,451,097 - 19,514,516 (+)RGD
RefSeq Acc Id: XM_006227692   ⟹   XP_006227754
Rat AssemblyChrPosition (strand)Source
GRCr8122,518,051 - 22,583,044 (+)NCBI
mRatBN7.2120,698,746 - 20,763,741 (+)NCBI
Rnor_6.0121,748,201 - 21,813,205 (+)NCBI
Rnor_5.0123,228,262 - 23,292,896 (+)NCBI
RefSeq Acc Id: XM_039092963   ⟹   XP_038948891
Rat AssemblyChrPosition (strand)Source
GRCr8122,557,702 - 22,583,044 (+)NCBI
mRatBN7.2120,738,390 - 20,763,741 (+)NCBI
RefSeq Acc Id: NP_445987   ⟸   NM_053535
- UniProtKB: G3V7V4 (UniProtKB/TrEMBL),   A6JUK6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006227754   ⟸   XM_006227692
- Peptide Label: isoform X1
- UniProtKB: Q924C3 (UniProtKB/Swiss-Prot),   Q920C8 (UniProtKB/Swiss-Prot),   Q91XQ3 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000019519   ⟸   ENSRNOT00000019519
RefSeq Acc Id: XP_038948891   ⟸   XM_039092963
- Peptide Label: isoform X2
- UniProtKB: A6JUK7 (UniProtKB/TrEMBL)
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q924C3-F1-model_v2 AlphaFold Q924C3 1-906 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13689527
Promoter ID:EPDNEW_R51
Type:single initiation site
Description:ectonucleotide pyrophosphatase/phosphodiesterase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.0121,748,230 - 21,748,290EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:628825 AgrOrtholog
BioCyc Gene G2FUF-62112 BioCyc
Ensembl Genes ENSRNOG00000013994 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000019519 ENTREZGENE
  ENSRNOT00000019519.7 UniProtKB/TrEMBL
Gene3D-CATH 3.40.570.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.720.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  4.10.410.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Alkaline_phosphatase_core_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DNA/RNA_non-sp_Endonuclease UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DNA/RNA_non-sp_Endonuclease_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Extracellular_endonuc_su_A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  His-Me_finger_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Phosphodiest/P_Trfase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Somatomedin_B-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Somatomedin_B_chordata UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Somatomedin_B_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:85496 UniProtKB/Swiss-Prot
  PTHR10151:SF77 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Endonuclease_NS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Phosphodiest UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Somatomedin_B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Enpp1 PhenoGen
PROSITE SMB_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SMB_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000013994 RatGTEx
SMART Endonuclease_NS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NUC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00201 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF53649 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF54060 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF90188 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENPP1_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q91XQ3 UniProtKB/Swiss-Prot
  Q920C8 UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Enpp1  ectonucleotide pyrophosphatase/phosphodiesterase 1      Symbol and Name status set to approved 1299863 APPROVED
2003-02-27 Enpp1  ectonucleotide pyrophosphatase/phosphodiesterase 1      Symbol and Name status set to provisional 70820 PROVISIONAL