Mbd1 (methyl-CpG binding domain protein 1) - Rat Genome Database

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Gene: Mbd1 (methyl-CpG binding domain protein 1) Rattus norvegicus
Analyze
Symbol: Mbd1
Name: methyl-CpG binding domain protein 1
RGD ID: 1305980
Description: Enables chromatin binding activity. Involved in several processes, including negative regulation of astrocyte differentiation; response to cocaine; and response to estradiol. Located in chromatin; cytoplasm; and nucleus. Biomarker of transient cerebral ischemia and visual epilepsy. Human ortholog(s) of this gene implicated in lung cancer. Orthologous to human MBD1 (methyl-CpG binding domain protein 1); PARTICIPATES IN DNA modification pathway; INTERACTS WITH 2,4-dinitrotoluene; bisphenol A; clofibrate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC291439; methyl-CpG-binding domain protein 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21867,869,870 - 67,884,501 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1867,869,992 - 67,886,554 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1869,978,196 - 69,992,672 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01870,643,315 - 70,657,818 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01868,509,485 - 68,523,993 (+)NCBIRnor_WKY
Rnor_6.01870,248,568 - 70,263,190 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1870,248,713 - 70,263,164 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01869,390,120 - 69,404,741 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41871,068,257 - 71,082,734 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11871,141,457 - 71,155,910 (+)NCBI
Celera1866,048,059 - 66,062,538 (+)NCBICelera
Cytogenetic Map18q12.2NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dinitrotoluene  (EXP)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
acrolein  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
alpha-pinene  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bortezomib  (ISO)
butanal  (ISO)
caffeine  (ISO)
carbon nanotube  (ISO)
chlordecone  (ISO)
chloroprene  (ISO)
choline  (ISO)
ciguatoxin CTX1B  (ISO)
clofibrate  (EXP)
cocaine  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
dioxygen  (ISO)
elemental selenium  (ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (ISO)
fenthion  (ISO)
fluoxetine  (EXP)
flutamide  (EXP)
folic acid  (ISO)
gallic acid  (ISO)
gentamycin  (EXP)
isoprenaline  (ISO)
L-methionine  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
morphine  (ISO)
N-ethyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (ISO)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
pentachlorophenol  (ISO)
phenobarbital  (EXP,ISO)
phosgene  (ISO)
pirinixic acid  (ISO)
resveratrol  (ISO)
selenium atom  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
tamoxifen  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
chromatin  (IDA,ISO)
cytoplasm  (IDA,ISO)
heterochromatin  (ISO)
nuclear matrix  (ISO)
nuclear speck  (ISO)
nucleolus  (ISO)
nucleus  (IDA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. The loss of methyl-CpG binding protein 1 leads to autism-like behavioral deficits. Allan AM, etal., Hum Mol Genet. 2008 Jul 1;17(13):2047-57. doi: 10.1093/hmg/ddn102. Epub 2008 Apr 1.
2. On how mammalian transcription factors recognize methylated DNA. Buck-Koehntop BA and Defossez PA, Epigenetics. 2013 Feb;8(2):131-7. doi: 10.4161/epi.23632. Epub 2013 Jan 16.
3. Fluoxetine and cocaine induce the epigenetic factors MeCP2 and MBD1 in adult rat brain. Cassel S, etal., Mol Pharmacol. 2006 Aug;70(2):487-92. Epub 2006 May 2.
4. Kindling induces the mRNA expression of methyl DNA-binding factors in the adult rat hippocampus. Francis J, etal., Neuroscience. 2002;113(1):79-87.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. A folate- and methyl-deficient diet alters the expression of DNA methyltransferases and methyl CpG binding proteins involved in epigenetic gene silencing in livers of F344 rats. Ghoshal K, etal., J Nutr. 2006 Jun;136(6):1522-7.
7. Methyl-CpG binding domain 1 gene polymorphisms and risk of primary lung cancer. Jang JS, etal., Cancer Epidemiol Biomarkers Prev. 2005 Nov;14(11 Pt 1):2474-80.
8. Transient forebrain ischemia alters the mRNA expression of methyl DNA-binding factors in the adult rat hippocampus. Jung BP, etal., Neuroscience. 2002;115(2):515-24.
9. Epigenetic regulation of neonatal cardiomyocytes differentiation. Kou CY, etal., Biochem Biophys Res Commun. 2010 Sep 17;400(2):278-83. doi: 10.1016/j.bbrc.2010.08.064. Epub 2010 Aug 22.
10. Epigenetic regulation of the stem cell mitogen Fgf-2 by Mbd1 in adult neural stem/progenitor cells. Li X, etal., J Biol Chem. 2008 Oct 10;283(41):27644-52. doi: 10.1074/jbc.M804899200. Epub 2008 Aug 8.
11. Methyl-CpG binding domain 1 gene polymorphisms and lung cancer risk in a Chinese population. Liu H, etal., Biomarkers. 2008 Sep;13(6):607-17. doi: 10.1080/13547500802168031 .
12. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
13. GOA pipeline RGD automated data pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Methyl-CpG binding proteins are involved in restricting differentiation plasticity in neurons. Setoguchi H, etal., J Neurosci Res. 2006 Oct;84(5):969-79.
17. Cellular epigenetic modifications of neural stem cell differentiation. Singh RP, etal., Cell Transplant. 2009;18(10):1197-211. doi: 10.3727/096368909X12483162197204. Epub 2009 Aug 5.
18. Neonatal exposure to estradiol/bisphenol A alters promoter methylation and expression of Nsbp1 and Hpcal1 genes and transcriptional programs of Dnmt3a/b and Mbd2/4 in the rat prostate gland throughout life. Tang WY, etal., Endocrinology. 2012 Jan;153(1):42-55. doi: 10.1210/en.2011-1308. Epub 2011 Nov 22.
Additional References at PubMed
PMID:9774669   PMID:11371345   PMID:12477932   PMID:14519686   PMID:15777793   PMID:17546630   PMID:18604195   PMID:25284789   PMID:29276034   PMID:32638524  


Genomics

Comparative Map Data
Mbd1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21867,869,870 - 67,884,501 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1867,869,992 - 67,886,554 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1869,978,196 - 69,992,672 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01870,643,315 - 70,657,818 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01868,509,485 - 68,523,993 (+)NCBIRnor_WKY
Rnor_6.01870,248,568 - 70,263,190 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1870,248,713 - 70,263,164 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01869,390,120 - 69,404,741 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41871,068,257 - 71,082,734 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11871,141,457 - 71,155,910 (+)NCBI
Celera1866,048,059 - 66,062,538 (+)NCBICelera
Cytogenetic Map18q12.2NCBI
MBD1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381850,266,885 - 50,281,767 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1850,266,882 - 50,281,774 (-)EnsemblGRCh38hg38GRCh38
GRCh371847,793,255 - 47,808,137 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361846,049,214 - 46,062,142 (-)NCBINCBI36Build 36hg18NCBI36
Celera1844,651,771 - 44,664,698 (-)NCBICelera
Cytogenetic Map18q21.1NCBI
HuRef1844,647,697 - 44,662,584 (-)NCBIHuRef
CHM1_11847,788,841 - 47,803,733 (-)NCBICHM1_1
T2T-CHM13v2.01850,468,627 - 50,483,509 (-)NCBIT2T-CHM13v2.0
Mbd1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391874,400,676 - 74,415,808 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1874,400,676 - 74,415,803 (+)EnsemblGRCm39 Ensembl
GRCm381874,267,605 - 74,282,737 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1874,267,605 - 74,282,732 (+)EnsemblGRCm38mm10GRCm38
MGSCv371874,427,942 - 74,442,338 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361874,393,660 - 74,408,054 (+)NCBIMGSCv36mm8
Celera1875,497,613 - 75,512,033 (+)NCBICelera
Cytogenetic Map18E2NCBI
cM Map1850.7NCBI
Mbd1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540235,319,810 - 35,334,678 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540235,320,755 - 35,334,751 (-)NCBIChiLan1.0ChiLan1.0
MBD1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11846,996,905 - 47,009,831 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1846,996,905 - 47,009,831 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01843,647,395 - 43,662,266 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
MBD1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1778,597,688 - 78,611,303 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl778,597,746 - 78,651,472 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha778,002,061 - 78,017,756 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0778,661,476 - 78,677,177 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl778,661,468 - 78,674,941 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1778,374,132 - 78,389,826 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0778,406,559 - 78,422,248 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0778,691,272 - 78,706,975 (+)NCBIUU_Cfam_GSD_1.0
Mbd1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494437,609,864 - 37,629,471 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649712,848,874 - 12,871,639 (+)EnsemblSpeTri2.0
SpeTri2.0NW_00493649712,848,918 - 12,868,504 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MBD1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl199,900,801 - 99,917,323 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1199,848,193 - 99,917,347 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21109,589,957 - 109,606,298 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MBD1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11830,675,419 - 30,690,111 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1830,675,653 - 30,685,946 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660504,822,001 - 4,835,406 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mbd1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477813,896,447 - 13,907,656 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477813,892,179 - 13,907,576 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mbd1
19 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:392
Count of miRNA genes:213
Interacting mature miRNAs:250
Transcripts:ENSRNOT00000032202
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578661Bss20Bone structure and strength QTL 203.7femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)181179151883218561Rat
1578667Bss21Bone structure and strength QTL 213.5femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)181179151883218561Rat
1600373Mamtr6Mammary tumor resistance QTL 6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)181927890183218561Rat
1331741Bp232Blood pressure QTL 2323.59112arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)182137289383213037Rat
1331733Bp233Blood pressure QTL 2333.97196arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182479697779788953Rat
2325839Bp348Blood pressure QTL 3480.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182557098570570985Rat
2293704Bss35Bone structure and strength QTL 354.590.0002femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)182896485373964853Rat
2300157Bmd66Bone mineral density QTL 6613.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)182896485373964853Rat
2300177Bmd65Bone mineral density QTL 6519.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)182896485373964853Rat
9589816Gluco68Glucose level QTL 687.250.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)182979296574792965Rat
8694378Bw157Body weight QTL 1573.590.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)182979296574792965Rat
9590318Scort22Serum corticosterone level QTL 227.640.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)182979296574792965Rat
1331754Bp230Blood pressure QTL 2304.61609arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182979296574792965Rat
738005Anxrr11Anxiety related response QTL 113.4exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)183003981375039813Rat
61429Cia17Collagen induced arthritis QTL 174.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)183135940870263868Rat
2303120Mamtr8Mammary tumor resistance QTL 80.001mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)183135940883218561Rat
631274Sprol1Serum protein level QTL 15.3blood total protein amount (VT:0005567)serum total protein level (CMO:0000661)183139332077209694Rat
631518Bw11Body weight QTL 112.8body mass (VT:0001259)body weight (CMO:0000012)183587072380870723Rat
61367Iddm4Insulin dependent diabetes mellitus QTL 42.330.0074blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)183819245583192455Rat
1598826Anxrr20Anxiety related response QTL 203.04body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)184143297183828827Rat
6893683Bw110Body weight QTL 1102.70.002body mass (VT:0001259)body weight (CMO:0000012)184334502283828827Rat
8694366Abfw8Abdominal fat weight QTL 86.380.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)184664067583828827Rat
8694432Bw165Body weight QTL 1653.810.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)184664067583828827Rat
9589041Epfw12Epididymal fat weight QTL 1217.080.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)184664067583828827Rat
2303571Bw92Body weight QTL 923body mass (VT:0001259)body weight (CMO:0000012)184852004483828827Rat
2303584Gluco55Glucose level QTL 552blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)184852004483828827Rat
738008Hcar14Hepatocarcinoma resistance QTL 144.3liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion number (CMO:0001462)185146473383218561Rat
1359020Ppulsi2Prepulse inhibition QTL 22.71prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)185229287573997283Rat
631509Sald2Serum aldosterone level QTL 22.9blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)185253976369140759Rat
12880368Bw187Body weight QTL 1870.045body mass (VT:0001259)body weight (CMO:0000012)185253976376104388Rat
12904067Cm122Cardiac mass QTL 1220.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)185253976376104388Rat
12904069Cm123Cardiac mass QTL 1230.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)185253976376104388Rat
12904070Cm124Cardiac mass QTL 1240.01heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)185253976376104388Rat
12904071Am18Aortic mass QTL 180.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)185253976376104388Rat
12904073Kidm71Kidney mass QTL 710.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)185253976376104388Rat
2301417Bp319Blood pressure QTL 3190.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)185253976376104388Rat
1298072Cia26Collagen induced arthritis QTL 263.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)185470976983828827Rat
724542Kidm2Kidney mass QTL 22.6kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)185917211583828827Rat
2312600Bp341Blood pressure QTL 3410.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)185933040970263868Rat
2301969Bp324Blood pressure QTL 3244.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)185971241776477814Rat
70185BpQTLcluster15Blood pressure QTL cluster 154.61arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)185971241776477814Rat
70185BpQTLcluster15Blood pressure QTL cluster 154.61arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)185971241776477814Rat
70185BpQTLcluster15Blood pressure QTL cluster 154.61arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)185971241776477814Rat
70185BpQTLcluster15Blood pressure QTL cluster 154.61arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)185971241776477814Rat
1331770Bp234Blood pressure QTL 2343.807arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)185979647871893566Rat
6903353Bp353Blood pressure QTL 3532.8arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)185979647883828827Rat
6903356Bp354Blood pressure QTL 3544.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)185979647883828827Rat
61384Bp48Blood pressure QTL 4819.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)186062231177209844Rat
631675Iddm15Insulin dependent diabetes mellitus QTL 15urine glucose amount (VT:0001758)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)186062231177209844Rat

Markers in Region
BF389035  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21867,871,332 - 67,871,457 (+)MAPPERmRatBN7.2
Rnor_6.01870,250,024 - 70,250,148NCBIRnor6.0
Rnor_5.01869,391,571 - 69,391,695UniSTSRnor5.0
RGSC_v3.41871,069,568 - 71,069,692UniSTSRGSC3.4
Celera1866,049,370 - 66,049,494UniSTS
RH 3.4 Map18685.3UniSTS
Cytogenetic Map18q12.2UniSTS
RH135120  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21867,882,676 - 67,882,863 (+)MAPPERmRatBN7.2
Rnor_6.01870,261,366 - 70,261,552NCBIRnor6.0
Rnor_5.01869,402,913 - 69,403,099UniSTSRnor5.0
RGSC_v3.41871,080,911 - 71,081,097UniSTSRGSC3.4
Celera1866,060,715 - 66,060,901UniSTS
RH 3.4 Map18685.3UniSTS
Cytogenetic Map18q12.2UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 34 36 20 19 20 1 3 74 35 41 11 1
Low 9 21 21 21 7 8 7
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000032202   ⟹   ENSRNOP00000037640
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1867,870,022 - 67,884,475 (+)Ensembl
Rnor_6.0 Ensembl1870,248,713 - 70,263,164 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000099489   ⟹   ENSRNOP00000097486
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1867,869,992 - 67,886,554 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000102132   ⟹   ENSRNOP00000078508
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1867,869,998 - 67,884,485 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000111311   ⟹   ENSRNOP00000086562
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1867,869,998 - 67,883,010 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000113558   ⟹   ENSRNOP00000097211
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1867,869,998 - 67,884,485 (+)Ensembl
RefSeq Acc Id: NM_001011924   ⟹   NP_001011924
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21867,870,022 - 67,884,500 (+)NCBI
Rnor_6.01870,248,713 - 70,263,189 (+)NCBI
Rnor_5.01869,390,120 - 69,404,741 (+)NCBI
RGSC_v3.41871,068,257 - 71,082,734 (+)RGD
Celera1866,048,059 - 66,062,538 (+)RGD
Sequence:
RefSeq Acc Id: XM_006254909   ⟹   XP_006254971
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21867,869,877 - 67,884,501 (+)NCBI
Rnor_6.01870,248,571 - 70,263,190 (+)NCBI
Rnor_5.01869,390,120 - 69,404,741 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006254910   ⟹   XP_006254972
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21867,869,876 - 67,884,501 (+)NCBI
Rnor_6.01870,248,570 - 70,263,190 (+)NCBI
Rnor_5.01869,390,120 - 69,404,741 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006254911   ⟹   XP_006254973
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21867,869,877 - 67,884,501 (+)NCBI
Rnor_6.01870,248,571 - 70,263,190 (+)NCBI
Rnor_5.01869,390,120 - 69,404,741 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006254913   ⟹   XP_006254975
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21867,869,879 - 67,884,501 (+)NCBI
Rnor_6.01870,248,572 - 70,263,190 (+)NCBI
Rnor_5.01869,390,120 - 69,404,741 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006254914   ⟹   XP_006254976
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21867,869,879 - 67,884,501 (+)NCBI
Rnor_6.01870,248,572 - 70,263,190 (+)NCBI
Rnor_5.01869,390,120 - 69,404,741 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017600882   ⟹   XP_017456371
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21867,869,870 - 67,884,501 (+)NCBI
Rnor_6.01870,248,570 - 70,263,190 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017600883   ⟹   XP_017456372
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21867,869,876 - 67,884,501 (+)NCBI
Rnor_6.01870,248,570 - 70,263,190 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039096640   ⟹   XP_038952568
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21867,869,877 - 67,884,501 (+)NCBI
RefSeq Acc Id: XR_361462
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21867,869,877 - 67,884,501 (+)NCBI
Rnor_6.01870,248,571 - 70,263,190 (+)NCBI
Rnor_5.01869,390,120 - 69,404,741 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001011924   ⟸   NM_001011924
- UniProtKB: Q66HB8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006254973   ⟸   XM_006254911
- Peptide Label: isoform X3
- UniProtKB: A0A8I6A3W5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006254971   ⟸   XM_006254909
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006254972   ⟸   XM_006254910
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006254975   ⟸   XM_006254913
- Peptide Label: isoform X7
- Sequence:
RefSeq Acc Id: XP_006254976   ⟸   XM_006254914
- Peptide Label: isoform X8
- Sequence:
RefSeq Acc Id: XP_017456372   ⟸   XM_017600883
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_017456371   ⟸   XM_017600882
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: ENSRNOP00000037640   ⟸   ENSRNOT00000032202
RefSeq Acc Id: XP_038952568   ⟸   XM_039096640
- Peptide Label: isoform X5
RefSeq Acc Id: ENSRNOP00000078508   ⟸   ENSRNOT00000102132
RefSeq Acc Id: ENSRNOP00000097486   ⟸   ENSRNOT00000099489
RefSeq Acc Id: ENSRNOP00000097211   ⟸   ENSRNOT00000113558
RefSeq Acc Id: ENSRNOP00000086562   ⟸   ENSRNOT00000111311
Protein Domains
CXXC-type   MBD

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q66HB8-F1-model_v2 AlphaFold Q66HB8 1-533 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700865
Promoter ID:EPDNEW_R11388
Type:initiation region
Name:Mbd1_1
Description:methyl-CpG binding domain protein 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01870,248,700 - 70,248,760EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305980 AgrOrtholog
BioCyc Gene G2FUF-7032 BioCyc
Ensembl Genes ENSRNOG00000024104 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000037640 ENTREZGENE
  ENSRNOP00000037640.4 UniProtKB/TrEMBL
  ENSRNOP00000078508 ENTREZGENE
  ENSRNOP00000078508.1 UniProtKB/TrEMBL
  ENSRNOP00000086562 ENTREZGENE
  ENSRNOP00000086562.1 UniProtKB/TrEMBL
  ENSRNOP00000097211.1 UniProtKB/TrEMBL
  ENSRNOP00000097486 ENTREZGENE
  ENSRNOP00000097486.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000032202 ENTREZGENE
  ENSRNOT00000032202.5 UniProtKB/TrEMBL
  ENSRNOT00000099489 ENTREZGENE
  ENSRNOT00000099489.1 UniProtKB/TrEMBL
  ENSRNOT00000102132 ENTREZGENE
  ENSRNOT00000102132.1 UniProtKB/TrEMBL
  ENSRNOT00000111311 ENTREZGENE
  ENSRNOT00000111311.1 UniProtKB/TrEMBL
  ENSRNOT00000113558.1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7114194 IMAGE-MGC_LOAD
InterPro DNA-bd_integrase-typ UniProtKB/TrEMBL
  Methyl_CpG_DNA-bd UniProtKB/TrEMBL
  Znf_CXXC UniProtKB/TrEMBL
KEGG Report rno:291439 UniProtKB/TrEMBL
MGC_CLONE MGC:93958 IMAGE-MGC_LOAD
NCBI Gene 291439 ENTREZGENE
Pfam MBD UniProtKB/TrEMBL
  zf-CXXC UniProtKB/TrEMBL
PhenoGen Mbd1 PhenoGen
PROSITE MBD UniProtKB/TrEMBL
  ZF_CXXC UniProtKB/TrEMBL
SMART MBD UniProtKB/TrEMBL
Superfamily-SCOP DNA-binding_integrase-type UniProtKB/TrEMBL
UniProt A0A8I5ZMU8_RAT UniProtKB/TrEMBL
  A0A8I6A3W5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AS94_RAT UniProtKB/TrEMBL
  A0A8I6GMJ2_RAT UniProtKB/TrEMBL
  Q66HB8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-12-06 Mbd1  methyl-CpG binding domain protein 1  Mbd1_predicted  methyl-CpG binding domain protein 1 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Mbd1_predicted  methyl-CpG binding domain protein 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED