Ucp3 (uncoupling protein 3) - Rat Genome Database
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Gene: Ucp3 (uncoupling protein 3) Rattus norvegicus
Analyze
Symbol: Ucp3
Name: uncoupling protein 3
RGD ID: 3933
Description: Predicted to have oxidative phosphorylation uncoupler activity. Involved in several processes, including response to activity; response to insulin; and response to superoxide. Localizes to mitochondrion. Used to study type 2 diabetes mellitus. Biomarker of congestive heart failure; hypertension; hyperthyroidism; hypothyroidism; and prediabetes syndrome. Human ortholog(s) of this gene implicated in coronary restenosis; diabetic neuropathy; glucose metabolism disease (multiple); and obesity. Orthologous to human UCP3 (uncoupling protein 3); INTERACTS WITH (+)-catechin; ammonium chloride; amphetamine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: mitochondrial uncoupling protein 3; solute carrier family 25 member 9; UCP 3; uncoupling protein 3 (mitochondrial, proton carrier); Uncoupling protein 3 mitochondrial; Uncoupling protein 3, mitochondrial
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01165,482,912 - 165,495,895 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1165,482,155 - 165,496,206 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01171,683,566 - 171,697,139 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41157,896,001 - 157,909,608 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11157,974,793 - 157,988,399 (+)NCBI
Celera1152,898,320 - 152,911,676 (+)NCBICelera
Cytogenetic Map1q32NCBI
RH 3.4 Map11258.1RGD
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (EXP)
(+)-dexrazoxane  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (ISO)
3,5-diethoxycarbonyl-1,4-dihydrocollidine  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-methyl-4-oxido-2-pyrazin-4-iumcarboxylic acid  (ISO)
albuterol  (ISO)
aldehydo-D-glucose  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
aristolochic acid  (ISO)
ATP  (ISO)
beauvericin  (ISO)
bezafibrate  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP)
capsaicin  (EXP)
capsiate  (EXP)
carbon nanotube  (ISO)
ciglitazone  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
D-glucose  (ISO)
dehydroepiandrosterone  (EXP)
dexamethasone  (EXP)
dioxygen  (ISO)
doxorubicin  (EXP,ISO)
enniatin  (ISO)
fenofibrate  (EXP)
flavonoids  (EXP)
folic acid  (ISO)
fructose  (EXP)
glucose  (ISO)
GW 7647  (ISO)
isoprenaline  (EXP,ISO)
kaempferol  (ISO)
lipopolysaccharide  (EXP)
losartan  (EXP)
lutein  (ISO)
myo-inositol hexakisphosphate  (ISO)
nevirapine  (EXP)
ochratoxin A  (ISO)
oleic acid  (EXP,ISO)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
phenformin  (EXP)
picolinic acid  (EXP)
picrotoxin  (EXP)
pirinixic acid  (EXP,ISO)
potassium dichromate  (ISO)
propanal  (ISO)
quercetin  (ISO)
reactive oxygen species  (ISO)
resveratrol  (EXP,ISO)
rotenone  (EXP)
SB 203580  (ISO)
stavudine  (ISO)
streptozocin  (ISO)
T-2 toxin  (EXP)
telmisartan  (ISO)
testosterone  (ISO)
titanium dioxide  (ISO)
topiramate  (EXP)
triacsin C  (ISO)
trichloroethene  (ISO)
troglitazone  (EXP,ISO)
valproic acid  (ISO)
venlafaxine hydrochloride  (EXP)
vinclozolin  (EXP)
zinc atom  (EXP,ISO)
zinc sulfate  (EXP)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
1. Argyropoulos G, etal., J Clin Invest. 1998 Oct 1;102(7):1345-51.
2. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
3. Bo H, etal., Sheng Li Xue Bao. 2008 Dec 25;60(6):767-776.
4. Boss O, etal., FEBS Lett 1997 May 12;408(1):39-42.
5. Bugger H, etal., Cancer Chemother Pharmacol. 2011 Jun;67(6):1381-8. doi: 10.1007/s00280-010-1441-7. Epub 2010 Aug 31.
6. Bugger H, etal., Diabetes. 2008 Nov;57(11):2924-32. Epub 2008 Aug 4.
7. Casas F, etal., PLoS One. 2009 May 20;4(5):e5631. doi: 10.1371/journal.pone.0005631.
8. Choi CS, etal., J Clin Invest. 2007 Jul;117(7):1995-2003.
9. Clapham JC, etal., Biochem Biophys Res Commun. 2001 Oct 12;287(5):1058-62.
10. Clapham JC, etal., Nature 2000 Jul 27;406(6794):415-8.
11. Dalgaard LT, etal., Diabetologia. 2001 Aug;44(8):1065-7.
12. de Lange P, etal., Endocrinology. 2007 Aug;148(8):4064-72. Epub 2007 May 3.
13. Du Z, etal., Hear Res. 2012 May;287(1-2):15-24. doi: 10.1016/j.heares.2012.04.012. Epub 2012 Apr 21.
14. Echtay KS, etal., Nature 2002 Jan 3;415(6867):96-9.
15. Fukunaga Y, etal., J Hypertens. 2000 Sep;18(9):1233-8.
16. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
17. GOA data from the GO Consortium
18. Guillet-Deniau I, etal., Diabetes 2002 Jun;51(6):1722-8.
19. Gullicksen PS, etal., Physiol Behav 2002 Apr 1;75(4):473-82.
20. Guo JJ, etal., Biochem Biophys Res Commun. 2005 Jul 1;332(2):602-8.
21. Hamada T, etal., Metabolism. 2008 Mar;57(3):410-5.
22. Harper ME, etal., Diabetes. 2002 Aug;51(8):2459-66.
23. Havel PJ, etal., Diabetes. 2000 Feb;49(2):244-52.
24. Hoshovs'ka IuV, etal., Fiziol Zh. 2009;55(3):26-36.
25. Hsu YH, etal., Diabetes. 2008 Apr;57(4):1101-7. Epub 2008 Jan 25.
26. Jakus PB, etal., FEBS Lett 2002 May 22;519(1-3):210-4.
27. Jiang N, etal., Free Radic Biol Med. 2009 Jan 15;46(2):138-45. Epub 2008 Oct 9.
28. Jones TE, etal., Am J Physiol Endocrinol Metab 2003 Jan;284(1):E96-101.
29. Kitahara T, etal., Hear Res. 2004 Oct;196(1-2):39-48.
30. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
31. Larkin S, etal., Biochem Biophys Res Commun. 1997 Nov 7;240(1):222-7.
32. Matsuda J, etal., FEBS Lett 1997 Nov 24;418(1-2):200-4.
33. Meirhaeghe A, etal., Diabetologia. 2000 Nov;43(11):1424-8.
34. Mensink M, etal., Diabetes Obes Metab. 2007 Jul;9(4):594-6.
35. MGD data from the GO Consortium
36. Minnaard R, etal., FEBS Lett. 2006 Oct 2;580(22):5172-6. Epub 2006 Sep 5.
37. Mori Y, etal., J Atheroscler Thromb. 2004;11(4):224-31.
38. Murray AJ, etal., J Mol Cell Cardiol. 2008 Apr;44(4):694-700. Epub 2008 Feb 9.
39. NCBI rat LocusLink and RefSeq merged data July 26, 2002
40. Ochoa MC, etal., Mol Genet Metab. 2007 Dec;92(4):351-8. Epub 2007 Sep 17.
41. Oguri M, etal., Int J Mol Med. 2007 Oct;20(4):533-8.
42. OMIM Disease Annotation Pipeline
43. RGD automated data pipeline
44. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
45. RGD automated import pipeline for gene-chemical interactions
46. Rudofsky G Jr, etal., Diabetes Care. 2006 Jan;29(1):89-94.
47. Ryu JW, etal., Biochem Biophys Res Commun. 2003 Apr 4;303(2):726-31.
48. Schrauwen P, etal., Diabetes. 2001 Dec;50(12):2870-3.
49. Son C, etal., Diabetologia. 2004 Jan;47(1):47-54. Epub 2003 Dec 12.
50. Sprague JE, etal., J Pharmacol Exp Ther. 2007 Jan;320(1):274-80. Epub 2006 Sep 29.
51. Stavinoha MA, etal., Am J Physiol Endocrinol Metab. 2004 Nov;287(5):E888-95. Epub 2004 Aug 3.
52. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
53. Strutyns'ka NA, etal., Fiziol Zh. 2009;55(3):44-54.
54. Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
55. Vettor R, etal., Int J Obes Relat Metab Disord 2002 Jun;26(6):838-47.
56. Walder K, etal., Hum Mol Genet. 1998 Sep;7(9):1431-5.
57. Wang S, etal., Ann N Y Acad Sci. 2002 Jun;967:112-9.
58. Wyrwoll CS, etal., J Endocrinol. 2008 Sep;198(3):571-9. Epub 2008 Jun 30.
59. Zungu M, etal., Am J Physiol Heart Circ Physiol. 2007 Nov;293(5):H2819-25. Epub 2007 Aug 17.
Additional References at PubMed
PMID:9506477   PMID:9725803   PMID:10748195   PMID:10748196   PMID:11707458   PMID:12222743   PMID:12397391   PMID:12466947   PMID:12603007   PMID:12676547   PMID:12692085   PMID:12706490  
PMID:12721157   PMID:12750152   PMID:12782304   PMID:12813156   PMID:12912909   PMID:14605003   PMID:14651853   PMID:14733944   PMID:15064282   PMID:15262223   PMID:15308491   PMID:15346231  
PMID:15349725   PMID:15489334   PMID:15757654   PMID:15886224   PMID:16079144   PMID:16084485   PMID:16329595   PMID:16387447   PMID:16434555   PMID:16595124   PMID:17761668   PMID:17878603  
PMID:17884810   PMID:18239634   PMID:18614015   PMID:18685530   PMID:19227473   PMID:19954423   PMID:20428795   PMID:21084676   PMID:21524945   PMID:23084644   PMID:24950599   PMID:25944715  
PMID:30374710  


Genomics

Comparative Map Data
Ucp3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01165,482,912 - 165,495,895 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1165,482,155 - 165,496,206 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01171,683,566 - 171,697,139 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41157,896,001 - 157,909,608 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11157,974,793 - 157,988,399 (+)NCBI
Celera1152,898,320 - 152,911,676 (+)NCBICelera
Cytogenetic Map1q32NCBI
RH 3.4 Map11258.1RGD
UCP3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1174,000,277 - 74,009,085 (-)EnsemblGRCh38hg38GRCh38
GRCh381174,000,277 - 74,009,085 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371173,711,326 - 73,720,282 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361173,388,985 - 73,397,778 (-)NCBINCBI36hg18NCBI36
Build 341173,392,374 - 73,397,778NCBI
Celera1171,018,129 - 71,027,086 (-)NCBI
Cytogenetic Map11q13.4NCBI
HuRef1170,007,226 - 70,016,183 (-)NCBIHuRef
CHM1_11173,595,177 - 73,604,136 (-)NCBICHM1_1
Ucp3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397100,122,198 - 100,135,639 (+)NCBIGRCm39mm39
GRCm387100,472,991 - 100,486,432 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7100,472,990 - 100,486,432 (+)EnsemblGRCm38mm10GRCm38
MGSCv377107,621,500 - 107,634,941 (+)NCBIGRCm37mm9NCBIm37
MGSCv367100,347,073 - 100,360,514 (+)NCBImm8
Celera7100,810,580 - 100,824,026 (+)NCBICelera
Cytogenetic Map7E2NCBI
cM Map754.36NCBI
Ucp3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541417,558,889 - 17,578,737 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541417,558,889 - 17,578,108 (+)NCBIChiLan1.0ChiLan1.0
UCP3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11172,380,180 - 72,389,274 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1172,380,180 - 72,389,274 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01169,072,143 - 69,085,424 (-)NCBIMhudiblu_PPA_v0panPan3
UCP3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2124,277,896 - 24,288,639 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12124,272,522 - 24,290,304 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Ucp3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049364983,082,575 - 3,095,739 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
UCP3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl98,378,019 - 8,386,211 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.198,378,023 - 8,389,452 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.299,167,483 - 9,178,955 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap9p21-p24NCBI
UCP3
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1165,269,611 - 65,279,079 (-)NCBI
ChlSab1.1 Ensembl165,269,607 - 65,278,807 (-)Ensembl

Position Markers
D1Wox38  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01165,487,882 - 165,488,045NCBIRnor6.0
Rnor_5.01171,688,536 - 171,688,699UniSTSRnor5.0
RGSC_v3.41157,900,971 - 157,901,134UniSTSRGSC3.4
Celera1152,903,290 - 152,903,448UniSTS
Cytogenetic Map1q32UniSTS
D1Arb16  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01165,487,896 - 165,488,041NCBIRnor6.0
Rnor_5.01171,688,550 - 171,688,695UniSTSRnor5.0
RGSC_v3.41157,900,984 - 157,901,130RGDRGSC3.4
RGSC_v3.41157,900,985 - 157,901,130UniSTSRGSC3.4
RGSC_v3.11157,979,777 - 157,979,923RGD
Celera1152,903,304 - 152,903,444UniSTS
Cytogenetic Map1q32UniSTS
RH94827  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01165,494,629 - 165,494,791NCBIRnor6.0
Rnor_5.01171,695,873 - 171,696,035UniSTSRnor5.0
RGSC_v3.41157,908,342 - 157,908,504UniSTSRGSC3.4
Celera1152,910,410 - 152,910,572UniSTS
Cytogenetic Map1q32UniSTS
RH 3.4 Map11258.1UniSTS
AW533754  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01165,495,631 - 165,495,778NCBIRnor6.0
Rnor_5.01171,696,875 - 171,697,022UniSTSRnor5.0
RGSC_v3.41157,909,344 - 157,909,491UniSTSRGSC3.4
Celera1152,911,412 - 152,911,559UniSTS
Cytogenetic Map1q32UniSTS
RH 3.4 Map11260.3UniSTS
UCP3  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01165,489,142 - 165,489,880NCBIRnor6.0
Rnor_5.01171,689,796 - 171,690,534UniSTSRnor5.0
RGSC_v3.41157,902,231 - 157,902,969UniSTSRGSC3.4
Celera1152,904,545 - 152,905,283UniSTS
Cytogenetic Map1q32UniSTS
Ucp3  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01165,489,830 - 165,490,211NCBIRnor6.0
Rnor_5.01171,690,484 - 171,690,865UniSTSRnor5.0
Celera1152,905,233 - 152,905,614UniSTS
Cytogenetic Map1q32UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1156446196243311614Rat
631654Bp107Blood pressure QTL 107arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1133076978178076978Rat
6893347Bw98Body weight QTL 980.20.53body mass (VT:0001259)body weight (CMO:0000012)1144395993189395993Rat
6893361Bw104Body weight QTL 1040.590.27body mass (VT:0001259)body weight (CMO:0000012)1144395993189395993Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1100131562236763528Rat
738006Anxrr14Anxiety related response QTL 1440.00035locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1141296374186296374Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1106002252202571904Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1122614824262664716Rat
9685799Bp375Blood pressure QTL 375arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1133076978178076978Rat
9685802Bp376Blood pressure QTL 376arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1134089429179089429Rat
8693608Alc24Alcohol consumption QTL 242.30.74drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)1161072673178935582Rat
738028Anxrr12Anxiety related response QTL 124.90.00001locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1141296374186296374Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1153656062198656062Rat
631544Bp84Blood pressure QTL 845.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1130779148198585664Rat
634315Niddm45Non-insulin dependent diabetes mellitus QTL 457.16blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1156446783188289244Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1144634295241482368Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1125875758262433692Rat
1300158Bp173Blood pressure QTL 1733.48arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1122614824201146953Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)199983293198656062Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)135377692217372257Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)199983293188289386Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1108986301219232156Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1108986301238830534Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1108986301219232156Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1161784169219232156Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1161784169219232156Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1161784169219232156Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1161784169278228889Rat
1558645Bw55Body weight QTL 553.20.004body mass (VT:0001259)body weight (CMO:0000012)1144395993189395993Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1163796316282763074Rat
1358189Cstrr1Cold stress response QTL 10.0001catecholamine amount (VT:0010543)urine norepinephrine level (CMO:0001629)1130779148199254774Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1161784422246226103Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149578577169852184Rat
1641895Bp298Blood pressure QTL 298arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1130779148199254774Rat
1598850Bp297Blood pressure QTL 2972.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1131334152176334152Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1153834077232297227Rat
1598866Bp287Blood pressure QTL 2875.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1131334152176334152Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1161321256273791893Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1130779148199254774Rat
1578778Pur4Proteinuria QTL 43.30.003total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1161321256273791893Rat
61348Bp30Blood pressure QTL 302.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1154337847215828102Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)199983293216325819Rat
2293140Bp313Blood pressure QTL 313arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1129208943174208943Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134993530173445086Rat
71118Thym1Thymus enlargement QTL 110.170.001thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1153655976198655976Rat
631199Cm23Cardiac mass QTL 234.60.0004heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1124603592188289386Rat
631202Gluco13Glucose level QTL 130.0001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1139523928170246858Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1126240667217054291Rat
631206Niddm40Non-insulin dependent diabetes mellitus QTL 40blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1144723107174343537Rat
61442Strs1Sensitivity to stroke QTL 17.4cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)1133946489178946489Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)194201400184846632Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1161321152273792054Rat
724550Thym3Thymus enlargement QTL 37.820.001thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1153655976198655976Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1137787261236763528Rat
2313060Bss71Bone structure and strength QTL 712.60.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)1124090312169090312Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1137787261236763528Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1156446196274977688Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149578693217054291Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)194201400197187904Rat
634348Bp138Blood pressure QTL 138arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1133076978184188922Rat
61379Bp44Blood pressure QTL 4419.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1156446783189514504Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1161784169219232156Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1156446196214277437Rat
61370Mcs3Mammary carcinoma susceptibility QTL 32.15mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1108057233167517487Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1161784169278228889Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)182788437239853971Rat
631549Bp89Blood pressure QTL 895.7arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1130779320219238476Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1161784169278228889Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)199983293216213510Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:166
Count of miRNA genes:131
Interacting mature miRNAs:146
Transcripts:ENSRNOT00000024005
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 2 8 11 8
Low 2 23 13 17 11 9 11
Below cutoff 1 4 11 11 11 22 8 22

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000024005   ⟹   ENSRNOP00000024005
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1165,482,155 - 165,496,206 (+)Ensembl
RefSeq Acc Id: NM_013167   ⟹   NP_037299
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01165,482,912 - 165,495,895 (+)NCBI
Rnor_5.01171,683,566 - 171,697,139 (+)NCBI
RGSC_v3.41157,896,001 - 157,909,608 (+)RGD
Celera1152,898,320 - 152,911,676 (+)RGD
Sequence:
Reference Sequences
RefSeq Acc Id: NP_037299   ⟸   NM_013167
- UniProtKB: P56499 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000024005   ⟸   ENSRNOT00000024005

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690243
Promoter ID:EPDNEW_R766
Type:initiation region
Name:Ucp3_1
Description:uncoupling protein 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01165,482,884 - 165,482,944EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3933 AgrOrtholog
Ensembl Genes ENSRNOG00000017716 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000024005 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000024005 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 1.50.40.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7105743 IMAGE-MGC_LOAD
InterPro Mit_uncoupling_UCP-like UniProtKB/Swiss-Prot
  Mitochondrial_sb/sol_carrier UniProtKB/Swiss-Prot
  Mt_carrier_dom_sf UniProtKB/Swiss-Prot
KEGG Report rno:25708 UniProtKB/Swiss-Prot
MGC_CLONE MGC:91763 IMAGE-MGC_LOAD
NCBI Gene 25708 ENTREZGENE
Pfam Mito_carr UniProtKB/Swiss-Prot
PhenoGen Ucp3 PhenoGen
PRINTS MTUNCOUPLING UniProtKB/Swiss-Prot
PROSITE SOLCAR UniProtKB/Swiss-Prot
Superfamily-SCOP SSF103506 UniProtKB/Swiss-Prot
TIGR TC209775
UniProt P56499 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-05 Ucp3  uncoupling protein 3  Ucp3  uncoupling protein 3 (mitochondrial, proton carrier)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Ucp3  uncoupling protein 3 (mitochondrial, proton carrier)    uncoupling protein 3  Name updated 1299863 APPROVED
2002-06-10 Ucp3  Uncoupling protein 3, mitochondrial      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression mRNA highly expressed in the skeletal muscles after exercise, not detected in nonexercised muscle 628553
gene_process component of mitochondrial biogenesis involved in thermogenesis and energy expenditure 628553
gene_regulation exercise induces an increase in the skeletal muscle 628553
gene_regulation increased uncoupling activity and mitochondrial proton conductance is induced by superoxide 737664