Myb (MYB proto-oncogene, transcription factor) - Rat Genome Database

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Gene: Myb (MYB proto-oncogene, transcription factor) Rattus norvegicus
Analyze
Symbol: Myb
Name: MYB proto-oncogene, transcription factor
RGD ID: 1560020
Description: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and WD40-repeat domain binding activity. Involved in several processes, including positive regulation of biosynthetic process; positive regulation of cell population proliferation; and positive regulation of hepatic stellate cell activation. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of RNA polymerase II transcription regulator complex. Biomarker of transient cerebral ischemia. Orthologous to human MYB (MYB proto-oncogene, transcription factor); PARTICIPATES IN interleukin-4 signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 7,12-dimethyltetraphene; aflatoxin B1.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: RGD1560020; RGD1560020_predicted; similar to Myb proto-oncogene protein (C-myb); similar to Myb proto-oncogene protein (C-myb) (predicted); transcriptional activator Myb; v-myb avian myeloblastosis viral oncogene homolog
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8117,759,309 - 17,793,306 (-)NCBIGRCr8
mRatBN7.2115,939,771 - 15,973,367 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl115,939,761 - 15,973,057 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0116,658,178 - 16,690,135 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl116,659,442 - 16,687,817 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0117,817,157 - 17,846,532 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera114,360,650 - 14,392,555 (-)NCBICelera
Cytogenetic Map1p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R)-pantothenic acid  (ISO)
1,2-dimethylhydrazine  (ISO)
1,4-benzoquinone  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-butoxyethanol  (ISO)
2-palmitoylglycerol  (ISO)
3,3'-diindolylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
5-fluorouracil  (ISO)
7,12-dimethyltetraphene  (EXP)
8-Br-cAMP  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
amphetamine  (EXP)
Apafant  (ISO)
aristolochic acid A  (ISO)
atrazine  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzophenanthridine  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
calyculin a  (ISO)
capecitabine  (ISO)
carbon nanotube  (ISO)
catechol  (ISO)
chlordecone  (ISO)
chlorpyrifos  (ISO)
ciprofibrate  (ISO)
clofibrate  (ISO)
clomiphene  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
coumestrol  (ISO)
dexamethasone  (ISO)
diethylstilbestrol  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxifluridine  (ISO)
Enterolactone  (ISO)
entinostat  (ISO)
estrone  (ISO)
eugenol  (ISO)
folic acid  (ISO)
fulvestrant  (ISO)
gemcitabine  (ISO)
genistein  (ISO)
geraniol  (ISO)
glyphosate  (ISO)
hexestrol  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
hydroxyurea  (ISO)
irinotecan  (ISO)
iron(2+) sulfate (anhydrous)  (EXP)
L-ascorbic acid  (EXP)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
malonaldehyde  (EXP)
medroxyprogesterone acetate  (ISO)
mestranol  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
N-(6-acetamidohexyl)acetamide  (ISO)
N-ethyl-N-nitrosourea  (ISO)
ozone  (ISO)
p-anisidine  (ISO)
p-menthan-3-ol  (ISO)
perfluorooctanoic acid  (EXP)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
progesterone  (ISO)
quercetin  (ISO)
raloxifene  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
styrene  (ISO)
succimer  (ISO)
sulforaphane  (ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
thalidomide  (ISO)
thapsigargin  (ISO)
thifluzamide  (ISO)
titanium dioxide  (ISO)
Tributyltin oxide  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
troglitazone  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)
WR-1065  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
B cell differentiation  (ISO)
calcium ion transport  (ISO)
cellular response to hydrogen peroxide  (IEP)
cellular response to interleukin-6  (ISO)
cellular response to leukemia inhibitory factor  (ISO)
cellular response to retinoic acid  (IEP)
embryonic digestive tract development  (ISO)
erythrocyte differentiation  (ISO)
G1/S transition of mitotic cell cycle  (ISO)
homeostasis of number of cells  (ISO)
in utero embryonic development  (ISO)
mitotic cell cycle  (IBA)
myeloid cell differentiation  (ISO)
negative regulation of DNA-templated transcription  (ISO)
negative regulation of hematopoietic progenitor cell differentiation  (ISO)
negative regulation of megakaryocyte differentiation  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
positive regulation of cellular process  (IMP)
positive regulation of collagen biosynthetic process  (IMP)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of glial cell proliferation  (IMP)
positive regulation of hepatic stellate cell activation  (IMP)
positive regulation of hepatic stellate cell proliferation  (IMP)
positive regulation of miRNA transcription  (ISO)
positive regulation of neuron apoptotic process  (IMP)
positive regulation of smooth muscle cell proliferation  (IMP)
positive regulation of testosterone secretion  (IMP)
positive regulation of transcription by RNA polymerase II  (IBA,ISO)
positive regulation of transforming growth factor beta production  (IMP)
regulation of DNA-templated transcription  (ISO)
regulation of gene expression  (ISO)
response to hypoxia  (IEP)
response to ischemia  (IEP)
skeletal muscle cell proliferation  (IEP)
spleen development  (ISO)
stem cell division  (ISO)
T-helper 2 cell differentiation  (ISO)
thymus development  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. c-Myb modulates transcription of the alpha-smooth muscle actin gene in activated hepatic stellate cells. Buck M, etal., Am J Physiol Gastrointest Liver Physiol. 2000 Feb;278(2):G321-8.
2. Proto-oncogene expression in proliferating and differentiating cardiac and skeletal muscle. Claycomb WC and Lanson NA, Biochem J. 1987 Nov 1;247(3):701-6. doi: 10.1042/bj2470701.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Regulation of ischemic neuronal death by E2F4-p130 protein complexes. Iyirhiaro GO, etal., J Biol Chem. 2014 Jun 27;289(26):18202-13. doi: 10.1074/jbc.M114.574145. Epub 2014 May 14.
5. Inhibition of vascular smooth muscle cell proliferation by ribozymes that cleave c-myb mRNA. Jarvis TC, etal., RNA. 1996 May;2(5):419-28.
6. MicroRNA-150 aggravates H2O2-induced cardiac myocyte injury by down-regulating c-myb gene. Li X, etal., Acta Biochim Biophys Sin (Shanghai). 2013 Sep;45(9):734-41. doi: 10.1093/abbs/gmt067. Epub 2013 Jul 3.
7. B-myb and C-myb play required roles in neuronal apoptosis evoked by nerve growth factor deprivation and DNA damage. Liu DX, etal., J Neurosci. 2004 Oct 6;24(40):8720-5.
8. Effects of c-myb antisense RNA on TGF-beta1 and beta1-I collagen expression in cultured hepatic stellate cells. Ma HH, etal., World J Gastroenterol. 2004 Dec 15;10(24):3662-5.
9. Adenovirus-mediated expression of a ribozyme to c-myb mRNA inhibits smooth muscle cell proliferation and neointima formation in vivo. Macejak DG, etal., J Virol. 1999 Sep;73(9):7745-51.
10. Dysregulation of c-Myb pathway by aberrant expression of proto-oncogene MYB provides the basis for malignancy in adult T-cell leukemia/lymphoma cells. Nakano K, etal., Clin Cancer Res. 2016 Jun 15. pii: clincanres.1739.2015.
11. Stimulation of c-jun and c-myb in rat Sertoli cells following exposure to retinoids. Page KC, etal., Biochem Biophys Res Commun. 1996 May 15;222(2):595-600.
12. [Effects of chronic hypoxia on the expression of oncogene jun fos and myb mRNA in rat lung]. Ran P, etal., Zhongguo Ying Yong Sheng Li Xue Za Zhi. 1997 Feb;13(1):21-4.
13. GOA pipeline RGD automated data pipeline
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Comprehensive gene review and curation RGD comprehensive gene curation
16. [Effect of c-myb on hCG-induced testosterone secretion in isolated rat Leydig cells]. Xiao AJ, etal., Sheng Li Xue Bao. 2004 Jun 25;56(3):353-6.
17. [Inhibitory effect of cationic liposome-mediated antisense c-myb oligonucleotide on the growth of glioma]. Zhao D, etal., Hua Xi Yi Ke Da Xue Xue Bao. 2002 Jan;33(1):19-22.
18. Single molecule analysis of c-myb alternative splicing reveals novel classifiers for precursor B-ALL. Zhou YE, etal., PLoS One. 2011;6(8):e22880. doi: 10.1371/journal.pone.0022880. Epub 2011 Aug 11.
Additional References at PubMed
PMID:7987850   PMID:8302594   PMID:10233885   PMID:10523863   PMID:12244173   PMID:12628004   PMID:12660151   PMID:15094381   PMID:16162816   PMID:16847320   PMID:17927961   PMID:19360001  
PMID:20439489   PMID:20484083   PMID:20531406   PMID:21980308   PMID:31210326   PMID:33804806  


Genomics

Comparative Map Data
Myb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8117,759,309 - 17,793,306 (-)NCBIGRCr8
mRatBN7.2115,939,771 - 15,973,367 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl115,939,761 - 15,973,057 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0116,658,178 - 16,690,135 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl116,659,442 - 16,687,817 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0117,817,157 - 17,846,532 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera114,360,650 - 14,392,555 (-)NCBICelera
Cytogenetic Map1p12NCBI
MYB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386135,181,308 - 135,219,172 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6135,181,308 - 135,219,173 (+)EnsemblGRCh38hg38GRCh38
GRCh376135,502,446 - 135,540,310 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366135,544,146 - 135,582,003 (+)NCBINCBI36Build 36hg18NCBI36
Build 346135,544,145 - 135,582,002NCBI
Celera6136,242,804 - 136,280,663 (+)NCBICelera
Cytogenetic Map6q23.3NCBI
HuRef6133,066,684 - 133,104,587 (+)NCBIHuRef
CHM1_16135,764,731 - 135,802,560 (+)NCBICHM1_1
T2T-CHM13v2.06136,369,551 - 136,407,418 (+)NCBIT2T-CHM13v2.0
Myb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391021,000,829 - 21,036,883 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1021,000,834 - 21,036,883 (-)EnsemblGRCm39 Ensembl
GRCm381021,124,930 - 21,160,984 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1021,124,935 - 21,160,984 (-)EnsemblGRCm38mm10GRCm38
MGSCv371020,844,736 - 20,880,790 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361020,814,352 - 20,850,400 (-)NCBIMGSCv36mm8
Celera1021,025,990 - 21,061,964 (-)NCBICelera
Cytogenetic Map10A3NCBI
cM Map109.75NCBI
Myb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554391,521,292 - 1,560,220 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554391,523,516 - 1,560,185 (-)NCBIChiLan1.0ChiLan1.0
MYB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25155,158,995 - 155,196,836 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16153,064,563 - 153,102,392 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06132,952,728 - 132,990,560 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16136,974,525 - 137,086,194 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6137,048,812 - 137,086,194 (+)Ensemblpanpan1.1panPan2
MYB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1127,908,309 - 27,991,984 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl127,908,364 - 27,991,969 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha128,788,584 - 28,872,250 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0128,064,278 - 28,148,012 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl128,064,302 - 28,148,144 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1127,950,250 - 28,034,180 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0127,830,605 - 27,914,242 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0128,141,120 - 28,224,856 (+)NCBIUU_Cfam_GSD_1.0
Myb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946123,017,481 - 123,050,430 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365602,796,697 - 2,829,650 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365602,797,943 - 2,828,813 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MYB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl128,819,503 - 28,856,999 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1128,819,500 - 28,856,222 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2132,265,822 - 32,303,302 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MYB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11338,203,923 - 38,242,148 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1338,203,731 - 38,241,864 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604010,407,630 - 10,446,173 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Myb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248862,455,704 - 2,489,593 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Myb
203 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:155
Count of miRNA genes:110
Interacting mature miRNAs:126
Transcripts:ENSRNOT00000019299, ENSRNOT00000019313
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
1578650Bmd6Bone mineral density QTL 612.2femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)150910843284926Rat
1354647Despr8Despair related QTL 80.0000341locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1124744506Rat
1578651Bmd7Bone mineral density QTL 714.2femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)150910843284926Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)11148131282174945Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
7421626Bp360Blood pressure QTL 3600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1439328949393289Rat
2313070Bss52Bone structure and strength QTL 524.40.0001body length (VT:0001256)body length (CMO:0000013)1132356093Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)11148131282174945Rat
5684998Bss101Bone structure and strength QTL 1013.6tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)11543162149361612Rat
2298546Neuinf4Neuroinflammation QTL 45.1nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1128736750Rat
5684999Bss102Bone structure and strength QTL 1025.57e-07tibia strength trait (VT:1000284)tibia stiffness (CMO:0001735)11543162149361612Rat
1300167Hrtrt2Heart rate QTL 24.35heart pumping trait (VT:2000009)heart rate (CMO:0000002)11148131275088344Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)11148131282174945Rat
2317755Glom22Glomerulus QTL 223.8urine protein amount (VT:0005160)urine protein level (CMO:0000591)11148148232355910Rat
1578756Iddm22Insulin dependent diabetes mellitus QTL 222.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)11183518156835181Rat
631508Sald1Serum aldosterone level QTL 13.7blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)1985600154856001Rat
2313090Bmd69Bone mineral density QTL 694.40.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)1132356093Rat
4889451Eae29Experimental allergic encephalomyelitis QTL 295.51nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1592587724697545Rat
70179Xhs2X-ray hypersensitivity QTL 23.2intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)11532110019121980Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)11148131282174945Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
738020Pia8Pristane induced arthritis QTL 84.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1165833076Rat
1600360Mcs16Mammary carcinoma susceptibility QTL 162.4mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1224439043433040Rat
1578669Bss9Bone structure and strength QTL 96.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)150910843284926Rat
2302038Pia31Pristane induced arthritis QTL 315.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)11099206555992065Rat
2313053Bss51Bone structure and strength QTL 513.80.0001tibia length (VT:0004357)tibia length (CMO:0000450)1132356093Rat

Markers in Region
UniSTS:224764  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2115,959,007 - 15,959,167 (+)MAPPERmRatBN7.2
Rnor_6.0116,677,194 - 16,677,353NCBIRnor6.0
Rnor_5.0117,835,902 - 17,836,061UniSTSRnor5.0
RGSC_v3.4116,527,126 - 16,527,285UniSTSRGSC3.4
Celera114,379,949 - 14,380,108UniSTS
Cytogenetic Map1p12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 8 45 113 88 87 56 25 56 6 205 89 93 43 59 31

Sequence


Ensembl Acc Id: ENSRNOT00000081620   ⟹   ENSRNOP00000069389
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl115,939,764 - 15,971,599 (-)Ensembl
Rnor_6.0 Ensembl116,659,442 - 16,687,817 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000091376   ⟹   ENSRNOP00000072163
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl115,939,761 - 15,973,057 (-)Ensembl
Rnor_6.0 Ensembl116,659,442 - 16,687,817 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000096444   ⟹   ENSRNOP00000084005
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl115,939,764 - 15,971,599 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000099965   ⟹   ENSRNOP00000083005
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl115,939,764 - 15,971,599 (-)Ensembl
RefSeq Acc Id: NM_001427409   ⟹   NP_001414338
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8117,759,309 - 17,792,547 (-)NCBI
RefSeq Acc Id: XM_039098949   ⟹   XP_038954877
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8117,759,309 - 17,793,306 (-)NCBI
mRatBN7.2115,939,771 - 15,973,367 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001414338 (Get FASTA)   NCBI Sequence Viewer  
  XP_038954877 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL93809 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000069389.2
  ENSRNOP00000072163.2
  ENSRNOP00000083005.1
  ENSRNOP00000084005.1
Ensembl Acc Id: ENSRNOP00000069389   ⟸   ENSRNOT00000081620
Ensembl Acc Id: ENSRNOP00000072163   ⟸   ENSRNOT00000091376
RefSeq Acc Id: XP_038954877   ⟸   XM_039098949
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZUL7 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000084005   ⟸   ENSRNOT00000096444
Ensembl Acc Id: ENSRNOP00000083005   ⟸   ENSRNOT00000099965
RefSeq Acc Id: NP_001414338   ⟸   NM_001427409
- UniProtKB: A0A8I5ZY95 (UniProtKB/TrEMBL),   A0A0G2K2A4 (UniProtKB/TrEMBL)
Protein Domains
HTH myb-type   Myb-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K2A4-F1-model_v2 AlphaFold A0A0G2K2A4 1-739 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1560020 AgrOrtholog
BioCyc Gene G2FUF-62183 BioCyc
Ensembl Genes ENSRNOG00000055858 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000081620.2 UniProtKB/TrEMBL
  ENSRNOT00000091376.2 UniProtKB/TrEMBL
  ENSRNOT00000096444.1 UniProtKB/TrEMBL
  ENSRNOT00000099965.1 UniProtKB/TrEMBL
Gene3D-CATH Homeodomain-like UniProtKB/TrEMBL
InterPro C-myb_C UniProtKB/TrEMBL
  Homeodomain-like UniProtKB/TrEMBL
  Myb_dom UniProtKB/TrEMBL
  MYB_TF UniProtKB/TrEMBL
  SANT/Myb UniProtKB/TrEMBL
  Tscrpt_reg_Wos2-domain UniProtKB/TrEMBL
NCBI Gene RGD1560020_predicted ENTREZGENE
PANTHER MYB PROTEIN UniProtKB/TrEMBL
  MYB PROTEIN-RELATED UniProtKB/TrEMBL
  TRANSCRIPTIONAL ACTIVATOR MYB UniProtKB/TrEMBL
Pfam Cmyb_C UniProtKB/TrEMBL
  LMSTEN UniProtKB/TrEMBL
  Myb_DNA-binding UniProtKB/TrEMBL
PhenoGen Myb PhenoGen
PROSITE HTH_MYB UniProtKB/TrEMBL
  MYB_LIKE UniProtKB/TrEMBL
RatGTEx ENSRNOG00000055858 RatGTEx
SMART SANT UniProtKB/TrEMBL
Superfamily-SCOP SSF46689 UniProtKB/TrEMBL
UniProt A0A0G2JV86_RAT UniProtKB/TrEMBL
  A0A0G2K2A4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZUL7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZY95 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-09 Myb  MYB proto-oncogene, transcription factor  Myb  v-myb avian myeloblastosis viral oncogene homolog  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-06-08 Myb  v-myb avian myeloblastosis viral oncogene homolog  RGD1560020  similar to Myb proto-oncogene protein (C-myb)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-05 RGD1560020  similar to Myb proto-oncogene protein (C-myb)  RGD1560020  similar to Myb proto-oncogene protein (C-myb)  Gene reactivated at release of RGSC5.0 assembly 2298974 REACTIVATED