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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621239
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mt-atp6
Name: mitochondrially encoded ATP synthase membrane subunit 6
Acc ID: CHEBI:7719
Term: ochratoxin A
Definition: A phenylalanine derivative resulting from the formal condensation of the amino group of L-phenylalanine with the carboxy group of (3R)-5-chloro-8-hydroxy-3-methyl-1-oxo-3,4-dihydro-1H-2-benzopyran-7-carboxylic acid (ochratoxin alpha). It is among the most widely occurring food-contaminating mycotoxins, produced by Aspergillus ochraceus, Aspergillus carbonarius and Penicillium verrucosum.
Chemical ID: MESH:C025589
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mt-atp6increases expressionISOMT-ATP6 (Homo sapiens)6480464CTDochratoxin A results in increased expression of ATP6 mRNAPMID:34015425
Mt-atp6multiple interactionsISOMT-ATP6 (Homo sapiens)6480464CTD[beauvericin co-treated with enniatins co-treated with ochratoxin A] results in increased expression of ATP6 mRNA; [Plant Extracts co-treated with ochratoxin A co-treated with Zearalenone co-treated with beauvericin] results in decreased expression of ATP6 mRNA; [Plant Extracts co-treated with ochratoxin A] results in increased expression of ATP6 mRNAPMID:34015425
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