Acat1 (acetyl-CoA acetyltransferase 1) - Rat Genome Database

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Gene: Acat1 (acetyl-CoA acetyltransferase 1) Rattus norvegicus
Analyze
Symbol: Acat1
Name: acetyl-CoA acetyltransferase 1
RGD ID: 2016
Description: Enables several functions, including acetyl-CoA C-acetyltransferase activity; coenzyme A binding activity; and identical protein binding activity. Involved in several processes, including adipose tissue development; liver development; and metanephric proximal convoluted tubule development. Located in mitochondrial matrix. Biomarker of end stage renal disease and nephrotic syndrome. Human ortholog(s) of this gene implicated in beta-ketothiolase deficiency and carbohydrate metabolic disorder. Orthologous to human ACAT1 (acetyl-CoA acetyltransferase 1); PARTICIPATES IN 2-aminoadipic 2-oxoadipic aciduria pathway; 3-hydroxy-3-methylglutaryl-CoA lyase deficiency pathway; 3-hydroxyacyl-CoA dehydrogenase deficiency pathway; INTERACTS WITH (+)-schisandrin B; (R,R,R)-alpha-tocopherol; 1,2,4-trimethylbenzene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: acetoacetyl-CoA thiolase; Acetyl-Co A acetyltransferase 1 mitochondrial; Acetyl-Co A acetyltransferase 1, mitochondrial; acetyl-CoA acetyltransferase, mitochondrial; acetyl-Coenzyme A acetyltransferase 1; RATACAL
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Scl16
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8862,876,003 - 62,905,080 (-)NCBIGRCr8
mRatBN7.2853,979,813 - 54,008,861 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl853,979,813 - 54,008,855 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx859,505,211 - 59,534,213 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0857,784,239 - 57,813,235 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0855,648,477 - 55,677,476 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0858,166,990 - 58,195,884 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl858,166,990 - 58,195,884 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0856,749,861 - 56,778,336 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4857,044,478 - 57,072,970 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1857,063,521 - 57,092,024 (-)NCBI
Celera853,470,530 - 53,499,505 (-)NCBICelera
Cytogenetic Map8q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(R,R,R)-alpha-tocopherol  (EXP)
1,1-dichloroethene  (ISO)
1,2,4-trimethylbenzene  (EXP)
1,2-dimethylhydrazine  (ISO)
1,3-dinitrobenzene  (EXP)
1-aminobenzotriazole  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2,2-tetramine  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (EXP)
2-methoxyethanol  (EXP)
3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluoro-1-decanol  (EXP)
3,4-methylenedioxymethamphetamine  (EXP)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime  (ISO)
7,12-dimethyltetraphene  (ISO)
7-ketocholesterol  (ISO)
7H-xanthine  (EXP)
9H-xanthine  (EXP)
acetamide  (EXP)
acrylamide  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
Benzo[b]fluorene  (EXP)
bexarotene  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
cadmium dichloride  (EXP,ISO)
carbon nanotube  (ISO)
chenodeoxycholic acid  (ISO)
chlorotoluron  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (EXP,ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
Cryptotanshinone  (ISO)
cyclosporin A  (ISO)
cyproconazole  (ISO)
DDT  (EXP)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
dicrotophos  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
enzyme inhibitor  (ISO)
epoxiconazole  (ISO)
farnesol  (ISO)
fenofibrate  (EXP,ISO)
finasteride  (EXP)
folic acid  (ISO)
furan  (EXP)
furfural  (ISO)
GDP-beta-S  (ISO)
gentamycin  (EXP)
GW 4064  (ISO)
haloperidol  (ISO)
indometacin  (EXP,ISO)
irinotecan  (ISO)
isobutanol  (ISO)
ivermectin  (ISO)
lead diacetate  (ISO)
leflunomide  (EXP)
melatonin  (EXP,ISO)
methapyrilene  (EXP)
morphine  (EXP)
Muraglitazar  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
nitroglycerin  (EXP)
Nutlin-3  (ISO)
oleic acid  (ISO)
ozone  (EXP)
paracetamol  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (EXP,ISO)
phlorizin  (ISO)
phosphatidylcholine  (EXP)
picoxystrobin  (ISO)
pioglitazone  (ISO)
pirinixic acid  (EXP,ISO)
platycodin D  (ISO)
potassium dichromate  (ISO)
pravastatin  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
propiconazole  (ISO)
quercetin  (ISO)
rac-1,2-dichloropropane  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
rottlerin  (ISO)
sarpogrelate  (ISO)
serotonin  (ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
soybean oil  (EXP)
stigmasterol  (ISO)
streptozocin  (EXP,ISO)
tamoxifen  (EXP)
temozolomide  (ISO)
Tesaglitazar  (EXP)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
tributylstannane  (EXP)
troglitazone  (EXP)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
zaragozic acid A  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
endoplasmic reticulum  (IEA,ISO)
mitochondrial matrix  (IDA)
mitochondrion  (IBA,IDA,IEA,ISO)
peroxisome  (IDA)

Molecular Pathway Annotations     Click to see Annotation Detail View
2-aminoadipic 2-oxoadipic aciduria pathway  (ISO)
3-hydroxy-3-methylglutaryl-CoA lyase deficiency pathway  (ISO)
3-hydroxyacyl-CoA dehydrogenase deficiency pathway  (ISO)
3-hydroxyisobutyric aciduria pathway  (ISO)
3-methylcrotonyl CoA carboxylase 1 deficiency pathway  (ISO)
3-methylglutaconic aciduria type 1 pathway  (ISO)
3-methylglutaconic aciduria type 3 pathway  (ISO)
butanoate metabolic pathway  (IEA,ISO)
carnitine palmitoyltransferase I deficiency pathway  (ISO)
ethylmalonic encephalopathy pathway   (ISO)
fatty acid beta degradation pathway  (ISO)
fatty acid metabolic pathway  (IEA,ISO)
glutaric aciduria type I pathway  (ISO)
glyoxylate and dicarboxylate metabolic pathway  (IEA)
hyperlysinemia pathway  (ISO)
isobutyryl-CoA dehydrogenase deficiency pathway  (ISO)
isovaleric acidemia pathway   (ISO)
ketone bodies metabolic pathway  (IEA,ISO)
Leigh disease pathway  (ISO)
lysine degradation pathway  (IEA,ISO)
malonic aciduria pathway  (ISO)
maple syrup urine disease pathway  (ISO)
medium chain acyl-CoA dehydrogenase deficiency pathway  (ISO)
methylmalonate semialdehyde dehydrogenase deficiency pathway  (ISO)
methylmalonic acidemia pathway  (ISO)
methylmalonic aciduria, cobalamin-related pathway  (ISO)
primary hyperoxaluria type 2 pathway  (ISO)
propanoate metabolic pathway  (IEA,ISO)
propionic acidemia pathway  (ISO)
pyruvate decarboxylase deficiency pathway  (ISO)
pyruvate dehydrogenase E1 deficiency pathway  (ISO)
pyruvate kinase deficiency of red cells pathway   (ISO)
pyruvate metabolic pathway  (IEA,ISO)
saccharopinuria pathway  (ISO)
short-chain acyl-CoA dehydrogenase deficiency pathway  (ISO)
succinyl-CoA:3-oxoacid transferase deficiency pathway  (ISO)
terpenoid biosynthetic pathway  (IEA)
trifunctional protein deficiency pathway  (ISO)
tryptophan metabolic pathway  (IEA)
valine, leucine and isoleucine degradation pathway  (IEA,ISO)
very long-chain acyl-CoA dehydrogenase deficiency pathway  (ISO)

References

References - curated
# Reference Title Reference Citation
1. [A rare type of bone involvement in scleroderma (author's transl)] Bem Z and Birecka A, Pol Przegl Radiol Med Nukl 1978 Mar-Apr;42(2):115-7.
2. The influence of chylomicron remnants on cholesteryl ester metabolism in cultured rat hepatocytes: comparison of the effects of particles enriched in n-3 or n-6 polyunsaturated fatty acids. Botham KM, etal., Biochim Biophys Acta. 2001 Dec 30;1534(2-3):96-109.
3. Niacin improves renal lipid metabolism and slows progression in chronic kidney disease. Cho KH, etal., Biochim Biophys Acta. 2010 Jan;1800(1):6-15. Epub 2009 Oct 28.
4. Glycemia, ketonemia, and brain enzymes of ketone body utilization in suckling and adult rats undernourished from intrauterine life. Escriva F, etal., J Neurochem. 1985 May;44(5):1358-62.
5. Circulating glucose, insulin and ketone bodies and enzymes of ketone body utilization in brain mitochondria from suckling rats treated with high L-thyroxine doses. Escriva F, etal., Rev Esp Fisiol. 1983 Dec;39(4):363-71.
6. Genes of cholesterol metabolism in human atheroma: overexpression of perilipin and genes promoting cholesterol storage and repression of ABCA1 expression. Forcheron F, etal., Arterioscler Thromb Vasc Biol. 2005 Aug;25(8):1711-7. Epub 2005 Jun 16.
7. Molecular cloning and nucleotide sequence of cDNA encoding the entire precursor of rat mitochondrial acetoacetyl-CoA thiolase. Fukao T, etal., J Biochem (Tokyo) 1989 Aug;106(2):197-204.
8. Prenatal diagnosis in a family with mitochondrial acetoacetyl-coenzyme A thiolase deficiency with the use of the polymerase chain reaction followed by the heteroduplex detection method. Fukao T, etal., Prenat Diagn. 1995 Apr;15(4):363-7.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
11. Turnover of matrix proteins in mammalian mitochondria. Huth W, etal., Biochem J. 2002 May 15;364(Pt 1):275-84.
12. Evidence for an in vivo modification of mitochondrial proteins by coenzyme A. Huth W, etal., Biochim Biophys Acta. 1991 Mar 8;1077(1):1-10.
13. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
14. Sterol Regulatory Element-Binding Proteins, Liver X Receptor, ABCA1 Transporter, CD36, Scavenger Receptors A1 and B1 in Nephrotic Kidney. Kim HJ and Vaziri ND, Am J Nephrol. 2009 Jan 16;29(6):607-614.
15. Importance of acyl-coenzyme A:cholesterol acyltransferase 1/2 dual inhibition for anti-atherosclerotic potency of pactimibe. Kitayama K, etal., Eur J Pharmacol. 2006 Jul 1;540(1-3):121-30. Epub 2006 Apr 29.
16. Localization of the pre-squalene segment of the isoprenoid biosynthetic pathway in mammalian peroxisomes. Kovacs WJ, etal., Histochem Cell Biol. 2007 Mar;127(3):273-90. Epub 2006 Dec 19.
17. Overexpression of human diacylglycerol acyltransferase 1, acyl-coa:cholesterol acyltransferase 1, or acyl-CoA:cholesterol acyltransferase 2 stimulates secretion of apolipoprotein B-containing lipoproteins in McA-RH7777 cells. Liang JJ, etal., J Biol Chem 2004 Oct 22;279(43):44938-44. Epub 2004 Aug 11.
18. The course of ketosis and the activity of key enzymes of ketogenesis and ketone-body utilization during development of the postnatal rat. Lockwood EA and Bailey E, Biochem J. 1971 Aug;124(1):249-54.
19. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
20. The acetoacetyl-coenzyme A thiolases of rat brain and their relative activities during postnatal development. Middleton B Biochem J. 1973 Apr;132(4):731-7.
21. Cerebral ketone body metabolism. Morris AA J Inherit Metab Dis. 2005;28(2):109-21.
22. Naltrexone changes the expression of lipid metabolism-related proteins in the endoplasmic reticulum stress induced hepatic steatosis in mice. Moslehi A, etal., Clin Exp Pharmacol Physiol. 2017 Feb;44(2):207-212. doi: 10.1111/1440-1681.12695.
23. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
24. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
25. Biosynthesis of enzymes of rat-liver mitochondrial beta-oxidation. Ozasa H, etal., Eur J Biochem. 1984 Nov 2;144(3):453-8.
26. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
27. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
28. RefSeq and LocusLink: NCBI gene-centered resources Pruitt KD and Maglott DR, Nucleic Acids Res. 2001 Jan 1;29(1):137-40.
29. GOA pipeline RGD automated data pipeline
30. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
31. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
32. Comprehensive gene review and curation RGD comprehensive gene curation
33. Identification of the CoA-modified forms of mitochondrial acetyl-CoA acetyltransferase and of glutamate dehydrogenase as nearest-neighbour proteins. Schwerdt G, etal., Biochem J. 1991 Dec 1;280 ( Pt 2):353-7.
34. [Various roentgenomorphological parallels in ulcers of the pyloro-duodenal area] Sokolov IuN, etal., Vestn Rentgenol Radiol 1978 Nov-Dec;(6):3-11.
35. Thyroid hormones regulate development of energy metabolism enzymes in rat proximal convoluted tubule. Wijkhuisen A, etal., Am J Physiol. 1995 Apr;268(4 Pt 2):F634-42.
36. Activities of enzymes of acetoacetate metabolism in rat brown adipose tissue during development. Williamson DH and Ilic V, Biochem J. 1985 Nov 1;231(3):773-5.
Additional References at PubMed
PMID:1979337   PMID:7592824   PMID:8103405   PMID:12114517   PMID:12865426   PMID:14651853   PMID:17371050   PMID:18614015   PMID:19056867   PMID:23376485   PMID:23533145   PMID:25778834  
PMID:29867124  


Genomics

Comparative Map Data
Acat1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8862,876,003 - 62,905,080 (-)NCBIGRCr8
mRatBN7.2853,979,813 - 54,008,861 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl853,979,813 - 54,008,855 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx859,505,211 - 59,534,213 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0857,784,239 - 57,813,235 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0855,648,477 - 55,677,476 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0858,166,990 - 58,195,884 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl858,166,990 - 58,195,884 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0856,749,861 - 56,778,336 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4857,044,478 - 57,072,970 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1857,063,521 - 57,092,024 (-)NCBI
Celera853,470,530 - 53,499,505 (-)NCBICelera
Cytogenetic Map8q24NCBI
ACAT1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811108,116,705 - 108,147,603 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11108,116,695 - 108,148,957 (+)EnsemblGRCh38hg38GRCh38
GRCh3711107,987,432 - 108,018,330 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611107,497,468 - 107,523,485 (+)NCBINCBI36Build 36hg18NCBI36
Build 3411107,497,467 - 107,523,485NCBI
Celera11105,147,145 - 105,173,805 (+)NCBICelera
Cytogenetic Map11q22.3NCBI
HuRef11103,917,783 - 103,944,520 (+)NCBIHuRef
CHM1_111107,875,420 - 107,902,046 (+)NCBICHM1_1
T2T-CHM13v2.011108,124,245 - 108,155,151 (+)NCBIT2T-CHM13v2.0
Acat1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39953,491,822 - 53,521,650 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl953,491,822 - 53,521,682 (-)EnsemblGRCm39 Ensembl
GRCm38953,580,522 - 53,610,350 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl953,580,522 - 53,610,382 (-)EnsemblGRCm38mm10GRCm38
MGSCv37953,388,627 - 53,418,455 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36953,342,917 - 53,372,745 (-)NCBIMGSCv36mm8
Celera950,840,318 - 50,870,157 (-)NCBICelera
Cytogenetic Map9A5.3NCBI
cM Map929.12NCBI
Acat1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541210,349,593 - 10,369,806 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541210,350,088 - 10,369,806 (+)NCBIChiLan1.0ChiLan1.0
ACAT1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29108,866,381 - 108,892,867 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111109,959,287 - 109,985,798 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011103,008,564 - 103,034,697 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111106,483,563 - 106,509,793 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11106,483,563 - 106,509,787 (+)Ensemblpanpan1.1panPan2
ACAT1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1524,361,301 - 24,379,807 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl524,361,301 - 24,379,812 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha524,286,784 - 24,306,232 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0524,389,926 - 24,409,658 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl524,389,926 - 24,409,643 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1524,437,216 - 24,456,918 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0524,338,692 - 24,358,333 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0524,396,960 - 24,416,675 (-)NCBIUU_Cfam_GSD_1.0
Acat1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494790,910,486 - 90,941,886 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936551591,695 - 626,056 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936551594,647 - 626,016 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACAT1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl936,525,261 - 36,545,633 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1936,525,266 - 36,545,634 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2940,601,654 - 40,622,145 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ACAT1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1199,552,760 - 99,580,079 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl199,552,838 - 99,579,914 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604326,378,291 - 26,404,565 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Acat1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247842,833,344 - 2,879,043 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

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Variants in Acat1
177 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:23
Count of miRNA genes:17
Interacting mature miRNAs:21
Transcripts:ENSRNOT00000010573
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298065Scl16Serum cholesterol level QTL 163.8blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)83085640475856404Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)830848154101699754Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)84186687686866876Rat
11556286Cm81Cardiac mass QTL 810.01heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)83084815461290444Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84269268490165460Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)830848154101699754Rat
1582222Epfw2Epididymal fat weight QTL 23.20.0005epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)83173772976737729Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83558203280582032Rat
4889938Bss89Bone structure and strength QTL 893.8tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)85009524982460899Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)830848154101699754Rat
1300146Rf17Renal function QTL 172.9renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)82824291273242912Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)82824291299525068Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83084815482460899Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)82720571599103503Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)81933115293965294Rat
724514Uae15Urinary albumin excretion QTL 152.9urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)82950266570386295Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83084815461290444Rat
631842Inf1Infertility severity QTL 14.10.001seminal gland mass (VT:0010524)seminal vesicle wet weight (CMO:0001603)82266233067662330Rat
737824Hcar10Hepatocarcinoma resistance QTL 102.9liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)84071306682925667Rat
1359033Bp273Blood pressure QTL 273arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815461290444Rat
1331769Rf39Renal function QTL 393.871urine output (VT:0003620)timed urine volume (CMO:0000260)84186687675097878Rat
61358Bp39Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83555193880551938Rat
1358906Bp253Blood pressure QTL 25340.0004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)84071306693965294Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)82720571599103503Rat
1331744Bp217Blood pressure QTL 2173.398arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815458482492Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)846531639119088626Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)830848259105647037Rat
10402857Bp380Blood pressure QTL 3800.95arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)85396876598968765Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)82720571599103503Rat
631216Stl9Serum triglyceride level QTL 94.710.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)84186701070386132Rat
5684973Bss100Bone structure and strength QTL 1004.7tibia area (VT:1000281)tibia area measurement (CMO:0001382)85009524982460899Rat
61373Mcs4Mammary carcinoma susceptibility QTL 41.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)81629044461290444Rat
2313057Bss76Bone structure and strength QTL 7630.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)83084815482460899Rat
12879878Bw183Body weight QTL 1830.001body mass (VT:0001259)body weight (CMO:0000012)84329616998968765Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)83018886794457446Rat
12879879Cm99Cardiac mass QTL 990.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)84329616998968765Rat
2313067Bss77Bone structure and strength QTL 773.10.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)83084815482460899Rat
12879880Cm100Cardiac mass QTL 1000.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)84329616998968765Rat
12879881Cm101Cardiac mass QTL 1010.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)84329616998968765Rat
12879882Am8Aortic mass QTL 80.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)84329616998968765Rat
12879883Kidm65Kidney mass QTL 650.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)84329616998968765Rat
1358912Bw51Body weight QTL 512.95body mass (VT:0001259)body weight (CMO:0000012)851351728107062046Rat
2313086Bss60Bone structure and strength QTL 604.10.0001tibia length (VT:0004357)tibia length (CMO:0000450)85009524982460899Rat
1558646Swd5Spike wave discharge measurement QTL 53.450.00036brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)81490675159906751Rat
631648Stl5Serum triglyceride level QTL 540.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)82720571554998217Rat
1331837Bw23Body weight QTL 234.190.00007body mass (VT:0001259)body weight (CMO:0000012)84653172299083736Rat
1331838Niddm61Non-insulin dependent diabetes mellitus QTL 613.530.0004blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83646953599083736Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
631271Lecl1Lens clarity QTL 10.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)81898416884531599Rat
2303564Gluco43Glucose level QTL 433blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)82613018771130187Rat
2303570Gluco48Glucose level QTL 482blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)84980583194805831Rat
2313046Bss78Bone structure and strength QTL 783.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)83084815482460899Rat
2303572Insul13Insulin level QTL 132blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)82613018771130187Rat
2301402Bp316Blood pressure QTL 3160.005arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)85396876598968765Rat

Markers in Region
RH128334  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2853,979,961 - 53,980,148 (+)MAPPERmRatBN7.2
Rnor_6.0858,167,139 - 58,167,325NCBIRnor6.0
Rnor_5.0856,750,010 - 56,750,196UniSTSRnor5.0
RGSC_v3.4857,044,202 - 57,044,388UniSTSRGSC3.4
Celera853,470,679 - 53,470,865UniSTS
RH 3.4 Map8582.49UniSTS
Cytogenetic Map8q24.1UniSTS
RH133398  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8862,876,776 - 62,877,749 (+)Marker Load Pipeline
mRatBN7.2853,980,586 - 53,981,559 (+)MAPPERmRatBN7.2
Rnor_6.0858,167,764 - 58,168,736NCBIRnor6.0
Rnor_5.0856,750,635 - 56,751,607UniSTSRnor5.0
RGSC_v3.4857,044,827 - 57,045,799UniSTSRGSC3.4
Celera853,471,304 - 53,472,276UniSTS
RH 3.4 Map8585.5UniSTS
Cytogenetic Map8q24.1UniSTS
BE116581  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2854,008,126 - 54,008,327 (+)MAPPERmRatBN7.2
Rnor_6.0858,195,156 - 58,195,356NCBIRnor6.0
Rnor_5.0856,777,608 - 56,777,808UniSTSRnor5.0
RGSC_v3.4857,072,310 - 57,072,510UniSTSRGSC3.4
Celera853,498,777 - 53,498,977UniSTS
RH 3.4 Map8582.3UniSTS
Cytogenetic Map8q24.1UniSTS
RH141136  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2853,984,561 - 53,984,785 (+)MAPPERmRatBN7.2
Rnor_6.0858,171,739 - 58,171,962NCBIRnor6.0
Rnor_5.0856,754,610 - 56,754,833UniSTSRnor5.0
RGSC_v3.4857,048,802 - 57,049,025UniSTSRGSC3.4
Celera853,475,279 - 53,475,502UniSTS
Cytogenetic Map8q24.1UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000010573   ⟹   ENSRNOP00000010573
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl853,979,813 - 54,008,855 (-)Ensembl
Rnor_6.0 Ensembl858,166,990 - 58,195,884 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000093980   ⟹   ENSRNOP00000077152
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl853,979,813 - 54,008,855 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000105580   ⟹   ENSRNOP00000089343
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl853,979,813 - 54,008,855 (-)Ensembl
RefSeq Acc Id: NM_017075   ⟹   NP_058771
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8862,876,003 - 62,905,042 (-)NCBI
mRatBN7.2853,979,813 - 54,008,855 (-)NCBI
Rnor_6.0858,166,990 - 58,195,884 (-)NCBI
Rnor_5.0856,749,861 - 56,778,336 (-)NCBI
RGSC_v3.4857,044,478 - 57,072,970 (-)RGD
Celera853,470,530 - 53,499,505 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063264936   ⟹   XP_063121006
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8862,877,723 - 62,905,080 (-)NCBI
Protein Sequences
Protein RefSeqs NP_058771 (Get FASTA)   NCBI Sequence Viewer  
  XP_063121006 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAA00401 (Get FASTA)   NCBI Sequence Viewer  
  BAA03016 (Get FASTA)   NCBI Sequence Viewer  
  EDL95519 (Get FASTA)   NCBI Sequence Viewer  
  EDL95520 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000010573
  ENSRNOP00000010573.3
GenBank Protein P17764 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_058771   ⟸   NM_017075
- Peptide Label: precursor
- UniProtKB: P17764 (UniProtKB/Swiss-Prot),   A6J4J7 (UniProtKB/TrEMBL),   A0A8I5Y5Z3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000010573   ⟸   ENSRNOT00000010573
Ensembl Acc Id: ENSRNOP00000089343   ⟸   ENSRNOT00000105580
Ensembl Acc Id: ENSRNOP00000077152   ⟸   ENSRNOT00000093980
RefSeq Acc Id: XP_063121006   ⟸   XM_063264936
- Peptide Label: isoform X1
Protein Domains
Thiolase C-terminal   Thiolase N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P17764-F1-model_v2 AlphaFold P17764 1-424 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695971
Promoter ID:EPDNEW_R6496
Type:initiation region
Name:Acat1_1
Description:acetyl-CoA acetyltransferase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0858,195,873 - 58,195,933EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2016 AgrOrtholog
BioCyc Gene G2FUF-30432 BioCyc
BioCyc Pathway PWY-5177 [glutaryl-CoA degradation] BioCyc
  PWY-7948 [4-oxopentanoate degradation] BioCyc
  PWY-8182 [valproate beta-oxidation] BioCyc
  PWY-922 [mevalonate pathway I (eukaryotes and bacteria)] BioCyc
  PWY66-367 [ketogenesis] BioCyc
  PWY66-368 [ketolysis] BioCyc
BioCyc Pathway Image PWY-5177 BioCyc
  PWY-7948 BioCyc
  PWY-8182 BioCyc
  PWY-922 BioCyc
  PWY66-367 BioCyc
  PWY66-368 BioCyc
Ensembl Genes ENSRNOG00000007862 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000010573 ENTREZGENE
  ENSRNOT00000010573.6 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.47.10 UniProtKB/Swiss-Prot
InterPro Thiolase UniProtKB/Swiss-Prot
  Thiolase-like UniProtKB/Swiss-Prot
  Thiolase_acyl_enz_int_AS UniProtKB/Swiss-Prot
  Thiolase_AS UniProtKB/Swiss-Prot
  Thiolase_C UniProtKB/Swiss-Prot
  Thiolase_CS UniProtKB/Swiss-Prot
  Thiolase_N UniProtKB/Swiss-Prot
KEGG Report rno:25014 UniProtKB/Swiss-Prot
NCBI Gene 25014 ENTREZGENE
PANTHER ACETYL-COA ACETYLTRANSFERASE, MITOCHONDRIAL UniProtKB/Swiss-Prot
  ACETYL-COA C-ACYLTRANSFERASE UniProtKB/Swiss-Prot
Pfam Thiolase_C UniProtKB/Swiss-Prot
  Thiolase_N UniProtKB/Swiss-Prot
PhenoGen Acat1 PhenoGen
PIRSF Ac-CoA_Ac_transf UniProtKB/Swiss-Prot
PROSITE THIOLASE_1 UniProtKB/Swiss-Prot
  THIOLASE_2 UniProtKB/Swiss-Prot
  THIOLASE_3 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000007862 RatGTEx
Superfamily-SCOP SSF53901 UniProtKB/Swiss-Prot
UniProt A0A8I5Y5Z3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AA14_RAT UniProtKB/TrEMBL
  A6J4J6_RAT UniProtKB/TrEMBL
  A6J4J7 ENTREZGENE, UniProtKB/TrEMBL
  P17764 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-07-28 Acat1  acetyl-CoA acetyltransferase 1  Acat1  acetyl-coenzyme A acetyltransferase 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-11-06 Acat1  acetyl-coenzyme A acetyltransferase 1    Acetyl-Co A acetyltransferase 1, mitochondrial  Name updated 625702 APPROVED
2002-06-10 Acat1  Acetyl-Co A acetyltransferase 1, mitochondrial      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to mitochondria 631716
gene_function catalyzes the conversion of 2 acetyl-CoA molecules to acetoacetyl-CoA plus CoA 631716
gene_protein enzyme precursor is 44.7 kDa while the mature enzyme is 41.4 kDa 631716