Ctse (cathepsin E) - Rat Genome Database

Name: Ctse
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Ctse (cathepsin E) Rattus norvegicus

Analyze

Symbol:

Ctse

Name:

cathepsin E

RGD ID:

2446

Description:

Enables aspartic-type endopeptidase activity. Involved in antigen processing and presentation of exogenous peptide antigen via MHC class II and protein autoprocessing. Located in endosome. Orthologous to human CTSE (cathepsin E); INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

CEA; CEB; Ctsea

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	CTSE (cathepsin E)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Ctse (cathepsin E)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Ctse (cathepsin E)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	CTSE (cathepsin E)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	CTSE (cathepsin E)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Ctse (cathepsin E)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	CTSE (cathepsin E)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Ctse (cathepsin E)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Ctse (cathepsin E)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	CTSE (cathepsin E)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Bace	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER)
Saccharomyces cerevisiae (baker's yeast):	PEP4	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG33128	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER)
Drosophila melanogaster (fruit fly):	CG6508	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER)
Drosophila melanogaster (fruit fly):	Pgcl	Alliance	DIOPT (OMA\|OrthoFinder\|PANTHER)
Caenorhabditis elegans (roundworm):	asp-17	Alliance	DIOPT (Ensembl Compara\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	ctse	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Candidate Gene For:

Bp327

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	13	43,091,954 - 43,114,509 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	43,092,128 - 43,114,502 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	13	45,695,406 - 45,717,865 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	46,983,544 - 47,006,003 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	44,248,051 - 44,270,572 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	13	48,426,833 - 48,449,493 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	48,426,820 - 48,449,490 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	13	53,498,965 - 53,521,605 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	13	44,582,911 - 44,605,241 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	13	44,596,953 - 44,619,284 (+)	NCBI
Celera	13	43,430,588 - 43,452,924 (+)	NCBI		Celera
Cytogenetic Map	13	q13	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

atopic dermatitis (ISS)

autistic disorder (ISO)

Chemical and Drug Induced Liver Injury (ISO)

Experimental Liver Cirrhosis (ISO)

familial adult myoclonic epilepsy 5 (ISO)

gastrointestinal stromal tumor (ISO)

genetic disease (ISO)

Hypokalemic Periodic Paralysis, Type 1 (ISO)

parathyroid carcinoma (ISO)

prostate cancer (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,2-dimethylhydrazine (ISO)

1-naphthyl isothiocyanate (EXP)

17alpha-ethynylestradiol (EXP)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

2,6-dinitrotoluene (EXP)

3,3',5,5'-tetrabromobisphenol A (EXP)

3,3',5-triiodo-L-thyronine (EXP)

3,4-dichloroaniline (EXP)

4,4'-diaminodiphenylmethane (ISO)

5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole (EXP)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

aflatoxin B1 (EXP,ISO)

ammonium chloride (EXP)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP)

butyric acid (ISO)

cadmium dichloride (EXP)

cadmium sulfate (ISO)

carbon nanotube (ISO)

clofibrate (ISO)

cobalt dichloride (EXP)

copper(II) sulfate (ISO)

cyclosporin A (ISO)

cyproconazole (EXP)

diclofenac (ISO)

dioxygen (ISO)

diuron (EXP)

doxorubicin (ISO)

epoxiconazole (EXP)

ethanol (EXP)

furan (EXP)

hydrogen peroxide (ISO)

indole-3-methanol (EXP)

inulin (ISO)

ketamine (EXP)

lipopolysaccharide (ISO)

N-nitrosodiethylamine (EXP)

N-nitrosodimethylamine (EXP)

nitrofen (EXP)

omeprazole (EXP)

oxaliplatin (EXP)

ozone (ISO)

paclitaxel (EXP)

paracetamol (ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (ISO)

pirinixic acid (ISO)

progesterone (ISO)

propiconazole (ISO)

rotenone (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

sodium arsenite (ISO)

sodium dichromate (ISO)

tamoxifen (ISO)

testosterone (EXP)

tetrachloroethene (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

topotecan (EXP)

Tributyltin oxide (ISO)

trichloroethene (EXP,ISO)

triphenyl phosphate (EXP)

trovafloxacin (ISO)

tungsten (ISO)

zinc atom (ISO)

zinc(0) (ISO)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

antigen processing and presentation of exogenous peptide antigen via MHC class II (IBA,IDA,ISO)

protein autoprocessing (IMP)

proteolysis (IBA,ISO)

Cellular Component

endosome (IBA,IDA,ISO)

intracellular membrane-bounded organelle (ISO)

Molecular Function

aspartic-type endopeptidase activity (IBA,IDA,ISO)

identical protein binding (ISO)

peptidase activity (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Cathepsin E in follicle associated epithelium of intestine and tonsils: localization to M cells and possible role in antigen processing.	Finzi G, etal., Histochemistry. 1993 Mar;99(3):201-11.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	Age-related changes in activities and localizations of cathepsins D, E, B, and L in the rat brain tissues.	Nakanishi H, etal., Exp Neurol. 1994 Mar;126(1):119-28.
5.	Isolation and sequencing of two cDNA clones encoding rat spleen cathepsin E and analysis of the activation of purified procathepsin E.	Okamoto K, etal., Arch Biochem Biophys 1995 Sep 10;322(1):103-11.
6.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
8.	Identification of cellular compartments involved in processing of cathepsin E in primary cultures of rat microglia.	Sastradipura DF, etal., J Neurochem. 1998 May;70(5):2045-56.
9.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
10.	Tentative Sequence Identification Numbers	Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
11.	Characterization of rat cathepsin E and mutants with changed active-site residues and lacking propeptides and N-glycosylation, expressed in human embryonic kidney 293T cells.	Tsukuba T, etal., FEBS J. 2006 Jan;273(1):219-29.

Additional References at PubMed

PMID:1601038	PMID:2105725	PMID:7789521	PMID:7983070	PMID:8339772	PMID:8765029	PMID:8809073	PMID:9180269	PMID:11719510	PMID:12204120	PMID:12631277	PMID:15100295
PMID:15489334	PMID:16997486	PMID:22730688	PMID:23376485	PMID:27116544

Genomics

Comparative Map Data

Ctse
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	13	43,091,954 - 43,114,509 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	43,092,128 - 43,114,502 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	13	45,695,406 - 45,717,865 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	46,983,544 - 47,006,003 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	44,248,051 - 44,270,572 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	13	48,426,833 - 48,449,493 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	48,426,820 - 48,449,490 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	13	53,498,965 - 53,521,605 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	13	44,582,911 - 44,605,241 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	13	44,596,953 - 44,619,284 (+)	NCBI
Celera	13	43,430,588 - 43,452,924 (+)	NCBI		Celera
Cytogenetic Map	13	q13	NCBI

CTSE
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	206,009,264 - 206,023,895 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	206,008,535 - 206,023,909 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	206,317,473 - 206,332,104 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	204,484,082 - 204,498,727 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	1	179,116,519 - 179,131,198 (-)	NCBI		Celera
Cytogenetic Map	1	q32.1	NCBI
HuRef	1	177,247,760 - 177,262,405 (+)	NCBI		HuRef
T2T-CHM13v2.0	1	205,273,263 - 205,287,895 (-)	NCBI		T2T-CHM13v2.0

Ctse
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	131,566,052 - 131,603,245 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	131,566,044 - 131,603,243 (+)	Ensembl		GRCm39 Ensembl
GRCm38	1	131,638,314 - 131,675,507 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	131,638,306 - 131,675,505 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	1	133,534,891 - 133,572,084 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	1	133,465,860 - 133,503,049 (+)	NCBI		MGSCv36	mm8
Celera	1	134,250,340 - 134,281,876 (+)	NCBI		Celera
Cytogenetic Map	1	E4	NCBI
cM Map	1	57.14	NCBI

Ctse
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955406	41,641,311 - 41,653,296 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955406	41,641,412 - 41,653,261 (-)	NCBI	ChiLan1.0	ChiLan1.0

CTSE
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	1	43,311,665 - 43,326,899 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	181,617,421 - 181,632,260 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	185,900,746 - 185,915,368 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	185,900,746 - 185,915,519 (-)	Ensembl	panpan1.1		panPan2

CTSE
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	38	2,368,711 - 2,380,554 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	38	2,369,265 - 2,380,459 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	38	2,461,257 - 2,473,099 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	38	2,365,859 - 2,377,730 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	38	2,365,857 - 2,377,890 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	38	2,359,989 - 2,371,820 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	38	2,751,514 - 2,763,344 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	38	2,952,739 - 2,964,581 (-)	NCBI		UU_Cfam_GSD_1.0

Ctse
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	69,245,473 - 69,258,551 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936557	6,485,755 - 6,498,833 (+)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936557	6,485,783 - 6,498,805 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CTSE
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	25	23,318,421 - 23,333,885 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	25	23,319,248 - 23,332,980 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666055	24,017,015 - 24,031,766 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ctse
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624807	5,291,736 - 5,305,104 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624807	5,291,993 - 5,306,507 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Ctse
169 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	342
Count of miRNA genes:	178
Interacting mature miRNAs:	192
Transcripts:	ENSRNOT00000009241, ENSRNOT00000048391
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1354666	Bp244	Blood pressure QTL 244	4.9		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	13	1	101056920	Rat
1354666	Bp244	Blood pressure QTL 244	4.9		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	1	101056920	Rat
1354666	Bp244	Blood pressure QTL 244	4.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	1	101056920	Rat
61339	Bp24	Blood pressure QTL 24		0.05	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	5994668	44807491	Rat
1581554	Pur11	Proteinuria QTL 11			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	13	5994833	77046787	Rat
1581573	Uae36	Urinary albumin excretion QTL 36			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	13	5994833	77046787	Rat
1581570	Eae17	Experimental allergic encephalomyelitis QTL 17	4.1		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	13	8897350	101631289	Rat
7411662	Foco29	Food consumption QTL 29	20.8	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	13	9313465	54313465	Rat
9589141	Insul28	Insulin level QTL 28	10.82	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	13	9313465	54313465	Rat
2317040	Aia21	Adjuvant induced arthritis QTL 21	2.75		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	13	9831541	54831541	Rat
2317046	Aia8	Adjuvant induced arthritis QTL 8	3.9700000286102295		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	13	9831541	54831541	Rat
1300163	Cardf1	Cardiac cell morphology QTL 1	4.18		aorta morphology trait (VT:0000272)	artery lesion measurement (CMO:0000975)	13	11929449	45417941	Rat
2302275	Gluco37	Glucose level QTL 37	3.8		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	13	11929449	46193066	Rat
631645	Bp121	Blood pressure QTL 121	3.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	14915655	59915655	Rat
9589164	Gluco66	Glucose level QTL 66	6.67	0.001	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	13	15158722	60158722	Rat
1331784	Bp222	Blood pressure QTL 222	2.944		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	17694436	53050594	Rat
7207885	Glom27	Glomerulus QTL 27	3.9		kidney glomerulus integrity trait (VT:0010546)	kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)	13	20605871	101339738	Rat
61391	Bp5	Blood pressure QTL 5	5.6		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	13	22301875	67301875	Rat
70170	Eae14	Experimental allergic encephalomyelitis QTL 14		0.0024	nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	13	23203448	68203448	Rat
6893338	Cm76	Cardiac mass QTL 76	0	0.99	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	13	23692969	68692969	Rat
1558644	Cm45	Cardiac mass QTL 45	3.6	0.002	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	13	23692969	68692969	Rat
1354621	Rf47	Renal function QTL 47	3.7		kidney renin amount (VT:0010559)	kidney renin level (CMO:0002166)	13	30395351	101056920	Rat
2301962	Cm72	Cardiac mass QTL 72	4.12		heart left ventricle mass (VT:0007031)	heart left ventricle weight (CMO:0000776)	13	31241331	58363171	Rat
70181	BpQTLcluster11	Blood pressure QTL cluster 11	6.922		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	13	31241331	93395974	Rat
70181	BpQTLcluster11	Blood pressure QTL cluster 11	6.922		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	31241331	93395974	Rat
70181	BpQTLcluster11	Blood pressure QTL cluster 11	6.922		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	31241331	93395974	Rat
70181	BpQTLcluster11	Blood pressure QTL cluster 11	6.922		arterial blood pressure trait (VT:2000000)	absolute change in mean arterial blood pressure (CMO:0000533)	13	31241331	93395974	Rat
2303563	Bw89	Body weight QTL 89	6		body mass (VT:0001259)	body weight (CMO:0000012)	13	32284471	77284471	Rat
61340	Bp25	Blood pressure QTL 25	4.2	0.004	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	34535218	79535218	Rat
12879477	Bp401	Blood pressure QTL 401			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	37262092	82262092	Rat
61349	Bp31	Blood pressure QTL 31	5.75		arterial blood pressure trait (VT:2000000)	blood pressure measurement (CMO:0000003)	13	37374509	82374509	Rat
70220	Bp55	Blood pressure QTL 55	5.75		arterial blood pressure trait (VT:2000000)	blood pressure measurement (CMO:0000003)	13	37374509	82374509	Rat
4889861	Pur29	Proteinuria QTL 29	13.8	0.005	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	13	37415584	80753406	Rat
1331750	Bp220	Blood pressure QTL 220	2.98		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	13	37415584	82415584	Rat
1549897	Stresp12	Stress response QTL 12	3.35		stress-related behavior trait (VT:0010451)	number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)	13	38433408	83433408	Rat
619615	Bp80	Blood pressure QTL 80		0.0354	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	39754544	84754544	Rat
2303032	Bp328	Blood pressure QTL 328			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	41184022	45417941	Rat

Markers in Region

RH133382

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	13	43,114,058 - 43,114,246 (+)	MAPPER	mRatBN7.2
Rnor_6.0	13	48,449,047 - 48,449,234	NCBI	Rnor6.0
Rnor_5.0	13	53,521,159 - 53,521,346	UniSTS	Rnor5.0
RGSC_v3.4	13	44,604,798 - 44,604,985	UniSTS	RGSC3.4
Celera	13	43,452,481 - 43,452,668	UniSTS
Cytogenetic Map	13	q13	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	6	28	20	19	20				2	4	7
Low		35	29	21		21	7	8	50	33	34	4	7
Below cutoff		2					1	3	24		3		1

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001401267	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_012938	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006249749	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017598677	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC062002	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473958	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	D38104	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ233338	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000242	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000009241 ⟹ ENSRNOP00000009242

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	13	43,092,138 - 43,114,502 (+)	Ensembl
Rnor_6.0 Ensembl	13	48,427,038 - 48,449,490 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000048391 ⟹ ENSRNOP00000048353

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	13	43,092,128 - 43,114,492 (+)	Ensembl
Rnor_6.0 Ensembl	13	48,426,820 - 48,449,463 (+)	Ensembl

RefSeq Acc Id:

NM_001401267 ⟹ NP_001388196

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	13	43,091,999 - 43,114,505 (+)	NCBI

RefSeq Acc Id:

NM_012938 ⟹ NP_037070

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	13	43,091,999 - 43,114,505 (+)	NCBI
Rnor_6.0	13	48,427,038 - 48,449,490 (+)	NCBI
Rnor_5.0	13	53,498,965 - 53,521,605 (+)	NCBI
RGSC_v3.4	13	44,582,911 - 44,605,241 (+)	RGD
Celera	13	43,430,588 - 43,452,924 (+)	RGD

Sequence:

show sequence

GAGATCGGTCTCTGAGCCTGACCATCCACTTACTGCAGGAGAACGAAATTCTTGACATTTTGGT
TTATCTGGTAGCTTCAAAGACTGGGCAGGGCAGGTCTGGGCACCAGGAAGAGCTGGTGCTCCTG
CCCTGTGCACAAGAAGAAAGAAAGGTGGAAGGGAGATCGAAGCAGAGTGAGAGAGAAGCTGCCA
CTCACACCACAATGAAACCTCTCTTCGTGCTGCTGCTGCTGCTGCTGCTCCTGGACCTGGCACA
GGCCCAAGGGGTGCTGCACAGGGTGCCCCTCAGAAGACATCAGTCCCTCCGGAAGAAACTACGG
GCCCAAGGCCAGCTCTCAGACTTCTGGAGATCTCATAACTTGGACATGATCGAATTCAGCGAGT
CCTGTAATGTGGATAAGGGTATCAATGAGCCCCTCATCAACTACCTGGATATGGAATACTTTGG
CACCGTCTCCATCGGCTCCCCATCGCAGAACTTCACCGTCATCTTTGACACGGGCTCATCCAAC
CTCTGGGTCCCTTCTGTGTACTGCACCAGCTCAGCATGCAAGGCACACCCGGTGTTCCACCCAT
CGCAGTCCAGCACCTACATGGAGGTAGGGAATCACTTCTCCATCCAGTATGGTACTGGGAGCCT
GACAGGAATCATTGGAGCTGACCAAGTCTCTGTGGAAGGGTTGACTGTGGAAGGCCAGCAATTT
GGAGAAAGTGTCAAGGAGCCTGGTCAGACCTTTGTGAATGCGGAGTTTGACGGGATTCTGGGCC
TGGGATACCCCTCATTGGCTGTTGGAGGAGTGACCCCAGTGTTTGATAACATGATGGCCCAGAA
CCTTGTGGCTCTGCCTATGTTTTCTGTCTACTTGAGCAGTGACCCACAAGGTGGCTCAGGCAGT
GAACTGACTTTCGGAGGCTATGACCCCTCTCATTTCTCTGGGAGCCTCAATTGGATCCCAGTCA
CCAAGCAAGGCTACTGGCAGATTGCCCTGGATGGAATCCAGGTGGGAGACACTGTGATGTTCTG
CTCTGAGGGCTGCCAGGCCATAGTGGACACAGGGACCTCCCTCATCACTGGCCCCCCCAAGAAG
ATCAAACAGCTTCAAGAGGCCATTGGGGCCACACCCATGGATGGAGAAGACTTGGTGGATGGAA
TGCAGTTCTGCGGCAGTGGCTTTCAAGGACTTGACATTCAACCTCCGGCTGGACCCCTCTGGAT
CCTGGGGGATGTCTTCATCCGAAAGTTTTACTCAGTCTTTGATCGTGGAAATAACCAAGTGGGA
TTGGCCCCCGCAGTCCCTTAAAGAGGGCTGTATGCCTTCATGTGGATGTCTGATTTAACCTTTG
TAACTATCAAAACTGTCATTTCCCATGGGATGTAGCTATTCCAAACAGAGTAATCAGACCAAAC
AAAGCATGAGAGCCCACCCAGCCTCCCAGTCGCTGTACATGGACACACGCACCACCTCTACCAT
CACCATGATGAAAGTTCTGTCTATAGTCTTCATTGCTTATTGTTGACTTCCTGTTATGAAAATC
TCTAAACATAGACACTAGAAATAATGGTGTGATAAATAGCCACGCAGCTATGCCTCACGTCACA
ACCCATCCATGTGTGGCTCAGCCCCTCTATTTTCCATCCGTCTGGTTTTATGCCTCTAGATTTG
TAAGCAAATTCTAAGTACCATGCCGTTCTATCTAATGTCTAATAGTCTTAAAAATCAGAATTTA
AATATGTCTCACTCTCTCATAAATGTGGACCTGTTTTTACAGTTGGTTTATCTGTATCAGGATT
CAAACCAGATCTATAACTGGACAAAAAAATCATAAACTGAATTGATTTG

hide sequence

RefSeq Acc Id:

XM_006249749 ⟹ XP_006249811

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	13	43,091,954 - 43,114,509 (+)	NCBI
Rnor_6.0	13	48,426,833 - 48,449,493 (+)	NCBI
Rnor_5.0	13	53,498,965 - 53,521,605 (+)	NCBI

Sequence:

show sequence

AGAGCAGGCGCACTTCCTCTAAGTGCCAAAAACCTGTATGGCCACTACACAGGTCGTTTGTTCC
TCAGAACTGCAGATGCCCTGTGTGACTCCAGAAGCGGTTAGAAGGATCAGGCGTGGCTATCTCC
ATTTGCAGCTGAGGTGGCCAAGAGATAAGAGTTGCTTAAGGCCATAGTTAGCAAACAACAAAAC
GGGTTTCCACACAGAGATCGGTCTCTGAGCCTGACCATCCACTTACTGCAGGAGAACGAAATTC
TTGACATTTTGGTTTATCTGGTAGCTTCAAAGGTAAAAACGGACATTTTCTAAGAAGGCTGCCA
TTCGCTTGTTTTGCAATTGAAGCAGAACTGGGCAGGGCAGGTCTGGGCACCAGGAAGAGCTGGT
GCTCCTGCCCTGTGCACAAGAAGAAAGAAAGGTGGAAGGGAGATCGAAGCAGAGTGAGAGAGAA
GCTGCCACTCACACCACAATGAAACCTCTCTTCGTGCTGCTGCTGCTGCTGCTGCTCCTGGACC
TGGCACAGGCCCAAGGGGTGCTGCACAGGGTGCCCCTCAGAAGACATCAGTCCCTCCGGAAGAA
ACTACGGGCCCAAGGCCAGCTCTCAGACTTCTGGAGATCTCATAACTTGGACATGATCGAATTC
AGCGAGTCCTGTAATGTGGATAAGGGTATCAATGAGCCCCTCATCAACTACCTGGATATGGAAT
ACTTTGGCACCGTCTCCATCGGCTCCCCATCGCAGAACTTCACCGTCATCTTTGACACGGGCTC
ATCCAACCTCTGGGTCCCTTCTGTGTACTGCACCAGCCCAGCATGCAAGGCACACCCGGTGTTC
CACCCATCGCAGTCCAGCACCTACATGGAGGTAGGGAATCACTTCTCCATCCAGTATGGTACTG
GGAGCCTGACAGGAATCATTGGAGCTGACCAAGTCTCTGTGGAAGGGTTGACTGTGGAAGGCCA
GCAATTTGGAGAAAGTGTCAAGGAGCCTGGTCAGACCTTTGTGAATGCGGAGTTTGACGGGATT
CTGGGCCTGGGATACCCCTCATTGGCTGTTGGAGGAGTGACCCCAGTGTTTGATAACATGATGG
CCCAGAACCTTGTGGCTCTGCCTATGTTTTCTGTCTACTTGAGCAGTGACCCACAAGGTGGCTC
AGGCAGTGAACTGACTTTCGGAGGCTATGACCCCTCTCATTTCTCTGGGAGCCTCAATTGGATC
CCAGTCACCAAGCAAGGCTACTGGCAGATTGCCCTGGATGGAATCCAGGTGGGAGACACTGTGA
TGTTCTGCTCTGAGGGCTGCCAGGCCATAGTGGACACAGGGACCTCCCTCATCACTGGCCCCCC
CAAGAAGATCAAACAGCTTCAAGAGGCCATTGGGGCCACACCCATGGATGGAGAATATGCGGTG
GATTGTGCCACTCTCAACATGATGCCAAACGTCACCTTCCTCATCAACGGGGTTTCATACACCC
TCAGCCCAACTGCCTACATCCTGCCGGACTTGGTGGATGGAATGCAGTTCTGCGGCAGTGGCTT
TCAAGGACTTGACATTCAACCTCCGGCTGGACCCCTCTGGATCCTGGGGGATGTCTTCATCCGA
AAGTTTTACTCAGTCTTTGATCGTGGAAATAACCAAGTGGGATTGGCCCCCGCAGTCCCTTAAA
GAGGGCTGTATGCCTTCATGTGGATGTCTGATTTAACCTTTGTAACTATCAAAACTGTCATTTC
CCATGGGATGTAGCTATTCCAAACAGAGTAATCAGACCAAACAAAGCATGAGAGCCCACCCAGC
CTCCCAGTCGCTGTACATGGACACACGCACCACCTCTACCATCACCATGATGAAAGTTCTGTCT
ATAGTCTTCATTGCTTATTGTTGACTTCCTGTTATGAAAATCTCTAAACATAGACACTAGAAAT
AATGGTGTGATAAATAGCCACGCAGCTATGCCTCACGTCACAACCCATCCATGTGTGGCTCAGC
CCCTCTATTTTCCATCCGTCTGGTTTTATGCCTCTAGATTTGTAAGCAAATTCTAAGTACCATG
CCGTTCTATCTAATGTCTAATAGTCTTAAAAATCAGAATTTAAATATGTCTCACTCTCTCATAA
ATGTGGACCTGTTTTTACAGTTGGTTTATCTGTATCAGGATTCAAACCAGATCTATAACTGGAC
AAAAAAATCATAAACTGAATTGATTTGAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001388196	(Get FASTA)	NCBI Sequence Viewer
	NP_037070	(Get FASTA)	NCBI Sequence Viewer
	XP_006249811	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH62002	(Get FASTA)	NCBI Sequence Viewer
	BAA07285	(Get FASTA)	NCBI Sequence Viewer
	EDM09820	(Get FASTA)	NCBI Sequence Viewer
	EDM09821	(Get FASTA)	NCBI Sequence Viewer
	EDM09822	(Get FASTA)	NCBI Sequence Viewer
	EDM09823	(Get FASTA)	NCBI Sequence Viewer
	P16228	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_037070 ⟸ NM_012938
- Peptide Label:	isoform 1 precursor
- UniProtKB:	A6IC26 (UniProtKB/TrEMBL)
- Sequence:	show sequence MKPLFVLLLLLLLLDLAQAQGVLHRVPLRRHQSLRKKLRAQGQLSDFWRSHNLDMIEFSESCNV DKGINEPLINYLDMEYFGTVSIGSPSQNFTVIFDTGSSNLWVPSVYCTSSACKAHPVFHPSQSS TYMEVGNHFSIQYGTGSLTGIIGADQVSVEGLTVEGQQFGESVKEPGQTFVNAEFDGILGLGYP SLAVGGVTPVFDNMMAQNLVALPMFSVYLSSDPQGGSGSELTFGGYDPSHFSGSLNWIPVTKQG YWQIALDGIQVGDTVMFCSEGCQAIVDTGTSLITGPPKKIKQLQEAIGATPMDGEDLVDGMQFC GSGFQGLDIQPPAGPLWILGDVFIRKFYSVFDRGNNQVGLAPAVP hide sequence

RefSeq Acc Id:	XP_006249811 ⟸ XM_006249749
- Peptide Label:	isoform X1
- UniProtKB:	Q63701 (UniProtKB/Swiss-Prot), P16228 (UniProtKB/Swiss-Prot), A6IC25 (UniProtKB/TrEMBL)
- Sequence:	show sequence MKPLFVLLLLLLLLDLAQAQGVLHRVPLRRHQSLRKKLRAQGQLSDFWRSHNLDMIEFSESCNV DKGINEPLINYLDMEYFGTVSIGSPSQNFTVIFDTGSSNLWVPSVYCTSPACKAHPVFHPSQSS TYMEVGNHFSIQYGTGSLTGIIGADQVSVEGLTVEGQQFGESVKEPGQTFVNAEFDGILGLGYP SLAVGGVTPVFDNMMAQNLVALPMFSVYLSSDPQGGSGSELTFGGYDPSHFSGSLNWIPVTKQG YWQIALDGIQVGDTVMFCSEGCQAIVDTGTSLITGPPKKIKQLQEAIGATPMDGEYAVDCATLN MMPNVTFLINGVSYTLSPTAYILPDLVDGMQFCGSGFQGLDIQPPAGPLWILGDVFIRKFYSVF DRGNNQVGLAPAVP hide sequence

RefSeq Acc Id:

ENSRNOP00000048353 ⟸ ENSRNOT00000048391

RefSeq Acc Id:

ENSRNOP00000009242 ⟸ ENSRNOT00000009241

RefSeq Acc Id:	NP_001388196 ⟸ NM_001401267
- Peptide Label:	isoform 2 preproprotein
- UniProtKB:	P16228 (UniProtKB/Swiss-Prot), Q63701 (UniProtKB/Swiss-Prot), A6IC25 (UniProtKB/TrEMBL)

Protein Domains

Aspartic peptidase N-terminal Peptidase A1

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P16228-F1-model_v2	AlphaFold	P16228	1-398	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:2446	AgrOrtholog
BioCyc Gene	G2FUF-18343	BioCyc
Ensembl Genes	ENSRNOG00000006963	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein	ENSRNOP00000009242	ENTREZGENE, UniProtKB/Swiss-Prot
	ENSRNOP00000048353	ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000009241	ENTREZGENE, UniProtKB/Swiss-Prot
	ENSRNOT00000048391	ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH	2.40.70.10	UniProtKB/Swiss-Prot
	6.10.140.60	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Acid Proteases	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:5599861	IMAGE-MGC_LOAD
InterPro	Aspartic_peptidase_A1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Aspartic_peptidase_AS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Aspartic_peptidase_N	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PEPTIDASE_A1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Peptidase_aspartic_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:25424	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:72542	IMAGE-MGC_LOAD
NCBI Gene	25424	ENTREZGENE
PANTHER	BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED	UniProtKB/TrEMBL
	CATHEPSIN E	UniProtKB/TrEMBL
	PTHR47966	UniProtKB/Swiss-Prot
	PTHR47966:SF26	UniProtKB/Swiss-Prot
Pfam	A1_Propeptide	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Asp	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Ctse	PhenoGen
PRINTS	PEPSIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	ASP_PROTEASE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PEPTIDASE_A1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	Acid proteases	UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
TIGR	TC206570
UniProt	A6IC24_RAT	UniProtKB/TrEMBL
	A6IC25	ENTREZGENE, UniProtKB/TrEMBL
	A6IC26	ENTREZGENE, UniProtKB/TrEMBL
	A6IC27_RAT	UniProtKB/TrEMBL
	CATE_RAT	UniProtKB/Swiss-Prot, ENTREZGENE
	Q63701	ENTREZGENE
UniProt Secondary	Q63701	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2002-11-06	Ctse	cathepsin E	Ctsea	Cathepsin E	Symbol and Name updated	625702	APPROVED
2002-06-10	Ctsea	Cathepsin E			Symbol and Name status set to approved	70586	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_expression	present in spleen	728265
gene_protein	contains two identical subunits with molecular mass of 42 kDa	728265

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

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