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Gene: Dpyd (dihydropyrimidine dehydrogenase) Rattus norvegicus
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Symbol: Dpyd
Name: dihydropyrimidine dehydrogenase
Description: Exhibits several functions, including coenzyme binding activity; oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor; and protein homodimerization activity. Involved in several processes, including circadian rhythm; pyrimidine nucleobase metabolic process; and response to glucocorticoid. Localizes to the cytosol. Used to study colorectal cancer. Biomarker of liver disease. Human ortholog(s) of this gene implicated in dihydropyrimidine dehydrogenase deficiency; pancreatic cancer; and precursor lymphoblastic lymphoma/leukemia. Orthologous to human DPYD (dihydropyrimidine dehydrogenase); PARTICIPATES IN pyrimidine metabolic pathway; beta-alanine metabolic pathway; beta-ureidopropionase deficiency pathway; INTERACTS WITH (+)-schisandrin B; 1-benzylpiperazine; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: DHPDHase; dihydropyrimidine dehydrogenase [NADP(+)]; dihydropyrimidine dehydrogenase [NADP+]; dihydrothymine dehydrogenase; dihydrouracil dehydrogenase; DPD
Orthologs:
Homo sapiens (human) : DPYD (dihydropyrimidine dehydrogenase)  HGNC  Alliance
Mus musculus (house mouse) : Dpyd (dihydropyrimidine dehydrogenase)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dpyd (dihydropyrimidine dehydrogenase)
Pan paniscus (bonobo/pygmy chimpanzee) : DPYD (dihydropyrimidine dehydrogenase)
Canis lupus familiaris (dog) : DPYD (dihydropyrimidine dehydrogenase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dpyd (dihydropyrimidine dehydrogenase)
Sus scrofa (pig) : DPYD (dihydropyrimidine dehydrogenase)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.02221,823,692 - 222,694,627 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2221,823,687 - 222,694,627 (+)Ensembl
Rnor_5.02239,874,415 - 240,000,215 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.02240,072,322 - 240,744,042 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42214,931,901 - 215,818,809 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12214,894,962 - 215,781,871 (+)NCBI
Celera2199,080,477 - 199,932,183 (+)NCBICelera
Cytogenetic Map2q41NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Dpyd
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 621218
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2019-11-27
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.