Myb (MYB proto-oncogene, transcription factor)

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Gene: Myb (MYB proto-oncogene, transcription factor) Rattus norvegicus

Analyze

Symbol:

Myb

Name:

MYB proto-oncogene, transcription factor

RGD ID:

1560020

Description:

Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and WD40-repeat domain binding activity. Involved in several processes, including positive regulation of biosynthetic process; positive regulation of cell population proliferation; and positive regulation of hepatic stellate cell activation. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of RNA polymerase II transcription regulator complex. Biomarker of transient cerebral ischemia. Orthologous to human MYB (MYB proto-oncogene, transcription factor); PARTICIPATES IN interleukin-4 signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 7,12-dimethyltetraphene; amphetamine.

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

RGD1560020; RGD1560020_predicted; similar to Myb proto-oncogene protein (C-myb); similar to Myb proto-oncogene protein (C-myb) (predicted); transcriptional activator Myb; v-myb avian myeloblastosis viral oncogene homolog

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	1	15,939,771 - 15,973,367 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	15,939,761 - 15,973,057 (-)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	1	16,658,178 - 16,690,135 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	16,659,442 - 16,687,817 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	17,817,157 - 17,846,532 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	1	14,360,650 - 14,392,555 (-)	NCBI		Celera
Cytogenetic Map	1	p12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

adenoid cystic carcinoma (ISO)

adult T-cell leukemia/lymphoma (ISO)

asthma (ISO)

B-lymphoblastic leukemia/lymphoma (ISO)

Disease Progression (ISO)

essential thrombocythemia (ISS)

Familial Behcet-Like Autoinflammatory Syndrome (ISO)

genetic disease (ISO)

high grade glioma (ISO)

myelofibrosis (ISS)

Neointima (IMP)

neuroblastoma (ISO)

T-cell acute lymphoblastic leukemia (ISO)

transient cerebral ischemia (IEP)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(R)-pantothenic acid (ISO)

1,2-dimethylhydrazine (ISO)

1,4-benzoquinone (ISO)

1-chloro-2,4-dinitrobenzene (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2-butoxyethanol (ISO)

3,3'-diindolylmethane (ISO)

4,4'-sulfonyldiphenol (ISO)

4-(ethoxymethylene)-2-phenyloxazol-5-one (ISO)

5-fluorouracil (ISO)

7,12-dimethyltetraphene (EXP)

8-Br-cAMP (ISO)

afimoxifene (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

amphetamine (EXP)

Apafant (ISO)

aristolochic acid A (ISO)

atrazine (ISO)

benzene (ISO)

benzo[a]pyrene (EXP,ISO)

benzophenanthridine (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

Bisphenol B (ISO)

bisphenol F (ISO)

calcitriol (ISO)

calyculin a (ISO)

capecitabine (ISO)

carbon nanotube (ISO)

catechol (ISO)

chlordecone (ISO)

chlorpyrifos (ISO)

ciprofibrate (ISO)

clofibrate (ISO)

clomiphene (ISO)

cobalt dichloride (ISO)

copper atom (ISO)

copper(0) (ISO)

coumestrol (ISO)

dexamethasone (ISO)

diethylstilbestrol (ISO)

dioxygen (ISO)

dorsomorphin (ISO)

doxifluridine (ISO)

Enterolactone (ISO)

entinostat (ISO)

estrone (ISO)

eugenol (ISO)

folic acid (ISO)

fulvestrant (ISO)

gemcitabine (ISO)

genistein (ISO)

geraniol (ISO)

glyphosate (ISO)

hexestrol (ISO)

hydrogen peroxide (ISO)

hydroquinone (ISO)

hydroxyurea (ISO)

irinotecan (ISO)

iron(2+) sulfate (anhydrous) (EXP)

L-ascorbic acid (EXP)

leflunomide (ISO)

lipopolysaccharide (ISO)

malonaldehyde (EXP)

medroxyprogesterone acetate (ISO)

mestranol (ISO)

methotrexate (ISO)

methyl methanesulfonate (ISO)

methylmercury chloride (ISO)

N-(6-acetamidohexyl)acetamide (ISO)

N-ethyl-N-nitrosourea (ISO)

ozone (ISO)

p-anisidine (ISO)

p-menthan-3-ol (ISO)

phenylmercury acetate (ISO)

pirinixic acid (ISO)

progesterone (ISO)

quercetin (ISO)

raloxifene (ISO)

rotenone (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

SB 431542 (ISO)

silicon dioxide (ISO)

silver atom (ISO)

silver(0) (ISO)

sodium arsenite (ISO)

styrene (ISO)

succimer (ISO)

sulforaphane (ISO)

tamibarotene (ISO)

tamoxifen (ISO)

temozolomide (ISO)

testosterone (ISO)

thalidomide (ISO)

thapsigargin (ISO)

thifluzamide (ISO)

titanium dioxide (ISO)

Tributyltin oxide (ISO)

trichostatin A (ISO)

trimellitic anhydride (ISO)

troglitazone (ISO)

tunicamycin (ISO)

valproic acid (ISO)

vorinostat (ISO)

WR-1065 (ISO)

zinc atom (ISO)

zinc(0) (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

B cell differentiation (ISO)

calcium ion transport (ISO)

cellular response to hydrogen peroxide (IEP)

cellular response to interleukin-6 (ISO)

cellular response to leukemia inhibitory factor (ISO)

cellular response to retinoic acid (IEP)

embryonic digestive tract development (ISO)

erythrocyte differentiation (ISO)

G1/S transition of mitotic cell cycle (ISO)

homeostasis of number of cells (ISO)

in utero embryonic development (ISO)

mitotic cell cycle (IBA)

myeloid cell differentiation (ISO)

negative regulation of DNA-templated transcription (ISO)

negative regulation of hematopoietic progenitor cell differentiation (ISO)

negative regulation of megakaryocyte differentiation (ISO)

negative regulation of transcription by RNA polymerase II (ISO)

positive regulation of cellular process (IMP)

positive regulation of collagen biosynthetic process (IMP)

positive regulation of DNA-templated transcription (ISO)

positive regulation of glial cell proliferation (IMP)

positive regulation of hepatic stellate cell activation (IMP)

positive regulation of hepatic stellate cell proliferation (IMP)

positive regulation of miRNA transcription (ISO)

positive regulation of neuron apoptotic process (IMP)

positive regulation of smooth muscle cell proliferation (IMP)

positive regulation of testosterone secretion (IMP)

positive regulation of transcription by RNA polymerase II (IBA,ISO)

positive regulation of transforming growth factor beta production (IMP)

regulation of DNA-templated transcription (ISO)

regulation of gene expression (ISO)

response to hypoxia (IEP)

response to ischemia (IEP)

skeletal muscle cell proliferation (IEP)

spleen development (ISO)

stem cell division (ISO)

T-helper 2 cell differentiation (ISO)

thymus development (ISO)

Cellular Component

cytosol (ISO)

nucleoplasm (IEA,ISO)

nucleus (IBA,ISO)

RNA polymerase II transcription regulator complex (ISO)

Molecular Function

DNA binding (ISO)

DNA-binding transcription activator activity, RNA polymerase II-specific (ISO)

DNA-binding transcription factor activity (ISO)

DNA-binding transcription factor activity, RNA polymerase II-specific (IBA)

protein binding (ISO)

RNA polymerase II cis-regulatory region sequence-specific DNA binding (IBA,ISO)

WD40-repeat domain binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

interleukin-4 signaling pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	c-Myb modulates transcription of the alpha-smooth muscle actin gene in activated hepatic stellate cells.	Buck M, etal., Am J Physiol Gastrointest Liver Physiol. 2000 Feb;278(2):G321-8.
2.	Proto-oncogene expression in proliferating and differentiating cardiac and skeletal muscle.	Claycomb WC and Lanson NA, Biochem J. 1987 Nov 1;247(3):701-6. doi: 10.1042/bj2470701.
3.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4.	Regulation of ischemic neuronal death by E2F4-p130 protein complexes.	Iyirhiaro GO, etal., J Biol Chem. 2014 Jun 27;289(26):18202-13. doi: 10.1074/jbc.M114.574145. Epub 2014 May 14.
5.	Inhibition of vascular smooth muscle cell proliferation by ribozymes that cleave c-myb mRNA.	Jarvis TC, etal., RNA. 1996 May;2(5):419-28.
6.	MicroRNA-150 aggravates H2O2-induced cardiac myocyte injury by down-regulating c-myb gene.	Li X, etal., Acta Biochim Biophys Sin (Shanghai). 2013 Sep;45(9):734-41. doi: 10.1093/abbs/gmt067. Epub 2013 Jul 3.
7.	B-myb and C-myb play required roles in neuronal apoptosis evoked by nerve growth factor deprivation and DNA damage.	Liu DX, etal., J Neurosci. 2004 Oct 6;24(40):8720-5.
8.	Effects of c-myb antisense RNA on TGF-beta1 and beta1-I collagen expression in cultured hepatic stellate cells.	Ma HH, etal., World J Gastroenterol. 2004 Dec 15;10(24):3662-5.
9.	Adenovirus-mediated expression of a ribozyme to c-myb mRNA inhibits smooth muscle cell proliferation and neointima formation in vivo.	Macejak DG, etal., J Virol. 1999 Sep;73(9):7745-51.
10.	Dysregulation of c-Myb pathway by aberrant expression of proto-oncogene MYB provides the basis for malignancy in adult T-cell leukemia/lymphoma cells.	Nakano K, etal., Clin Cancer Res. 2016 Jun 15. pii: clincanres.1739.2015.
11.	Stimulation of c-jun and c-myb in rat Sertoli cells following exposure to retinoids.	Page KC, etal., Biochem Biophys Res Commun. 1996 May 15;222(2):595-600.
12.	[Effects of chronic hypoxia on the expression of oncogene jun fos and myb mRNA in rat lung].	Ran P, etal., Zhongguo Ying Yong Sheng Li Xue Za Zhi. 1997 Feb;13(1):21-4.
13.	GOA pipeline	RGD automated data pipeline
14.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
15.	Comprehensive gene review and curation	RGD comprehensive gene curation
16.	[Effect of c-myb on hCG-induced testosterone secretion in isolated rat Leydig cells].	Xiao AJ, etal., Sheng Li Xue Bao. 2004 Jun 25;56(3):353-6.
17.	[Inhibitory effect of cationic liposome-mediated antisense c-myb oligonucleotide on the growth of glioma].	Zhao D, etal., Hua Xi Yi Ke Da Xue Xue Bao. 2002 Jan;33(1):19-22.
18.	Single molecule analysis of c-myb alternative splicing reveals novel classifiers for precursor B-ALL.	Zhou YE, etal., PLoS One. 2011;6(8):e22880. doi: 10.1371/journal.pone.0022880. Epub 2011 Aug 11.

Additional References at PubMed

PMID:7987850	PMID:8302594	PMID:10233885	PMID:10523863	PMID:12244173	PMID:12628004	PMID:12660151	PMID:15094381	PMID:16162816	PMID:16847320	PMID:17927961	PMID:19360001
PMID:20439489	PMID:20484083	PMID:20531406	PMID:21980308	PMID:31210326	PMID:33804806

Genomics

Comparative Map Data

Myb
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	1	15,939,771 - 15,973,367 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	15,939,761 - 15,973,057 (-)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	1	16,658,178 - 16,690,135 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	16,659,442 - 16,687,817 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	17,817,157 - 17,846,532 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	1	14,360,650 - 14,392,555 (-)	NCBI		Celera
Cytogenetic Map	1	p12	NCBI

MYB
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	6	135,181,308 - 135,219,172 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	6	135,181,308 - 135,219,173 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	6	135,502,446 - 135,540,310 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	6	135,544,146 - 135,582,003 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	6	135,544,145 - 135,582,002	NCBI
Celera	6	136,242,804 - 136,280,663 (+)	NCBI		Celera
Cytogenetic Map	6	q23.3	NCBI
HuRef	6	133,066,684 - 133,104,587 (+)	NCBI		HuRef
CHM1_1	6	135,764,731 - 135,802,560 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	6	136,369,551 - 136,407,418 (+)	NCBI		T2T-CHM13v2.0

Myb
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	10	21,000,829 - 21,036,883 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	10	21,000,834 - 21,036,883 (-)	Ensembl		GRCm39 Ensembl
GRCm38	10	21,124,930 - 21,160,984 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	10	21,124,935 - 21,160,984 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	10	20,844,736 - 20,880,790 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	10	20,814,352 - 20,850,400 (-)	NCBI		MGSCv36	mm8
Celera	10	21,025,990 - 21,061,964 (-)	NCBI		Celera
Cytogenetic Map	10	A3	NCBI
cM Map	10	9.75	NCBI

Myb
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955439	1,521,292 - 1,560,220 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955439	1,523,516 - 1,560,185 (-)	NCBI	ChiLan1.0	ChiLan1.0

MYB
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	6	153,064,563 - 153,102,392 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	6	132,952,728 - 132,990,560 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	6	136,974,525 - 137,086,194 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	6	137,048,812 - 137,086,194 (+)	Ensembl	panpan1.1		panPan2

MYB
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	1	27,908,309 - 27,991,984 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	1	27,908,364 - 27,991,969 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	1	28,788,584 - 28,872,250 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	1	28,064,278 - 28,148,012 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	1	28,064,302 - 28,148,144 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	1	27,950,250 - 28,034,180 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	1	27,830,605 - 27,914,242 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	1	28,141,120 - 28,224,856 (+)	NCBI		UU_Cfam_GSD_1.0

Myb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404946	123,017,481 - 123,050,430 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936560	2,796,697 - 2,829,650 (+)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936560	2,797,943 - 2,828,813 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

MYB
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	28,819,503 - 28,856,999 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	1	28,819,500 - 28,856,222 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	32,265,822 - 32,303,302 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

MYB
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	13	38,203,923 - 38,242,148 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	13	38,203,731 - 38,241,864 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666040	10,407,630 - 10,446,173 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Myb
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624886	2,455,704 - 2,489,593 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Myb
190 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	155
Count of miRNA genes:	110
Interacting mature miRNAs:	126
Transcripts:	ENSRNOT00000019299, ENSRNOT00000019313
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1354647	Despr8	Despair related QTL 8		0.0000341	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	1	1	24744506	Rat
2298546	Neuinf4	Neuroinflammation QTL 4	5.1		nervous system integrity trait (VT:0010566)	spinal cord RT1-B protein level (CMO:0002132)	1	1	28736750	Rat
2313053	Bss51	Bone structure and strength QTL 51	3.8	0.0001	tibia length (VT:0004357)	tibia length (CMO:0000450)	1	1	32356093	Rat
2313070	Bss52	Bone structure and strength QTL 52	4.4	0.0001	body length (VT:0001256)	body length (CMO:0000013)	1	1	32356093	Rat
2313090	Bmd69	Bone mineral density QTL 69	4.4	0.0001	tibia mineral mass (VT:1000283)	compact volumetric bone mineral density (CMO:0001730)	1	1	32356093	Rat
738020	Pia8	Pristane induced arthritis QTL 8	4.7		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	1	1	65833076	Rat
1578650	Bmd6	Bone mineral density QTL 6	12.2		femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	1	509108	43284926	Rat
1578651	Bmd7	Bone mineral density QTL 7	14.2		femur mineral mass (VT:0010011)	compact volumetric bone mineral density (CMO:0001730)	1	509108	43284926	Rat
1578669	Bss9	Bone structure and strength QTL 9	6.3		femur morphology trait (VT:0000559)	bone trabecular cross-sectional area (CMO:0002311)	1	509108	43284926	Rat
1554320	Bmd1	Bone mineral density QTL 1	12.2	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	1	509108	86060548	Rat
1600360	Mcs16	Mammary carcinoma susceptibility QTL 16	2.4		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	1	2244390	43433040	Rat
7421626	Bp360	Blood pressure QTL 360		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	4393289	49393289	Rat
631688	Hcas2	Hepatocarcinoma susceptibility QTL 2	3	0.0001	liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	1	5925874	115540829	Rat
4889451	Eae29	Experimental allergic encephalomyelitis QTL 29	5.51		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis severity score (CMO:0001419)	1	5925877	24697545	Rat
631508	Sald1	Serum aldosterone level QTL 1	3.7		blood aldosterone amount (VT:0005346)	serum aldosterone level (CMO:0000487)	1	9856001	54856001	Rat
2302038	Pia31	Pristane induced arthritis QTL 31	5.5	0.001	blood autoantibody amount (VT:0003725)	serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)	1	10992065	55992065	Rat
1300167	Hrtrt2	Heart rate QTL 2	4.35		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	1	11481312	75088344	Rat
2313062	Bmd73	Bone mineral density QTL 73	3.9	0.0001	tibia mineral mass (VT:1000283)	compact volumetric bone mineral density (CMO:0001730)	1	11481312	82174945	Rat
2313065	Bss67	Bone structure and strength QTL 67	3.1	0.0001	tibia area (VT:1000281)	tibia total energy absorbed before break (CMO:0001736)	1	11481312	82174945	Rat
2313069	Bss68	Bone structure and strength QTL 68	2.9	0.0001	tibia size trait (VT:0100001)	tibia total energy absorbed before break (CMO:0001736)	1	11481312	82174945	Rat
2313075	Bss66	Bone structure and strength QTL 66	3.4	0.0001	tibia length (VT:0004357)	tibia length (CMO:0000450)	1	11481312	82174945	Rat
2313077	Bss69	Bone structure and strength QTL 69	3.5	0.0001	tibia strength trait (VT:1000284)	bone polar moment of inertia (CMO:0001558)	1	11481312	82174945	Rat
2313092	Bmd72	Bone mineral density QTL 72	2.5	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	1	11481312	82174945	Rat
2313097	Bss70	Bone structure and strength QTL 70	3.5	0.0001	tibia strength trait (VT:1000284)	tibia total energy absorbed before break (CMO:0001736)	1	11481312	82174945	Rat
2317755	Glom22	Glomerulus QTL 22	3.8		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	1	11481482	32355910	Rat
1578756	Iddm22	Insulin dependent diabetes mellitus QTL 22	2.7		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	11835181	56835181	Rat
70179	Xhs2	X-ray hypersensitivity QTL 2	3.2		intestine integrity trait (VT:0010554)	post-insult time to onset of moribundity (CMO:0001896)	1	15321100	19121980	Rat
5684998	Bss101	Bone structure and strength QTL 101	3.6		tibia strength trait (VT:1000284)	tibia ultimate force (CMO:0001734)	1	15431621	49361612	Rat
5684999	Bss102	Bone structure and strength QTL 102	5.5	0.00000072	tibia strength trait (VT:1000284)	tibia stiffness (CMO:0001735)	1	15431621	49361612	Rat

Markers in Region

UniSTS:224764

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	15,959,007 - 15,959,167 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	16,677,194 - 16,677,353	NCBI	Rnor6.0
Rnor_5.0	1	17,835,902 - 17,836,061	UniSTS	Rnor5.0
RGSC_v3.4	1	16,527,126 - 16,527,285	UniSTS	RGSC3.4
Celera	1	14,379,949 - 14,380,108	UniSTS
Cytogenetic Map	1	p12	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3		24	16	18	16			8		3	7
Low		24	13	11	1	11	3	3	64	30	31	4	3
Below cutoff		15	18	12		12	5	5	2	3	6		5

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003753133	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_003753134	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006222838	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006222839	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008774281	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017589834	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039098940	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039098949	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473994	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000008	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000081620 ⟹ ENSRNOP00000069389

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	1	15,939,764 - 15,971,599 (-)	Ensembl
Rnor_6.0 Ensembl	1	16,659,442 - 16,687,817 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000091376 ⟹ ENSRNOP00000072163

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	1	15,939,761 - 15,973,057 (-)	Ensembl
Rnor_6.0 Ensembl	1	16,659,442 - 16,687,817 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000096444 ⟹ ENSRNOP00000084005

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	1	15,939,764 - 15,971,599 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000099965 ⟹ ENSRNOP00000083005

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	1	15,939,764 - 15,971,599 (-)	Ensembl

RefSeq Acc Id:

XM_039098940 ⟹ XP_038954868

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	1	15,939,771 - 15,973,367 (-)	NCBI

RefSeq Acc Id:

XM_039098949 ⟹ XP_038954877

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	1	15,939,771 - 15,973,367 (-)	NCBI

Protein Sequences


Protein RefSeqs	XP_038954868	(Get FASTA)	NCBI Sequence Viewer
	XP_038954877	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL93809	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

ENSRNOP00000069389 ⟸ ENSRNOT00000081620

RefSeq Acc Id:

ENSRNOP00000072163 ⟸ ENSRNOT00000091376

RefSeq Acc Id:	XP_038954877 ⟸ XM_039098949
- Peptide Label:	isoform X2
- UniProtKB:	A0A8I5ZUL7 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038954868 ⟸ XM_039098940
- Peptide Label:	isoform X1
- UniProtKB:	A0A0G2K2A4 (UniProtKB/TrEMBL), A0A8I5ZY95 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSRNOP00000084005 ⟸ ENSRNOT00000096444

RefSeq Acc Id:

ENSRNOP00000083005 ⟸ ENSRNOT00000099965

Protein Domains

HTH myb-type Myb-like

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-A0A0G2K2A4-F1-model_v2	AlphaFold	A0A0G2K2A4	1-739	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1560020	AgrOrtholog
BioCyc Gene	G2FUF-62183	BioCyc
Ensembl Genes	ENSRNOG00000055858	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000069389	ENTREZGENE
	ENSRNOP00000069389.2	UniProtKB/TrEMBL
	ENSRNOP00000072163	ENTREZGENE
	ENSRNOP00000072163.2	UniProtKB/TrEMBL
	ENSRNOP00000083005.1	UniProtKB/TrEMBL
	ENSRNOP00000084005.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000081620	ENTREZGENE
	ENSRNOT00000081620.2	UniProtKB/TrEMBL
	ENSRNOT00000091376	ENTREZGENE
	ENSRNOT00000091376.2	UniProtKB/TrEMBL
	ENSRNOT00000096444.1	UniProtKB/TrEMBL
	ENSRNOT00000099965.1	UniProtKB/TrEMBL
Gene3D-CATH	Homeodomain-like	UniProtKB/TrEMBL
InterPro	C-myb_C	UniProtKB/TrEMBL
	Homeodomain-like	UniProtKB/TrEMBL
	Myb_dom	UniProtKB/TrEMBL
	SANT/Myb	UniProtKB/TrEMBL
	Tscrpt_reg_Wos2-domain	UniProtKB/TrEMBL
NCBI Gene	RGD1560020_predicted	ENTREZGENE
PANTHER	MYB PROTEIN-RELATED	UniProtKB/TrEMBL
	MYB-LIKE DNA-BINDING PROTEIN BAS1	UniProtKB/TrEMBL
Pfam	Cmyb_C	UniProtKB/TrEMBL
	LMSTEN	UniProtKB/TrEMBL
	Myb_DNA-binding	UniProtKB/TrEMBL
PhenoGen	Myb	PhenoGen
PROSITE	HTH_MYB	UniProtKB/TrEMBL
	MYB_LIKE	UniProtKB/TrEMBL
SMART	SANT	UniProtKB/TrEMBL
Superfamily-SCOP	SSF46689	UniProtKB/TrEMBL
UniProt	A0A0G2JV86_RAT	UniProtKB/TrEMBL
	A0A0G2K2A4	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I5ZUL7	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I5ZY95	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-03-09	Myb	MYB proto-oncogene, transcription factor	Myb	v-myb avian myeloblastosis viral oncogene homolog	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2015-06-08	Myb	v-myb avian myeloblastosis viral oncogene homolog	RGD1560020	similar to Myb proto-oncogene protein (C-myb)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2012-07-05	RGD1560020	similar to Myb proto-oncogene protein (C-myb)	RGD1560020	similar to Myb proto-oncogene protein (C-myb)	Gene reactivated at release of RGSC5.0 assembly	2298974	REACTIVATED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - MGI

Imported Annotations - PID (archival)

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Imported Annotations - PID (archival)