Lipc (lipase C, hepatic type) - Rat Genome Database

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Gene: Lipc (lipase C, hepatic type) Rattus norvegicus
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Symbol: Lipc
Name: lipase C, hepatic type
RGD ID: 3009
Description: Enables several functions, including heparan sulfate proteoglycan binding activity; lipase activity; and lipoprotein particle binding activity. Involved in several processes, including glycerolipid metabolic process; low-density lipoprotein particle clearance; and plasma lipoprotein particle remodeling. Located in several cellular components, including cell surface; endosome; and microvillus. Used to study several diseases, including end stage renal disease; hepatitis; hyperinsulinism; obesity; and protein-energy malnutrition. Biomarker of ischemia. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; coronary artery disease; familial combined hyperlipidemia; peripheral vascular disease; and type 2 diabetes mellitus. Orthologous to human LIPC (lipase C, hepatic type); PARTICIPATES IN D-glycericacidemia pathway; familial lipoprotein lipase deficiency pathway; glycerol kinase deficiency pathway; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: hepatic lipase; hepatic triacylglycerol lipase; HL; lipase C; lipase C, hepatic; lipase member C; lipase, hepatic; lysophospholipase; MGC108746; phospholipase A1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2871,509,633 - 71,635,663 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl871,509,635 - 71,635,464 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx877,037,525 - 77,163,423 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0875,310,544 - 75,436,448 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0873,147,548 - 73,273,430 (-)NCBIRnor_WKY
Rnor_6.0877,272,582 - 77,398,485 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl877,272,570 - 77,398,248 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0875,686,187 - 75,812,459 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4875,323,442 - 75,450,353 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1875,342,496 - 75,469,407 (-)NCBI
Celera870,101,863 - 70,227,531 (+)NCBICelera
Cytogenetic Map8q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1-naphthyl isothiocyanate  (EXP)
1-octadecanoyl-2-[(9Z)-octadecenoyl]-sn-glycerol  (ISO)
1-palmitoyl-2-oleoyl-sn-glycerol  (ISO)
1-stearoyl-2-linoleoyl-sn-glycerol  (ISO)
1-stearoyl-sn-glycero-3-phosphocholine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
acetamide  (EXP)
acrolein  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (EXP)
ammonium chloride  (EXP)
arachidonic acid  (ISO)
aristolochic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atazanavir sulfate  (ISO)
atenolol  (ISO)
bazedoxifene  (ISO)
benzbromarone  (EXP)
benzo[a]pyrene  (ISO)
bezafibrate  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
buspirone  (EXP)
butanal  (ISO)
C60 fullerene  (EXP)
cadmium dichloride  (EXP)
carbon nanotube  (ISO)
chenodeoxycholic acid  (ISO)
chloroform  (EXP)
cholesteryl arachidonate  (ISO)
cholesteryl linoleate  (ISO)
cholesteryl linolenate  (ISO)
cholesteryl myristate  (ISO)
cholesteryl oleate  (ISO)
cholesteryl palmitate  (ISO)
ciglitazone  (ISO)
clofibrate  (EXP)
copper(II) sulfate  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
deoxycholic acid  (ISO)
dexamethasone  (EXP,ISO)
dichlorine  (EXP)
diclofenac  (ISO)
dimethylarsinic acid  (ISO)
diosgenin  (EXP)
erythromycin estolate  (EXP)
ethanol  (ISO)
farnesol  (ISO)
fipronil  (EXP)
flutamide  (EXP)
fluvastatin  (ISO)
folic acid  (ISO)
furan  (EXP)
genistein  (EXP)
glafenine  (EXP)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
GW 4064  (ISO)
GW 501516  (ISO)
hexadecanoic acid  (ISO)
high-density lipoprotein cholesterol  (ISO)
hydrazine  (EXP)
indometacin  (ISO)
isotretinoin  (ISO)
L-ethionine  (EXP)
linoleic acid  (ISO)
lipopolysaccharide  (ISO)
lovastatin  (ISO)
methapyrilene  (EXP)
methotrexate  (EXP)
methylarsonic acid  (ISO)
N-hexadecanoylsphingosine  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-Nitrosopyrrolidine  (ISO)
naloxone  (EXP)
nefazodone  (EXP,ISO)
nimesulide  (EXP)
nitrofen  (EXP)
O-methyleugenol  (ISO)
obeticholic acid  (ISO)
oleic acid  (ISO)
omeprazole  (EXP)
ozone  (EXP)
paracetamol  (EXP,ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (EXP,ISO)
phosphatidylcholine  (ISO)
pioglitazone  (ISO)
pirinixic acid  (EXP,ISO)
propiconazole  (ISO)
quercetin  (ISO)
quinidine  (EXP)
rebaudioside A  (ISO)
rimonabant  (ISO)
rotenone  (EXP)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sorafenib  (ISO)
steviol  (ISO)
stevioside  (ISO)
streptozocin  (ISO)
tamoxifen  (ISO)
tartrazine  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP)
theophylline  (EXP)
thioacetamide  (EXP)
trimellitic anhydride  (ISO)
triphenyl phosphate  (EXP)
valdecoxib  (EXP)
valproic acid  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular response to hormone stimulus  (IEP)
cholesterol homeostasis  (IEA,ISO)
cholesterol metabolic process  (IEA,ISO)
cholesterol transport  (IEA,ISO)
chylomicron remnant clearance  (IDA)
chylomicron remodeling  (IDA)
circadian rhythm  (IEP)
developmental growth  (IEP)
fatty acid biosynthetic process  (IBA,IEA,ISO)
fatty acid metabolic process  (IDA)
glycerophospholipid catabolic process  (IDA)
heparan sulfate proteoglycan biosynthetic process  (IDA)
high-density lipoprotein particle remodeling  (IDA,IEA,ISO)
lipid catabolic process  (IBA)
lipid metabolic process  (IEA)
liver development  (IEP)
low-density lipoprotein particle clearance  (IDA)
low-density lipoprotein particle remodeling  (IDA,IEA,ISO)
neutral lipid catabolic process  (IDA)
phosphatidic acid metabolic process  (IDA)
phosphatidylcholine metabolic process  (IDA)
phosphatidylethanolamine metabolic process  (IDA)
phosphatidylserine metabolic process  (IDA)
regulation of plasma lipoprotein particle levels  (IMP)
response to acetate  (IEP)
response to amino acid  (IEP)
response to calcium ion  (IEP)
response to carbohydrate  (IEP)
response to copper ion  (IEP)
response to fatty acid  (IEP)
response to glucocorticoid  (IEP)
response to hormone  (IEP)
response to hypoxia  (IEP)
response to inorganic substance  (IEP)
response to lipid  (IEP)
response to magnesium ion  (IEP)
response to nutrient levels  (IEP)
response to organic cyclic compound  (IEP)
response to peptide hormone  (IEP)
response to xenobiotic stimulus  (IEP)
triglyceride catabolic process  (IBA,IEA,ISO)
triglyceride homeostasis  (IEA,ISO)
triglyceride metabolic process  (IDA)
very-low-density lipoprotein particle remodeling  (IDA,IEA,ISO)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Plasma high density lipoproteins and lipolytic enzyme activities in diabetic patients. Agardh CD, etal., Acta Med Scand. 1983;213(2):123-8.
2. Verapamil prevents chronic renal failure-induced abnormalities in lipid metabolism. Akmal M, etal., Am J Kidney Dis. 1993 Jul;22(1):158-63.
3. The effect of sensitisation to insulin with pioglitazone on fasting and postprandial lipid metabolism, lipoprotein modification by lipases, and lipid transfer activities in type 2 diabetic patients. Al Majali K, etal., Diabetologia. 2006 Mar;49(3):527-37. Epub 2006 Jan 21.
4. Hepatic lipase induces the formation of pre-beta 1 high density lipoprotein (HDL) from triacylglycerol-rich HDL2. A study comparing liver perfusion to in vitro incubation with lipases. Barrans A, etal., J Biol Chem. 1994 Apr 15;269(15):11572-7.
5. Effect of hepatic lipase -514C->T polymorphism and its interactions with apolipoprotein C3 -482C->T and apolipoprotein E exon 4 polymorphisms on the risk of nephropathy in chinese type 2 diabetic patients. Baum L, etal., Diabetes Care. 2005 Jul;28(7):1704-9.
6. The response of hepatic lipase and serum lipoproteins to acute hyperinsulinaemia in type 2 diabetes. Baynes C, etal., Eur J Clin Invest. 1992 May;22(5):341-6.
7. The genetic association database. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
8. Circadian rhythms of lipoprotein lipase and hepatic lipase activities in intermediate metabolism of adult rat. Benavides A, etal., Am J Physiol. 1998 Sep;275(3 Pt 2):R811-7.
9. Role of the liver in the degradation of very low density lipoproteins: a study of lipolysis by heparin releasable liver lipase and uptake during isolated rat liver perfusion. Berry EM, etal., Eur J Clin Invest. 1981 Jun;11(3):151-9.
10. Oligomeric structure of hepatic lipase: evidence from a novel epitope tag technique. Berryman DE, etal., Biochim Biophys Acta. 1998 Feb 17;1382(2):217-29.
11. Lipoprotein lipase and hepatic lipase deficiencies associated with impaired chylomicron clearance in D-(+) galactosamine hepatitis. Black DD, etal., Metabolism. 1982 Jun;31(6):620-6.
12. Annexin II inhibits calcium-dependent phospholipase A1 and lysophospholipase but not triacyl glycerol lipase activities of rat liver hepatic lipase. Bohn E, etal., FEBS Lett. 1992 Jan 27;296(3):237-40.
13. Transient induction of a variant hepatic lipase messenger RNA by corticotropic hormone in rat adrenals. Botma GJ, etal., Metabolism. 2006 Apr;55(4):467-77.
14. Purified chickpea or lentil proteins impair VLDL metabolism and lipoprotein lipase activity in epididymal fat, but not in muscle, compared to casein, in growing rats. Boualga A, etal., Eur J Nutr. 2009 Apr;48(3):162-9. Epub 2009 Jan 22.
15. Hepatic lipase is localized at the parenchymal cell microvilli in rat liver. Breedveld B, etal., Biochem J. 1997 Jan 15;321 ( Pt 2):425-30.
16. Metabolic consequences of hypoxia from birth and dexamethasone treatment in the neonatal rat: comprehensive hepatic lipid and fatty acid profiling. Bruder ED, etal., Endocrinology. 2004 Nov;145(11):5364-72. Epub 2004 Jul 22.
17. Effects of a short-acting insulin analog (Insulin Lispro) versus regular insulin on lipid metabolism in insulin-dependent diabetes mellitus. Caixas A, etal., Metabolism. 1998 Apr;47(4):371-6.
18. Genetic variation in the hepatic lipase gene is associated with combined hyperlipidemia, plasma lipid concentrations, and lipid-lowering drug response. Cenarro A, etal., Am Heart J. 2005 Dec;150(6):1154-62.
19. Interaction between ApoB and hepatic lipase mediates the uptake of ApoB-containing lipoproteins. Choi SY, etal., J Biol Chem. 1998 Aug 7;273(32):20456-62.
20. Acceleration of uptake of LDL but not chylomicrons or chylomicron remnants by cells that secrete apoE and hepatic lipase. Choi SY, etal., J Lipid Res. 1994 May;35(5):848-59.
21. Identifying genetic susceptibilities to diabetes-related complications among individuals at low risk of complications: An application of tree-structured survival analysis. Costacou T, etal., Am J Epidemiol. 2006 Nov 1;164(9):862-72. Epub 2006 Aug 23.
22. Association between -250G/A polymorphism of the hepatic lipase gene promoter and coronary artery disease and HDL-C levels in a Southern Brazilian population. de Andrade FM, etal., Clin Genet. 2004 May;65(5):390-5.
23. Hepatic lipase may act as a ligand in the uptake of artificial chylomicron remnant-like particles by isolated rat hepatocytes. Diard P, etal., Biochem J. 1994 May 1;299 ( Pt 3):889-94.
24. Decreased activity of lecithin:cholesterol acyltransferase and hepatic lipase in chronic hypothyroid rats: implications for reverse cholesterol transport. Franco M, etal., Mol Cell Biochem. 2003 Apr;246(1-2):51-6.
25. Acute regulation of hepatic lipase secretion by rat hepatocytes. Galan X, etal., Biochem Cell Biol. 2002;80(4):467-74.
26. Catabolism of very low density lipoproteins in experimental nephrosis. Garber DW, etal., J Clin Invest. 1984 Oct;74(4):1375-83.
27. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
28. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
29. Multiple lipoprotein abnormalities in type I diabetic patients with renal disease. Groop PH, etal., Diabetes. 1996 Jul;45(7):974-9.
30. A common promoter polymorphism in the hepatic lipase gene (LIPC-480C>T) is associated with an increase in coronary calcification in type 1 diabetes. Hokanson JE, etal., Diabetes. 2002 Apr;51(4):1208-13.
31. Growth hormone normalizes hepatic lipase in hypothyroid rat liver. Hoogerbrugge N, etal., Metabolism. 1993 Jun;42(6):669-71.
32. Triacylglycerol lipase, monoacylglycerol lipase and phospholipase activities of highly purified rat hepatic lipase. Jensen GL, etal., Biochim Biophys Acta. 1982 Mar 12;710(3):464-70. doi: 10.1016/0005-2760(82)90130-8.
33. High fat feeding and dietary L-arginine supplementation differentially regulate gene expression in rat white adipose tissue. Jobgen W, etal., Amino Acids. 2009 May;37(1):187-98. Epub 2009 Feb 12.
34. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
35. Abnormalities in hepatic lipase in chronic renal failure: role of excess parathyroid hormone. Klin M, etal., J Clin Invest. 1996 May 15;97(10):2167-73.
36. Hepatic triacylglycerol lipase activities after induction of diabetes and administration of insulin or glucagon. Knauer TE, etal., J Lipid Res. 1982 May;23(4):631-7.
37. Expression of rat hepatic lipase in heterologous systems: evidence for different sites for interface binding and catalysis. Komaromy MC and Reed M, J Lipid Res. 1991 Jun;32(6):963-75.
38. Cloning of rat hepatic lipase cDNA: evidence for a lipase gene family. Komaromy MC and Schotz MC, Proc Natl Acad Sci U S A 1987 Mar;84(6):1526-30.
39. Smoking is associated with increased hepatic lipase activity, insulin resistance, dyslipidaemia and early atherosclerosis in Type 2 diabetes. Kong C, etal., Atherosclerosis. 2001 Jun;156(2):373-8.
40. Effect of copper deficiency on the lymphatic absorption of cholesterol, plasma chylomicron clearance, and postheparin lipase activities. Koo SI, etal., Proc Soc Exp Biol Med. 1988 Sep;188(4):410-9.
41. Localization of the heparin-releasable lipase in situ in the rat liver. Kuusi T, etal., Biochem J. 1979 Jul 1;181(1):245-6.
42. Rat plasma VLDL composition and concentration and hepatic lipase and lipoprotein lipase activities are impaired during two types of protein malnutrition and unaffected by balanced refeeding. Lamri MY, etal., J Nutr. 1995 Sep;125(9):2425-34.
43. A role for hepatic lipase in chylomicron and high density lipoprotein phospholipid metabolism. Landin B, etal., J Lipid Res. 1984 Jun;25(6):559-63.
44. Effect of neonatal hypoxia on the development of hepatic lipase in the rat. Lee PC, etal., Am J Physiol Regul Integr Comp Physiol. 2000 Oct;279(4):R1341-7.
45. Association of hepatic lipase with proteoglycans stimulates the production of proteoglycans in vivo and in vitro. Lee SJ, etal., J Lipid Res. 2004 Jul;45(7):1266-71. Epub 2004 Apr 21.
46. Lipoprotein lipase in experimental diabetic rats: beneficial effect of vanadate treatment. Levy E and Bendayan M, Diabete Metab. 1991 Jan-Feb;17(1):44-8.
47. Combined (n-3 and n-6) essential fatty deficiency is a potent modulator of plasma lipids, lipoprotein composition, and lipolytic enzymes. Levy E, etal., J Lipid Res. 1990 Nov;31(11):2009-17.
48. Down-regulation of hepatic lipase expression in experimental nephrotic syndrome. Liang K and Vaziri ND, Kidney Int. 1997 Jun;51(6):1933-7.
49. Postnatal development of plasma-lipid-clearing enzymes (lipoprotein lipase, hepatic lipase and lecithin:cholesterol acyl transferase) and lipid profiles in suckling rats. Mao J and Hamosh M, Biol Neonate. 1992;62(1):1-9.
50. Effect of the calcium channel antagonist nitrendipine on lipoprotein lipase and hepatic lipase in the normal rat. Marotta T, etal., Eur J Pharmacol. 1998 Jun 26;351(3):357-61.
51. Gram-negative bacteria sepsis in the rat and tissue lipolytic activity on LCT and MCT/LCT-based commercial parenteral emulsions. Meraihi Z, etal., Infusionstherapie. 1990 Apr;17(2):104-7.
52. Time course of changes in serum glucose, insulin, lipids and tissue lipase activities in macrosomic offspring of rats with streptozotocin-induced diabetes. Merzouk H, etal., Clin Sci (Lond). 2000 Jan;98(1):21-30.
53. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
54. Comparative effect of fish oil feeding and other dietary fatty acids on plasma lipoproteins, biliary lipids, and hepatic expression of proteins involved in reverse cholesterol transport in the rat. Morgado N, etal., Ann Nutr Metab. 2005 Nov-Dec;49(6):397-406. Epub 2005 Oct 14.
55. Stimulatory release of hepatic lipase activity from rat hepatocytes by ruthenium red. Morita T, etal., Biol Pharm Bull. 2000 May;23(5):549-54.
56. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
57. Effects of the heparin-mimicking compound RG-13577 on lipoprotein lipase and on lipase mediated binding of LDL to cells. Neuger L, etal., Atherosclerosis. 2001 Jul;157(1):13-21.
58. Maturation and secretion of rat hepatic lipase is inhibited by alpha1B-adrenergic stimulation through changes in Ca2+ homoeostasis: thapsigargin and EGTA both mimic the effect of adrenaline. Neve BP, etal., Biochem J. 1998 Mar 1;330 ( Pt 2):701-6.
59. Growth hormone restores hepatic lipase mRNA levels but the translation is impaired in hepatocytes of hypothyroid rats. Neve BP, etal., Biochim Biophys Acta. 1997 Apr 1;1345(2):172-9.
60. Postheparin plasma lipoprotein lipase and hepatic lipase in diabetes mellitus. Relationship to plasma triglyceride metabolism. Nikkila EA, etal., Diabetes. 1977 Jan;26(1):11-21.
61. Metabolism of chylomicron phosphatidylinositol in the rat: fate in vivo and hydrolysis with lipoprotein lipase and hepatic lipase in vitro. Nilsson A, etal., J Lipid Res. 1994 Dec;35(12):2151-60.
62. Reverse cholesterol transport and cholesterol efflux in atherosclerosis. Ohashi R, etal., QJM. 2005 Dec;98(12):845-56. Epub 2005 Oct 28.
63. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
64. Hepatic lipase C514T polymorphism and its relationship with plasma HDL-C levels and coronary artery disease in Koreans. Park KW, etal., J Biochem Mol Biol. 2003 Mar 31;36(2):237-42.
65. Lipoprotein lipase and cholesterol transfer activities of lean and obese Zucker rats. Peinado-Onsurbe J, etal., Horm Metab Res. 2001 Aug;33(8):458-62.
66. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
67. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
68. Effect of magnesium deficiency on post-heparin lipase activity and tissue lipoprotein lipase in the rat. Rayssiguier Y, etal., Lipids. 1991 Mar;26(3):182-6.
69. GOA pipeline RGD automated data pipeline
70. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
71. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
72. Oxidized fat reduces milk triacylglycerol concentrations by inhibiting gene expression of lipoprotein lipase and fatty acid transporters in the mammary gland of rats. Ringseis R, etal., J Nutr. 2007 Sep;137(9):2056-61.
73. Effect of insulin and sulfonylurea therapy, at the same level of blood glucose control, on low density lipoprotein subfractions in type 2 diabetic patients. Rivellese AA, etal., J Clin Endocrinol Metab. 2000 Nov;85(11):4188-92.
74. Protein restriction and AST-120 improve lipoprotein lipase and VLDL receptor in focal glomerulosclerosis. Sato T, etal., Kidney Int. 2003 Nov;64(5):1780-6.
75. Binding of hepatic lipase to heparin. Identification of specific heparin-binding residues in two distinct positive charge clusters. Sendak RA, etal., J Lipid Res. 2000 Feb;41(2):260-8.
76. Isolation and characterization of clones for the rat hepatic lipase gene upstream regulatory region. Sensel MG, etal., Biochim Biophys Acta 1990 Apr 6;1048(2-3):297-302.
77. Estrogen effects on triglyceride metabolism in analbuminemic rats. Shearer GC, etal., Kidney Int. 2000 Jun;57(6):2268-74.
78. Hepatocyte nuclear factor-1alpha is an essential regulator of bile acid and plasma cholesterol metabolism. Shih DQ, etal., Nat Genet. 2001 Apr;27(4):375-82.
79. Visceral obesity, hepatic lipase activity, and dyslipidemia in type 1 diabetes. Sibley SD, etal., J Clin Endocrinol Metab. 2003 Jul;88(7):3379-84.
80. Role of apolipoprotein A-IV in hepatic lipase-catalyzed dolichol acylation and phospholipid hydrolysis. Sindelar PJ, etal., Biochemistry. 1997 Feb 18;36(7):1807-13.
81. Metabolic responses to intermittent hepatic dearterialization in the rat. Sjovall S, etal., J Hepatol. 1991 Jul;13(1):33-7.
82. Effect of dietary cholesterol on activity and mRNA levels of hepatic lipase in rat. Sultan F, etal., Life Sci. 1995;56(1):31-7.
83. Involvement of Ca2+/calmodulin-dependent protein kinase II in heparin-stimulated release of hepatic lipase activity from rat hepatocytes. Tagashira H, etal., Biol Pharm Bull. 2005 Mar;28(3):409-12.
84. Effects of gender, hepatic lipase gene polymorphism and type 2 diabetes mellitus on hepatic lipase activity in Chinese. Tan KC, etal., Atherosclerosis. 2001 Jul;157(1):233-9.
85. Hydrolysis of lipid mixtures by rat hepatic lipase. Thuren T, etal., Biochim Biophys Acta. 1990 Sep 18;1046(2):178-84.
86. Activation of hepatic lipase catalyzed phosphatidylcholine hydrolysis by apolipoprotein E. Thuren T, etal., Biochim Biophys Acta. 1991 May 8;1083(2):217-20.
87. Hepatic lipase. Purification and characterization. Twu JS, etal., Biochim Biophys Acta. 1984 Mar 7;792(3):330-7.
88. Association of the -250G/A promoter polymorphism of the hepatic lipase gene with the risk of peripheral arterial disease in type 2 diabetic patients. Valdivielso P, etal., J Diabetes Complications. 2008 Jul-Aug;22(4):273-7. Epub 2008 Apr 16.
89. Glucose increases hepatic lipase expression in HepG2 liver cells through upregulation of upstream stimulatory factors 1 and 2. van Deursen D, etal., Diabetologia. 2008 Nov;51(11):2078-87. Epub 2008 Aug 30.
90. Down-regulation of hepatic lipase expression by elevation of cAMP in human hepatoma but not adrenocortical cells. van Deursen D, etal., Mol Cell Endocrinol. 2008 Nov 6;294(1-2):37-44. Epub 2008 Jul 15.
91. Endocytosis of hepatic lipase and lipoprotein lipase into rat liver hepatocytes in vivo is mediated by the low density lipoprotein receptor-related protein. Verges M, etal., J Biol Chem. 2004 Mar 5;279(10):9030-6. Epub 2003 Dec 29.
92. Intracellular activation of rat hepatic lipase requires transport to the Golgi compartment and is associated with a decrease in sedimentation velocity. Verhoeven AJ, etal., J Biol Chem. 2000 Mar 31;275(13):9332-9.
93. Induction of adrenal scavenger receptor BI and increased high density lipoprotein-cholesteryl ether uptake by in vivo inhibition of hepatic lipase. Vieira-van Bruggen D, etal., J Biol Chem. 1998 Nov 27;273(48):32038-41.
94. Rabbit hepatic lipase cDNA sequence: low activity is associated with low messenger RNA levels. Warren RJ, etal., J Lipid Res. 1991 Aug;32(8):1333-9.
95. Poloxamer 407-mediated alterations in the activities of enzymes regulating lipid metabolism in rats. Wasan KM, etal., J Pharm Pharm Sci. 2003 May-Aug;6(2):189-97.
96. Hydrolysis of neutral lipid substrates by rat hepatic lipase. Wilcox RW, etal., Lipids. 1991 Apr;26(4):283-8.
97. Inhibition of Coix seed extract on fatty acid synthase, a novel target for anticancer activity. Yu F, etal., J Ethnopharmacol. 2008 Sep 26;119(2):252-8. Epub 2008 Jul 23.
98. The G-250A substitution in the promoter region of the hepatic lipase gene is associated with the conversion from impaired glucose tolerance to type 2 diabetes: the STOP-NIDDM trial. Zacharova J, etal., J Intern Med. 2005 Feb;257(2):185-93.
99. Hepatic lipase: a marker for cardiovascular disease risk and response to therapy. Zambon A, etal., Curr Opin Lipidol. 2003 Apr;14(2):179-89.
100. Interactions between the -514C->T polymorphism of the hepatic lipase gene and lifestyle factors in relation to HDL concentrations among US diabetic men. Zhang C, etal., Am J Clin Nutr. 2005 Jun;81(6):1429-35.
101. Genetic variation in the hepatic lipase gene and the risk of coronary heart disease among US diabetic men: potential interaction with obesity. Zhang C, etal., Diabetologia. 2006 Jul;49(7):1552-9. Epub 2006 Mar 29.
102. Lack of association of hepatic lipase polymorphisms with late-onset Alzheimer's disease. Zhu H, etal., Neurobiol Aging. 2006 Dec 15;.
Additional References at PubMed
PMID:182536   PMID:1883393   PMID:2839510   PMID:3244012   PMID:7592706   PMID:8640403   PMID:8798380   PMID:8798474   PMID:10357838   PMID:12032167   PMID:12477932   PMID:12951367  
PMID:12975454   PMID:15520453   PMID:15995171   PMID:26193433  


Genomics

Comparative Map Data
Lipc
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2871,509,633 - 71,635,663 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl871,509,635 - 71,635,464 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx877,037,525 - 77,163,423 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0875,310,544 - 75,436,448 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0873,147,548 - 73,273,430 (-)NCBIRnor_WKY
Rnor_6.0877,272,582 - 77,398,485 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl877,272,570 - 77,398,248 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0875,686,187 - 75,812,459 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4875,323,442 - 75,450,353 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1875,342,496 - 75,469,407 (-)NCBI
Celera870,101,863 - 70,227,531 (+)NCBICelera
Cytogenetic Map8q24NCBI
LIPC
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381558,410,554 - 58,569,844 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1558,410,569 - 58,569,844 (+)EnsemblGRCh38hg38GRCh38
GRCh371558,724,190 - 58,862,043 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361556,511,467 - 56,648,364 (+)NCBINCBI36Build 36hg18NCBI36
Build 341556,511,466 - 56,648,364NCBI
Celera1535,612,421 - 35,749,365 (+)NCBICelera
Cytogenetic Map15q21.3NCBI
HuRef1535,547,160 - 35,684,065 (+)NCBIHuRef
CHM1_11558,842,117 - 58,978,999 (+)NCBICHM1_1
T2T-CHM13v2.01556,233,960 - 56,371,844 (+)NCBIT2T-CHM13v2.0
Lipc
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39970,705,410 - 70,859,503 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl970,705,410 - 70,859,508 (-)EnsemblGRCm39 Ensembl
GRCm38970,798,128 - 70,952,221 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl970,798,128 - 70,952,226 (-)EnsemblGRCm38mm10GRCm38
MGSCv37970,645,935 - 70,782,615 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36970,597,345 - 70,734,025 (-)NCBIMGSCv36mm8
Celera968,015,071 - 68,150,792 (-)NCBICelera
Cytogenetic Map9DNCBI
cM Map939.57NCBI
Lipc
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545015,948,187 - 16,048,766 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545015,947,869 - 16,062,449 (-)NCBIChiLan1.0ChiLan1.0
LIPC
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11555,688,414 - 55,847,005 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1555,814,017 - 55,847,005 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01537,363,507 - 37,537,723 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
LIPC
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13023,432,460 - 23,584,037 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3023,432,493 - 23,584,037 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3023,404,560 - 23,555,900 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03023,597,357 - 23,749,167 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3023,597,357 - 23,852,590 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13023,523,240 - 23,674,537 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03023,608,314 - 23,759,924 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03023,750,266 - 23,901,905 (+)NCBIUU_Cfam_GSD_1.0
Lipc
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640101,755,855 - 101,885,658 (+)NCBIHiC_Itri_2
SpeTri2.0NW_00493647119,604,083 - 19,733,721 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LIPC
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1113,433,687 - 113,583,963 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11113,433,684 - 113,604,139 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21125,418,537 - 125,667,649 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LIPC
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12624,946,843 - 25,109,338 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2624,946,673 - 25,087,921 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666048116,211,906 - 116,373,902 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lipc
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478113,342,357 - 13,455,055 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478113,342,469 - 13,468,120 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Position Markers
D8Got335  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2871,595,480 - 71,595,646 (+)MAPPERmRatBN7.2
Rnor_6.0877,358,455 - 77,358,620NCBIRnor6.0
Rnor_5.0875,725,924 - 75,726,089UniSTSRnor5.0
RGSC_v3.4875,410,486 - 75,410,651UniSTSRGSC3.4
Celera870,141,597 - 70,141,766UniSTS
Cytogenetic Map8q24UniSTS
RH94786  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2871,509,684 - 71,509,760 (+)MAPPERmRatBN7.2
Rnor_6.0877,272,634 - 77,272,709NCBIRnor6.0
Rnor_5.0875,812,332 - 75,812,407UniSTSRnor5.0
RGSC_v3.4875,323,493 - 75,323,568UniSTSRGSC3.4
Celera870,227,405 - 70,227,480UniSTS
Cytogenetic Map8q24UniSTS
RH94586  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2871,509,664 - 71,509,769 (+)MAPPERmRatBN7.2
Rnor_6.0877,272,614 - 77,272,718NCBIRnor6.0
Rnor_5.0875,812,323 - 75,812,427UniSTSRnor5.0
RGSC_v3.4875,323,473 - 75,323,577UniSTSRGSC3.4
Celera870,227,396 - 70,227,500UniSTS
Cytogenetic Map8q24UniSTS
G47926  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2871,619,322 - 71,619,536 (+)MAPPERmRatBN7.2
Rnor_6.0877,382,135 - 77,382,348NCBIRnor6.0
Rnor_5.0875,702,308 - 75,702,521UniSTSRnor5.0
RGSC_v3.4875,434,212 - 75,434,425UniSTSRGSC3.4
Celera870,117,791 - 70,117,994UniSTS
Cytogenetic Map8q24UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
631271Lecl1Lens clarity QTL 10.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)81898416884531599Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)81933115293965294Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)82720571599103503Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)82720571599103503Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)82720571599103503Rat
1300146Rf17Renal function QTL 172.9renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)82824291273242912Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)82824291299525068Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)83018886794457446Rat
2313046Bss78Bone structure and strength QTL 783.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)83084815482460899Rat
2313057Bss76Bone structure and strength QTL 7630.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)83084815482460899Rat
2313067Bss77Bone structure and strength QTL 773.10.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)83084815482460899Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83084815482460899Rat
1578755Pur5Proteinuria QTL 53.30.0001total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)830848154101699754Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)830848154101699754Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)830848154101699754Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)830848259105647037Rat
1298065Scl16Serum cholesterol level QTL 163.8blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)83085640475856404Rat
1582222Epfw2Epididymal fat weight QTL 23.20.0005epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)83173772976737729Rat
61358Bp39Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83555193880551938Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83558203280582032Rat
1331838Niddm61Non-insulin dependent diabetes mellitus QTL 613.530.0004blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83646953599083736Rat
737824Hcar10Hepatocarcinoma resistance QTL 102.9liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)84071306682925667Rat
1358906Bp253Blood pressure QTL 25340.0004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)84071306693965294Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
1331769Rf39Renal function QTL 393.871urine output (VT:0003620)timed urine volume (CMO:0000260)84186687675097878Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)84186687686866876Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84269268490165460Rat
12879882Am8Aortic mass QTL 80.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)84329616998968765Rat
12879878Bw183Body weight QTL 1830.001body mass (VT:0001259)body weight (CMO:0000012)84329616998968765Rat
12879879Cm99Cardiac mass QTL 990.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)84329616998968765Rat
12879880Cm100Cardiac mass QTL 1000.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)84329616998968765Rat
12879881Cm101Cardiac mass QTL 1010.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)84329616998968765Rat
12879883Kidm65Kidney mass QTL 650.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)84329616998968765Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)846531639119088624Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)846531639119088624Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)846531639119088624Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)846531639119088624Rat
1331837Bw23Body weight QTL 234.190.00007body mass (VT:0001259)body weight (CMO:0000012)84653172299083736Rat
2303570Gluco48Glucose level QTL 482blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)84980583194805831Rat
2313086Bss60Bone structure and strength QTL 604.10.0001tibia length (VT:0004357)tibia length (CMO:0000450)85009524982460899Rat
4889938Bss89Bone structure and strength QTL 893.8tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)85009524982460899Rat
5684973Bss100Bone structure and strength QTL 1004.7tibia area (VT:1000281)tibia area measurement (CMO:0001382)85009524982460899Rat
1358912Bw51Body weight QTL 512.95body mass (VT:0001259)body weight (CMO:0000012)851351728107062046Rat
10402857Bp380Blood pressure QTL 3800.95arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)85396876598968765Rat
2301402Bp316Blood pressure QTL 3160.005arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)85396876598968765Rat
2293697Bmd39Bone mineral density QTL 39femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)85404374498968765Rat
1582243Bw66Body weight QTL 663.40.0048body mass (VT:0001259)body weight (CMO:0000012)85423764485365202Rat
1582254Kidm31Kidney mass QTL 313kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)85423764485365202Rat
631664Hcar3Hepatocarcinoma resistance QTL 32.90.0005liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)85423764499103503Rat
1300177Cm2Cardiac mass QTL 23.65heart mass (VT:0007028)heart weight (CMO:0000017)854259986100382532Rat
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)861290298119084929Rat
631653Bp125Blood pressure QTL 1253.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)866142385111142385Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)869349194112783834Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)870513503118219066Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:61
Count of miRNA genes:55
Interacting mature miRNAs:57
Transcripts:ENSRNOT00000049976
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 41 41 41
Low 1 13 14 1 1 1 13 14 2 1
Below cutoff 2 32 3 5 6 7 13 21 26 9 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000082763   ⟹   ENSRNOP00000074623
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl871,509,635 - 71,635,464 (-)Ensembl
Rnor_6.0 Ensembl877,272,584 - 77,398,248 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000085349   ⟹   ENSRNOP00000073927
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl871,509,635 - 71,635,464 (-)Ensembl
Rnor_6.0 Ensembl877,272,570 - 77,398,201 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000091858   ⟹   ENSRNOP00000070550
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl877,272,606 - 77,398,156 (-)Ensembl
RefSeq Acc Id: NM_012597   ⟹   NP_036729
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2871,509,634 - 71,635,464 (-)NCBI
Rnor_6.0877,272,583 - 77,398,248 (-)NCBI
Rnor_5.0875,686,187 - 75,812,459 (+)NCBI
RGSC_v3.4875,323,442 - 75,450,353 (-)RGD
Celera870,101,863 - 70,227,531 (+)RGD
Sequence:
RefSeq Acc Id: XM_006243359   ⟹   XP_006243421
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2871,509,633 - 71,635,663 (-)NCBI
Rnor_6.0877,272,582 - 77,398,485 (-)NCBI
Rnor_5.0875,686,187 - 75,812,459 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006243360   ⟹   XP_006243422
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2871,509,633 - 71,635,660 (-)NCBI
Rnor_6.0877,272,582 - 77,398,484 (-)NCBI
Rnor_5.0875,686,187 - 75,812,459 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_036729   ⟸   NM_012597
- Peptide Label: precursor
- UniProtKB: Q5M895 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006243421   ⟸   XM_006243359
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K6S7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006243422   ⟸   XM_006243360
- Peptide Label: isoform X2
- UniProtKB: Q5M895 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000074623   ⟸   ENSRNOT00000082763
RefSeq Acc Id: ENSRNOP00000073927   ⟸   ENSRNOT00000085349
RefSeq Acc Id: ENSRNOP00000070550   ⟸   ENSRNOT00000091858
Protein Domains
PLAT

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P07867-F1-model_v2 AlphaFold P07867 1-494 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696112
Promoter ID:EPDNEW_R6634
Type:multiple initiation site
Name:Lipc_1
Description:lipase C, hepatic type
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0877,398,205 - 77,398,265EPDNEW

Strain Variation

Strain Sequence Variants (mRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3009 AgrOrtholog
BioCyc Gene G2FUF-29907 BioCyc
BioCyc Pathway LIPAS-PWY [triacylglycerol degradation] BioCyc
  PWY-8052 [2-arachidonoylglycerol biosynthesis] BioCyc
Ensembl Genes ENSRNOG00000060338 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000073927 ENTREZGENE
  ENSRNOP00000073927.1 UniProtKB/TrEMBL
  ENSRNOP00000074623 ENTREZGENE
  ENSRNOP00000074623.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000082763 ENTREZGENE
  ENSRNOT00000082763.2 UniProtKB/TrEMBL
  ENSRNOT00000085349 ENTREZGENE
  ENSRNOT00000085349.2 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.1820 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7323251 IMAGE-MGC_LOAD
InterPro AB_hydrolase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lipase/vitellogenin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lipase_hep UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lipase_LIPH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lipase_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLAT/LH2_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLAT/LH2_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TAG_lipase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24538 UniProtKB/TrEMBL
MGC_CLONE MGC:108746 IMAGE-MGC_LOAD
NCBI Gene 24538 ENTREZGENE
PANTHER PTHR11610 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11610:SF2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Lipase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB LIPC RGD
PhenoGen Lipc PhenoGen
PIRSF Lipoprotein_lipase_LIPH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS HEPLIPASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TAGLIPASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE LIPASE_SER UniProtKB/Swiss-Prot
  PLAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART LH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49723 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF53474 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K6S7 ENTREZGENE, UniProtKB/TrEMBL
  LIPC_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q5M895 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-17 Lipc  lipase C, hepatic type  Lipc  lipase C, hepatic  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-02-03 Lipc  lipase C, hepatic  Lipc  lipase, hepatic  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Lipc  Lipase, hepatic      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains contains two potential sites for N-glycosylation 729157
gene_protein unglycosylated protein has a predicted molecular weight of 53,222 Da 729157