Dpyd (dihydropyrimidine dehydrogenase) - Rat Genome Database

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Gene: Dpyd (dihydropyrimidine dehydrogenase) Rattus norvegicus
Analyze
Symbol: Dpyd
Name: dihydropyrimidine dehydrogenase
RGD ID: 621218
Description: Enables several functions, including dihydropyrimidine dehydrogenase (NADP+) activity; heterocyclic compound binding activity; and protein homodimerization activity. Involved in several processes, including circadian rhythm; pyrimidine nucleobase metabolic process; and response to glucocorticoid. Located in cytosol. Used to study colorectal cancer. Biomarker of liver disease. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; dihydropyrimidine dehydrogenase deficiency; and pancreatic cancer. Orthologous to human DPYD (dihydropyrimidine dehydrogenase); PARTICIPATES IN pyrimidine metabolic pathway; beta-alanine metabolic pathway; beta-ureidopropionase deficiency pathway; INTERACTS WITH (+)-schisandrin B; 1-benzylpiperazine; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: DHPDHase; dihydropyrimidine dehydrogenase [NADP(+)]; dihydropyrimidine dehydrogenase [NADP+]; dihydrothymine dehydrogenase; dihydrouracil dehydrogenase; DPD
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82209,293,902 - 210,159,777 (+)NCBIGRCr8
mRatBN7.22206,609,043 - 207,474,982 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2206,609,122 - 207,474,982 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2214,264,321 - 215,128,440 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02212,171,713 - 213,035,662 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02206,997,314 - 207,861,463 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02221,823,692 - 222,694,627 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2221,823,687 - 222,694,627 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02239,874,415 - 240,000,215 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.02240,072,322 - 240,744,042 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42214,931,901 - 215,818,809 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12214,894,962 - 215,781,871 (+)NCBI
Celera2199,080,477 - 199,932,183 (+)NCBICelera
Cytogenetic Map2q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
1-benzylpiperazine  (EXP)
1-chloro-2,4-dinitrobenzene  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-nitrofluorene  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4'-epidoxorubicin  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (ISO)
5-fluorouracil  (ISO)
5-formyltetrahydrofolic acid  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (EXP,ISO)
amiodarone  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
azathioprine  (ISO)
benzbromarone  (EXP)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
butanal  (ISO)
cadmium dichloride  (ISO)
camptothecin  (ISO)
capecitabine  (ISO)
carbon nanotube  (ISO)
carboplatin  (ISO)
CGP 52608  (ISO)
chromium(6+)  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (EXP)
clofibric acid  (EXP)
cobalt dichloride  (ISO)
cyclosporin A  (ISO)
DDE  (EXP)
DDT  (EXP)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
diethylstilbestrol  (EXP)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxifluridine  (ISO)
elemental selenium  (ISO)
epoxiconazole  (EXP,ISO)
ethyl methanesulfonate  (ISO)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
furan  (EXP)
gemcitabine  (ISO)
gentamycin  (EXP)
Gimeracil  (ISO)
glafenine  (EXP)
glycidol  (EXP)
Heliotrine  (ISO)
indometacin  (EXP)
ionomycin  (ISO)
irinotecan  (ISO)
ivermectin  (ISO)
kojic acid  (EXP)
L-ethionine  (EXP)
lead diacetate  (ISO)
linuron  (EXP)
lipopolysaccharide  (ISO)
maneb  (ISO)
menadione  (ISO)
methapyrilene  (EXP)
methidathion  (ISO)
methimazole  (EXP)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
methylseleninic acid  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
N-nitrosomorpholine  (EXP)
nickel atom  (ISO)
nickel sulfate  (ISO)
nimesulide  (EXP)
O-methyleugenol  (ISO)
obeticholic acid  (ISO)
omeprazole  (EXP)
oxaliplatin  (ISO)
ozone  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
permethrin  (EXP)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
PhIP  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP,ISO)
piroxicam  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
prochloraz  (EXP)
procymidone  (EXP)
propanal  (ISO)
propiconazole  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
senecionine  (ISO)
Senkirkine  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sirolimus  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP,ISO)
Soman  (EXP)
succimer  (ISO)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
Tegafur  (ISO)
temozolomide  (ISO)
Temsirolimus  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
toluene 2,4-diisocyanate  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
tunicamycin  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)
wogonin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA,ISO,ISS)
cytosol  (IBA,IDA,IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Circadian variation in intestinal dihydropyrimidine dehydrogenase (DPD) expression: a potential mechanism for benefits of 5FU chrono-chemotherapy. Abolmaali K, etal., Surgery. 2009 Aug;146(2):269-73.
2. Thymidylate synthase and dihydropyrimidine dehydrogenase expressions in gallbladder cancer. Ajiki T, etal., Anticancer Res. 2006 Mar-Apr;26(2B):1391-6.
3. Combination of low-dose docetaxel and standard-dose S-1 for the treatment of advanced gastric cancer: efficacy, toxicity, and potential predictive factor. Cui Y, etal., Cancer Chemother Pharmacol. 2013 Jan;71(1):145-52. doi: 10.1007/s00280-012-1991-y. Epub 2012 Oct 12.
4. The effect of dietary protein depletion on hepatic 5-fluorouracil metabolism. Davis LE, etal., Cancer. 1993 Dec 15;72(12):3715-22.
5. Role of dihydropyrimidine dehydrogenase in the uridine nucleotide metabolism in the rat liver. Fujimoto S, etal., J Nutr Sci Vitaminol (Tokyo). 1992 Feb;38(1):39-48.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. Visualization of dihydrouracil dehydrogenase activity after disc gel electrophoresis. Hallock RO and Yamada EW, Anal Biochem. 1973 Nov;56(1):84-90.
9. Circadian rhythm of rat liver dihydropyrimidine dehydrogenase. Possible relevance to fluoropyrimidine chemotherapy. Harris BE, etal., Biochem Pharmacol. 1988 Dec 15;37(24):4759-62.
10. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
11. Cloning of rat dihydropyrimidine dehydrogenase and correlation of its mRNA increase in the rat liver with age. Kimura M, etal., J Nutr Sci Vitaminol (Tokyo) 1998 Aug;44(4):537-46.
12. Influence of dihydropyrimidine dehydrogenase gene (DPYD) coding sequence variants on the development of fluoropyrimidine-related toxicity in patients with high-grade toxicity and patients with excellent tolerance of fluoropyrimidine-based chemotherapy. Kleibl Z, etal., Neoplasma. 2009;56(4):303-16.
13. Pharmacokinetics of 5-fluorouracil and increased hepatic dihydropyrimidine dehydrogenase activity levels in 1,2-dimethylhydrazine-induced colorectal cancer model rats. Kobuchi S, etal., Eur J Drug Metab Pharmacokinet. 2013 Sep;38(3):171-81. doi: 10.1007/s13318-012-0114-9. Epub 2012 Nov 30.
14. High intratumoral dihydropyrimidine dehydrogenase mRNA levels in pancreatic cancer associated with a high rate of response to S-1. Kuramochi H, etal., Cancer Chemother Pharmacol. 2008 Dec;63(1):85-9. Epub 2008 Feb 29.
15. Comparison of dihydropyrimidine dehydrogenase from human, rat, pig and cow liver. Biochemical and immunological properties. Lu ZH, etal., Biochem Pharmacol. 1993 Sep 1;46(5):945-52.
16. Autoregulation of 5-fluorouracil metabolism. McLeod HL, etal., Eur J Cancer. 1998 Sep;34(10):1623-7.
17. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
18. Clinical significance of dihydropyrimidine dehydrogenase and thymidylate synthase expression in patients with pancreatic cancer. Nakahara O, etal., Int J Clin Oncol. 2010 Feb;15(1):39-45.
19. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
20. [Relationship between the anti-metastatic effect of UFT and in vitro chemosensitivity to 5-FU in metastatic tumors from orthotopic implanted colon cancer in nude rats]. Ogata Y, etal., Gan To Kagaku Ryoho. 2001 May;28(5):655-60.
21. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
22. Identification of new SNPs associated with severe toxicity to capecitabine. Pellicer M, etal., Pharmacol Res. 2017 Jun;120:133-137. doi: 10.1016/j.phrs.2017.03.021. Epub 2017 Mar 27.
23. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
24. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
25. 5-ethynyl-2(1H)-pyrimidinone: aldehyde oxidase-activation to 5-ethynyluracil, a mechanism-based inactivator of dihydropyrimidine dehydrogenase. Porter DJ, etal., Biochem Pharmacol. 1994 Mar 29;47(7):1165-71.
26. Mechanism-based inactivation of dihydropyrimidine dehydrogenase by 5-ethynyluracil. Porter DJ, etal., J Biol Chem. 1992 Mar 15;267(8):5236-42.
27. GOA pipeline RGD automated data pipeline
28. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
29. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
30. Purification and properties of dihydrothymine dehydrogenase from rat liver. Shiotani T and Weber G, J Biol Chem. 1981 Jan 10;256(1):219-24.
31. Analysis of cyclic feed intake in rats fed on a zinc-deficient diet and the level of dihydropyrimidinase (EC 3.5.2.2). Tamaki N, etal., Br J Nutr. 1995 May;73(5):711-22.
32. Dihydropyrimidine dehydrogenase activity and fluorouracil pharmacokinetics with liver damage induced by bile duct ligation in rats. Tateishi T, etal., Drug Metab Dispos. 1999 Jun;27(6):651-4.
33. 3-Cyano-2,6-dihydroxypyridine (CNDP), a new potent inhibitor of dihydrouracil dehydrogenase. Tatsumi K, etal., J Biochem. 1993 Dec;114(6):912-8.
34. Potential of dihydropyrimidine dehydrogenase genotypes in personalizing 5-fluorouracil therapy among colorectal cancer patients. Teh LK, etal., Ther Drug Monit. 2013 Oct;35(5):624-30. doi: 10.1097/FTD.0b013e318290acd2.
35. Subcellular localization of dihydropyrimidine dehydrogenase. Van Kuilenburg AB, etal., Biol Chem. 1997 Sep;378(9):1047-53.
36. Clinical implications of dihydropyrimidine dehydrogenase (DPD) deficiency in patients with severe 5-fluorouracil-associated toxicity: identification of new mutations in the DPD gene. van Kuilenburg AB, etal., Clin Cancer Res. 2000 Dec;6(12):4705-12.
37. Increased risk of grade IV neutropenia after administration of 5-fluorouracil due to a dihydropyrimidine dehydrogenase deficiency: high prevalence of the IVS14+1g>a mutation. Van Kuilenburg AB, etal., Int J Cancer. 2002 Sep 20;101(3):253-8.
38. Relationship between circadian-dependent toxicity of 5-fluorodeoxyuridine and circadian rhythms of pyrimidine enzymes: possible relevance to fluoropyrimidine chemotherapy. Zhang R, etal., Cancer Res. 1993 Jun 15;53(12):2816-22.
39. DPYD gene polymorphisms are associated with risk and chemotherapy prognosis in pediatric patients with acute lymphoblastic leukemia. Zhao XQ, etal., Tumour Biol. 2016 Feb 4.
Additional References at PubMed
PMID:1512248   PMID:9860876   PMID:10410956   PMID:11988088   PMID:12651209   PMID:18075467  


Genomics

Comparative Map Data
Dpyd
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82209,293,902 - 210,159,777 (+)NCBIGRCr8
mRatBN7.22206,609,043 - 207,474,982 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2206,609,122 - 207,474,982 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2214,264,321 - 215,128,440 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02212,171,713 - 213,035,662 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02206,997,314 - 207,861,463 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02221,823,692 - 222,694,627 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2221,823,687 - 222,694,627 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02239,874,415 - 240,000,215 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.02240,072,322 - 240,744,042 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42214,931,901 - 215,818,809 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12214,894,962 - 215,781,871 (+)NCBI
Celera2199,080,477 - 199,932,183 (+)NCBICelera
Cytogenetic Map2q42NCBI
DPYD
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38197,077,743 - 97,921,059 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl197,077,743 - 97,995,000 (-)EnsemblGRCh38hg38GRCh38
GRCh37197,543,299 - 98,386,615 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36197,315,887 - 98,159,203 (-)NCBINCBI36Build 36hg18NCBI36
Build 34197,255,322 - 98,098,600NCBI
Celera195,797,301 - 96,640,303 (-)NCBICelera
Cytogenetic Map1p21.3NCBI
HuRef195,664,181 - 96,508,076 (-)NCBIHuRef
CHM1_1197,659,318 - 98,502,216 (-)NCBICHM1_1
T2T-CHM13v2.0196,925,834 - 97,768,903 (-)NCBIT2T-CHM13v2.0
Dpyd
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393118,355,758 - 119,226,573 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3118,355,778 - 119,226,573 (+)EnsemblGRCm39 Ensembl
GRCm383118,562,109 - 119,432,924 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3118,562,129 - 119,432,924 (+)EnsemblGRCm38mm10GRCm38
MGSCv373118,265,096 - 119,135,836 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363118,554,182 - 119,424,922 (+)NCBIMGSCv36mm8
Celera3124,970,410 - 125,843,833 (+)NCBICelera
Cytogenetic Map3G1NCBI
cM Map351.96NCBI
Dpyd
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554352,007,185 - 2,766,138 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554352,007,185 - 2,800,907 (-)NCBIChiLan1.0ChiLan1.0
DPYD
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21129,109,066 - 129,949,725 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11128,263,454 - 129,104,473 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0199,736,145 - 100,576,663 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1198,457,934 - 99,300,094 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl198,457,934 - 99,300,100 (-)Ensemblpanpan1.1panPan2
DPYD
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1651,789,786 - 52,564,802 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl651,814,573 - 52,580,923 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha654,459,524 - 55,250,294 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0652,128,811 - 52,919,237 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl652,128,798 - 52,936,245 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1651,820,117 - 52,610,968 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0651,800,205 - 52,590,810 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0652,232,854 - 53,023,930 (+)NCBIUU_Cfam_GSD_1.0
Dpyd
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405058106,508,890 - 107,287,521 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365371,660,477 - 2,439,273 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365371,660,461 - 2,439,305 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DPYD
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4119,931,414 - 120,712,459 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14119,931,471 - 120,712,461 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24131,845,556 - 132,550,018 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DPYD
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12035,376,738 - 36,215,388 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2035,377,266 - 36,215,679 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603555,476 - 898,213 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Dpyd
7069 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:204
Count of miRNA genes:109
Interacting mature miRNAs:143
Transcripts:ENSRNOT00000055723
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2112456140212696837Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2112456140212696837Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2114837527211674221Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2114837675212549332Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2136916935213594495Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2141194931223265385Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2141194931223265385Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2143157029210020885Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561221167075Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2157142078211086598Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2157142078226277316Rat
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2161699179222436696Rat
7488927Bp365Blood pressure QTL 3650.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2162765032207765032Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2164073756227146641Rat
1598838Bp290Blood pressure QTL 2901.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166539266211539266Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168358098223265385Rat
2307174Activ3Activity QTL 34.830.000058locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2168594495213594495Rat
61469Bp16Blood pressure QTL 165.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
70162Bp63Blood pressure QTL 635.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
2293084Iddm26Insulin dependent diabetes mellitus QTL 262.9blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2174930955213594495Rat
2300189Bmd48Bone mineral density QTL 485.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)2179335906224335906Rat
61417Cia10Collagen induced arthritis QTL 103.4joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)2179946951224946951Rat
8694435Bw166Body weight QTL 16614.080.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)2182171407227171407Rat
9589044Scfw1Subcutaneous fat weight QTL 15.80.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)2182171407227171407Rat
8694383Bw158Body weight QTL 1587.690.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)2182171407227171407Rat
8694194Abfw1Abdominal fat weight QTL 111.70.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)2182171407227171407Rat
738013Alc15Alcohol consumption QTL 154.10.00022consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)2184165752229165752Rat
1359031Bp275Blood pressure QTL 275arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2185876309219753474Rat
1359031Bp275Blood pressure QTL 275arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2185876309219753474Rat
61458Bp10Blood pressure QTL 103.42arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2189020722215287351Rat
1298083Bp158Blood pressure QTL 1582.62arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2189020722215287351Rat
1331745Bp203Blood pressure QTL 2034.377arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2189599258218414891Rat
1581499Esta2Estrogen-induced thymic atrophy QTL 2thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2189599258226936289Rat
61366Iddm3Insulin dependent diabetes mellitus QTL 34.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2189599258234599258Rat
61398Bp50Blood pressure QTL 504.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2189599258234599258Rat
2301408Kidm36Kidney mass QTL 360.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2190613715226808892Rat
2317752Glom23Glomerulus QTL 233.6urine protein amount (VT:0005160)urine protein level (CMO:0000591)2193452645245889826Rat
1598813Memor9Memory QTL 92.7exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2199341726234244620Rat
1598835Anxrr18Anxiety related response QTL 182.98body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)2200990457245990457Rat
2298479Eau5Experimental allergic uveoretinitis QTL 50.0021uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)2202446871237938339Rat
2299161Iddm33Insulin dependent diabetes mellitus QTL 332.98blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2206312063220876787Rat
631203Gluco14Glucose level QTL 140.0001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)2206665645219003804Rat

Markers in Region
D2Rat118  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22206,665,645 - 206,665,859 (+)MAPPERmRatBN7.2
Rnor_6.02221,880,206 - 221,880,419NCBIRnor6.0
Rnor_5.02239,931,503 - 239,931,716UniSTSRnor5.0
RGSC_v3.42214,988,814 - 214,989,298RGDRGSC3.4
RGSC_v3.42214,988,989 - 214,989,202UniSTSRGSC3.4
RGSC_v3.12214,952,051 - 214,952,264RGD
Celera2199,135,027 - 199,135,240UniSTS
RH 3.4 Map21487.2RGD
RH 3.4 Map21487.2UniSTS
SHRSP x BN Map279.6198UniSTS
SHRSP x BN Map279.6198RGD
FHH x ACI Map292.0499RGD
Cytogenetic Map2q41UniSTS
D2Got145  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22207,071,189 - 207,071,463 (+)MAPPERmRatBN7.2
Rnor_6.02222,305,831 - 222,306,104NCBIRnor6.0
Rnor_5.02240,357,351 - 240,357,624UniSTSRnor5.0
RGSC_v3.42215,401,394 - 215,401,666RGDRGSC3.4
RGSC_v3.42215,401,395 - 215,401,668UniSTSRGSC3.4
RGSC_v3.12215,364,456 - 215,364,728RGD
Celera2199,536,771 - 199,537,044UniSTS
RH 3.4 Map21490.1UniSTS
RH 3.4 Map21490.1RGD
RH 2.0 Map21066.4RGD
Cytogenetic Map2q41UniSTS
D2Uwm10  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22206,849,322 - 206,849,464 (+)MAPPERmRatBN7.2
Rnor_6.02222,078,625 - 222,078,766NCBIRnor6.0
Rnor_5.02240,129,905 - 240,130,046UniSTSRnor5.0
RGSC_v3.42215,175,419 - 215,175,560RGDRGSC3.4
RGSC_v3.42215,175,420 - 215,175,561UniSTSRGSC3.4
RGSC_v3.12215,138,481 - 215,138,622RGD
Celera2199,318,772 - 199,318,913UniSTS
Cytogenetic Map2q41UniSTS
D2Got395  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22207,207,297 - 207,207,396 (+)MAPPERmRatBN7.2
Rnor_6.02222,445,503 - 222,445,601NCBIRnor6.0
Rnor_5.02240,496,013 - 240,496,111UniSTSRnor5.0
RGSC_v3.42215,540,425 - 215,540,523UniSTSRGSC3.4
Celera2199,665,816 - 199,665,914UniSTS
Cytogenetic Map2q41UniSTS
RH137409  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22206,719,620 - 206,719,809 (+)MAPPERmRatBN7.2
Rnor_6.02221,934,779 - 221,934,967NCBIRnor6.0
Rnor_5.02239,986,252 - 239,986,440UniSTSRnor5.0
RGSC_v3.42215,043,738 - 215,043,926UniSTSRGSC3.4
Celera2199,189,036 - 199,189,224UniSTS
RH 3.4 Map21490.2UniSTS
Cytogenetic Map2q41UniSTS
AW520962  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22207,474,441 - 207,474,652 (+)MAPPERmRatBN7.2
Rnor_6.02222,694,087 - 222,694,297NCBIRnor6.0
Rnor_5.02240,743,502 - 240,743,712UniSTSRnor5.0
RGSC_v3.42215,818,269 - 215,818,479UniSTSRGSC3.4
Celera2199,931,643 - 199,931,853UniSTS
RH 3.4 Map21487.2UniSTS
Cytogenetic Map2q41UniSTS
AU049339  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22207,259,428 - 207,259,657 (+)MAPPERmRatBN7.2
Rnor_6.02222,497,619 - 222,497,847NCBIRnor6.0
Rnor_5.02240,548,209 - 240,548,437UniSTSRnor5.0
RGSC_v3.42215,592,621 - 215,592,849UniSTSRGSC3.4
Celera2199,717,935 - 199,718,165UniSTS
Cytogenetic Map2q41UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 37 27 4 27 15 7 8
Low 1 31 20 14 15 14 8 10 74 20 33 3 8
Below cutoff 12 1 1

Sequence


RefSeq Acc Id: ENSRNOT00000055723   ⟹   ENSRNOP00000052583
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2206,791,721 - 207,474,982 (+)Ensembl
Rnor_6.0 Ensembl2222,214,885 - 222,694,627 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000072735   ⟹   ENSRNOP00000065421
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl2221,823,687 - 222,165,727 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000086125   ⟹   ENSRNOP00000072507
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2206,609,122 - 207,474,982 (+)Ensembl
Rnor_6.0 Ensembl2222,021,103 - 222,693,410 (+)Ensembl
RefSeq Acc Id: NM_031027   ⟹   NP_112289
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82209,293,980 - 210,159,777 (+)NCBI
mRatBN7.22206,609,124 - 207,474,982 (+)NCBI
Rnor_6.02221,823,692 - 222,694,627 (+)NCBI
Rnor_5.02239,874,415 - 240,000,215 (+)NCBI
Rnor_5.02240,072,322 - 240,744,042 (+)NCBI
RGSC_v3.42214,931,901 - 215,818,809 (+)RGD
Celera2199,080,477 - 199,932,183 (+)RGD
Sequence:
RefSeq Acc Id: XM_039103213   ⟹   XP_038959141
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82209,293,902 - 209,822,620 (+)NCBI
mRatBN7.22206,609,045 - 207,132,703 (+)NCBI
RefSeq Acc Id: XM_039103214   ⟹   XP_038959142
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82209,293,902 - 209,710,528 (+)NCBI
mRatBN7.22206,609,045 - 207,009,100 (+)NCBI
RefSeq Acc Id: XM_039103215   ⟹   XP_038959143
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82209,293,904 - 209,580,348 (+)NCBI
mRatBN7.22206,609,043 - 206,856,898 (+)NCBI
RefSeq Acc Id: XR_005500378
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82209,293,904 - 209,620,727 (+)NCBI
mRatBN7.22206,609,044 - 206,935,930 (+)NCBI
RefSeq Acc Id: NP_112289   ⟸   NM_031027
- UniProtKB: O89000 (UniProtKB/Swiss-Prot),   A0A0G2K355 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000052583   ⟸   ENSRNOT00000055723
RefSeq Acc Id: ENSRNOP00000065421   ⟸   ENSRNOT00000072735
RefSeq Acc Id: ENSRNOP00000072507   ⟸   ENSRNOT00000086125
RefSeq Acc Id: XP_038959143   ⟸   XM_039103215
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038959141   ⟸   XM_039103213
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038959142   ⟸   XM_039103214
- Peptide Label: isoform X2
Protein Domains
4Fe-4S ferredoxin-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O89000-F1-model_v2 AlphaFold O89000 1-1025 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691723
Promoter ID:EPDNEW_R2238
Type:initiation region
Name:Dpyd_1
Description:dihydropyrimidine dehydrogenase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02221,823,637 - 221,823,697EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621218 AgrOrtholog
BioCyc Gene G2FUF-51448 BioCyc
BioCyc Pathway PWY-3982 [uracil degradation I (reductive)] BioCyc
  PWY-6430 [thymine degradation] BioCyc
BioCyc Pathway Image PWY-3982 BioCyc
  PWY-6430 BioCyc
Ensembl Genes ENSRNOG00000017105 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000055723.5 UniProtKB/TrEMBL
  ENSRNOT00000086125 ENTREZGENE
  ENSRNOT00000086125.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.1060.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.20.20.70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.70.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.50.50.60 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro 4Fe4S_Fe-S-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  4Fe4S_Fe_S_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aldolase_TIM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Dihydroorotate_DH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DPD_II UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FAD/NAD-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FAD/NAD-binding_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Helical_ferredxn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:81656 UniProtKB/Swiss-Prot
NCBI Gene 81656 ENTREZGENE
PANTHER DIHYDROPYRIMIDINE DEHYDROGENASE [NADP(+)] UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR43073 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam DHO_dh UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fer4_20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fer4_21 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pyr_redox_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB DPYD RGD
PhenoGen Dpyd PhenoGen
PRINTS ADXRDTASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE 4FE4S_FER_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  4FE4S_FER_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000017105 RatGTEx
Superfamily-SCOP 4Fe-4S ferredoxins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  alpha-helical ferredoxin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FMN-linked oxidoreductases UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nucleotide-binding domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K355 ENTREZGENE, UniProtKB/TrEMBL
  DPYD_RAT UniProtKB/Swiss-Prot
  F1M891_RAT UniProtKB/TrEMBL
  O89000 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-01-20 Dpyd  dihydropyrimidine dehydrogenase      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Dpyd  dihydropyrimidine dehydrogenase      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in liver 632636
gene_protein 1,025 amino acids; 111.4 kDa 632636
gene_regulation mRNA increased after glucocorticoid administration 632636