Predicted to enable oxidative phosphorylation uncoupler activity and proton transmembrane transporter activity. Involved in several processes, including response to activity; response to insulin; and response to superoxide. Predicted to be located in mitochondrial inner membrane. Used to study type 2 diabetes mellitus. Biomarker of congestive heart failure; hypertension; hyperthyroidism; hypothyroidism; and prediabetes syndrome. Human ortholog(s) of this gene implicated in coronary restenosis; diabetic neuropathy; glucose metabolism disease (multiple); and obesity. Orthologous to human UCP3 (uncoupling protein 3); INTERACTS WITH (+)-catechin; 6-propyl-2-thiouracil; ammonium chloride.
mitochondrial uncoupling protein 3; putative mitochondrial transporter UCP3; solute carrier family 25 member 9; UCP 3; uncoupling protein 3 (mitochondrial, proton carrier); Uncoupling protein 3 mitochondrial; Uncoupling protein 3, mitochondrial
[Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in decreased expression of UCP3 mRNA, [Air Pollutants results in increased abundance of Ozone] which results in decreased expression of UCP3 mRNA
perfluorooctane sulfonic acid results in increased expression of UCP3 mRNA, perfluorooctane sulfonic acid results in increased expression of UCP3 protein
Uncoupling protein downregulation in doxorubicin-induced heart failure improves mitochondrial coupling but increases reactive oxygen species generation.
Type 1 diabetic akita mouse hearts are insulin sensitive but manifest structurally abnormal mitochondria that remain coupled despite increased uncoupling protein 3.
Concordant mRNA expression of UCP-3, but not UCP-2, with mitochondrial thioesterase-1 in brown adipose tissue and skeletal muscle in db/db diabetic mice.
Sterol regulatory element binding protein-1c expression and action in rat muscles: insulin-like effects on the control of glycolytic and lipogenic enzymes and UCP3 gene expression.
The common -55 C/T polymorphism in the promoter region of the uncoupling protein 3 gene reduces prevalence of obesity and elevates serum high-density lipoprotein cholesterol levels in the general Japanese population.
Effects of streptozotocin-induced diabetes and insulin treatment on the hypothalamic melanocortin system and muscle uncoupling protein 3 expression in rats.
An uncoupling protein 3 gene polymorphism associated with a lower risk of developing Type II diabetes and with atherogenic lipid profile in a French cohort.
Bezafibrate-induced changes over time in the expression of uncoupling protein (UCP) mRNA in the tissues: a study in spontaneously type 2 diabetic rats with visceral obesity.
Roles of norepinephrine, free Fatty acids, thyroid status, and skeletal muscle uncoupling protein 3 expression in sympathomimetic-induced thermogenesis.
[Expression of UCP3 and the sensitivity of mitochondrial permeability transition pore opening to Ca2+ in old rat heart under activation of biosynthesis of coenzyme Q]
Developmental programming of adult hyperinsulinemia, increased proinflammatory cytokine production, and altered skeletal muscle expression of SLC2A4 (GLUT4) and uncoupling protein 3.
