RGD Reference Report - Non-random patterns of nucleotide substitutions and codon strategy in the mammalian mitochondrial genes coding for identified and unidentified reading frames. - Rat Genome Database

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Non-random patterns of nucleotide substitutions and codon strategy in the mammalian mitochondrial genes coding for identified and unidentified reading frames.

Authors: Pepe, G  Holtrop, M  Gadaleta, G  Kroon, AM  Cantatore, P  Gallerani, R  De Benedetto, C  Quagliariello, C  Sbisa, E  Saccone, C 
Citation: Pepe G, etal., Biochem Int 1983 Apr;6(4):553-63.
RGD ID: 631902
Pubmed: PMID:6091655   (View Abstract at PubMed)

The base sequence of large part of the mitochondrial DNA of Wistar rats is presented. The sequence is compared with those of other mammalian mitochondrial DNAs. The nucleotide and amino acid homologies, codon strategy, nature and patterns of substitutions are reported. It results a very high amount of silent substitutions and, in short divergence time, a predominance of transitions on transversions. In both types of substitutions a strong bias in avoiding the use of the G in the third codon position is observed.

Objects referenced in this article
Gene Mt-atp6 mitochondrially encoded ATP synthase membrane subunit 6 Rattus norvegicus
Gene Mt-co1 mitochondrially encoded cytochrome c oxidase I Rattus norvegicus
Gene Mt-co2 mitochondrially encoded cytochrome c oxidase II Rattus norvegicus
Gene Mt-co3 mitochondrially encoded cytochrome c oxidase III Rattus norvegicus

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