Lipc (lipase C, hepatic type) - Rat Genome Database

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Gene: Lipc (lipase C, hepatic type) Rattus norvegicus
Analyze
Symbol: Lipc
Name: lipase C, hepatic type
RGD ID: 3009
Description: Enables several functions, including heparan sulfate proteoglycan binding activity; lipase activity; and lipoprotein particle binding activity. Involved in several processes, including glycerolipid metabolic process; low-density lipoprotein particle clearance; and plasma lipoprotein particle remodeling. Located in several cellular components, including cell surface; endosome; and microvillus. Used to study several diseases, including end stage renal disease; hepatitis; hyperinsulinism; obesity; and protein-energy malnutrition. Biomarker of ischemia. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; coronary artery disease; familial combined hyperlipidemia; peripheral vascular disease; and type 2 diabetes mellitus. Orthologous to human LIPC (lipase C, hepatic type); PARTICIPATES IN D-glycericacidemia pathway; familial lipoprotein lipase deficiency pathway; glycerol kinase deficiency pathway; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: hepatic lipase; hepatic triacylglycerol lipase; HL; lipase C; lipase C, hepatic; lipase member C; lipase, hepatic; lysophospholipase; MGC108746; phospholipase A1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2871,509,633 - 71,635,663 (-)NCBI
Rnor_6.0 Ensembl877,272,570 - 77,398,248 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0877,272,582 - 77,398,485 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0875,686,187 - 75,812,459 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4875,323,442 - 75,450,353 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1875,342,496 - 75,469,407 (-)NCBI
Celera870,101,863 - 70,227,531 (+)NCBICelera
Cytogenetic Map8q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1-naphthyl isothiocyanate  (EXP)
1-octadecanoyl-2-[(9Z)-octadecenoyl]-sn-glycerol  (ISO)
1-palmitoyl-2-oleoyl-sn-glycerol  (ISO)
1-stearoyl-2-linoleoyl-sn-glycerol  (ISO)
1-stearoyl-sn-glycero-3-phosphocholine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
acetamide  (EXP)
acrolein  (ISO)
aflatoxin B1  (ISO)
amiodarone  (EXP)
ammonium chloride  (EXP)
arachidonic acid  (ISO)
aristolochic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atenolol  (ISO)
bazedoxifene  (ISO)
benzbromarone  (EXP)
benzo[a]pyrene  (ISO)
bezafibrate  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
buspirone  (EXP)
butanal  (ISO)
C60 fullerene  (EXP)
cadmium dichloride  (EXP)
carbon nanotube  (ISO)
chloroform  (EXP)
cholesteryl arachidonate  (ISO)
cholesteryl linoleate  (ISO)
cholesteryl linolenate  (ISO)
cholesteryl myristate  (ISO)
cholesteryl oleate  (ISO)
cholesteryl palmitate  (ISO)
ciglitazone  (ISO)
clofibrate  (EXP)
copper(II) sulfate  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
dexamethasone  (EXP,ISO)
dichlorine  (EXP)
diclofenac  (ISO)
diosgenin  (EXP)
erythromycin estolate  (EXP)
ethanol  (ISO)
farnesol  (ISO)
fipronil  (EXP)
flutamide  (EXP)
fluvastatin  (ISO)
folic acid  (ISO)
furan  (EXP)
genistein  (EXP)
glafenine  (EXP)
GW 4064  (ISO)
GW 501516  (ISO)
hexadecanoic acid  (ISO)
high-density lipoprotein cholesterol  (ISO)
hydrazine  (EXP)
indometacin  (ISO)
isotretinoin  (ISO)
L-ethionine  (EXP)
linoleic acid  (ISO)
lipopolysaccharide  (ISO)
lovastatin  (ISO)
methapyrilene  (EXP)
methotrexate  (EXP)
N-hexadecanoylsphingosine  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-Nitrosopyrrolidine  (ISO)
naloxone  (EXP)
nefazodone  (EXP)
nimesulide  (EXP)
O-methyleugenol  (ISO)
obeticholic acid  (ISO)
oleic acid  (ISO)
omeprazole  (EXP)
ozone  (EXP)
paracetamol  (EXP,ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (EXP,ISO)
phosphatidylcholine  (ISO)
pioglitazone  (ISO)
pirinixic acid  (EXP,ISO)
propiconazole  (ISO)
quercetin  (ISO)
quinidine  (EXP)
rebaudioside A  (ISO)
rimonabant  (ISO)
rotenone  (EXP)
silicon dioxide  (ISO)
sodium dichromate  (EXP)
sorafenib  (ISO)
steviol  (ISO)
stevioside  (ISO)
streptozocin  (ISO)
tamoxifen  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP)
theophylline  (EXP)
thioacetamide  (EXP)
trimellitic anhydride  (ISO)
triphenyl phosphate  (EXP)
valdecoxib  (EXP)
valproic acid  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular response to hormone stimulus  (IEP)
cholesterol homeostasis  (IEA,ISO)
cholesterol metabolic process  (IEA,ISO)
cholesterol transport  (IEA,ISO)
chylomicron remnant clearance  (IDA)
chylomicron remodeling  (IDA)
circadian rhythm  (IEP)
developmental growth  (IEP)
fatty acid biosynthetic process  (IBA,IEA,ISO)
fatty acid metabolic process  (IDA)
glycerophospholipid catabolic process  (IDA)
heparan sulfate proteoglycan biosynthetic process  (IDA)
high-density lipoprotein particle remodeling  (IDA,IEA,ISO)
lipid catabolic process  (IBA)
lipid metabolic process  (IEA)
liver development  (IEP)
low-density lipoprotein particle clearance  (IDA)
low-density lipoprotein particle remodeling  (IDA,IEA,ISO)
neutral lipid catabolic process  (IDA)
phosphatidic acid metabolic process  (IDA)
phosphatidylcholine metabolic process  (IDA)
phosphatidylethanolamine metabolic process  (IDA)
phosphatidylserine metabolic process  (IDA)
regulation of plasma lipoprotein particle levels  (IMP)
response to acetate  (IEP)
response to amino acid  (IEP)
response to calcium ion  (IEP)
response to carbohydrate  (IEP)
response to copper ion  (IEP)
response to fatty acid  (IEP)
response to glucocorticoid  (IEP)
response to hormone  (IEP)
response to hypoxia  (IEP)
response to inorganic substance  (IEP)
response to lipid  (IEP)
response to magnesium ion  (IEP)
response to nutrient levels  (IEP)
response to organic cyclic compound  (IEP)
response to peptide hormone  (IEP)
response to xenobiotic stimulus  (IEP)
triglyceride catabolic process  (IBA,IEA,ISO)
triglyceride homeostasis  (IEA,ISO)
triglyceride metabolic process  (IDA)
very-low-density lipoprotein particle remodeling  (IDA,IEA,ISO)

Cellular Component

References

References - curated
1. Agardh CD, etal., Acta Med Scand. 1983;213(2):123-8.
2. Akmal M, etal., Am J Kidney Dis. 1993 Jul;22(1):158-63.
3. Al Majali K, etal., Diabetologia. 2006 Mar;49(3):527-37. Epub 2006 Jan 21.
4. Barrans A, etal., J Biol Chem. 1994 Apr 15;269(15):11572-7.
5. Baum L, etal., Diabetes Care. 2005 Jul;28(7):1704-9.
6. Baynes C, etal., Eur J Clin Invest. 1992 May;22(5):341-6.
7. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
8. Benavides A, etal., Am J Physiol. 1998 Sep;275(3 Pt 2):R811-7.
9. Berry EM, etal., Eur J Clin Invest. 1981 Jun;11(3):151-9.
10. Berryman DE, etal., Biochim Biophys Acta. 1998 Feb 17;1382(2):217-29.
11. Black DD, etal., Metabolism. 1982 Jun;31(6):620-6.
12. Bohn E, etal., FEBS Lett. 1992 Jan 27;296(3):237-40.
13. Botma GJ, etal., Metabolism. 2006 Apr;55(4):467-77.
14. Boualga A, etal., Eur J Nutr. 2009 Apr;48(3):162-9. Epub 2009 Jan 22.
15. Breedveld B, etal., Biochem J. 1997 Jan 15;321 ( Pt 2):425-30.
16. Bruder ED, etal., Endocrinology. 2004 Nov;145(11):5364-72. Epub 2004 Jul 22.
17. Caixas A, etal., Metabolism. 1998 Apr;47(4):371-6.
18. Cenarro A, etal., Am Heart J. 2005 Dec;150(6):1154-62.
19. Choi SY, etal., J Biol Chem. 1998 Aug 7;273(32):20456-62.
20. Choi SY, etal., J Lipid Res. 1994 May;35(5):848-59.
21. Costacou T, etal., Am J Epidemiol. 2006 Nov 1;164(9):862-72. Epub 2006 Aug 23.
22. de Andrade FM, etal., Clin Genet. 2004 May;65(5):390-5.
23. Diard P, etal., Biochem J. 1994 May 1;299 ( Pt 3):889-94.
24. Franco M, etal., Mol Cell Biochem. 2003 Apr;246(1-2):51-6.
25. Galan X, etal., Biochem Cell Biol. 2002;80(4):467-74.
26. Garber DW, etal., J Clin Invest. 1984 Oct;74(4):1375-83.
27. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
28. GOA data from the GO Consortium
29. Groop PH, etal., Diabetes. 1996 Jul;45(7):974-9.
30. Hokanson JE, etal., Diabetes. 2002 Apr;51(4):1208-13.
31. Hoogerbrugge N, etal., Metabolism. 1993 Jun;42(6):669-71.
32. Jensen GL, etal., Biochim Biophys Acta. 1982 Mar 12;710(3):464-70. doi: 10.1016/0005-2760(82)90130-8.
33. Jobgen W, etal., Amino Acids. 2009 May;37(1):187-98. Epub 2009 Feb 12.
34. KEGG
35. Klin M, etal., J Clin Invest. 1996 May 15;97(10):2167-73.
36. Knauer TE, etal., J Lipid Res. 1982 May;23(4):631-7.
37. Komaromy MC and Reed M, J Lipid Res. 1991 Jun;32(6):963-75.
38. Komaromy MC and Schotz MC, Proc Natl Acad Sci U S A 1987 Mar;84(6):1526-30.
39. Kong C, etal., Atherosclerosis. 2001 Jun;156(2):373-8.
40. Koo SI, etal., Proc Soc Exp Biol Med. 1988 Sep;188(4):410-9.
41. Kuusi T, etal., Biochem J. 1979 Jul 1;181(1):245-6.
42. Lamri MY, etal., J Nutr. 1995 Sep;125(9):2425-34.
43. Landin B, etal., J Lipid Res. 1984 Jun;25(6):559-63.
44. Lee PC, etal., Am J Physiol Regul Integr Comp Physiol. 2000 Oct;279(4):R1341-7.
45. Lee SJ, etal., J Lipid Res. 2004 Jul;45(7):1266-71. Epub 2004 Apr 21.
46. Levy E and Bendayan M, Diabete Metab. 1991 Jan-Feb;17(1):44-8.
47. Levy E, etal., J Lipid Res. 1990 Nov;31(11):2009-17.
48. Liang K and Vaziri ND, Kidney Int. 1997 Jun;51(6):1933-7.
49. Mao J and Hamosh M, Biol Neonate. 1992;62(1):1-9.
50. Marotta T, etal., Eur J Pharmacol. 1998 Jun 26;351(3):357-61.
51. Meraihi Z, etal., Infusionstherapie. 1990 Apr;17(2):104-7.
52. Merzouk H, etal., Clin Sci (Lond). 2000 Jan;98(1):21-30.
53. MGD data from the GO Consortium
54. Morgado N, etal., Ann Nutr Metab. 2005 Nov-Dec;49(6):397-406. Epub 2005 Oct 14.
55. Morita T, etal., Biol Pharm Bull. 2000 May;23(5):549-54.
56. NCBI rat LocusLink and RefSeq merged data July 26, 2002
57. Neuger L, etal., Atherosclerosis. 2001 Jul;157(1):13-21.
58. Neve BP, etal., Biochem J. 1998 Mar 1;330 ( Pt 2):701-6.
59. Neve BP, etal., Biochim Biophys Acta. 1997 Apr 1;1345(2):172-9.
60. Nikkila EA, etal., Diabetes. 1977 Jan;26(1):11-21.
61. Nilsson A, etal., J Lipid Res. 1994 Dec;35(12):2151-60.
62. Ohashi R, etal., QJM. 2005 Dec;98(12):845-56. Epub 2005 Oct 28.
63. OMIM Disease Annotation Pipeline
64. Park KW, etal., J Biochem Mol Biol. 2003 Mar 31;36(2):237-42.
65. Peinado-Onsurbe J, etal., Horm Metab Res. 2001 Aug;33(8):458-62.
66. Pipeline to import KEGG annotations from KEGG into RGD
67. Pipeline to import SMPDB annotations from SMPDB into RGD
68. Rayssiguier Y, etal., Lipids. 1991 Mar;26(3):182-6.
69. RGD automated data pipeline
70. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
71. RGD automated import pipeline for gene-chemical interactions
72. Ringseis R, etal., J Nutr. 2007 Sep;137(9):2056-61.
73. Rivellese AA, etal., J Clin Endocrinol Metab. 2000 Nov;85(11):4188-92.
74. Sato T, etal., Kidney Int. 2003 Nov;64(5):1780-6.
75. Sendak RA, etal., J Lipid Res. 2000 Feb;41(2):260-8.
76. Sensel MG, etal., Biochim Biophys Acta 1990 Apr 6;1048(2-3):297-302.
77. Shearer GC, etal., Kidney Int. 2000 Jun;57(6):2268-74.
78. Shih DQ, etal., Nat Genet. 2001 Apr;27(4):375-82.
79. Sibley SD, etal., J Clin Endocrinol Metab. 2003 Jul;88(7):3379-84.
80. Sindelar PJ, etal., Biochemistry. 1997 Feb 18;36(7):1807-13.
81. Sjovall S, etal., J Hepatol. 1991 Jul;13(1):33-7.
82. Sultan F, etal., Life Sci. 1995;56(1):31-7.
83. Tagashira H, etal., Biol Pharm Bull. 2005 Mar;28(3):409-12.
84. Tan KC, etal., Atherosclerosis. 2001 Jul;157(1):233-9.
85. Thuren T, etal., Biochim Biophys Acta. 1990 Sep 18;1046(2):178-84.
86. Thuren T, etal., Biochim Biophys Acta. 1991 May 8;1083(2):217-20.
87. Twu JS, etal., Biochim Biophys Acta. 1984 Mar 7;792(3):330-7.
88. Valdivielso P, etal., J Diabetes Complications. 2008 Jul-Aug;22(4):273-7. Epub 2008 Apr 16.
89. van Deursen D, etal., Diabetologia. 2008 Nov;51(11):2078-87. Epub 2008 Aug 30.
90. van Deursen D, etal., Mol Cell Endocrinol. 2008 Nov 6;294(1-2):37-44. Epub 2008 Jul 15.
91. Verges M, etal., J Biol Chem. 2004 Mar 5;279(10):9030-6. Epub 2003 Dec 29.
92. Verhoeven AJ, etal., J Biol Chem. 2000 Mar 31;275(13):9332-9.
93. Vieira-van Bruggen D, etal., J Biol Chem. 1998 Nov 27;273(48):32038-41.
94. Warren RJ, etal., J Lipid Res. 1991 Aug;32(8):1333-9.
95. Wasan KM, etal., J Pharm Pharm Sci. 2003 May-Aug;6(2):189-97.
96. Wilcox RW, etal., Lipids. 1991 Apr;26(4):283-8.
97. Yu F, etal., J Ethnopharmacol. 2008 Sep 26;119(2):252-8. Epub 2008 Jul 23.
98. Zacharova J, etal., J Intern Med. 2005 Feb;257(2):185-93.
99. Zambon A, etal., Curr Opin Lipidol. 2003 Apr;14(2):179-89.
100. Zhang C, etal., Am J Clin Nutr. 2005 Jun;81(6):1429-35.
101. Zhang C, etal., Diabetologia. 2006 Jul;49(7):1552-9. Epub 2006 Mar 29.
102. Zhu H, etal., Neurobiol Aging. 2006 Dec 15;.
Additional References at PubMed
PMID:182536   PMID:1883393   PMID:2839510   PMID:3244012   PMID:7592706   PMID:8640403   PMID:8798380   PMID:8798474   PMID:10357838   PMID:12032167   PMID:12477932   PMID:12951367  
PMID:12975454   PMID:15520453   PMID:15995171   PMID:26193433  


Genomics

Comparative Map Data
Lipc
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2871,509,633 - 71,635,663 (-)NCBI
Rnor_6.0 Ensembl877,272,570 - 77,398,248 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0877,272,582 - 77,398,485 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0875,686,187 - 75,812,459 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4875,323,442 - 75,450,353 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1875,342,496 - 75,469,407 (-)NCBI
Celera870,101,863 - 70,227,531 (+)NCBICelera
Cytogenetic Map8q24NCBI
LIPC
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1558,410,569 - 58,569,844 (+)EnsemblGRCh38hg38GRCh38
GRCh381558,410,457 - 58,569,844 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371558,724,190 - 58,862,043 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361556,511,467 - 56,648,364 (+)NCBINCBI36hg18NCBI36
Build 341556,511,466 - 56,648,364NCBI
Celera1535,612,421 - 35,749,365 (+)NCBI
Cytogenetic Map15q21.3NCBI
HuRef1535,547,160 - 35,684,065 (+)NCBIHuRef
CHM1_11558,842,117 - 58,978,999 (+)NCBICHM1_1
Lipc
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39970,705,410 - 70,859,503 (-)NCBIGRCm39mm39
GRCm39 Ensembl970,705,410 - 70,859,508 (-)Ensembl
GRCm38970,798,128 - 70,952,221 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl970,798,128 - 70,952,226 (-)EnsemblGRCm38mm10GRCm38
MGSCv37970,645,935 - 70,782,615 (-)NCBIGRCm37mm9NCBIm37
MGSCv36970,597,345 - 70,734,025 (-)NCBImm8
Celera968,015,071 - 68,150,792 (-)NCBICelera
Cytogenetic Map9DNCBI
cM Map939.57NCBI
Lipc
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545015,948,187 - 16,048,766 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545015,947,869 - 16,062,449 (-)NCBIChiLan1.0ChiLan1.0
LIPC
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11555,688,414 - 55,847,005 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1555,814,017 - 55,847,005 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01537,363,507 - 37,537,723 (+)NCBIMhudiblu_PPA_v0panPan3
LIPC
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13023,432,460 - 23,584,037 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3023,432,493 - 23,584,037 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3023,404,560 - 23,555,900 (+)NCBI
ROS_Cfam_1.03023,597,357 - 23,749,167 (+)NCBI
UMICH_Zoey_3.13023,523,240 - 23,674,537 (+)NCBI
UNSW_CanFamBas_1.03023,608,314 - 23,759,924 (+)NCBI
UU_Cfam_GSD_1.03023,750,266 - 23,901,905 (+)NCBI
Lipc
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640101,755,855 - 101,885,658 (+)NCBI
SpeTri2.0NW_00493647119,604,083 - 19,733,721 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LIPC
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1113,433,679 - 113,604,306 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11113,433,684 - 113,604,139 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21125,418,537 - 125,667,649 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LIPC
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12624,946,843 - 25,109,338 (-)NCBI
ChlSab1.1 Ensembl2624,946,673 - 25,087,921 (-)Ensembl
Vero_WHO_p1.0NW_023666048116,211,906 - 116,373,902 (+)NCBI
Lipc
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462478113,342,469 - 13,468,120 (-)NCBI

Position Markers
D8Got335  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2871,595,480 - 71,595,646 (+)MAPPER
Rnor_6.0877,358,455 - 77,358,620NCBIRnor6.0
Rnor_5.0875,725,924 - 75,726,089UniSTSRnor5.0
RGSC_v3.4875,410,486 - 75,410,651UniSTSRGSC3.4
Celera870,141,597 - 70,141,766UniSTS
Cytogenetic Map8q24UniSTS
RH94786  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2871,509,684 - 71,509,760 (+)MAPPER
Rnor_6.0877,272,634 - 77,272,709NCBIRnor6.0
Rnor_5.0875,812,332 - 75,812,407UniSTSRnor5.0
RGSC_v3.4875,323,493 - 75,323,568UniSTSRGSC3.4
Celera870,227,405 - 70,227,480UniSTS
Cytogenetic Map8q24UniSTS
RH94586  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2871,509,664 - 71,509,769 (+)MAPPER
Rnor_6.0877,272,614 - 77,272,718NCBIRnor6.0
Rnor_5.0875,812,323 - 75,812,427UniSTSRnor5.0
RGSC_v3.4875,323,473 - 75,323,577UniSTSRGSC3.4
Celera870,227,396 - 70,227,500UniSTS
Cytogenetic Map8q24UniSTS
G47926  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2871,619,322 - 71,619,536 (+)MAPPER
Rnor_6.0877,382,135 - 77,382,348NCBIRnor6.0
Rnor_5.0875,702,308 - 75,702,521UniSTSRnor5.0
RGSC_v3.4875,434,212 - 75,434,425UniSTSRGSC3.4
Celera870,117,791 - 70,117,994UniSTS
Cytogenetic Map8q24UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)850529480128036471Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)850529480128036471Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)850529480128036471Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)850529480128036471Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)874917593121080545Rat
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)865717449128033050Rat
2303570Gluco48Glucose level QTL 482blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)855659105100659105Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83995802284958022Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84658843796998640Rat
1331769Rf39Renal function QTL 393.871urine output (VT:0003620)timed urine volume (CMO:0000260)84571234480003418Rat
737824Hcar10Hepatocarcinoma resistance QTL 102.9liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)84421919789542960Rat
1298065Scl16Serum cholesterol level QTL 163.8blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)83504141480041414Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)84571234490712344Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810938911120496129Rat
631653Bp125Blood pressure QTL 1253.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)872849686117849686Rat
631664Hcar3Hepatocarcinoma resistance QTL 32.90.0005liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)858425510106526740Rat
1331837Bw23Body weight QTL 234.190.00007body mass (VT:0001259)body weight (CMO:0000012)850529563106506973Rat
1331838Niddm61Non-insulin dependent diabetes mellitus QTL 613.530.0004blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)839230130106506973Rat
1582222Epfw2Epididymal fat weight QTL 23.20.0005epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)83592559480925594Rat
1582243Bw66Body weight QTL 663.40.0048body mass (VT:0001259)body weight (CMO:0000012)85842551091990535Rat
1582254Kidm31Kidney mass QTL 313kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)85842551091990535Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)821813070100873963Rat
631271Lecl1Lens clarity QTL 10.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)82146491991140553Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)876103982127182642Rat
1300177Cm2Cardiac mass QTL 23.65heart mass (VT:0007028)heart weight (CMO:0000017)859234112108068306Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)89531047119211942Rat
2301402Bp316Blood pressure QTL 3160.005arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)861394378106394378Rat
2293697Bmd39Bone mineral density QTL 39femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)858230766106394378Rat
1578755Pur5Proteinuria QTL 53.30.0001total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)833558660109028082Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)833558660109028082Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)833558660109028082Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)832888352101374135Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)833558764113580387Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)844458129118087517Rat
2313046Bss78Bone structure and strength QTL 783.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)83355866089058369Rat
2313057Bss76Bone structure and strength QTL 7630.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)83355866089058369Rat
2313067Bss77Bone structure and strength QTL 773.10.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)83355866089058369Rat
2313086Bss60Bone structure and strength QTL 604.10.0001tibia length (VT:0004357)tibia length (CMO:0000450)85406504489058369Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83355866089058369Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)829867983106526740Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)829867983106526740Rat
1358906Bp253Blood pressure QTL 25340.0004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)844219197100873963Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)829867983106526740Rat
1358912Bw51Body weight QTL 512.95body mass (VT:0001259)body weight (CMO:0000012)855435004115812386Rat
61358Bp39Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83992790184927901Rat
4889938Bss89Bone structure and strength QTL 893.8tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)85406504489058369Rat
5684973Bss100Bone structure and strength QTL 1004.7tibia area (VT:1000281)tibia area measurement (CMO:0001382)85406504489058369Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)830918112107206309Rat
10402857Bp380Blood pressure QTL 3800.95arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)861394378106394378Rat
12879882Am8Aortic mass QTL 80.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)847200750106394378Rat
12879879Cm99Cardiac mass QTL 990.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)847200750106394378Rat
12879881Cm101Cardiac mass QTL 1010.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)847200750106394378Rat
12879883Kidm65Kidney mass QTL 650.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)847200750106394378Rat
12879880Cm100Cardiac mass QTL 1000.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)847200750106394378Rat
12879878Bw183Body weight QTL 1830.001body mass (VT:0001259)body weight (CMO:0000012)847200750106394378Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:61
Count of miRNA genes:55
Interacting mature miRNAs:57
Transcripts:ENSRNOT00000049976
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 41 41 41
Low 1 13 14 1 1 1 13 14 2 1
Below cutoff 2 32 3 5 6 7 13 21 26 9 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000082763   ⟹   ENSRNOP00000074623
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl877,272,584 - 77,398,248 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000085349   ⟹   ENSRNOP00000073927
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl877,272,570 - 77,398,201 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000091858   ⟹   ENSRNOP00000070550
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl877,272,606 - 77,398,156 (-)Ensembl
RefSeq Acc Id: NM_012597   ⟹   NP_036729
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2871,509,634 - 71,635,464 (-)NCBI
Rnor_6.0877,272,583 - 77,398,248 (-)NCBI
Rnor_5.0875,686,187 - 75,812,459 (+)NCBI
RGSC_v3.4875,323,442 - 75,450,353 (-)RGD
Celera870,101,863 - 70,227,531 (+)RGD
Sequence:
RefSeq Acc Id: XM_006243359   ⟹   XP_006243421
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2871,509,633 - 71,635,663 (-)NCBI
Rnor_6.0877,272,582 - 77,398,485 (-)NCBI
Rnor_5.0875,686,187 - 75,812,459 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006243360   ⟹   XP_006243422
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2871,509,633 - 71,635,660 (-)NCBI
Rnor_6.0877,272,582 - 77,398,484 (-)NCBI
Rnor_5.0875,686,187 - 75,812,459 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_036729   ⟸   NM_012597
- Peptide Label: precursor
- UniProtKB: Q5M895 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006243421   ⟸   XM_006243359
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K6S7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006243422   ⟸   XM_006243360
- Peptide Label: isoform X2
- UniProtKB: Q5M895 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000074623   ⟸   ENSRNOT00000082763
RefSeq Acc Id: ENSRNOP00000073927   ⟸   ENSRNOT00000085349
RefSeq Acc Id: ENSRNOP00000070550   ⟸   ENSRNOT00000091858
Protein Domains
PLAT

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696112
Promoter ID:EPDNEW_R6634
Type:multiple initiation site
Name:Lipc_1
Description:lipase C, hepatic type
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0877,398,205 - 77,398,265EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3009 AgrOrtholog
Ensembl Genes ENSRNOG00000060338 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000070550 UniProtKB/TrEMBL
  ENSRNOP00000073927 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000074623 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000082763 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000085349 UniProtKB/TrEMBL
  ENSRNOT00000091858 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.1820 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7323251 IMAGE-MGC_LOAD
InterPro AB_hydrolase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lipase/vitellogenin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lipase_hep UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lipase_LIPH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lipase_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLAT/LH2_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLAT/LH2_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TAG_lipase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24538 UniProtKB/TrEMBL
MGC_CLONE MGC:108746 IMAGE-MGC_LOAD
NCBI Gene 24538 ENTREZGENE
PANTHER PTHR11610 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11610:SF2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Lipase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB LIPC RGD
PhenoGen Lipc PhenoGen
PIRSF Lipoprotein_lipase_LIPH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS HEPLIPASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TAGLIPASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE LIPASE_SER UniProtKB/Swiss-Prot
  PLAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART LH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49723 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF53474 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JY79_RAT UniProtKB/TrEMBL
  A0A0G2K6S7 ENTREZGENE, UniProtKB/TrEMBL
  LIPC_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q5M895 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-17 Lipc  lipase C, hepatic type  Lipc  lipase C, hepatic  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-02-03 Lipc  lipase C, hepatic  Lipc  lipase, hepatic  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Lipc  Lipase, hepatic      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains contains two potential sites for N-glycosylation 729157
gene_protein unglycosylated protein has a predicted molecular weight of 53,222 Da 729157