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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2016
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Acat1
Name: acetyl-CoA acetyltransferase 1
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Acat1decreases expressionEXP 6480464CTDCisplatin results in decreased expression of ACAT1 mRNAPMID:36006825
Acat1multiple interactionsEXP 6480464CTDMelatonin inhibits the reaction [Cisplatin results in decreased expression of ACAT1 mRNA]PMID:36006825
Acat1decreases expressionISOAcat1 (Mus musculus)6480464CTDCisplatin results in decreased expression of ACAT1 mRNAPMID:35367536
Acat1increases expressionISOACAT1 (Homo sapiens)6480464CTDCisplatin results in increased expression of ACAT1 mRNAPMID:27392435
Acat1multiple interactionsISOAcat1 (Mus musculus)6480464CTDMelatonin inhibits the reaction [Cisplatin results in decreased expression of ACAT1 mRNA]PMID:35367536
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