RGD Reference Report - Thyroid hormones regulate development of energy metabolism enzymes in rat proximal convoluted tubule. - Rat Genome Database

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Thyroid hormones regulate development of energy metabolism enzymes in rat proximal convoluted tubule.

Authors: Wijkhuisen, A  Djouadi, F  Vilar, J  Merlet-Benichou, C  Bastin, J 
Citation: Wijkhuisen A, etal., Am J Physiol. 1995 Apr;268(4 Pt 2):F634-42.
RGD ID: 2326090
Pubmed: PMID:7733320   (View Abstract at PubMed)

Ketone bodies represent preferred energy substrates in the adult rat proximal tubule. They are abundant in the plasma of suckling rats and might represent an important oxidative substrate for the immature proximal tubule. The postnatal development of two enzymes involved in ketone body oxidation pathway, 3-ketoacid-CoA transferase and acetoacetyl-CoA thiolase, and of citrate synthase and carnitine acetyltransferase was studied in microdissected rat proximal convoluted tubule (PCT) at 1, 8, 16, and 21 days after birth. The enzyme levels in PCT of juxtamedullary and subcapsular nephrons were compared at 8, 16, and 21 days. A role of thyroid hormones in regulating the development of these enzymes was investigated by studying 8- and 21-day-old pups made hypothyroid by propylthiouracyl (PTU) treatment, as well as 21-day hyperthyroid rats. PTU treatment had no effect on enzyme activities on day 8. In contrast, the activity of all mitochondrial enzymes, except acetoacetyl-CoA thiolase, was significantly decreased in 21-day-old hypothyroid pups. In hypothyroid animals, the normal development of 3-ketoacid-CoA transferase, citrate synthase, and carnitine acetyltransferase could be restored after treatment by triiodothyronine (T3). In addition, one single injection of T3 to 8-day-old control pups induced a precocious rise in the activity of 3-ketoacid-CoA transferase, citrate synthase, and carnitine acetyltransferase in juxtamedullary PCT and in the activity of citrate synthase and carnitine acetyltransferase in subcapsular PCT. Altogether, these results point out the importance of the postnatal physiological rise in T3 in triggering the development of some mitochondrial oxidative enzymes in the PCT.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Acat1Ratmetanephric proximal convoluted tubule development  IEP  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Acat1  (acetyl-CoA acetyltransferase 1)


Additional Information