Gdf9 (growth differentiation factor 9) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Gdf9 (growth differentiation factor 9) Rattus norvegicus
Analyze
Symbol: Gdf9
Name: growth differentiation factor 9
RGD ID: 71038
Description: Predicted to enable cytokine activity and type I activin receptor binding activity. Predicted to be involved in several processes, including embryonic cleavage; positive regulation of protein phosphorylation; and transmembrane receptor protein serine/threonine kinase signaling pathway. Predicted to act upstream of or within negative regulation of cell growth and oocyte growth. Predicted to be located in cytoplasm. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in primary ovarian insufficiency 14. Orthologous to human GDF9 (growth differentiation factor 9); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,7-dihydropurine-6-thione; 3-methylcholanthrene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: growth/differentiation factor 9
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21037,589,200 - 37,599,970 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1037,595,679 - 37,599,672 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1042,288,545 - 42,292,495 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01041,778,598 - 41,782,548 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01037,282,314 - 37,286,264 (+)NCBIRnor_WKY
Rnor_6.01038,782,519 - 38,793,238 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1038,788,992 - 38,792,940 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01038,564,774 - 38,574,967 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41038,899,125 - 38,903,073 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11038,905,554 - 38,909,503 (+)NCBI
Celera1036,942,737 - 36,946,686 (+)NCBICelera
Cytogenetic Map10q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Recombinant growth differentiation factor-9 (GDF-9) enhances growth and differentiation of cultured early ovarian follicles. Hayashi M, etal., Endocrinology 1999 Mar;140(3):1236-44.
4. Localization of growth differentiation factor-9 (GDF-9) mRNA and protein in rat ovaries and cDNA cloning of rat GDF-9 and its novel homolog GDF-9B. Jaatinen R, etal., Mol Cell Endocrinol 1999 Oct 25;156(1-2):189-93.
5. Gene Data Set MGD Curation, June 12, 2002
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12050262   PMID:14970198   PMID:16740654   PMID:17641088   PMID:17905242   PMID:18063682   PMID:19106224   PMID:19213837   PMID:19366876   PMID:19480014   PMID:19505950   PMID:19833718  
PMID:20660033   PMID:24169563   PMID:24313324  


Genomics

Comparative Map Data
Gdf9
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21037,589,200 - 37,599,970 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1037,595,679 - 37,599,672 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1042,288,545 - 42,292,495 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01041,778,598 - 41,782,548 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01037,282,314 - 37,286,264 (+)NCBIRnor_WKY
Rnor_6.01038,782,519 - 38,793,238 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1038,788,992 - 38,792,940 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01038,564,774 - 38,574,967 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41038,899,125 - 38,903,073 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11038,905,554 - 38,909,503 (+)NCBI
Celera1036,942,737 - 36,946,686 (+)NCBICelera
Cytogenetic Map10q22NCBI
GDF9
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385132,861,185 - 132,866,651 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl5132,861,181 - 132,866,884 (-)EnsemblGRCh38hg38GRCh38
GRCh375132,196,877 - 132,202,343 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365132,224,777 - 132,228,376 (-)NCBINCBI36Build 36hg18NCBI36
Build 345132,225,179 - 132,228,124NCBI
Celera5128,326,902 - 128,330,501 (-)NCBICelera
Cytogenetic Map5q31.1NCBI
HuRef5127,389,594 - 127,393,194 (-)NCBIHuRef
CHM1_15131,630,163 - 131,633,762 (-)NCBICHM1_1
T2T-CHM13v2.05133,380,938 - 133,386,405 (-)NCBIT2T-CHM13v2.0
Gdf9
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391153,321,773 - 53,328,731 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1153,321,850 - 53,328,731 (+)EnsemblGRCm39 Ensembl
GRCm381153,430,774 - 53,437,904 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1153,431,023 - 53,437,904 (+)EnsemblGRCm38mm10GRCm38
MGSCv371153,246,788 - 53,251,405 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361153,276,801 - 53,281,323 (+)NCBIMGSCv36mm8
Celera1158,013,006 - 58,017,623 (+)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1131.94NCBI
Gdf9
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554084,234,208 - 4,239,795 (-)NCBIChiLan1.0ChiLan1.0
GDF9
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.15134,437,497 - 134,442,706 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5134,437,497 - 134,442,846 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v05128,278,496 - 128,284,003 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
GDF9
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11121,143,982 - 21,148,945 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1121,143,975 - 21,149,825 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1119,947,216 - 19,950,085 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01121,931,257 - 21,936,235 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1121,931,265 - 21,936,196 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11120,650,008 - 20,652,875 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01120,497,735 - 20,500,586 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01121,140,232 - 21,143,105 (-)NCBIUU_Cfam_GSD_1.0
Gdf9
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213115,347,586 - 115,353,836 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366472,353,198 - 2,356,790 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049366472,351,604 - 2,357,043 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GDF9
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2135,181,089 - 135,187,026 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12135,181,494 - 135,184,451 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22140,650,007 - 140,652,964 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GDF9
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12335,678,956 - 35,684,378 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2335,679,368 - 35,682,338 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603442,258,633 - 42,263,520 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gdf9
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473339,237,296 - 39,240,206 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473339,235,128 - 39,240,557 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gdf9
53 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:72
Count of miRNA genes:69
Interacting mature miRNAs:71
Transcripts:ENSRNOT00000009727
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138328221Rat
7411611Foco17Food consumption QTL 1718.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)10142315980Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1041834445418344Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)cortical volumetric bone mineral density (CMO:0001730)10538701450387014Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10538701450387014Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10538701450387014Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10580199062146030Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10637574651375746Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
9590310Scort19Serum corticosterone level QTL 196.30.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9590268Scort13Serum corticosterone level QTL 133.260.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101147401056474010Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101502851360430477Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101527595560275955Rat
6893350Bw99Body weight QTL 990.870.16body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
6893352Bw100Body weight QTL 1000.330.6body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101790711351786432Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101816784163167841Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)101960648364606483Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)101960648364606483Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102132980561345413Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102652195761345413Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102694462871944628Rat
10402859Bp381Blood pressure QTL 3810.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
2292441Bp308Blood pressure QTL 308arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102845313673453136Rat
1600371Mcs21Mammary carcinoma susceptibility QTL 213mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)102887565052200160Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102929950464155584Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
631557Bp136Blood pressure QTL 1360.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)103063205375632053Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103122402675632053Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103129743976297439Rat
1576319Cia29Collagen induced arthritis QTL 29joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103397392178973921Rat
61332Eau3Experimental allergic uveoretinitis QTL 30.004uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)103449055945579777Rat
1354614Hpcl1Hepatic cholesterol level QTL 13.3liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)103539226751793994Rat
1358897Stresp6Stress response QTL 64.170.022blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)103539226764155584Rat
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103539245763642539Rat
2317042Aia20Adjuvant induced arthritis QTL 203.38joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)103756507982565079Rat
2317043Aia7Adjuvant induced arthritis QTL 73.82joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)103756507982565079Rat

Markers in Region
RH144020  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21037,599,789 - 37,599,945 (+)MAPPERmRatBN7.2
Rnor_6.01038,793,058 - 38,793,213NCBIRnor6.0
Rnor_5.01038,574,787 - 38,574,942UniSTSRnor5.0
RGSC_v3.41038,903,191 - 38,903,346UniSTSRGSC3.4
Celera1036,946,804 - 36,946,959UniSTS
RH 3.4 Map10402.0UniSTS
Cytogenetic Map10q22UniSTS
L06444  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21037,599,659 - 37,599,811 (+)MAPPERmRatBN7.2
Rnor_6.01038,792,928 - 38,793,079NCBIRnor6.0
Rnor_5.01038,574,657 - 38,574,808UniSTSRnor5.0
RGSC_v3.41038,903,061 - 38,903,212UniSTSRGSC3.4
Celera1036,946,674 - 36,946,825UniSTS
Cytogenetic Map10q22UniSTS
Gdf9  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21037,595,779 - 37,595,895 (+)MAPPERmRatBN7.2
Rnor_6.01038,789,048 - 38,789,163NCBIRnor6.0
Rnor_5.01038,570,777 - 38,570,892UniSTSRnor5.0
RGSC_v3.41038,899,181 - 38,899,296UniSTSRGSC3.4
Celera1036,942,793 - 36,942,908UniSTS
Cytogenetic Map10q22UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 5
Low 9 9
Below cutoff 2 28 8 5 6 5 1 2 54 6 15 3 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000009727   ⟹   ENSRNOP00000009727
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1037,595,679 - 37,599,672 (+)Ensembl
Rnor_6.0 Ensembl1038,788,992 - 38,792,940 (+)Ensembl
RefSeq Acc Id: NM_021672   ⟹   NP_067704
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21037,595,724 - 37,599,672 (+)NCBI
Rnor_6.01038,788,992 - 38,792,940 (+)NCBI
Rnor_5.01038,564,774 - 38,574,967 (+)NCBI
RGSC_v3.41038,899,125 - 38,903,073 (+)RGD
Celera1036,942,737 - 36,946,686 (+)RGD
Sequence:
RefSeq Acc Id: XM_017597501   ⟹   XP_017452990
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21037,589,200 - 37,599,970 (+)NCBI
Rnor_6.01038,782,519 - 38,793,238 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017597502   ⟹   XP_017452991
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21037,589,224 - 37,599,970 (+)NCBI
Rnor_6.01038,782,520 - 38,793,238 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_067704 (Get FASTA)   NCBI Sequence Viewer  
  XP_017452990 (Get FASTA)   NCBI Sequence Viewer  
  XP_017452991 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAD16406 (Get FASTA)   NCBI Sequence Viewer  
  CAA57488 (Get FASTA)   NCBI Sequence Viewer  
  EDM04383 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_067704   ⟸   NM_021672
- Peptide Label: precursor
- UniProtKB: Q9Z0X3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017452990   ⟸   XM_017597501
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017452991   ⟸   XM_017597502
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000009727   ⟸   ENSRNOT00000009727
Protein Domains
TGF_BETA_2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9QYW4-F1-model_v2 AlphaFold Q9QYW4 1-440 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:71038 AgrOrtholog
BioCyc Gene G2FUF-25141 BioCyc
Ensembl Genes ENSRNOG00000007301 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000009727 ENTREZGENE
  ENSRNOP00000009727.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000009727 ENTREZGENE
  ENSRNOT00000009727.3 UniProtKB/TrEMBL
Gene3D-CATH 2.10.90.10 UniProtKB/TrEMBL
InterPro Cystine-knot_cytokine UniProtKB/TrEMBL
  Growth_differentiation_fac-9 UniProtKB/TrEMBL
  TGFb UniProtKB/TrEMBL
  TGFb_CS UniProtKB/TrEMBL
  TGFbeta UniProtKB/TrEMBL
KEGG Report rno:59304 UniProtKB/TrEMBL
NCBI Gene 59304 ENTREZGENE
PANTHER PTHR11848:SF19 UniProtKB/TrEMBL
  TGFbeta UniProtKB/TrEMBL
Pfam TGF_beta UniProtKB/TrEMBL
PhenoGen Gdf9 PhenoGen
PROSITE TGF_BETA_1 UniProtKB/TrEMBL
  TGF_BETA_2 UniProtKB/TrEMBL
SMART TGFB UniProtKB/TrEMBL
Superfamily-SCOP SSF57501 UniProtKB/TrEMBL
UniProt Q9QYW4_RAT UniProtKB/TrEMBL
  Q9Z0X3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-07-09 Gdf9  growth differentiation factor 9      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression protein expressed in the oocytes during folliculogenesis in the in primary and preantral follicles 70646
gene_process deficiency causes arrest of folliculogenesis and infertility in mice 70646
gene_product member of the TGF-beta family 70646