Tmem263 (transmembrane protein 263) - Rat Genome Database

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Gene: Tmem263 (transmembrane protein 263) Rattus norvegicus
Analyze
Symbol: Tmem263
Name: transmembrane protein 263
RGD ID: 1563325
Description: Predicted to be located in membrane. Orthologous to human TMEM263 (transmembrane protein 263); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; buspirone.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: hypothetical protein LOC362857; LOC362857; RGD1563325; similar to hypothetical protein MGC17943; uncharacterized protein LOC362857
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2718,607,077 - 18,628,436 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl718,610,149 - 18,628,534 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx720,571,007 - 20,589,177 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0722,733,705 - 22,751,875 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0722,510,667 - 22,528,838 (-)NCBIRnor_WKY
Rnor_6.0724,647,083 - 24,668,381 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl724,647,083 - 24,668,250 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0724,797,541 - 24,818,593 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4720,722,309 - 20,742,528 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera715,835,115 - 15,855,334 (-)NCBICelera
Cytogenetic Map7q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
membrane  (IEA)

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:25002582  


Genomics

Comparative Map Data
Tmem263
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2718,607,077 - 18,628,436 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl718,610,149 - 18,628,534 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx720,571,007 - 20,589,177 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0722,733,705 - 22,751,875 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0722,510,667 - 22,528,838 (-)NCBIRnor_WKY
Rnor_6.0724,647,083 - 24,668,381 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl724,647,083 - 24,668,250 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0724,797,541 - 24,818,593 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4720,722,309 - 20,742,528 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera715,835,115 - 15,855,334 (-)NCBICelera
Cytogenetic Map7q13NCBI
TMEM263
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812106,955,907 - 106,974,035 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl12106,955,719 - 106,978,778 (+)EnsemblGRCh38hg38GRCh38
GRCh3712107,349,685 - 107,367,813 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3612105,873,835 - 105,891,892 (+)NCBINCBI36Build 36hg18NCBI36
Celera12107,015,122 - 107,033,374 (+)NCBICelera
Cytogenetic Map12q23.3NCBI
HuRef12104,410,080 - 104,428,317 (+)NCBIHuRef
CHM1_112107,315,174 - 107,333,443 (+)NCBICHM1_1
T2T-CHM13v2.012106,919,542 - 106,937,669 (+)NCBIT2T-CHM13v2.0
Tmem263
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391084,938,491 - 84,953,611 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1084,938,491 - 84,956,482 (+)EnsemblGRCm39 Ensembl
GRCm381085,102,627 - 85,117,747 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1085,102,627 - 85,120,618 (+)EnsemblGRCm38mm10GRCm38
MGSCv371084,565,372 - 84,580,492 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361084,532,573 - 84,547,385 (+)NCBIMGSCv36mm8
Celera1087,078,973 - 87,094,095 (+)NCBICelera
Cytogenetic Map10C1NCBI
Tmem263
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540540,851,888 - 40,868,085 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540540,851,908 - 40,868,085 (+)NCBIChiLan1.0ChiLan1.0
TMEM263
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.112107,918,464 - 107,935,525 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12107,918,464 - 107,935,525 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v012104,523,044 - 104,541,549 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
TMEM263
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11031,798,002 - 31,812,553 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1031,800,632 - 31,812,444 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1031,783,547 - 31,797,988 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01032,639,423 - 32,653,856 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1032,639,436 - 32,654,013 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11032,375,648 - 32,390,074 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01032,666,058 - 32,680,481 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01032,852,103 - 32,866,522 (-)NCBIUU_Cfam_GSD_1.0
Tmem263
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494515,000,012 - 15,014,011 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364928,008,672 - 8,028,624 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049364928,010,426 - 8,017,038 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TMEM263
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl513,379,780 - 13,398,360 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1513,379,490 - 13,397,412 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2513,232,264 - 13,250,897 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TMEM263
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111102,168,776 - 102,186,976 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl11102,168,715 - 102,184,333 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037142,859,851 - 142,882,868 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tmem263
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247502,543,323 - 2,557,909 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tmem263
59 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:146
Count of miRNA genes:114
Interacting mature miRNAs:130
Transcripts:ENSRNOT00000009154
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7127829089Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7131962314Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7131962314Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134000259Rat
2317047Wbc4White blood cell count QTL 40.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)7135342956Rat
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7144782185Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7144822433Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)766427026029351Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
10755438Coatc9Coat color QTL 90coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7352928048529280Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7532901950329019Rat
10755440Coatc10Coat color QTL 100coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7749649952496499Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7757398552573985Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)7946224658265113Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)7946224698011544Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)7986646760460686Rat
738033Anxrr6Anxiety related response QTL 64.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)71557388960573889Rat
1582260Bw72Body weight QTL 723.20.0043body mass (VT:0001259)body weight (CMO:0000012)71579556538073970Rat
1582261Bw69Body weight QTL 693.20.0048body mass (VT:0001259)body weight (CMO:0000012)71579556538073970Rat
1582262Bw75Body weight QTL 7530.0038body mass (VT:0001259)body weight (CMO:0000012)71579556538073970Rat
2317059Aia15Adjuvant induced arthritis QTL 152.46joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)71700459862004598Rat
10755451Coatc11Coat color QTL 110coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)71794435762944357Rat
70207Niddm31Non-insulin dependent diabetes mellitus QTL 313.9blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)71816950526029351Rat

Markers in Region
RH132121  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2718,608,022 - 18,608,226 (+)MAPPERmRatBN7.2
Rnor_6.0724,648,029 - 24,648,232NCBIRnor6.0
Rnor_5.0724,798,487 - 24,798,690UniSTSRnor5.0
RGSC_v3.4720,723,255 - 20,723,458UniSTSRGSC3.4
Celera715,836,061 - 15,836,264UniSTS
Cytogenetic Map7q13UniSTS
RH143899  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2718,612,578 - 18,612,794 (+)MAPPERmRatBN7.2
Rnor_6.0724,652,585 - 24,652,800NCBIRnor6.0
Rnor_5.0724,803,043 - 24,803,258UniSTSRnor5.0
RGSC_v3.4720,727,811 - 20,728,026UniSTSRGSC3.4
Celera715,840,617 - 15,840,832UniSTS
Cytogenetic Map7q13UniSTS
RH140291  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2718,612,061 - 18,612,251 (+)MAPPERmRatBN7.2
Rnor_6.0724,652,068 - 24,652,257NCBIRnor6.0
Rnor_5.0724,802,526 - 24,802,715UniSTSRnor5.0
RGSC_v3.4720,727,294 - 20,727,483UniSTSRGSC3.4
Celera715,840,100 - 15,840,289UniSTS
Cytogenetic Map7q13UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 34 43 28 18 28 6 6 74 27 38 11 6
Low 2 9 14 13 1 13 2 5 8 3 2
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000009154   ⟹   ENSRNOP00000009154
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl724,647,083 - 24,667,301 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000083806   ⟹   ENSRNOP00000074548
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl724,651,854 - 24,668,250 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000097967   ⟹   ENSRNOP00000096684
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl718,610,149 - 18,628,534 (-)Ensembl
RefSeq Acc Id: NM_001108739   ⟹   NP_001102209
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2718,607,077 - 18,627,297 (-)NCBI
Rnor_6.0724,647,083 - 24,667,301 (-)NCBI
Rnor_5.0724,797,541 - 24,818,593 (-)NCBI
RGSC_v3.4720,722,309 - 20,742,528 (-)RGD
Celera715,835,115 - 15,855,334 (-)RGD
Sequence:
RefSeq Acc Id: XM_006241164   ⟹   XP_006241226
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2718,610,151 - 18,628,436 (-)NCBI
Rnor_6.0724,650,159 - 24,668,381 (-)NCBI
Rnor_5.0724,797,541 - 24,818,593 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017594918   ⟹   XP_017450407
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2718,610,151 - 18,628,247 (-)NCBI
Rnor_6.0724,650,159 - 24,668,354 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001102209 (Get FASTA)   NCBI Sequence Viewer  
  XP_006241226 (Get FASTA)   NCBI Sequence Viewer  
  XP_017450407 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI66979 (Get FASTA)   NCBI Sequence Viewer  
  EDM17103 (Get FASTA)   NCBI Sequence Viewer  
  EDM17104 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001102209   ⟸   NM_001108739
- UniProtKB: B2RZ08 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006241226   ⟸   XM_006241164
- Peptide Label: isoform X1
- UniProtKB: B2RZ08 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017450407   ⟸   XM_017594918
- Peptide Label: isoform X1
- UniProtKB: B2RZ08 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000009154   ⟸   ENSRNOT00000009154
RefSeq Acc Id: ENSRNOP00000074548   ⟸   ENSRNOT00000083806
RefSeq Acc Id: ENSRNOP00000096684   ⟸   ENSRNOT00000097967

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B2RZ08-F1-model_v2 AlphaFold B2RZ08 1-115 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695106
Promoter ID:EPDNEW_R5623
Type:initiation region
Name:Tmem263_1
Description:transmembrane protein 263
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0724,668,318 - 24,668,378EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1563325 AgrOrtholog
BioCyc Gene G2FUF-34628 BioCyc
Ensembl Genes ENSRNOG00000006987 Ensembl
  ENSRNOG00000067167 Ensembl, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000096684.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000097967.1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7315264 IMAGE-MGC_LOAD
InterPro UPF0444 UniProtKB/TrEMBL
KEGG Report rno:362857 UniProtKB/TrEMBL
MGC_CLONE MGC:189068 IMAGE-MGC_LOAD
NCBI Gene 362857 ENTREZGENE
PANTHER PTHR31443 UniProtKB/TrEMBL
Pfam UPF0444 UniProtKB/TrEMBL
PhenoGen Tmem263 PhenoGen
UniProt A0A8I6AQR3_RAT UniProtKB/TrEMBL
  B2RZ08 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-03-27 Tmem263  transmembrane protein 263  RGD1563325  similar to hypothetical protein MGC17943  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1563325  similar to hypothetical protein MGC17943   RGD1563325_predicted  similar to hypothetical protein MGC17943 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1563325_predicted  similar to hypothetical protein MGC17943 (predicted)  LOC362857  similar to hypothetical protein MGC17943  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC362857  similar to hypothetical protein MGC17943      Symbol and Name status set to provisional 70820 PROVISIONAL