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Gene: Lipc (lipase C, hepatic type) Rattus norvegicus
Symbol: Lipc
Name: lipase C, hepatic type
Description: Exhibits several functions, including anion binding activity; lipase activity; and lipoprotein particle binding activity. Involved in several processes, including glycerolipid metabolic process; low-density lipoprotein particle clearance; and plasma lipoprotein particle remodeling. Localizes to several cellular components, including cell surface; endosome; and microvillus. Used to study several diseases, including end stage renal disease; hepatitis; hyperinsulinism; obesity; and protein-energy malnutrition. Biomarker of ischemia. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; coronary artery disease; familial combined hyperlipidemia; peripheral vascular disease; and type 2 diabetes mellitus. Orthologous to human LIPC (lipase C, hepatic type); PARTICIPATES IN D-glycericacidemia pathway; familial lipoprotein lipase deficiency pathway; glycerol kinase deficiency pathway; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
Also known as: hepatic lipase; hepatic triacylglycerol lipase; HL; lipase C; lipase C, hepatic; lipase member C; lipase, hepatic; lysophospholipase; MGC108746; phospholipase A1
Homo sapiens (human) : LIPC (lipase C, hepatic type)  HGNC  Alliance
Mus musculus (house mouse) : Lipc (lipase, hepatic)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Lipc (lipase C, hepatic type)
Pan paniscus (bonobo/pygmy chimpanzee) : LIPC (lipase C, hepatic type)
Canis lupus familiaris (dog) : LIPC (lipase C, hepatic type)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Lipc (lipase C, hepatic type)
Sus scrofa (pig) : LIPC (lipase C, hepatic type)
Chlorocebus sabaeus (African green monkey) : LIPC (lipase C, hepatic type)
Heterocephalus glaber (naked mole-rat) : Lipc (lipase C, hepatic type)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0877,272,582 - 77,398,485 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl877,272,570 - 77,398,248 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0875,686,187 - 75,812,459 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4875,323,442 - 75,450,353 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1875,342,496 - 75,469,407 (-)NCBI
Celera870,101,863 - 70,227,531 (+)NCBICelera
Cytogenetic Map8q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Lipc
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3009
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-06-30
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.