Acat1 (acetyl-CoA acetyltransferase 1) - Rat Genome Database

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Gene: Acat1 (acetyl-CoA acetyltransferase 1) Rattus norvegicus
Analyze
Symbol: Acat1
Name: acetyl-CoA acetyltransferase 1
RGD ID: 2016
Description: Exhibits several functions, including acetyl-CoA C-acetyltransferase activity; coenzyme A binding activity; and identical protein binding activity. Involved in several processes, including animal organ development; response to hormone; and response to starvation. Localizes to mitochondrial matrix. Biomarker of end stage renal disease and nephrotic syndrome. Human ortholog(s) of this gene implicated in beta-ketothiolase deficiency and carbohydrate metabolic disorder. Orthologous to human ACAT1 (acetyl-CoA acetyltransferase 1); PARTICIPATES IN 2-aminoadipic 2-oxoadipic aciduria pathway; 3-hydroxy-3-methylglutaryl-CoA lyase deficiency pathway; 3-hydroxyacyl-CoA dehydrogenase deficiency pathway; INTERACTS WITH (+)-alpha-tocopherol; (+)-schisandrin B; 1,2,4-trimethylbenzene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: acetoacetyl-CoA thiolase; Acetyl-Co A acetyltransferase 1 mitochondrial; Acetyl-Co A acetyltransferase 1, mitochondrial; acetyl-CoA acetyltransferase, mitochondrial; acetyl-Coenzyme A acetyltransferase 1; RATACAL
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2853,979,813 - 54,008,861 (-)NCBI
Rnor_6.0 Ensembl858,166,990 - 58,195,884 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0858,166,990 - 58,195,884 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0856,749,861 - 56,778,336 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4857,044,478 - 57,072,970 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1857,063,521 - 57,092,024 (-)NCBI
Celera853,470,530 - 53,499,505 (-)NCBICelera
Cytogenetic Map8q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-alpha-tocopherol  (EXP)
(+)-schisandrin B  (EXP)
1,1-dichloroethene  (ISO)
1,2,4-trimethylbenzene  (EXP)
1,2-dimethylhydrazine  (ISO)
1,3-dinitrobenzene  (EXP)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (EXP)
2,2,2-tetramine  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (EXP)
2-methoxyethanol  (EXP)
3,4-methylenedioxymethamphetamine  (EXP)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime  (ISO)
7-ketocholesterol  (ISO)
7H-xanthine  (EXP)
9H-xanthine  (EXP)
acetamide  (EXP)
aflatoxin B1  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
bexarotene  (EXP)
bisphenol A  (EXP)
bisphenol F  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
chenodeoxycholic acid  (ISO)
cisplatin  (ISO)
clofibrate  (EXP,ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
cyproconazole  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP,ISO)
dicrotophos  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
enzyme inhibitor  (ISO)
epoxiconazole  (ISO)
farnesol  (ISO)
fenofibrate  (EXP,ISO)
finasteride  (EXP)
folic acid  (ISO)
furan  (EXP)
GDP-beta-S  (ISO)
gentamycin  (EXP)
GW 4064  (ISO)
indometacin  (ISO)
irinotecan  (ISO)
isobutanol  (ISO)
lead diacetate  (ISO)
leflunomide  (EXP)
methapyrilene  (EXP)
morphine  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
nitroglycerin  (EXP)
oleic acid  (ISO)
ozone  (EXP)
paracetamol  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (EXP,ISO)
phlorizin  (ISO)
phosphatidylcholine  (EXP)
pioglitazone  (ISO)
pirinixic acid  (EXP,ISO)
platycodin D  (ISO)
potassium dichromate  (ISO)
pravastatin  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
propiconazole  (ISO)
quercetin  (ISO)
rac-1,2-dichloropropane  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
rottlerin  (ISO)
sarpogrelate  (ISO)
serotonin  (ISO)
sodium arsenite  (EXP)
soybean oil  (EXP)
stigmasterol  (ISO)
streptozocin  (EXP)
tamoxifen  (EXP)
Tesaglitazar  (EXP)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
titanium dioxide  (ISO)
tributylstannane  (EXP)
troglitazone  (EXP)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vitamin E  (EXP)
zaragozic acid A  (EXP,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
2-aminoadipic 2-oxoadipic aciduria pathway  (ISO)
3-hydroxy-3-methylglutaryl-CoA lyase deficiency pathway  (ISO)
3-hydroxyacyl-CoA dehydrogenase deficiency pathway  (ISO)
3-hydroxyisobutyric aciduria pathway  (ISO)
3-methylcrotonyl CoA carboxylase 1 deficiency pathway  (ISO)
3-methylglutaconic aciduria type 1 pathway  (ISO)
3-methylglutaconic aciduria type 3 pathway  (ISO)
butanoate metabolic pathway  (IEA,ISO)
carnitine palmitoyltransferase I deficiency pathway  (ISO)
ethylmalonic encephalopathy pathway  (ISO)
fatty acid beta degradation pathway  (ISO)
fatty acid metabolic pathway  (IEA,ISO)
glutaric aciduria type I pathway  (ISO)
glyoxylate and dicarboxylate metabolic pathway  (IEA)
hyperlysinemia pathway  (ISO)
isobutyryl-CoA dehydrogenase deficiency pathway  (ISO)
isovaleric acidemia pathway  (ISO)
ketone bodies metabolic pathway  (IEA,ISO)
Leigh disease pathway  (ISO)
lysine degradation pathway  (IEA,ISO)
malonic aciduria pathway  (ISO)
maple syrup urine disease pathway  (ISO)
medium chain acyl-CoA dehydrogenase deficiency pathway  (ISO)
methylmalonate semialdehyde dehydrogenase deficiency pathway  (ISO)
methylmalonic acidemia pathway  (ISO)
methylmalonic aciduria, cobalamin-related pathway  (ISO)
primary hyperoxaluria type 2 pathway  (ISO)
propanoate metabolic pathway  (IEA,ISO)
propionic acidemia pathway  (ISO)
pyruvate decarboxylase deficiency pathway  (ISO)
pyruvate dehydrogenase E1 deficiency pathway  (ISO)
pyruvate kinase deficiency of red cells pathway  (ISO)
pyruvate metabolic pathway  (IEA,ISO)
saccharopinuria pathway  (ISO)
short-chain acyl-CoA dehydrogenase deficiency pathway  (ISO)
succinyl-CoA:3-oxoacid transferase deficiency pathway  (ISO)
terpenoid biosynthetic pathway  (IEA)
trifunctional protein deficiency pathway  (ISO)
tryptophan metabolic pathway  (IEA)
valine, leucine and isoleucine degradation pathway  (IEA,ISO)
very long-chain acyl-CoA dehydrogenase deficiency pathway  (ISO)

References

References - curated
1. Bem Z and Birecka A, Pol Przegl Radiol Med Nukl 1978 Mar-Apr;42(2):115-7.
2. Botham KM, etal., Biochim Biophys Acta. 2001 Dec 30;1534(2-3):96-109.
3. Cho KH, etal., Biochim Biophys Acta. 2010 Jan;1800(1):6-15. Epub 2009 Oct 28.
4. Escriva F, etal., J Neurochem. 1985 May;44(5):1358-62.
5. Escriva F, etal., Rev Esp Fisiol. 1983 Dec;39(4):363-71.
6. Forcheron F, etal., Arterioscler Thromb Vasc Biol. 2005 Aug;25(8):1711-7. Epub 2005 Jun 16.
7. Fukao T, etal., J Biochem (Tokyo) 1989 Aug;106(2):197-204.
8. Fukao T, etal., Prenat Diagn. 1995 Apr;15(4):363-7.
9. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. GOA data from the GO Consortium
11. Huth W, etal., Biochem J. 2002 May 15;364(Pt 1):275-84.
12. Huth W, etal., Biochim Biophys Acta. 1991 Mar 8;1077(1):1-10.
13. KEGG
14. Kim HJ and Vaziri ND, Am J Nephrol. 2009 Jan 16;29(6):607-614.
15. Kitayama K, etal., Eur J Pharmacol. 2006 Jul 1;540(1-3):121-30. Epub 2006 Apr 29.
16. Kovacs WJ, etal., Histochem Cell Biol. 2007 Mar;127(3):273-90. Epub 2006 Dec 19.
17. Liang JJ, etal., J Biol Chem 2004 Oct 22;279(43):44938-44. Epub 2004 Aug 11.
18. Lockwood EA and Bailey E, Biochem J. 1971 Aug;124(1):249-54.
19. MGD data from the GO Consortium
20. Middleton B Biochem J. 1973 Apr;132(4):731-7.
21. Morris AA J Inherit Metab Dis. 2005;28(2):109-21.
22. NCBI rat LocusLink and RefSeq merged data July 26, 2002
23. OMIM Disease Annotation Pipeline
24. Ozasa H, etal., Eur J Biochem. 1984 Nov 2;144(3):453-8.
25. Pipeline to import KEGG annotations from KEGG into RGD
26. Pipeline to import SMPDB annotations from SMPDB into RGD
27. Pruitt KD and Maglott DR, Nucleic Acids Res. 2001 Jan 1;29(1):137-40.
28. RGD automated data pipeline
29. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
30. RGD automated import pipeline for gene-chemical interactions
31. RGD comprehensive gene curation
32. Schwerdt G, etal., Biochem J. 1991 Dec 1;280 ( Pt 2):353-7.
33. Sokolov IuN, etal., Vestn Rentgenol Radiol 1978 Nov-Dec;(6):3-11.
34. Wijkhuisen A, etal., Am J Physiol. 1995 Apr;268(4 Pt 2):F634-42.
35. Williamson DH and Ilic V, Biochem J. 1985 Nov 1;231(3):773-5.
Additional References at PubMed
PMID:1979337   PMID:7592824   PMID:8103405   PMID:12114517   PMID:12865426   PMID:14651853   PMID:17371050   PMID:18614015   PMID:19056867   PMID:23376485   PMID:23533145   PMID:25778834  
PMID:29867124  


Genomics

Candidate Gene Status
Acat1 is a candidate Gene for QTL Scl16
Comparative Map Data
Acat1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2853,979,813 - 54,008,861 (-)NCBI
Rnor_6.0 Ensembl858,166,990 - 58,195,884 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0858,166,990 - 58,195,884 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0856,749,861 - 56,778,336 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4857,044,478 - 57,072,970 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1857,063,521 - 57,092,024 (-)NCBI
Celera853,470,530 - 53,499,505 (-)NCBICelera
Cytogenetic Map8q24NCBI
ACAT1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl11108,116,695 - 108,147,603 (+)EnsemblGRCh38hg38GRCh38
GRCh3811108,116,705 - 108,148,822 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3711107,987,432 - 108,018,330 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611107,497,468 - 107,523,485 (+)NCBINCBI36hg18NCBI36
Build 3411107,497,467 - 107,523,485NCBI
Celera11105,147,145 - 105,173,805 (+)NCBI
Cytogenetic Map11q22.3NCBI
HuRef11103,917,783 - 103,944,520 (+)NCBIHuRef
CHM1_111107,875,420 - 107,902,046 (+)NCBICHM1_1
Acat1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39953,491,822 - 53,521,650 (-)NCBIGRCm39mm39
GRCm39 Ensembl953,491,822 - 53,521,682 (-)Ensembl
GRCm38953,580,522 - 53,610,350 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl953,580,522 - 53,610,382 (-)EnsemblGRCm38mm10GRCm38
MGSCv37953,388,627 - 53,418,455 (-)NCBIGRCm37mm9NCBIm37
MGSCv36953,342,917 - 53,372,745 (-)NCBImm8
Celera950,840,318 - 50,870,157 (-)NCBICelera
Cytogenetic Map9A5.3NCBI
cM Map929.12NCBI
Acat1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541210,349,593 - 10,369,806 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541210,350,088 - 10,369,806 (+)NCBIChiLan1.0ChiLan1.0
ACAT1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.111106,483,563 - 106,509,793 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11106,483,563 - 106,509,787 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v011103,008,564 - 103,034,697 (+)NCBIMhudiblu_PPA_v0panPan3
ACAT1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1524,361,301 - 24,379,807 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl524,361,301 - 24,379,812 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha524,286,784 - 24,306,232 (-)NCBI
ROS_Cfam_1.0524,389,926 - 24,409,658 (-)NCBI
UMICH_Zoey_3.1524,437,216 - 24,456,918 (-)NCBI
UNSW_CanFamBas_1.0524,338,692 - 24,358,333 (-)NCBI
UU_Cfam_GSD_1.0524,396,960 - 24,416,675 (-)NCBI
Acat1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494790,910,486 - 90,941,886 (+)NCBI
SpeTri2.0NW_004936551594,647 - 626,016 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACAT1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl936,525,261 - 36,545,633 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1936,525,266 - 36,545,634 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2940,601,654 - 40,622,145 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ACAT1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1199,552,760 - 99,580,079 (+)NCBI
ChlSab1.1 Ensembl199,552,838 - 99,579,914 (+)Ensembl
Acat1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247842,833,344 - 2,879,043 (+)NCBI

Position Markers
RH128334  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0858,167,139 - 58,167,325NCBIRnor6.0
Rnor_5.0856,750,010 - 56,750,196UniSTSRnor5.0
RGSC_v3.4857,044,202 - 57,044,388UniSTSRGSC3.4
Celera853,470,679 - 53,470,865UniSTS
RH 3.4 Map8582.49UniSTS
Cytogenetic Map8q24.1UniSTS
RH133398  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0858,167,764 - 58,168,736NCBIRnor6.0
Rnor_5.0856,750,635 - 56,751,607UniSTSRnor5.0
RGSC_v3.4857,044,827 - 57,045,799UniSTSRGSC3.4
Celera853,471,304 - 53,472,276UniSTS
RH 3.4 Map8585.5UniSTS
Cytogenetic Map8q24.1UniSTS
BE116581  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0858,195,156 - 58,195,356NCBIRnor6.0
Rnor_5.0856,777,608 - 56,777,808UniSTSRnor5.0
RGSC_v3.4857,072,310 - 57,072,510UniSTSRGSC3.4
Celera853,498,777 - 53,498,977UniSTS
RH 3.4 Map8582.3UniSTS
Cytogenetic Map8q24.1UniSTS
RH141136  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0858,171,739 - 58,171,962NCBIRnor6.0
Rnor_5.0856,754,610 - 56,754,833UniSTSRnor5.0
RGSC_v3.4857,048,802 - 57,049,025UniSTSRGSC3.4
Celera853,475,279 - 53,475,502UniSTS
Cytogenetic Map8q24.1UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)89531047119211942Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810938911120496129Rat
1558646Swd5Spike wave discharge measurement QTL 53.450.00036brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)81766655562666555Rat
61373Mcs4Mammary carcinoma susceptibility QTL 41.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)82071759265717592Rat
631271Lecl1Lens clarity QTL 10.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)82146491991140553Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)821813070100873963Rat
631842Inf1Infertility severity QTL 14.10.001seminal gland mass (VT:0010524)seminal vesicle wet weight (CMO:0001603)82784149672841496Rat
631648Stl5Serum triglyceride level QTL 540.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)82986798359908353Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)829867983106526740Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)829867983106526740Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)829867983106526740Rat
2303564Gluco43Glucose level QTL 433blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)83014480075144800Rat
2303572Insul13Insulin level QTL 132blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)83014480075144800Rat
1331804Cm30Cardiac mass QTL 303.77443heart mass (VT:0007028)heart wet weight (CMO:0000069)83091811258858224Rat
1300146Rf17Renal function QTL 172.9renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)83091811275918112Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)830918112107206309Rat
724514Uae15Urinary albumin excretion QTL 152.9urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)83220198175971421Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)832888352101374135Rat
1331744Bp217Blood pressure QTL 2173.398arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83355866062857995Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83355866065717592Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83355866065717592Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83355866065717592Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83355866065717592Rat
1359033Bp273Blood pressure QTL 273arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83355866065717592Rat
11556286Cm81Cardiac mass QTL 810.01heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)83355866065717592Rat
2313046Bss78Bone structure and strength QTL 783.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)83355866089058369Rat
2313057Bss76Bone structure and strength QTL 7630.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)83355866089058369Rat
2313067Bss77Bone structure and strength QTL 773.10.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)83355866089058369Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83355866089058369Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)833558660109028082Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)833558660109028082Rat
1578755Pur5Proteinuria QTL 53.30.0001total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)833558660109028082Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)833558764113580387Rat
1298065Scl16Serum cholesterol level QTL 163.8blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)83504141480041414Rat
1582222Epfw2Epididymal fat weight QTL 23.20.0005epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)83592559480925594Rat
1331838Niddm61Non-insulin dependent diabetes mellitus QTL 613.530.0004blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)839230130106506973Rat
61358Bp39Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83992790184927901Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83995802284958022Rat
737824Hcar10Hepatocarcinoma resistance QTL 102.9liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)84421919789542960Rat
1358906Bp253Blood pressure QTL 25340.0004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)844219197100873963Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)844458129118087517Rat
1331769Rf39Renal function QTL 393.871urine output (VT:0003620)timed urine volume (CMO:0000260)84571234480003418Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)84571234490712344Rat
631216Stl9Serum triglyceride level QTL 94.710.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)84571247575971259Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84658843796998640Rat
12879882Am8Aortic mass QTL 80.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)847200750106394378Rat
12879878Bw183Body weight QTL 1830.001body mass (VT:0001259)body weight (CMO:0000012)847200750106394378Rat
12879879Cm99Cardiac mass QTL 990.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)847200750106394378Rat
12879880Cm100Cardiac mass QTL 1000.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)847200750106394378Rat
12879881Cm101Cardiac mass QTL 1010.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)847200750106394378Rat
12879883Kidm65Kidney mass QTL 650.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)847200750106394378Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)850529480128036471Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)850529480128036471Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)850529480128036471Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)850529480128036471Rat
1331837Bw23Body weight QTL 234.190.00007body mass (VT:0001259)body weight (CMO:0000012)850529563106506973Rat
2313086Bss60Bone structure and strength QTL 604.10.0001tibia length (VT:0004357)tibia length (CMO:0000450)85406504489058369Rat
4889938Bss89Bone structure and strength QTL 893.8tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)85406504489058369Rat
5684973Bss100Bone structure and strength QTL 1004.7tibia area (VT:1000281)tibia area measurement (CMO:0001382)85406504489058369Rat
1358912Bw51Body weight QTL 512.95body mass (VT:0001259)body weight (CMO:0000012)855435004115812386Rat
2303570Gluco48Glucose level QTL 482blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)855659105100659105Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:23
Count of miRNA genes:17
Interacting mature miRNAs:21
Transcripts:ENSRNOT00000010573
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000010573   ⟹   ENSRNOP00000010573
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl858,166,990 - 58,195,884 (-)Ensembl
RefSeq Acc Id: NM_017075   ⟹   NP_058771
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2853,979,813 - 54,008,855 (-)NCBI
Rnor_6.0858,166,990 - 58,195,884 (-)NCBI
Rnor_5.0856,749,861 - 56,778,336 (-)NCBI
RGSC_v3.4857,044,478 - 57,072,970 (-)RGD
Celera853,470,530 - 53,499,505 (-)NCBI
Sequence:
RefSeq Acc Id: XR_005487742
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2853,979,819 - 54,008,861 (-)NCBI
Protein Sequences
Protein RefSeqs NP_058771 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAA00401 (Get FASTA)   NCBI Sequence Viewer  
  BAA03016 (Get FASTA)   NCBI Sequence Viewer  
  EDL95519 (Get FASTA)   NCBI Sequence Viewer  
  EDL95520 (Get FASTA)   NCBI Sequence Viewer  
  P17764 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_058771   ⟸   NM_017075
- Peptide Label: precursor
- UniProtKB: P17764 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000010573   ⟸   ENSRNOT00000010573

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695971
Promoter ID:EPDNEW_R6496
Type:initiation region
Name:Acat1_1
Description:acetyl-CoA acetyltransferase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0858,195,873 - 58,195,933EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Damaging Variants


Assembly: Rnor_5.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
8 56756623 56756624 T C snv FHH/EurMcwi (MCW), FHL/EurMcwi (MCW), DOB/Oda (KyushuU), FHH/EurMcwi (KNAW), FHL/EurMcwi (KNAW), LL/MavRrrc (KNAW)


Assembly: Rnor_6.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
8 58173752 58173753 T C snv FHH/EurMcwi (MCW), FHL/EurMcwi (MCW), LL/MavRrrc (RGD), FHH/EurMcwi (RGD), FHL/EurMcwi (RGD)


Assembly: RGSC_v3.4

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
8 57050815 57050816 T C snv FHH/EurMcwi (MDC), FHH/EurMcwi (MCW), LL/MavRrrc (ICL), FHH/EurMcwi (ICL), FHL/EurMcwi (ICL), FHL/EurMcwi (MCW)


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2016 AgrOrtholog
Ensembl Genes ENSRNOG00000007862 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000010573 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000010573 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.47.10 UniProtKB/Swiss-Prot
InterPro Thiolase UniProtKB/Swiss-Prot
  Thiolase-like UniProtKB/Swiss-Prot
  Thiolase_acyl_enz_int_AS UniProtKB/Swiss-Prot
  Thiolase_AS UniProtKB/Swiss-Prot
  Thiolase_C UniProtKB/Swiss-Prot
  Thiolase_CS UniProtKB/Swiss-Prot
  Thiolase_N UniProtKB/Swiss-Prot
KEGG Report rno:25014 UniProtKB/Swiss-Prot
NCBI Gene 25014 ENTREZGENE
Pfam Thiolase_C UniProtKB/Swiss-Prot
  Thiolase_N UniProtKB/Swiss-Prot
PhenoGen Acat1 PhenoGen
PIRSF Ac-CoA_Ac_transf UniProtKB/Swiss-Prot
PROSITE THIOLASE_1 UniProtKB/Swiss-Prot
  THIOLASE_2 UniProtKB/Swiss-Prot
  THIOLASE_3 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF53901 UniProtKB/Swiss-Prot
TIGRFAMs AcCoA-C-Actrans UniProtKB/Swiss-Prot
UniProt P17764 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-07-28 Acat1  acetyl-CoA acetyltransferase 1  Acat1  acetyl-coenzyme A acetyltransferase 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-11-06 Acat1  acetyl-coenzyme A acetyltransferase 1    Acetyl-Co A acetyltransferase 1, mitochondrial  Name updated 625702 APPROVED
2002-06-10 Acat1  Acetyl-Co A acetyltransferase 1, mitochondrial      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to mitochondria 631716
gene_function catalyzes the conversion of 2 acetyl-CoA molecules to acetoacetyl-CoA plus CoA 631716
gene_protein enzyme precursor is 44.7 kDa while the mature enzyme is 41.4 kDa 631716