Gene: Dpyd (dihydropyrimidine dehydrogenase) Rattus norvegicus
Analyze
Symbol:
Dpyd
Name:
dihydropyrimidine dehydrogenase
Description:
Exhibits several functions, including coenzyme binding activity; oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor; and protein homodimerization activity. Involved in several processes, including circadian rhythm; pyrimidine nucleobase metabolic process; and response to glucocorticoid. Localizes to the cytosol. Used to study colorectal cancer. Biomarker of liver disease. Human ortholog(s) of this gene implicated in dihydropyrimidine dehydrogenase deficiency; pancreatic cancer; and precursor lymphoblastic lymphoma/leukemia. Orthologous to human DPYD (dihydropyrimidine dehydrogenase); PARTICIPATES IN pyrimidine metabolic pathway; beta-alanine metabolic pathway; beta-ureidopropionase deficiency pathway; INTERACTS WITH (+)-schisandrin B; 1-benzylpiperazine; 17beta-estradiol.
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
DHPDHase; dihydropyrimidine dehydrogenase [NADP(+)]; dihydropyrimidine dehydrogenase [NADP+]; dihydrothymine dehydrogenase; dihydrouracil dehydrogenase; DPD
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
DPYD (dihydropyrimidine dehydrogenase) HGNC
Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, Treefam
Mus musculus (house mouse):
Dpyd (dihydropyrimidine dehydrogenase) HGNC
Treefam, NCBI, OMA, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Dpyd (dihydropyrimidine dehydrogenase) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
DPYD (dihydropyrimidine dehydrogenase) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
DPYD (dihydropyrimidine dehydrogenase) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Dpyd (dihydropyrimidine dehydrogenase) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
DPYD (dihydropyrimidine dehydrogenase) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):
DPYD (dihydropyrimidine dehydrogenase) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Homo sapiens (human):
DPYD (dihydropyrimidine dehydrogenase)
Alliance
DIOPT (HGNC, Hieranoid, InParanoid, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB)
Mus musculus (house mouse):
Dpyd (dihydropyrimidine dehydrogenase)
Alliance
DIOPT (Hieranoid, InParanoid, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB)
Danio rerio (zebrafish):
dpydb (dihydropyrimidine dehydrogenase b)
Alliance
DIOPT (Hieranoid, InParanoid, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB)
Caenorhabditis elegans (roundworm):
dpyd-1
Alliance
DIOPT (Hieranoid, InParanoid, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB)
Drosophila melanogaster (fruit fly):
su(r)
Alliance
DIOPT (Hieranoid, InParanoid, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information:
Annotation category: partial on reference assembly
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 2 221,823,692 - 222,694,627 (+) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 2 221,823,687 - 222,694,627 (+) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 2 239,874,415 - 240,000,215 (+) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 Rnor_5.0 2 240,072,322 - 240,744,042 (+) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 2 214,931,901 - 215,818,809 (+) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 2 214,894,962 - 215,781,871 (+) NCBI Celera 2 199,080,477 - 199,932,183 (+) NCBI Celera Cytogenetic Map 2 q41 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Disease Annotations
RGD Manual Annotations
colorectal cancer IDA 11251746 protein:increased activity:liver RGD Drug-Induced Immune Thrombocytopenia treatment ISO RGD:731730 11098817 associated with Neoplasms, DNA:SNP:intron:IVS14+1G>A (human) RGD Drug-Induced Immune Thrombocytopenia treatment ISO RGD:731730 11251740 associated with Stomach Neoplasms RGD Drug-induced Neutropenia treatment ISO RGD:731730 11251737 associated with Colorectal Neoplasms, DNA:SNPs: :rs1801159 (1896T>C), rs17376848 (human) RGD Drug-induced Neutropenia no_association ISO RGD:731730 11098817 associated with Neoplasms, DNA:missense mutations: :multiple RGD Drug-induced Neutropenia treatment ISO RGD:731730 11251738 DNA:splice-site mutation, missense mutations: :multiple RGD Drug-induced Neutropenia treatment ISO RGD:731730 11098817 associated with Neoplasms, DNA:missense mutation: :p.M166V (496A>G) (human) RGD Drug-induced Neutropenia treatment ISO RGD:731730 11251736 associated with Neoplasms, DNA:splice-site mutation:intron:IVS14+1G>A (human) RGD gallbladder cancer disease_progression ISO RGD:731730 2317631 RGD liver disease IEP 1599789 mRNA, Protein:increased expression RGD Neoplasm Metastasis treatment ISO RGD:731730 11251755 associated with Colonic Neoplasms RGD pancreatic cancer ISO RGD:731730 2317630 RGD pancreatic cancer disease_progression ISO RGD:731730 2317629 protein:increased expression:pancreas RGD precursor lymphoblastic lymphoma/leukemia ISO RGD:731730 11098453 DNA:SNP: :85T>C (human) RGD precursor lymphoblastic lymphoma/leukemia no_association ISO RGD:731730 11098453 DNA:SNPs: :2194G>A, 1156G>T (human) RGD precursor lymphoblastic lymphoma/leukemia disease_progression ISO RGD:731730 11098453 DNA:splice-site mutation:intron:IVS14+1G>A (human) RGD Sarcoma, Yoshida treatment IMP 11251753 RGD
Imported Annotations - ClinVar
autistic disorder ISO RGD:731730 8554872 ClinVar Annotator: match by term: Autistic disorder of childhood onset ClinVar PMID:10071185 more ... Bunion ISO RGD:731730 8554872 ClinVar Annotator: match by term: Bunion ClinVar PMID:10071185 more ... Cognitive Dysfunction ISO RGD:731730 8554872 ClinVar Annotator: match by term: Cognitive impairment ClinVar PMID:10071185 more ... Developmental Disabilities ISO RGD:731730 8554872 ClinVar Annotator: match by term: Developmental delay ClinVar PMID:10071185 more ... dihydropyrimidine dehydrogenase deficiency ISO RGD:731730 8554872 ClinVar Annotator: match by OMIM:274270 ClinVar PMID:9254861 dihydropyrimidine dehydrogenase deficiency ISO RGD:731730 8554872 ClinVar Annotator: match by term: Dihydropyrimidine dehydrogenase deficiency ClinVar PMID:14635116 more ... dihydropyrimidine dehydrogenase deficiency ISO RGD:731730 8554872 ClinVar Annotator: match by term: Hereditary Thymine-Uraciluria ClinVar PMID:10071185 more ... dihydropyrimidine dehydrogenase deficiency ISO RGD:731730 8554872 ClinVar Annotator: match by term: Hereditary Thymine-Uraciluria ClinVar PMID:10071185 more ... dihydropyrimidine dehydrogenase deficiency ISO RGD:731730 8554872 ClinVar Annotator: match by term: Hereditary Thymine-Uraciluria ClinVar PMID:16361556 more ... dihydropyrimidine dehydrogenase deficiency ISO RGD:731730 8554872 ClinVar Annotator: match by term: Dihydropyrimidine dehydrogenase deficiency ClinVar PMID:25087612 , PMID:25741868 dihydropyrimidine dehydrogenase deficiency ISO RGD:731730 8554872 ClinVar Annotator: match by term: Hereditary Thymine-Uraciluria ClinVar PMID:10803677 more ... dihydropyrimidine dehydrogenase deficiency ISO RGD:731730 8554872 ClinVar Annotator: match by term: Dihydropyrimidine dehydrogenase deficiency ClinVar PMID:19822137 more ... dihydropyrimidine dehydrogenase deficiency ISO RGD:731730 8554872 ClinVar Annotator: match by term: Dihydropyrimidine dehydrogenase deficiency ClinVar PMID:26467025 more ... dihydropyrimidine dehydrogenase deficiency ISO RGD:731730 8554872 ClinVar Annotator: match by term: Dihydropyrimidine dehydrogenase deficiency ClinVar PMID:19473056 more ... dihydropyrimidine dehydrogenase deficiency ISO RGD:731730 8554872 ClinVar Annotator: match by term: Dihydropyrimidine dehydrogenase deficiency ClinVar PMID:26467025 dihydropyrimidine dehydrogenase deficiency ISO RGD:731730 8554872 ClinVar Annotator: match by term: Dihydropyrimidine dehydrogenase deficiency ClinVar PMID:25741868 , PMID:26467025 dihydropyrimidine dehydrogenase deficiency ISO RGD:731730 8554872 ClinVar Annotator: match by term: Hereditary Thymine-Uraciluria ClinVar PMID:10071185 more ... dihydropyrimidine dehydrogenase deficiency ISO RGD:731730 8554872 ClinVar Annotator: match by term: Dihydropyrimidine dehydrogenase deficiency ClinVar PMID:10671643 more ... dihydropyrimidine dehydrogenase deficiency ISO RGD:731730 8554872 ClinVar Annotator: match by term: Dihydropyrimidine dehydrogenase deficiency ClinVar PMID:24648345 dihydropyrimidine dehydrogenase deficiency ISO RGD:731730 8554872 ClinVar Annotator: match by term: Dihydropyrimidine dehydrogenase deficiency ClinVar PMID:27727460 dihydropyrimidine dehydrogenase deficiency ISO RGD:731730 8554872 ClinVar Annotator: match by term: Dihydropyrimidine dehydrogenase deficiency ClinVar PMID:16033824 more ... dihydropyrimidine dehydrogenase deficiency ISO RGD:731730 8554872 ClinVar Annotator: match by term: Dihydropyrimidine dehydrogenase deficiency ClinVar PMID:21590448 dihydropyrimidine dehydrogenase deficiency ISO RGD:731730 8554872 ClinVar Annotator: match by term: Dihydropyrimidine dehydrogenase deficiency ClinVar PMID:19473056 dihydropyrimidine dehydrogenase deficiency ISO RGD:731730 8554872 ClinVar Annotator: match by term: Dihydropyrimidine dehydrogenase deficiency ClinVar PMID:11988088 , PMID:24648345 dihydropyrimidine dehydrogenase deficiency ISO RGD:731730 8554872 ClinVar Annotator: match by term: Dihydropyrimidine dehydrogenase deficiency ClinVar PMID:11988088 more ... dihydropyrimidine dehydrogenase deficiency ISO RGD:731730 8554872 ClinVar Annotator: match by term: Dihydropyrimidine dehydrogenase deficiency ClinVar PMID:18600544 dihydropyrimidine dehydrogenase deficiency ISO RGD:731730 8554872 ClinVar Annotator: match by term: Dihydropyrimidine dehydrogenase deficiency ClinVar PMID:24648345 , PMID:9439663 dihydropyrimidine dehydrogenase deficiency ISO RGD:731730 8554872 ClinVar Annotator: match by term: Hereditary Thymine-Uraciluria ClinVar PMID:11156223 more ... dihydropyrimidine dehydrogenase deficiency ISO RGD:731730 8554872 ClinVar Annotator: match by term: Dihydropyrimidine dehydrogenase deficiency ClinVar PMID:15899693 , PMID:25565930 dihydropyrimidine dehydrogenase deficiency ISO RGD:731730 8554872 ClinVar Annotator: match by term: Dihydropyrimidine dehydrogenase deficiency ClinVar PMID:14523039 more ... dihydropyrimidine dehydrogenase deficiency ISO RGD:731730 8554872 ClinVar Annotator: match by term: Dihydropyrimidine dehydrogenase deficiency ClinVar PMID:25741868 dihydropyrimidine dehydrogenase deficiency ISO RGD:731730 8554872 ClinVar Annotator: match by OMIM:274270 ClinVar dihydropyrimidine dehydrogenase deficiency ISO RGD:731730 8554872 ClinVar Annotator: match by OMIM:274270 ClinVar PMID:15899693 dihydropyrimidine dehydrogenase deficiency ISO RGD:731730 8554872 ClinVar Annotator: match by OMIM:274270 ClinVar PMID:26804652 dihydropyrimidine dehydrogenase deficiency ISO RGD:731730 8554872 ClinVar Annotator: match by OMIM:274270 ClinVar PMID:19296131 , PMID:9254861 dihydropyrimidine dehydrogenase deficiency ISO RGD:731730 8554872 ClinVar Annotator: match by OMIM:274270 ClinVar PMID:22353294 dihydropyrimidine dehydrogenase deficiency ISO RGD:731730 8554872 ClinVar Annotator: match by OMIM:274270 ClinVar PMID:12562666 more ... dihydropyrimidine dehydrogenase deficiency ISO RGD:731730 8554872 ClinVar Annotator: match by term: Dihydropyrimidine dehydrogenase deficiency ClinVar PMID:11875367 more ... epilepsy ISO RGD:731730 8554872 ClinVar Annotator: match by term: Epilepsy ClinVar PMID:10071185 more ... genetic disease ISO RGD:731730 8554872 ClinVar Annotator: match by term: Inborn genetic diseases ClinVar PMID:10071185 more ... genetic disease ISO RGD:731730 8554872 ClinVar Annotator: match by term: Inborn genetic diseases ClinVar PMID:10071185 more ... Hallux Valgus ISO RGD:731730 8554872 ClinVar Annotator: match by term: Hallux valgus ClinVar PMID:10071185 more ... head and neck squamous cell carcinoma ISO RGD:731730 8554872 ClinVar Annotator: match by term: Squamous cell carcinoma of the head and neck ClinVar Hirschsprung Disease 1 ISO RGD:731730 8554872 ClinVar Annotator: match by term: Hirschsprung disease 1 ClinVar PMID:10071185 more ... Hirschsprung's disease ISO RGD:731730 8554872 ClinVar Annotator: match by term: Hirschsprung Disease ClinVar PMID:10071185 more ... intellectual disability ISO RGD:731730 8554872 ClinVar Annotator: match by term: Mental-retardation ClinVar PMID:10071185 more ... Macroglossia ISO RGD:731730 8554872 ClinVar Annotator: match by term: Macroglossia ClinVar PMID:10071185 more ... melanoma ISO RGD:731730 8554872 ClinVar Annotator: match by term: Malignant melanoma ClinVar Prognathism ISO RGD:731730 8554872 ClinVar Annotator: match by term: Prognathism ClinVar PMID:10071185 more ... prostate cancer ISO RGD:731730 8554872 ClinVar Annotator: match by term: Prostate cancer ClinVar PMID:23265383 visual epilepsy ISO RGD:731730 8554872 ClinVar Annotator: match by term: Seizure ClinVar PMID:10071185 more ...
Imported Annotations - CTD
autism spectrum disorder ISO RGD:731730 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:18252227 , PMID:20844286 autistic disorder ISO RGD:731730 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:21114665 Breast Neoplasms ISO RGD:731730 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:19020767 Colonic Neoplasms ISO RGD:731730 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:18652704 Colorectal Neoplasms ISO RGD:731730 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:15222106 more ... dihydropyrimidine dehydrogenase deficiency ISO RGD:731730 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:9816193 , PMID:16151913 Head and Neck Neoplasms ISO RGD:731730 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:19020767 hepatocellular carcinoma ISO RGD:731730 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:18019677 Language Development Disorders ISO RGD:731730 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:21114665 Leukoencephalopathies ISO RGD:731730 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:11148247 Lung Neoplasms ISO RGD:731730 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:19020767 Neoplasm Metastasis ISO RGD:731730 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:17611699 nervous system disease ISO RGD:731730 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:16435204 neutropenia ISO RGD:731730 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:12562666 obesity ISO RGD:731730 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:20882379 pancreatic cancer ISO RGD:731730 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:17443278 , PMID:19020767 peripheral nervous system disease ISO RGD:731730 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:20864405 purine-pyrimidine metabolic disorder ISO RGD:731730 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:3335642 , PMID:15571261 schizophrenia ISO RGD:731730 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:21822266 , PMID:23042115 Stomach Neoplasms ISO RGD:731730 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:15837757 more ... Imported Annotations - OMIM
dihydropyrimidine dehydrogenase deficiency ISO RGD:731730 7240710 OMIM
(+)-schisandrin B multiple interactions EXP 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of DPYD mRNA] CTD PMID:31150632 1-benzylpiperazine decreases expression EXP 6480464 N-benzylpiperazine results in decreased expression of DPYD mRNA CTD PMID:26821219 1-chloro-2,4-dinitrobenzene decreases expression ISO RGD:731730 6480464 Dinitrochlorobenzene results in decreased expression of DPYD mRNA CTD PMID:17374397 17beta-estradiol multiple interactions EXP 6480464 [bisphenol A co-treated with Estradiol] results in increased expression of DPYD mRNA CTD PMID:26496021 17beta-estradiol multiple interactions ISO RGD:731730 6480464 [Estradiol co-treated with TGFB1 protein] results in decreased expression of DPYD mRNA CTD PMID:30165855 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:1550111 6480464 Tetrachlorodibenzodioxin results in increased expression of DPYD mRNA CTD PMID:19770486 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of DPYD mRNA CTD PMID:18796159 , PMID:21215274 2,4-dinitrotoluene affects expression EXP 6480464 2, 4-dinitrotoluene affects the expression of DPYD mRNA CTD PMID:21346803 2,6-dinitrotoluene affects expression EXP 6480464 2, 6-dinitrotoluene affects the expression of DPYD mRNA CTD PMID:21346803 2-nitrofluorene decreases expression EXP 6480464 2-nitrofluorene results in decreased expression of DPYD mRNA CTD PMID:15890375 3,4-methylenedioxymethamphetamine decreases expression ISO RGD:1550111 6480464 N-Methyl-3, 4-methylenedioxyamphetamine results in decreased expression of DPYD mRNA CTD PMID:20188158 , PMID:26251327 3H-1,2-dithiole-3-thione decreases expression EXP 6480464 1, 2-dithiol-3-thione results in decreased expression of DPYD mRNA CTD PMID:19162173 4'-epidoxorubicin multiple interactions ISO RGD:731730 6480464 DPYD protein affects the susceptibility to [Fluorouracil co-treated with Epirubicin] CTD PMID:16646564 4,4'-diaminodiphenylmethane increases expression ISO RGD:1550111 6480464 4, 4'-diaminodiphenylmethane results in increased expression of DPYD mRNA CTD PMID:18648102 4-(ethoxymethylene)-2-phenyloxazol-5-one decreases expression ISO RGD:731730 6480464 Oxazolone results in decreased expression of DPYD mRNA CTD PMID:17374397 4-(ethoxymethylene)-2-phenyloxazol-5-one decreases expression ISO RGD:1550111 6480464 Oxazolone results in decreased expression of DPYD mRNA CTD PMID:21404309 4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one decreases expression EXP 6480464 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of DPYD mRNA CTD PMID:15890375 4-hydroxyphenyl retinamide increases expression ISO RGD:1550111 6480464 Fenretinide results in increased expression of DPYD mRNA CTD PMID:28973697 5-aza-2'-deoxycytidine increases expression ISO RGD:731730 6480464 Decitabine results in increased expression of DPYD mRNA CTD PMID:17612628 5-aza-2'-deoxycytidine decreases methylation ISO RGD:731730 6480464 Decitabine results in decreased methylation of DPYD promoter CTD PMID:17612628 5-azacytidine multiple interactions ISO RGD:731730 6480464 [Azacitidine results in decreased methylation of DPYD promoter] which results in increased expression of DPYD mRNA CTD PMID:15501990 5-azacytidine decreases response to substance ISO RGD:731730 6480464 DPYD protein results in decreased susceptibility to Azacitidine CTD PMID:15501990 5-azacytidine decreases methylation ISO RGD:731730 6480464 Azacitidine results in decreased methylation of DPYD promoter CTD PMID:15501990 5-fluorouracil increases response to substance ISO RGD:731730 6480464 DPYD gene mutant form results in increased susceptibility to Fluorouracil more ... CTD PMID:15239142 more ... 5-fluorouracil decreases expression ISO RGD:731730 6480464 Fluorouracil results in decreased expression of DPYD mRNA CTD PMID:15109396 more ... 5-fluorouracil increases metabolic processing ISO RGD:731730 6480464 DPYD protein results in increased metabolism of Fluorouracil CTD PMID:15591715 more ... 5-fluorouracil decreases response to substance ISO RGD:731730 6480464 DPYD mRNA results in decreased susceptibility to Fluorouracil, DPYD protein results in decreased susceptibility to Fluorouracil CTD PMID:14689231 more ... 5-fluorouracil decreases response to substance ISO RGD:1550111 6480464 DPYD mRNA results in decreased susceptibility to Fluorouracil CTD PMID:16525674 5-fluorouracil increases activity ISO RGD:731730 6480464 Fluorouracil results in increased activity of DPYD protein CTD PMID:16557585 5-fluorouracil increases expression ISO RGD:731730 6480464 Fluorouracil results in increased expression of DPYD mRNA, Fluorouracil results in increased expression of DPYD protein CTD PMID:15865071 more ... 5-fluorouracil affects activity ISO RGD:731730 6480464 Fluorouracil metabolite affects the activity of DPYD protein CTD PMID:16761622 5-fluorouracil increases degradation ISO RGD:731730 6480464 DPYD protein results in increased degradation of Fluorouracil CTD PMID:17046731 5-fluorouracil decreases metabolic processing ISO RGD:731730 6480464 DPYD gene polymorphism results in decreased metabolism of Fluorouracil, DPYD protein mutant form results in decreased metabolism of Fluorouracil CTD PMID:15591715 more ... 5-fluorouracil affects degradation ISO RGD:731730 6480464 DPYD protein affects the degradation of Fluorouracil CTD PMID:15858133 5-fluorouracil affects response to substance ISO RGD:731730 6480464 DPYD gene polymorphism affects the susceptibility to Fluorouracil more ... CTD PMID:10099659 more ... 5-fluorouracil affects metabolic processing ISO RGD:731730 6480464 DPYD affects the metabolism of Fluorouracil, DPYD protein affects the metabolism of Fluorouracil CTD PMID:11148247 more ... 5-fluorouracil multiple interactions ISO RGD:731730 6480464 [Cisplatin co-treated with Fluorouracil] results in decreased expression of DPYD mRNA more ... CTD PMID:12044515 more ... 5-formyltetrahydrofolic acid multiple interactions ISO RGD:731730 6480464 [Leucovorin co-treated with Fluorouracil] results in decreased activity of DPYD protein CTD PMID:7503095 5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole affects expression EXP 6480464 Omeprazole affects the expression of DPYD mRNA CTD PMID:19483382 6-propyl-2-thiouracil affects expression EXP 6480464 Propylthiouracil affects the expression of DPYD mRNA CTD PMID:19483382 6-propyl-2-thiouracil increases expression EXP 6480464 Propylthiouracil results in increased expression of DPYD mRNA CTD PMID:24780913 aflatoxin B1 decreases expression EXP 6480464 Aflatoxin B1 results in decreased expression of DPYD mRNA CTD PMID:15890375 aflatoxin B1 decreases expression ISO RGD:731730 6480464 Aflatoxin B1 results in decreased expression of DPYD mRNA CTD PMID:21632981 , PMID:21641981 aflatoxin B1 decreases expression ISO RGD:1550111 6480464 Aflatoxin B1 results in decreased expression of DPYD mRNA CTD PMID:19770486 aflatoxin B1 affects expression ISO RGD:731730 6480464 Aflatoxin B1 affects the expression of DPYD protein CTD PMID:20106945 amiodarone affects expression EXP 6480464 Amiodarone affects the expression of DPYD mRNA CTD PMID:19483382 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of DPYD mRNA CTD PMID:16483693 antirheumatic drug decreases expression ISO RGD:731730 6480464 Antirheumatic Agents results in decreased expression of DPYD mRNA CTD PMID:24449571 arsenous acid increases expression ISO RGD:731730 6480464 Arsenic Trioxide results in increased expression of DPYD mRNA CTD PMID:22521957 azathioprine decreases expression ISO RGD:731730 6480464 Azathioprine results in decreased expression of DPYD mRNA CTD PMID:22623647 benzbromarone affects expression EXP 6480464 Benzbromarone affects the expression of DPYD mRNA CTD PMID:19483382 benzo[a]pyrene increases expression ISO RGD:1550111 6480464 Benzo(a)pyrene results in increased expression of DPYD mRNA CTD PMID:19770486 benzo[a]pyrene decreases expression ISO RGD:731730 6480464 Benzo(a)pyrene results in decreased expression of DPYD mRNA CTD PMID:20064835 more ... benzo[a]pyrene decreases expression ISO RGD:1550111 6480464 Benzo(a)pyrene results in decreased expression of DPYD mRNA CTD PMID:21569818 bis(2-ethylhexyl) phthalate multiple interactions EXP 6480464 [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of DPYD mRNA CTD PMID:25607892 bisphenol A multiple interactions EXP 6480464 [bisphenol A co-treated with Estradiol] results in increased expression of DPYD mRNA CTD PMID:26496021 bisphenol A increases methylation EXP 6480464 bisphenol A results in increased methylation of DPYD gene CTD PMID:28505145 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of DPYD mRNA CTD PMID:25181051 , PMID:30816183 butanal decreases expression ISO RGD:731730 6480464 butyraldehyde results in decreased expression of DPYD mRNA CTD PMID:26079696 camptothecin multiple interactions ISO RGD:731730 6480464 Camptothecin inhibits the reaction [Fluorouracil results in increased expression of DPYD mRNA] CTD PMID:16568373 camptothecin decreases activity ISO RGD:731730 6480464 Camptothecin results in decreased activity of DPYD protein CTD PMID:16568373 camptothecin decreases expression ISO RGD:731730 6480464 Camptothecin results in decreased expression of DPYD mRNA CTD PMID:16568373 capecitabine increases expression ISO RGD:731730 6480464 Capecitabine results in increased expression of DPYD mRNA CTD PMID:17611699 capecitabine decreases response to substance ISO RGD:731730 6480464 DPYD protein results in decreased susceptibility to Capecitabine CTD PMID:16734730 capecitabine affects response to substance ISO RGD:731730 6480464 DPYD protein affects the susceptibility to Capecitabine CTD PMID:18846242 carbon nanotube decreases expression ISO RGD:1550111 6480464 Nanotubes, Carbon analog results in decreased expression of DPYD mRNA, Nanotubes, Carbon results in decreased expression of DPYD mRNA CTD PMID:25554681 carboplatin multiple interactions ISO RGD:731730 6480464 PCNA mRNA affects the reaction [DPYD mRNA affects the susceptibility to Carboplatin] CTD PMID:16685392 chromium(6+) affects expression ISO RGD:1550111 6480464 chromium hexavalent ion affects the expression of DPYD mRNA CTD PMID:28472532 cisplatin multiple interactions ISO RGD:731730 6480464 [Cisplatin co-treated with Fluorouracil] results in decreased expression of DPYD mRNA more ... CTD PMID:15737843 more ... cisplatin decreases expression EXP 6480464 Cisplatin results in decreased expression of DPYD mRNA CTD PMID:22023808 cisplatin affects response to substance ISO RGD:731730 6480464 DPYD protein affects the susceptibility to Cisplatin CTD PMID:18728667 cisplatin decreases expression ISO RGD:731730 6480464 Cisplatin results in decreased expression of DPYD mRNA CTD PMID:16568373 , PMID:27392435 cisplatin decreases activity ISO RGD:731730 6480464 Cisplatin results in decreased activity of DPYD protein CTD PMID:16568373 clofibrate affects expression EXP 6480464 Clofibrate affects the expression of DPYD mRNA CTD PMID:19483382 clofibric acid multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of DPYD mRNA CTD PMID:17602206 cobalt dichloride decreases expression ISO RGD:731730 6480464 cobaltous chloride results in decreased expression of DPYD mRNA CTD PMID:19320972 cyclosporin A decreases expression ISO RGD:1550111 6480464 Cyclosporine results in decreased expression of DPYD mRNA CTD PMID:23830897 cyclosporin A decreases expression ISO RGD:731730 6480464 Cyclosporine results in decreased expression of DPYD mRNA CTD PMID:20106945 , PMID:23830897 DDE multiple interactions EXP 6480464 [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of DPYD mRNA CTD PMID:25607892 dextran sulfate multiple interactions ISO RGD:1550111 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in increased expression of DPYD mRNA CTD PMID:29950665 diarsenic trioxide increases expression ISO RGD:731730 6480464 Arsenic Trioxide results in increased expression of DPYD mRNA CTD PMID:22521957 dibutyl phthalate decreases expression EXP 6480464 Dibutyl Phthalate results in decreased expression of DPYD mRNA CTD PMID:21266533 dibutyl phthalate multiple interactions EXP 6480464 [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of DPYD mRNA CTD PMID:25607892 dibutyl phthalate increases expression ISO RGD:1550111 6480464 Dibutyl Phthalate results in increased expression of DPYD mRNA CTD PMID:21266533 diethylstilbestrol decreases expression EXP 6480464 Diethylstilbestrol results in decreased expression of DPYD mRNA CTD PMID:15890375 dioxygen multiple interactions ISO RGD:1550111 6480464 [NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of DPYD mRNA CTD PMID:30529165 dorsomorphin multiple interactions ISO RGD:731730 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 doxifluridine affects expression ISO RGD:731730 6480464 doxifluridine affects the expression of DPYD mRNA CTD PMID:18630517 doxifluridine affects response to substance ISO RGD:731730 6480464 DPYD protein affects the susceptibility to doxifluridine CTD PMID:16646564 doxifluridine decreases response to substance ISO RGD:731730 6480464 DPYD protein results in decreased susceptibility to doxifluridine CTD PMID:16734730 doxifluridine multiple interactions ISO RGD:731730 6480464 [Paclitaxel co-treated with doxifluridine] affects the expression of DPYD mRNA CTD PMID:18630517 elemental selenium decreases expression ISO RGD:731730 6480464 Selenium results in decreased expression of DPYD mRNA CTD PMID:19244175 epoxiconazole multiple interactions EXP 6480464 [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of DPYD mRNA CTD PMID:25607892 ethyl methanesulfonate decreases expression ISO RGD:731730 6480464 Ethyl Methanesulfonate results in decreased expression of DPYD mRNA CTD PMID:23649840 flutamide decreases expression EXP 6480464 Flutamide results in decreased expression of DPYD mRNA CTD PMID:24136188 formaldehyde decreases expression ISO RGD:731730 6480464 Formaldehyde results in decreased expression of DPYD mRNA CTD PMID:23649840 furan decreases expression EXP 6480464 furan results in decreased expression of DPYD mRNA CTD PMID:25539665 gemcitabine multiple interactions ISO RGD:731730 6480464 [TYMP protein co-treated with DPYD protein] affects the susceptibility to gemcitabine CTD PMID:18728667 Gimeracil multiple interactions ISO RGD:731730 6480464 DPYD results in increased susceptibility to [Fluorouracil co-treated with gimeracil] more ... CTD PMID:12044515 more ... Gimeracil decreases activity ISO RGD:731730 6480464 gimeracil results in decreased activity of DPYD protein CTD PMID:17699726 glafenine decreases expression EXP 6480464 Glafenine results in decreased expression of DPYD mRNA CTD PMID:24136188 glycidol decreases expression EXP 6480464 glycidol results in decreased expression of DPYD mRNA CTD PMID:24915197 Heliotrine decreases expression ISO RGD:731730 6480464 heliotrine results in decreased expression of DPYD mRNA CTD PMID:26100227 ionomycin multiple interactions ISO RGD:731730 6480464 [Tetradecanoylphorbol Acetate co-treated with Ionomycin] promotes the reaction [[FOS protein binds to JUN protein] which binds to DPYD promoter] more ... CTD PMID:15705907 irinotecan decreases response to substance ISO RGD:731730 6480464 DPYD protein results in decreased susceptibility to Irinotecan CTD PMID:16734730 irinotecan decreases expression ISO RGD:731730 6480464 Irinotecan metabolite results in decreased expression of DPYD mRNA, Irinotecan results in decreased expression of DPYD mRNA CTD PMID:15956246 kojic acid multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with kojic acid] results in increased expression of DPYD mRNA CTD PMID:18544905 L-ethionine affects expression EXP 6480464 Ethionine affects the expression of DPYD mRNA CTD PMID:19483382 linuron multiple interactions EXP 6480464 [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of DPYD mRNA CTD PMID:25607892 lipopolysaccharide decreases expression ISO RGD:1550111 6480464 Lipopolysaccharides results in decreased expression of DPYD mRNA CTD PMID:27339419 menadione affects expression ISO RGD:1550111 6480464 Vitamin K 3 affects the expression of DPYD mRNA CTD PMID:20829426 methapyrilene decreases expression EXP 6480464 Methapyrilene results in decreased expression of DPYD mRNA CTD PMID:15890375 , PMID:30467583 methyl methanesulfonate decreases expression ISO RGD:731730 6480464 Methyl Methanesulfonate results in decreased expression of DPYD mRNA CTD PMID:23649840 methylseleninic acid increases expression ISO RGD:731730 6480464 methylselenic acid results in increased expression of DPYD mRNA CTD PMID:18548127 N-nitrosodiethylamine multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of DPYD mRNA, [Diethylnitrosamine co-treated with kojic acid] results in increased expression of DPYD mRNA CTD PMID:17602206 , PMID:18544905 N-nitrosodiethylamine decreases expression EXP 6480464 Diethylnitrosamine results in decreased expression of DPYD mRNA CTD PMID:19638242 N-nitrosodimethylamine decreases expression EXP 6480464 Dimethylnitrosamine results in decreased expression of DPYD mRNA CTD PMID:15890375 N-nitrosomorpholine decreases expression EXP 6480464 N-nitrosomorpholine results in decreased expression of DPYD mRNA CTD PMID:19716841 nickel atom decreases expression ISO RGD:731730 6480464 Nickel results in decreased expression of DPYD mRNA CTD PMID:23195993 nickel sulfate decreases expression ISO RGD:731730 6480464 nickel sulfate results in decreased expression of DPYD mRNA CTD PMID:17374397 nimesulide decreases expression EXP 6480464 nimesulide results in decreased expression of DPYD mRNA CTD PMID:24136188 obeticholic acid decreases expression ISO RGD:731730 6480464 obeticholic acid results in decreased expression of DPYD mRNA CTD PMID:27939613 omeprazole affects expression EXP 6480464 Omeprazole affects the expression of DPYD mRNA CTD PMID:19483382 oxaliplatin multiple interactions ISO RGD:731730 6480464 [TYMP protein co-treated with DPYD protein] affects the susceptibility to oxaliplatin CTD PMID:18728667 paclitaxel affects expression ISO RGD:731730 6480464 Paclitaxel affects the expression of DPYD mRNA CTD PMID:18630517 paclitaxel multiple interactions ISO RGD:731730 6480464 [Paclitaxel co-treated with doxifluridine] affects the expression of DPYD mRNA CTD PMID:18630517 paclitaxel decreases expression ISO RGD:731730 6480464 Paclitaxel results in decreased expression of DPYD mRNA CTD PMID:16568373 paracetamol affects expression ISO RGD:1550111 6480464 Acetaminophen affects the expression of DPYD mRNA CTD PMID:17562736 paracetamol decreases expression ISO RGD:731730 6480464 Acetaminophen results in decreased expression of DPYD mRNA CTD PMID:29067470 paracetamol multiple interactions ISO RGD:1550111 6480464 PANX1 gene mutant form inhibits the reaction [Acetaminophen results in decreased expression of DPYD mRNA] CTD PMID:29246445 paracetamol decreases expression ISO RGD:1550111 6480464 Acetaminophen results in decreased expression of DPYD mRNA CTD PMID:29246445 paracetamol increases expression ISO RGD:731730 6480464 Acetaminophen results in increased expression of DPYD mRNA CTD PMID:26690555 perfluorooctanoic acid decreases expression EXP 6480464 perfluorooctanoic acid results in decreased expression of DPYD mRNA CTD PMID:19162173 phenobarbital multiple interactions ISO RGD:1550111 6480464 NR1I3 protein affects the reaction [Phenobarbital results in decreased expression of DPYD mRNA] CTD PMID:19482888 phenobarbital decreases expression ISO RGD:1550111 6480464 Phenobarbital results in decreased expression of DPYD mRNA CTD PMID:19482888 phenylmercury acetate increases expression ISO RGD:731730 6480464 Phenylmercuric Acetate results in increased expression of DPYD mRNA CTD PMID:26272509 phenylmercury acetate multiple interactions ISO RGD:731730 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DPYD mRNA CTD PMID:27188386 phorbol 13-acetate 12-myristate multiple interactions ISO RGD:731730 6480464 [Tetradecanoylphorbol Acetate co-treated with Ionomycin] promotes the reaction [[FOS protein binds to JUN protein] which binds to DPYD promoter] more ... CTD PMID:15705907 piperonyl butoxide decreases expression EXP 6480464 Piperonyl Butoxide results in decreased expression of DPYD mRNA CTD PMID:15890375 pirinixic acid multiple interactions ISO RGD:1550111 6480464 [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of DPYD mRNA CTD PMID:19710929 pirinixic acid decreases expression ISO RGD:1550111 6480464 pirinixic acid results in decreased expression of DPYD mRNA CTD PMID:23811191 pirinixic acid decreases expression EXP 6480464 pirinixic acid results in decreased expression of DPYD mRNA CTD PMID:15890375 pirinixic acid affects expression EXP 6480464 pirinixic acid affects the expression of DPYD mRNA CTD PMID:19483382 piroxicam multiple interactions ISO RGD:731730 6480464 [Piroxicam co-treated with Cisplatin] results in increased expression of DPYD mRNA CTD PMID:21858171 potassium chromate increases expression ISO RGD:731730 6480464 potassium chromate(VI) results in increased expression of DPYD mRNA CTD PMID:22714537 potassium dichromate increases expression ISO RGD:1550111 6480464 Potassium Dichromate results in increased expression of DPYD mRNA CTD PMID:23608068 prochloraz multiple interactions EXP 6480464 [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of DPYD mRNA CTD PMID:25607892 procymidone multiple interactions EXP 6480464 [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of DPYD mRNA CTD PMID:25607892 propanal increases expression ISO RGD:731730 6480464 propionaldehyde results in increased expression of DPYD mRNA CTD PMID:26079696 propiconazole decreases expression ISO RGD:1550111 6480464 propiconazole results in decreased expression of DPYD mRNA CTD PMID:21278054 quercetin decreases expression ISO RGD:731730 6480464 Quercetin results in decreased expression of DPYD mRNA CTD PMID:21632981 SB 431542 multiple interactions ISO RGD:731730 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 selenium atom decreases expression ISO RGD:731730 6480464 Selenium results in decreased expression of DPYD mRNA CTD PMID:19244175 senecionine decreases expression ISO RGD:731730 6480464 senecionine results in decreased expression of DPYD mRNA CTD PMID:26100227 Senkirkine decreases expression ISO RGD:731730 6480464 senkirkine results in decreased expression of DPYD mRNA CTD PMID:26100227 silver atom decreases expression ISO RGD:1550111 6480464 Silver results in decreased expression of DPYD mRNA CTD PMID:27131904 silver(0) decreases expression ISO RGD:1550111 6480464 Silver results in decreased expression of DPYD mRNA CTD PMID:27131904 sirolimus decreases expression ISO RGD:731730 6480464 Sirolimus results in decreased expression of DPYD mRNA CTD PMID:19764996 sodium dichromate affects expression EXP 6480464 sodium bichromate affects the expression of DPYD mRNA CTD PMID:22110744 sodium dichromate decreases expression EXP 6480464 sodium bichromate results in decreased expression of DPYD mRNA CTD PMID:25993096 sodium dichromate decreases expression ISO RGD:731730 6480464 sodium bichromate results in decreased expression of DPYD mRNA CTD PMID:17685462 Soman decreases expression EXP 6480464 Soman results in decreased expression of DPYD mRNA CTD PMID:19281266 succimer multiple interactions ISO RGD:731730 6480464 [Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of DPYD mRNA CTD PMID:26378955 sulforaphane increases expression ISO RGD:731730 6480464 sulforafan results in increased expression of DPYD mRNA CTD PMID:26833863 Tegafur affects response to substance ISO RGD:731730 6480464 DPYD gene polymorphism affects the susceptibility to Tegafur CTD PMID:18537153 Temsirolimus decreases expression ISO RGD:731730 6480464 temsirolimus results in decreased expression of DPYD mRNA CTD PMID:19764996 tetrachloromethane decreases expression ISO RGD:1550111 6480464 Carbon Tetrachloride results in decreased expression of DPYD mRNA CTD PMID:27339419 tetrachloromethane multiple interactions EXP 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of DPYD mRNA] CTD PMID:31150632 tetrachloromethane decreases expression EXP 6480464 Carbon Tetrachloride results in decreased expression of DPYD mRNA CTD PMID:31150632 thioacetamide affects expression EXP 6480464 Thioacetamide affects the expression of DPYD mRNA CTD PMID:19483382 thioacetamide decreases expression EXP 6480464 Thioacetamide results in decreased expression of DPYD mRNA CTD PMID:23411599 titanium dioxide decreases expression ISO RGD:1550111 6480464 titanium dioxide results in decreased expression of DPYD mRNA CTD PMID:23557971 titanium dioxide multiple interactions ISO RGD:1550111 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in increased expression of DPYD mRNA CTD PMID:29950665 toluene 2,4-diisocyanate decreases expression ISO RGD:1550111 6480464 Toluene 2, 4-Diisocyanate results in decreased expression of DPYD mRNA CTD PMID:21404309 trichostatin A increases expression ISO RGD:731730 6480464 trichostatin A results in increased expression of DPYD mRNA CTD PMID:24935251 , PMID:26272509 trichostatin A multiple interactions ISO RGD:731730 6480464 [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DPYD mRNA CTD PMID:27188386 trimellitic anhydride decreases expression ISO RGD:1550111 6480464 trimellitic anhydride results in decreased expression of DPYD mRNA CTD PMID:19042947 tris(2-butoxyethyl) phosphate decreases expression ISO RGD:731730 6480464 tris(2-butoxyethyl) phosphate results in decreased expression of DPYD mRNA CTD PMID:29024780 tunicamycin decreases expression ISO RGD:1550111 6480464 Tunicamycin results in decreased expression of DPYD mRNA CTD PMID:17127020 valdecoxib decreases expression EXP 6480464 valdecoxib results in decreased expression of DPYD mRNA CTD PMID:24136188 valproic acid decreases methylation ISO RGD:731730 6480464 Valproic Acid results in decreased methylation of DPYD gene CTD PMID:29154799 valproic acid multiple interactions ISO RGD:731730 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DPYD mRNA CTD PMID:27188386 valproic acid increases expression ISO RGD:731730 6480464 Valproic Acid results in increased expression of DPYD mRNA CTD PMID:23179753 more ... valproic acid affects expression ISO RGD:731730 6480464 Valproic Acid affects the expression of DPYD mRNA CTD PMID:25979313 vancomycin increases expression ISO RGD:1550111 6480464 Vancomycin results in increased expression of DPYD mRNA CTD PMID:18930951 vinclozolin multiple interactions EXP 6480464 [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of DPYD mRNA CTD PMID:25607892 vincristine increases response to substance ISO RGD:731730 6480464 DPYD gene SNP results in increased susceptibility to Vincristine CTD PMID:20864405 wogonin decreases expression ISO RGD:731730 6480464 wogonin results in decreased expression of DPYD mRNA CTD PMID:20570612
Gene-Chemical Interaction Annotations
