Wapl (WAPL cohesin release factor) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Wapl (WAPL cohesin release factor) Rattus norvegicus
Analyze
Symbol: Wapl
Name: WAPL cohesin release factor
RGD ID: 1590924
Description: Predicted to be involved in several processes, including negative regulation of chromatin binding activity; positive regulation of fibroblast proliferation; and regulation of chromosome organization. Predicted to localize to several cellular components, including intercellular bridge; microtubule cytoskeleton; and nuclear lumen. Orthologous to human WAPL (WAPL cohesin release factor); INTERACTS WITH bisphenol A; cobalt dichloride; flutamide.
Type: protein-coding
RefSeq Status: MODEL
Also known as: hypothetical LOC290577; LOC290577; LOC290578; LOW QUALITY PROTEIN: wings apart-like protein homolog; RGD1308960; similar to parallel sister chromatids protein (84.3 kD) (4F208); Wapal; wings apart-like; wings apart-like homolog; wings apart-like homolog (Drosophila); wings apart-like protein homolog
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21610,005,520 - 10,075,270 (+)NCBI
Rnor_6.0 Ensembl1611,032,531 - 11,106,589 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01611,029,325 - 11,108,867 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0169,354,539 - 9,434,346 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41610,337,231 - 10,408,154 (+)NCBIRGSC3.4rn4RGSC3.4
Celera165,142,468 - 5,211,200 (-)NCBICelera
Cytogenetic Map16p15NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
centrosome  (IEA,ISO)
chromatin  (ISO)
cytoplasm  (ISO)
cytosol  (IEA,ISO)
Golgi apparatus  (IEA,ISO)
intercellular bridge  (IEA,ISO)
mitotic spindle  (IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (ISO)
synaptonemal complex  (ISO)

Molecular Function

References

Additional References at PubMed
PMID:15620708   PMID:17113138   PMID:19696148   PMID:19907496   PMID:21111234   PMID:23920377   PMID:23975099  


Genomics

Comparative Map Data
Wapl
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21610,005,520 - 10,075,270 (+)NCBI
Rnor_6.0 Ensembl1611,032,531 - 11,106,589 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01611,029,325 - 11,108,867 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0169,354,539 - 9,434,346 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41610,337,231 - 10,408,154 (+)NCBIRGSC3.4rn4RGSC3.4
Celera165,142,468 - 5,211,200 (-)NCBICelera
Cytogenetic Map16p15NCBI
WAPL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1086,435,256 - 86,521,792 (-)EnsemblGRCh38hg38GRCh38
GRCh381086,435,256 - 86,521,816 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371088,195,013 - 88,281,549 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361088,184,993 - 88,271,521 (-)NCBINCBI36hg18NCBI36
Build 341088,184,993 - 88,271,521NCBI
Celera1082,193,855 - 82,283,880 (-)NCBI
Cytogenetic Map10q23.2NCBI
HuRef1082,045,663 - 82,136,011 (-)NCBIHuRef
CHM1_11088,476,841 - 88,563,395 (-)NCBICHM1_1
Wapl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391434,394,086 - 34,469,940 (+)NCBIGRCm39mm39
GRCm39 Ensembl1434,395,885 - 34,469,940 (+)Ensembl
GRCm381434,672,379 - 34,747,983 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1434,673,928 - 34,747,983 (+)EnsemblGRCm38mm10GRCm38
MGSCv371435,487,114 - 35,559,403 (+)NCBIGRCm37mm9NCBIm37
MGSCv361433,503,214 - 33,575,044 (+)NCBImm8
Celera1430,941,041 - 31,013,556 (+)NCBICelera
Cytogenetic Map14BNCBI
Wapl
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555105,593,335 - 5,674,221 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555105,596,622 - 5,674,221 (-)NCBIChiLan1.0ChiLan1.0
WAPL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11086,422,170 - 86,512,224 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1086,422,170 - 86,512,207 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01082,862,852 - 82,953,284 (-)NCBIMhudiblu_PPA_v0panPan3
WAPL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1434,219,644 - 34,297,456 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl434,219,645 - 34,302,839 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha434,208,790 - 34,290,635 (-)NCBI
ROS_Cfam_1.0434,549,886 - 34,631,818 (-)NCBI
UMICH_Zoey_3.1434,422,845 - 34,504,994 (-)NCBI
UNSW_CanFamBas_1.0434,592,237 - 34,674,023 (-)NCBI
UU_Cfam_GSD_1.0435,097,493 - 35,179,330 (-)NCBI
Wapl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721344,243,869 - 44,321,323 (+)NCBI
SpeTri2.0NW_004936804354,201 - 431,655 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
WAPL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1487,492,453 - 87,588,570 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11487,492,452 - 87,588,678 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21494,746,694 - 94,842,934 (-)NCBISscrofa10.2Sscrofa10.2susScr3
WAPL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1945,335,423 - 45,420,785 (+)NCBI
ChlSab1.1 Ensembl945,334,981 - 45,420,787 (+)Ensembl
Vero_WHO_p1.0NW_0236660485,449,262 - 5,535,020 (+)NCBI
Wapl
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624841534,148 - 611,014 (+)NCBI

Position Markers
AU046803  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21610,034,415 - 10,034,657 (+)MAPPER
Rnor_6.01611,057,795 - 11,058,034NCBIRnor6.0
Rnor_5.0169,382,774 - 9,383,013UniSTSRnor5.0
RGSC_v3.41610,365,960 - 10,366,199UniSTSRGSC3.4
Celera165,182,680 - 5,182,891UniSTS
Cytogenetic Map16p15UniSTS
RH130055  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2260,889,134 - 60,889,352 (+)MAPPER
mRatBN7.21610,074,951 - 10,075,169 (+)MAPPER
Rnor_6.01611,108,549 - 11,108,766NCBIRnor6.0
Rnor_6.0261,907,585 - 61,907,802NCBIRnor6.0
Rnor_5.0169,434,028 - 9,434,245UniSTSRnor5.0
Rnor_5.0282,783,104 - 82,783,321UniSTSRnor5.0
RGSC_v3.4261,297,441 - 61,297,658UniSTSRGSC3.4
RGSC_v3.41610,409,488 - 10,409,705UniSTSRGSC3.4
Celera165,142,569 - 5,142,786UniSTS
Celera257,802,577 - 57,802,794UniSTS
RH 3.4 Map1698.1UniSTS
Cytogenetic Map2q16UniSTS
Cytogenetic Map16p15UniSTS
RH143495  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21610,052,583 - 10,052,703 (+)MAPPER
Rnor_6.01611,082,661 - 11,082,780NCBIRnor6.0
Rnor_5.0169,409,048 - 9,409,167UniSTSRnor5.0
RGSC_v3.41610,385,306 - 10,385,425UniSTSRGSC3.4
Celera165,164,632 - 5,164,751UniSTS
RH 3.4 Map1698.2UniSTS
Cytogenetic Map16p15UniSTS
BE116851  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21610,040,808 - 10,040,964 (+)MAPPER
Rnor_6.01611,064,182 - 11,064,337NCBIRnor6.0
Rnor_5.0169,389,161 - 9,389,316UniSTSRnor5.0
RGSC_v3.41610,372,351 - 10,372,506UniSTSRGSC3.4
Celera165,176,372 - 5,176,527UniSTS
RH 3.4 Map16100.5UniSTS
Cytogenetic Map16p15UniSTS
RH137292  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21610,005,025 - 10,005,208 (+)MAPPER
Rnor_6.01611,028,425 - 11,028,607NCBIRnor6.0
Rnor_5.0169,353,404 - 9,353,586UniSTSRnor5.0
RGSC_v3.41610,336,196 - 10,336,378UniSTSRGSC3.4
Celera165,212,158 - 5,212,340UniSTS
RH 3.4 Map1698.0UniSTS
Cytogenetic Map16p15UniSTS
AI179133  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21610,023,908 - 10,024,004 (+)MAPPER
Rnor_6.01611,047,291 - 11,047,386NCBIRnor6.0
Rnor_5.0169,372,270 - 9,372,365UniSTSRnor5.0
RGSC_v3.41610,355,332 - 10,355,427UniSTSRGSC3.4
Celera165,193,294 - 5,193,389UniSTS
RH 3.4 Map1698.0UniSTS
Cytogenetic Map16p15UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1600369Hcas8Hepatocarcinoma susceptibility QTL 8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)16124228366Rat
631830Alc7Alcohol consumption QTL 72.9consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16127556253Rat
634355Rends4Renal damage susceptibility QTL 40.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)16127556253Rat
1582235Insul8Insulin level QTL 83.30.0063blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)16127556253Rat
9590151Scort8Serum corticosterone level QTL 88.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)16131816439Rat
2302380Slep6Serum leptin concentration QTL 63.36blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)16133160624Rat
2307172Activ4Activity QTL 43.710.00023locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)16134465490Rat
1354584Despr6Despair related QTL 63.10.0067locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16141240937Rat
2303566Bw90Body weight QTL 902body mass (VT:0001259)body weight (CMO:0000012)16141240937Rat
631561Hcuc2Hepatic copper content QTL 22.8hepatic copper amount (VT:0003065)liver total copper weight (CMO:0001507)16141240957Rat
6903319Bw114Body weight QTL 1142.70.0037body mass (VT:0001259)body weight (CMO:0000012)1624459345244593Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)16109005486162972Rat
7411664Foco30Food consumption QTL 30110.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)16134074146340741Rat
2293343Glom16Glomerulus QTL 167.4kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)16155018749247447Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)16155018763210301Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)16155018763210301Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)16155018763210301Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)16155018763210301Rat
1354625Despr7Despair related QTL 73.160.016locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16172829746728297Rat
2301406Kidm39Kidney mass QTL 390.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)16329668817464293Rat
1300133Rf24Renal function QTL 243.64blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)16413635523105837Rat
2306902Bp339Blood pressure QTL 3390.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16413635545905331Rat
737825Alc13Alcohol consumption QTL 134.5consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16501380218360147Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)16501380245905331Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16501380245905331Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)16501380245905331Rat
61338Bp23Blood pressure QTL 234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16501380250013802Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16501380250169318Rat
61405Niddm6Non-insulin dependent diabetes mellitus QTL 63.660.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)16501380252144919Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16501380264012784Rat
61372Bp40Blood pressure QTL 402.2blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)16509870419398181Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 42 57 41 19 41 8 10 74 35 41 11 8
Low 1 1
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000078390   ⟹   ENSRNOP00000070173
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1611,032,531 - 11,106,589 (+)Ensembl
RefSeq Acc Id: XM_006252723   ⟹   XP_006252785
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21610,005,520 - 10,075,270 (+)NCBI
Rnor_6.01611,029,325 - 11,108,867 (+)NCBI
Rnor_5.0169,354,539 - 9,434,346 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006252724   ⟹   XP_006252786
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21610,006,341 - 10,075,270 (+)NCBI
Rnor_6.01611,029,763 - 11,108,867 (+)NCBI
Rnor_5.0169,354,539 - 9,434,346 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006252725   ⟹   XP_006252787
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21610,005,520 - 10,075,270 (+)NCBI
Rnor_6.01611,029,325 - 11,108,867 (+)NCBI
Rnor_5.0169,354,539 - 9,434,346 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006252726   ⟹   XP_006252788
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21610,005,520 - 10,075,270 (+)NCBI
Rnor_6.01611,029,325 - 11,108,867 (+)NCBI
Rnor_5.0169,354,539 - 9,434,346 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017605001   ⟹   XP_017460490
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Celera165,142,468 - 5,211,200 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_006252785 (Get FASTA)   NCBI Sequence Viewer  
  XP_006252786 (Get FASTA)   NCBI Sequence Viewer  
  XP_006252787 (Get FASTA)   NCBI Sequence Viewer  
  XP_006252788 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_006252785   ⟸   XM_006252723
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006252788   ⟸   XM_006252726
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_006252787   ⟸   XM_006252725
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006252786   ⟸   XM_006252724
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017460490   ⟸   XM_017605001
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: ENSRNOP00000070173   ⟸   ENSRNOT00000078390
Protein Domains
WAPL

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1590924 AgrOrtholog
Ensembl Genes ENSRNOG00000052513 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000070173 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000078390 UniProtKB/TrEMBL
Gene3D-CATH 1.25.10.10 UniProtKB/TrEMBL
InterPro ARM-like UniProtKB/TrEMBL
  ARM-type_fold UniProtKB/TrEMBL
  WAPL UniProtKB/TrEMBL
  WAPL_metazoan_plants UniProtKB/TrEMBL
  WAPL_prot UniProtKB/TrEMBL
KEGG Report rno:290577 UniProtKB/TrEMBL
NCBI Gene 290577 ENTREZGENE
PANTHER PTHR22100 UniProtKB/TrEMBL
Pfam WAPL UniProtKB/TrEMBL
PhenoGen Wapl PhenoGen
PROSITE WAPL UniProtKB/TrEMBL
Superfamily-SCOP ARM-type_fold UniProtKB/TrEMBL
UniProt D4ADT3_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-08-13 Wapl  WAPL cohesin release factor  Wapal  wings apart-like homolog (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-09-17 Wapal  wings apart-like homolog (Drosophila)  LOC290577  hypothetical LOC290577  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-06-15 LOC290577  hypothetical LOC290577  RGD1308960  similar to parallel sister chromatids protein (84.3 kD) (4F208)   Data Merged 1643240 APPROVED
2008-04-30 RGD1308960  similar to parallel sister chromatids protein (84.3 kD) (4F208)   RGD1308960_predicted  similar to parallel sister chromatids protein (84.3 kD) (4F208) (predicted)  'predicted' is removed 2292626 APPROVED
2006-11-20 LOC290577  hypothetical LOC290577      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-01-20 RGD1308960_predicted  similar to parallel sister chromatids protein (84.3 kD) (4F208) (predicted)  LOC290578_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC290578_predicted  similar to parallel sister chromatids protein (84.3 kD) (4F208) (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL