Mt-atp6 (mitochondrially encoded ATP synthase membrane subunit 6) - Rat Genome Database
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Gene: Mt-atp6 (mitochondrially encoded ATP synthase membrane subunit 6) Rattus norvegicus
Analyze
Symbol: Mt-atp6
Name: mitochondrially encoded ATP synthase membrane subunit 6
RGD ID: 621239
Description: Predicted to contribute to proton-transporting ATP synthase activity, rotational mechanism. Involved in aging and response to hyperoxia. Predicted to localize to mitochondrial proton-transporting ATP synthase complex. Human ortholog(s) of this gene implicated in Leber hereditary optic neuropathy; NARP syndrome; Parkinson's disease; multiple sclerosis; and systemic lupus erythematosus. Orthologous to human MT-ATP6 (mitochondrially encoded ATP synthase membrane subunit 6); PARTICIPATES IN electron transport chain pathway; INTERACTS WITH 3-chloropropane-1,2-diol; aldehydo-D-glucose; apigenin.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: ATP synthase 6, mitochondrial; ATP synthase F0 subunit 6; Atp6; ATPase subunit 6; mitochondrially encoded ATP synthase 6
RGD Orthologs
Human
Mouse
Dog
Pig
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0MT7,919 - 8,599 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblMT7,919 - 8,599 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0MT7,919 - 8,599 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4MT7,919 - 8,599 (+)NCBIRGSC3.4rn4RGSC3.4
Cytogenetic MapMT NCBI


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
1. Ahari SE, etal., Cell Mol Neurobiol. 2007 Sep;27(6):695-700. Epub 2007 Jul 6.
2. Baracca A, etal., Biochim Biophys Acta. 2007 Jul;1767(7):913-9. Epub 2007 May 18.
3. Cai C, etal., J Huazhong Univ Sci Technolog Med Sci. 2008 Apr;28(2):207-10. Epub 2008 May 15.
4. Carelli V, etal., Arch Neurol. 2002 Feb;59(2):264-70.
5. Childs AM, etal., Neuropediatrics. 2007 Dec;38(6):313-6.
6. Desguerre I, etal., Neuropediatrics. 2003 Jun;34(5):265-9.
7. Gadaleta G, etal., J Mol Evol 1989 Jun;28(6):497-516.
8. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Jacobs LJ, etal., Mol Hum Reprod. 2005 Mar;11(3):223-8. Epub 2005 Feb 11.
10. Ji Y, etal., Am J Hum Genet. 2008 Dec;83(6):760-8. Epub 2008 Nov 20.
11. KEGG
12. Kumar M, etal., Mol Vis. 2010 Apr 30;16:782-92.
13. Marin-Garcia J, etal., Biochem Cell Biol. 1997;75(2):137-42.
14. Mathews CE, etal., FASEB J 1995 Dec;9(15):1638-42.
15. MGD data from the GO Consortium
16. NCBI rat LocusLink and RefSeq merged data July 26, 2002
17. Pepe G, etal., Biochem Int 1983 Apr;6(4):553-63.
18. Pipeline to import SMPDB annotations from SMPDB into RGD
19. RGD automated data pipeline
20. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
21. RGD automated import pipeline for gene-chemical interactions
22. RGD comprehensive gene curation
23. Sikorska M, etal., Muscle Nerve. 2009 Sep;40(3):381-94.
24. van der Walt JM, etal., Am J Hum Genet. 2003 Apr;72(4):804-11. Epub 2003 Feb 28.
25. Vyshkina T, etal., Clin Immunol. 2008 Oct;129(1):31-5. Epub 2008 Aug 16.
26. Zhang Y, etal., Zhonghua Yi Xue Za Zhi. 2010 Mar 16;90(10):708-11.

Genomics

Comparative Map Data
Mt-atp6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0MT7,919 - 8,599 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblMT7,919 - 8,599 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0MT7,919 - 8,599 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4MT7,919 - 8,599 (+)NCBIRGSC3.4rn4RGSC3.4
Cytogenetic MapMT NCBI
MT-ATP6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 EnsemblMT8,527 - 9,207 (+)EnsemblGRCh38hg38GRCh38
GRCh38MT8,527 - 9,207 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37MT8,527 - 9,207 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36MT8,528 - 9,208 (+)NCBINCBI36hg18NCBI36
mt-Atp6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39MT7,927 - 8,607 (+)NCBIGRCm39mm39
GRCm38MT7,927 - 8,607 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblMT7,927 - 8,607 (+)EnsemblGRCm38mm10GRCm38
MGSCv37MT7,927 - 8,607 (+)NCBIGRCm37mm9NCBIm37
MT-ATP6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 EnsemblMT7,964 - 8,644 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1MT7,964 - 8,644 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
ATP6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblMT9,120 - 9,800 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1MT9,120 - 9,800 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2MT9,120 - 9,800 (+)NCBISscrofa10.2Sscrofa10.2susScr3

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:26
Count of miRNA genes:25
Interacting mature miRNAs:26
Transcripts:ENSRNOT00000046108
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 3 43 53 37 14 37 8 11 74 35 41 11 8
Medium 4 4 5 4
Low
Below cutoff

Sequence

Nucleotide Sequences
GenBank Nucleotide AY172581 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY769440 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ673908 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ673909 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ673910 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ673914 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ673915 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ673916 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ673917 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ919761 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ919762 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ919763 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ919764 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ919765 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GU997608 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GU997611 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JX105355 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JX105356 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KJ530565 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KJ939360 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KJ939361 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KM009112 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KM009113 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KM009114 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KM114603 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KM114604 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KM114605 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KM114606 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KM114607 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KM114608 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KM577635 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KM657952 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KM657953 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KM820831 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KM820832 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KM820833 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KM820837 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KP100657 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KP233827 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KP244683 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000046108   ⟹   ENSRNOP00000049769
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblMT7,919 - 8,599 (+)Ensembl
Protein Sequences
Protein RefSeqs YP_665634 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAN77599 (Get FASTA)   NCBI Sequence Viewer  
  AAV31044 (Get FASTA)   NCBI Sequence Viewer  
  ABG11778 (Get FASTA)   NCBI Sequence Viewer  
  ABG11786 (Get FASTA)   NCBI Sequence Viewer  
  ABG11799 (Get FASTA)   NCBI Sequence Viewer  
  ABG11851 (Get FASTA)   NCBI Sequence Viewer  
  ABG11864 (Get FASTA)   NCBI Sequence Viewer  
  ABG11877 (Get FASTA)   NCBI Sequence Viewer  
  ABG11890 (Get FASTA)   NCBI Sequence Viewer  
  ACP50311 (Get FASTA)   NCBI Sequence Viewer  
  ACP50324 (Get FASTA)   NCBI Sequence Viewer  
  ACP50337 (Get FASTA)   NCBI Sequence Viewer  
  ACP50350 (Get FASTA)   NCBI Sequence Viewer  
  ACP50363 (Get FASTA)   NCBI Sequence Viewer  
  ADE05970 (Get FASTA)   NCBI Sequence Viewer  
  ADE05983 (Get FASTA)   NCBI Sequence Viewer  
  AFN06283 (Get FASTA)   NCBI Sequence Viewer  
  AFN06296 (Get FASTA)   NCBI Sequence Viewer  
  AHZ60971 (Get FASTA)   NCBI Sequence Viewer  
  AIU45580 (Get FASTA)   NCBI Sequence Viewer  
  AIU45593 (Get FASTA)   NCBI Sequence Viewer  
  AIU45606 (Get FASTA)   NCBI Sequence Viewer  
  AIU45619 (Get FASTA)   NCBI Sequence Viewer  
  AIU45632 (Get FASTA)   NCBI Sequence Viewer  
  AIU45645 (Get FASTA)   NCBI Sequence Viewer  
  AIU45658 (Get FASTA)   NCBI Sequence Viewer  
  AIU45671 (Get FASTA)   NCBI Sequence Viewer  
  AIU45684 (Get FASTA)   NCBI Sequence Viewer  
  AIU45697 (Get FASTA)   NCBI Sequence Viewer  
  AIU45710 (Get FASTA)   NCBI Sequence Viewer  
  AIY51547 (Get FASTA)   NCBI Sequence Viewer  
  AIZ58327 (Get FASTA)   NCBI Sequence Viewer  
  AIZ58340 (Get FASTA)   NCBI Sequence Viewer  
  AJE26535 (Get FASTA)   NCBI Sequence Viewer  
  AJE61344 (Get FASTA)   NCBI Sequence Viewer  
  AJE61357 (Get FASTA)   NCBI Sequence Viewer  
  AJE61370 (Get FASTA)   NCBI Sequence Viewer  
  AJE61409 (Get FASTA)   NCBI Sequence Viewer  
  AJJ48754 (Get FASTA)   NCBI Sequence Viewer  
  AJK30562 (Get FASTA)   NCBI Sequence Viewer  
  P05504 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: ENSRNOP00000049769   ⟸   ENSRNOT00000046108

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621239 AgrOrtholog
Ensembl Genes ENSRNOG00000031979 Ensembl, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000049769 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000046108 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.120.220 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ATP_synth_F0_asu UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATP_synth_F0_asu_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  F0_ATP_A_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:26197 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 26197 ENTREZGENE
Pfam ATP-synt_A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mt-atp6 PhenoGen
PRINTS ATPASEA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ATPASE_A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF81336 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs ATP_synt_6_or_A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt ATP6_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q8HIC7 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary Q9T2E9 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-03-17 Mt-atp6  mitochondrially encoded ATP synthase membrane subunit 6  Mt-atp6  mitochondrially encoded ATP synthase 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-09 Mt-atp6  mitochondrially encoded ATP synthase 6  mt-Atp6  ATP synthase 6, mitochondrial  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-11 mt-Atp6  ATP synthase 6, mitochondrial      Symbol and Name status set to approved 625702 APPROVED
2002-08-07 mt-Atp6  ATP synthase 6, mitochondrial      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_disease point mutations may be associated with diabetes  
gene_function may mediate mitochondrial translation and transcription mechanisms 631900