Gene: Acat1 (acetyl-CoA acetyltransferase 1) Rattus norvegicus
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Symbol: Acat1
Name: acetyl-CoA acetyltransferase 1
Description: ENCODES a protein that exhibits acetyl-CoA C-acetyltransferase activity; coenzyme binding; enzyme binding; INVOLVED IN adipose tissue development; brain development; liver development; PARTICIPATES IN 2-aminoadipic 2-oxoadipic aciduria pathway; 3-hydroxy-3-methylglutaryl-CoA lyase deficiency pathway; 3-hydroxyacyl-CoA dehydrogenase deficiency pathway; ASSOCIATED WITH end stage renal failure; nephrotic syndrome; arteriosclerosis (ortholog); FOUND IN mitochondrial matrix; mitochondrion; INTERACTS WITH (+)-alpha-tocopherol; 1,2,4-trimethylbenzene; 1,3-dinitrobenzene
AGR Description: Exhibits several functions, including acetyl-CoA C-acetyltransferase activity, coenzyme binding activity, and enzyme binding activity; involved in several processes, including animal organ development, protein homooligomerization, and response to hormone; localizes to the mitochondrial matrix; biomarker of end stage renal failure and nephrotic syndrome; orthologous to human ACAT1 (acetyl-CoA acetyltransferase 1).
Merged Description: Exhibits several functions, including acetyl-CoA C-acetyltransferase activity, coenzyme binding activity, and enzyme binding activity; involved in several processes, including animal organ development, protein homooligomerization, and response to hormone; localizes to the mitochondrial matrix; biomarker of end stage renal failure and nephrotic syndrome; orthologous to human ACAT1 (acetyl-CoA acetyltransferase 1); PARTICIPATES IN 2-aminoadipic 2-oxoadipic aciduria pathway; 3-hydroxy-3-methylglutaryl-CoA lyase deficiency pathway; 3-hydroxyacyl-CoA dehydrogenase deficiency pathway; INTERACTS WITH (+)-alpha-tocopherol; 1,2,4-trimethylbenzene; 1,3-dinitrobenzene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: acetoacetyl-CoA thiolase; Acetyl-Co A acetyltransferase 1 mitochondrial; Acetyl-Co A acetyltransferase 1, mitochondrial; acetyl-CoA acetyltransferase, mitochondrial; acetyl-Coenzyme A acetyltransferase 1; RATACAL
Orthologs:
Homo sapiens (human) : ACAT1 (acetyl-CoA acetyltransferase 1)  HGNC  Alliance
Mus musculus (house mouse) : Acat1 (acetyl-Coenzyme A acetyltransferase 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Acat1 (acetyl-CoA acetyltransferase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : ACAT1 (acetyl-CoA acetyltransferase 1)
Canis lupus familiaris (dog) : ACAT1 (acetyl-CoA acetyltransferase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Acat1 (acetyl-CoA acetyltransferase 1)
Sus scrofa (pig) : ACAT1 (acetyl-CoA acetyltransferase 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0858,166,990 - 58,195,884 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0856,749,861 - 56,778,336 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4857,044,478 - 57,072,970 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1857,063,521 - 57,092,024 (-)NCBI
Celera853,470,530 - 53,499,505 (-)NCBICelera
Cytogenetic Map8q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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References - uncurated
RGD Disease Portals

Genomics

Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
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Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Acat1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2016
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-04-12
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.