Mt-atp6 (mitochondrially encoded ATP synthase membrane subunit 6) - Rat Genome Database

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Gene: Mt-atp6 (mitochondrially encoded ATP synthase membrane subunit 6) Rattus norvegicus
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Symbol: Mt-atp6
Name: mitochondrially encoded ATP synthase membrane subunit 6
RGD ID: 621239
Description: Predicted to contribute to proton-transporting ATP synthase activity, rotational mechanism. Involved in aging and response to hyperoxia. Predicted to be part of mitochondrial proton-transporting ATP synthase complex. Human ortholog(s) of this gene implicated in Leber hereditary optic neuropathy; NARP syndrome; Parkinson's disease; multiple sclerosis; and systemic lupus erythematosus. Orthologous to human MT-ATP6 (mitochondrially encoded ATP synthase membrane subunit 6); PARTICIPATES IN electron transport chain pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol; aldehydo-D-glucose.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: ATP synthase 6, mitochondrial; ATP synthase F0 subunit 6; Atp6; ATPase subunit 6; mitochondrially encoded ATP synthase 6
RGD Orthologs
Human
Mouse
Dog
Pig
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2MT7,919 - 8,599 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblMT7,919 - 8,599 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0MT7,919 - 8,599 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblMT7,919 - 8,599 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0MT7,919 - 8,599 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4MT7,919 - 8,599 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Cytogenetic MapMT NCBI


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-hydroxy-17beta-estradiol  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxy-17beta-estradiol  (ISO)
5-fluorouracil  (ISO)
aldehydo-D-glucose  (EXP)
apigenin  (EXP)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
ATP  (EXP)
atrazine  (EXP,ISO)
azoxystrobin  (ISO)
beauvericin  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
cadmium dichloride  (EXP)
carbidopa  (ISO)
clorgyline  (ISO)
corosolic acid  (ISO)
D-glucose  (EXP)
desferrioxamine B  (ISO)
diarsenic trioxide  (ISO)
doxorubicin  (ISO)
enniatin  (ISO)
flutamide  (ISO)
fructose  (EXP)
gentamycin  (EXP)
glucose  (EXP)
herbicide  (ISO)
hydrogen peroxide  (EXP,ISO)
irinotecan  (ISO)
ivermectin  (ISO)
lipopolysaccharide  (ISO)
methylparaben  (ISO)
microcystin-LR  (EXP)
N-acetyl-L-cysteine  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
ochratoxin A  (ISO)
paracetamol  (EXP,ISO)
picloram  (ISO)
quercetin  (EXP,ISO)
reactive oxygen species  (EXP)
rotenone  (ISO)
sarpogrelate  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
sodium hydrogensulfite  (EXP)
sulfur dioxide  (EXP)
sunitinib  (ISO)
T-2 toxin  (EXP)
tetrachloromethane  (ISO)
thapsigargin  (ISO)
tributylstannane  (ISO)
trichlopyr  (ISO)
trichloroethene  (EXP)
trilobatin  (EXP)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
zearalenone  (ISO)
zidovudine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Investigation on mitochondrial tRNA(Leu/Lys), NDI and ATPase 6/8 in Iranian multiple sclerosis patients. Ahari SE, etal., Cell Mol Neurobiol. 2007 Sep;27(6):695-700. Epub 2007 Jul 6.
2. Biochemical phenotypes associated with the mitochondrial ATP6 gene mutations at nt8993. Baracca A, etal., Biochim Biophys Acta. 2007 Jul;1767(7):913-9. Epub 2007 May 18.
3. Effects of hyperoxia on mitochondrial multienzyme complex III and V in premature newborn rat lung. Cai C, etal., J Huazhong Univ Sci Technolog Med Sci. 2008 Apr;28(2):207-10. Epub 2008 May 15.
4. Biochemical-clinical correlation in patients with different loads of the mitochondrial DNA T8993G mutation. Carelli V, etal., Arch Neurol. 2002 Feb;59(2):264-70.
5. Variable phenotype including Leigh syndrome with a 9185T>C mutation in the MTATP6 gene. Childs AM, etal., Neuropediatrics. 2007 Dec;38(6):313-6.
6. Infantile spasms with basal ganglia MRI hypersignal may reveal mitochondrial disorder due to T8993G MT DNA mutation. Desguerre I, etal., Neuropediatrics. 2003 Jun;34(5):265-9.
7. The complete nucleotide sequence of the Rattus norvegicus mitochondrial genome: cryptic signals revealed by comparative analysis between vertebrates. Gadaleta G, etal., J Mol Evol 1989 Jun;28(6):497-516.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Transmission and prenatal diagnosis of the T9176C mitochondrial DNA mutation. Jacobs LJ, etal., Mol Hum Reprod. 2005 Mar;11(3):223-8. Epub 2005 Feb 11.
10. Mitochondrial DNA haplogroups M7b1'2 and M8a affect clinical expression of leber hereditary optic neuropathy in Chinese families with the m.11778G-->a mutation. Ji Y, etal., Am J Hum Genet. 2008 Dec;83(6):760-8. Epub 2008 Nov 20.
11. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
12. Identification of novel mitochondrial mutations in Leber's hereditary optic neuropathy. Kumar M, etal., Mol Vis. 2010 Apr 30;16:782-92.
13. Mitochondrial gene expression in rat heart and liver during growth and development. Marin-Garcia J, etal., Biochem Cell Biol. 1997;75(2):137-42.
14. A point mutation in the mitochondrial DNA of diabetes-prone BHE/cdb rats. Mathews CE, etal., FASEB J 1995 Dec;9(15):1638-42.
15. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
16. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
17. Non-random patterns of nucleotide substitutions and codon strategy in the mammalian mitochondrial genes coding for identified and unidentified reading frames. Pepe G, etal., Biochem Int 1983 Apr;6(4):553-63.
18. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
19. GOA pipeline RGD automated data pipeline
20. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
21. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
22. Comprehensive gene review and curation RGD comprehensive gene curation
23. Identification of ataxia-associated mtDNA mutations (m.4052T>C and m.9035T>C) and evaluation of their pathogenicity in transmitochondrial cybrids. Sikorska M, etal., Muscle Nerve. 2009 Sep;40(3):381-94.
24. Mitochondrial polymorphisms significantly reduce the risk of Parkinson disease. van der Walt JM, etal., Am J Hum Genet. 2003 Apr;72(4):804-11. Epub 2003 Feb 28.
25. Association of common mitochondrial DNA variants with multiple sclerosis and systemic lupus erythematosus. Vyshkina T, etal., Clin Immunol. 2008 Oct;129(1):31-5. Epub 2008 Aug 16.
26. [Altered expression of mitochondrial DNA encoding ATP 6, 8 and encoding protein in energy metabolism during cold preservation and reperfusion injury in rat liver transplantation]. Zhang Y, etal., Zhonghua Yi Xue Za Zhi. 2010 Mar 16;90(10):708-11.

Genomics

Comparative Map Data
Mt-atp6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2MT7,919 - 8,599 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblMT7,919 - 8,599 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0MT7,919 - 8,599 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblMT7,919 - 8,599 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0MT7,919 - 8,599 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4MT7,919 - 8,599 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Cytogenetic MapMT NCBI
MT-ATP6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38MT8,527 - 9,207 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 EnsemblMT8,527 - 9,207 (+)EnsemblGRCh38hg38GRCh38
GRCh37MT8,527 - 9,207 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36MT8,528 - 9,208 (+)NCBINCBI36Build 36hg18NCBI36
mt-Atp6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39MT7,927 - 8,607 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblMT7,927 - 8,607 (+)EnsemblGRCm39 Ensembl
GRCm38MT7,927 - 8,607 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblMT7,927 - 8,607 (+)EnsemblGRCm38mm10GRCm38
MGSCv37MT7,927 - 8,607 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MT-ATP6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1MT7,964 - 8,644 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblMT7,964 - 8,644 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaMT7,964 - 8,644 (+)NCBIDog10K_Boxer_Tasha
MT-ATP6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblMT9,120 - 9,800 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1MT9,120 - 9,800 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2MT9,120 - 9,800 (+)NCBISscrofa10.2Sscrofa10.2susScr3

Variants

.
Variants in Mt-atp6
8 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:26
Count of miRNA genes:25
Interacting mature miRNAs:26
Transcripts:ENSRNOT00000046108
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 3 43 53 37 14 37 8 11 74 35 41 11 8
Medium 4 4 5 4
Low
Below cutoff

Sequence

Nucleotide Sequences
GenBank Nucleotide AY172581 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY769440 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ673908 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ673909 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ673910 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ673914 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ673915 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ673916 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ673917 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ919761 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ919762 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ919763 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ919764 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ919765 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GU997608 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GU997611 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JX105355 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JX105356 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KJ530565 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KJ939360 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KJ939361 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KM009112 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KM009113 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KM009114 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KM114603 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KM114604 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KM114605 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KM114606 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KM114607 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KM114608 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KM577635 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KM657952 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KM657953 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KM820831 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KM820832 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KM820833 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KM820837 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KP100657 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KP233827 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KP244683 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000046108   ⟹   ENSRNOP00000049769
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblMT7,919 - 8,599 (+)Ensembl
Rnor_6.0 EnsemblMT7,919 - 8,599 (+)Ensembl
Protein Sequences
Protein RefSeqs YP_665634 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAN77599 (Get FASTA)   NCBI Sequence Viewer  
  AAV31044 (Get FASTA)   NCBI Sequence Viewer  
  ABG11778 (Get FASTA)   NCBI Sequence Viewer  
  ABG11786 (Get FASTA)   NCBI Sequence Viewer  
  ABG11799 (Get FASTA)   NCBI Sequence Viewer  
  ABG11851 (Get FASTA)   NCBI Sequence Viewer  
  ABG11864 (Get FASTA)   NCBI Sequence Viewer  
  ABG11877 (Get FASTA)   NCBI Sequence Viewer  
  ABG11890 (Get FASTA)   NCBI Sequence Viewer  
  ACP50311 (Get FASTA)   NCBI Sequence Viewer  
  ACP50324 (Get FASTA)   NCBI Sequence Viewer  
  ACP50337 (Get FASTA)   NCBI Sequence Viewer  
  ACP50350 (Get FASTA)   NCBI Sequence Viewer  
  ACP50363 (Get FASTA)   NCBI Sequence Viewer  
  ADE05970 (Get FASTA)   NCBI Sequence Viewer  
  ADE05983 (Get FASTA)   NCBI Sequence Viewer  
  AFN06283 (Get FASTA)   NCBI Sequence Viewer  
  AFN06296 (Get FASTA)   NCBI Sequence Viewer  
  AHZ60971 (Get FASTA)   NCBI Sequence Viewer  
  AIU45580 (Get FASTA)   NCBI Sequence Viewer  
  AIU45593 (Get FASTA)   NCBI Sequence Viewer  
  AIU45606 (Get FASTA)   NCBI Sequence Viewer  
  AIU45619 (Get FASTA)   NCBI Sequence Viewer  
  AIU45632 (Get FASTA)   NCBI Sequence Viewer  
  AIU45645 (Get FASTA)   NCBI Sequence Viewer  
  AIU45658 (Get FASTA)   NCBI Sequence Viewer  
  AIU45671 (Get FASTA)   NCBI Sequence Viewer  
  AIU45684 (Get FASTA)   NCBI Sequence Viewer  
  AIU45697 (Get FASTA)   NCBI Sequence Viewer  
  AIU45710 (Get FASTA)   NCBI Sequence Viewer  
  AIY51547 (Get FASTA)   NCBI Sequence Viewer  
  AIZ58327 (Get FASTA)   NCBI Sequence Viewer  
  AIZ58340 (Get FASTA)   NCBI Sequence Viewer  
  AJE26535 (Get FASTA)   NCBI Sequence Viewer  
  AJE61344 (Get FASTA)   NCBI Sequence Viewer  
  AJE61357 (Get FASTA)   NCBI Sequence Viewer  
  AJE61370 (Get FASTA)   NCBI Sequence Viewer  
  AJE61409 (Get FASTA)   NCBI Sequence Viewer  
  AJJ48754 (Get FASTA)   NCBI Sequence Viewer  
  AJK30562 (Get FASTA)   NCBI Sequence Viewer  
  P05504 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: ENSRNOP00000049769   ⟸   ENSRNOT00000046108

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P05504-F1-model_v2 AlphaFold P05504 1-226 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621239 AgrOrtholog
BioCyc Gene G2FUF-16 BioCyc
BioCyc Pathway PWY-7980 [ATP biosynthesis] BioCyc
Ensembl Genes ENSRNOG00000031979 Ensembl, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000049769 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000046108 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.120.220 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ATP_synth_F0_asu UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATP_synth_F0_asu_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATP_synth_F0_asu_bact/mt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  F0_ATP_A_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:26197 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 26197 ENTREZGENE
PANTHER PTHR11410 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ATP-synt_A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mt-atp6 PhenoGen
PRINTS ATPASEA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ATPASE_A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF81336 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs ATP_synt_6_or_A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt ATP6_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q8HIC7 ENTREZGENE, UniProtKB/TrEMBL
  Q9T2E9 ENTREZGENE
UniProt Secondary Q9T2E9 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-03-17 Mt-atp6  mitochondrially encoded ATP synthase membrane subunit 6  Mt-atp6  mitochondrially encoded ATP synthase 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-09 Mt-atp6  mitochondrially encoded ATP synthase 6  mt-Atp6  ATP synthase 6, mitochondrial  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-11 mt-Atp6  ATP synthase 6, mitochondrial      Symbol and Name status set to approved 625702 APPROVED
2002-08-07 mt-Atp6  ATP synthase 6, mitochondrial      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_disease point mutations may be associated with diabetes  
gene_function may mediate mitochondrial translation and transcription mechanisms 631900