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Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Wapl | Rat | (1->4)-beta-D-glucan | multiple interactions | ISO | Wapl (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of WAPL mRNA | CTD | PMID:36331819 | Wapl | Rat | 1,2-dimethylhydrazine | multiple interactions | ISO | Wapl (Mus musculus) | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in increased expression of WAPL mRNA | CTD | PMID:22206623 | Wapl | Rat | 1,2-dimethylhydrazine | decreases expression | ISO | Wapl (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in decreased expression of WAPAL mRNA | CTD | PMID:22206623 | Wapl | Rat | 17beta-estradiol | increases expression | EXP | | 6480464 | Estradiol results in increased expression of WAPL protein | CTD | PMID:32145629 | Wapl | Rat | 2,2',4,4'-Tetrabromodiphenyl ether | decreases expression | ISO | WAPL (Homo sapiens) | 6480464 | 2 more ... | CTD | PMID:31675489 | Wapl | Rat | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | Wapl (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of WAPL mRNA | CTD | PMID:15620708 | Wapl | Rat | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of WAPL mRNA | CTD | PMID:34747641 | Wapl | Rat | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Wapl (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of WAPL mRNA | CTD | PMID:26377647 | Wapl | Rat | 2,4,6-tribromophenol | decreases expression | ISO | WAPL (Homo sapiens) | 6480464 | 2 more ... | CTD | PMID:31675489 | Wapl | Rat | 2-hydroxypropanoic acid | decreases expression | ISO | WAPL (Homo sapiens) | 6480464 | Lactic Acid results in decreased expression of WAPL mRNA | CTD | PMID:30851411 | Wapl | Rat | 3,3',5,5'-tetrabromobisphenol A | decreases expression | ISO | WAPL (Homo sapiens) | 6480464 | tetrabromobisphenol A results in decreased expression of WAPL protein | CTD | PMID:31675489 | Wapl | Rat | aflatoxin B1 | increases expression | ISO | Wapl (Mus musculus) | 6480464 | Aflatoxin B1 results in increased expression of WAPL mRNA | CTD | PMID:19770486 | Wapl | Rat | aflatoxin B1 | decreases methylation | ISO | WAPL (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased methylation of WAPL gene | CTD | PMID:27153756 | Wapl | Rat | alpha-naphthoflavone | multiple interactions | ISO | WAPL (Homo sapiens) | 6480464 | alpha-naphthoflavone promotes the reaction [3-methylcholanthrylene results in increased expression of WAPL mRNA] | CTD | PMID:15797623 | Wapl | Rat | aristolochic acid A | decreases expression | ISO | WAPL (Homo sapiens) | 6480464 | aristolochic acid I results in decreased expression of WAPL mRNA | CTD | PMID:33212167 | Wapl | Rat | arsenite(3-) | multiple interactions | ISO | WAPL (Homo sapiens) | 6480464 | arsenite inhibits the reaction [G3BP1 protein binds to WAPL mRNA] | CTD | PMID:32406909 | Wapl | Rat | arsenous acid | increases expression | ISO | WAPL (Homo sapiens) | 6480464 | Arsenic Trioxide results in increased expression of WAPL mRNA | CTD | PMID:20458559 | Wapl | Rat | atrazine | increases expression | ISO | WAPL (Homo sapiens) | 6480464 | Atrazine results in increased expression of WAPL mRNA | CTD | PMID:22378314 | Wapl | Rat | benzo[a]pyrene diol epoxide I | increases expression | ISO | WAPL (Homo sapiens) | 6480464 | 7 more ... | CTD | PMID:26238291 | Wapl | Rat | benzo[a]pyrene diol epoxide I | decreases expression | ISO | WAPL (Homo sapiens) | 6480464 | 7 more ... | CTD | PMID:19150397 | Wapl | Rat | bis(2-ethylhexyl) phthalate | decreases expression | ISO | Wapl (Mus musculus) | 6480464 | Diethylhexyl Phthalate results in decreased expression of WAPL mRNA | CTD | PMID:33754040 | Wapl | Rat | bisphenol A | affects expression | EXP | | 6480464 | bisphenol A affects the expression of WAPL mRNA and bisphenol A affects the expression of WAPL protein | CTD | PMID:30816183 and PMID:32145629 | Wapl | Rat | bisphenol A | decreases expression | ISO | WAPL (Homo sapiens) | 6480464 | bisphenol A results in decreased expression of WAPL protein | CTD | PMID:31675489 | Wapl | Rat | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of WAPAL mRNA | CTD | PMID:32145629 | Wapl | Rat | bisphenol F | increases expression | ISO | Wapl (Mus musculus) | 6480464 | bisphenol F results in increased expression of WAPL mRNA | CTD | PMID:38685157 | Wapl | Rat | cadmium atom | decreases expression | ISO | WAPL (Homo sapiens) | 6480464 | Cadmium results in decreased expression of WAPL mRNA | CTD | PMID:23369406 | Wapl | Rat | caffeine | increases phosphorylation | ISO | WAPL (Homo sapiens) | 6480464 | Caffeine results in increased phosphorylation of WAPL protein | CTD | PMID:35688186 | Wapl | Rat | carbon nanotube | increases expression | ISO | Wapl (Mus musculus) | 6480464 | Nanotubes more ... | CTD | PMID:25554681 | Wapl | Rat | CGP 52608 | multiple interactions | ISO | WAPL (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to WAPAL gene] | CTD | PMID:28238834 | Wapl | Rat | cisplatin | multiple interactions | ISO | WAPL (Homo sapiens) | 6480464 | [Cisplatin co-treated with jinfukang] results in decreased expression of WAPL mRNA | CTD | PMID:27392435 | Wapl | Rat | cobalt dichloride | increases expression | EXP | | 6480464 | cobaltous chloride results in increased expression of WAPL mRNA | CTD | PMID:24386269 | Wapl | Rat | cobalt dichloride | increases expression | ISO | WAPL (Homo sapiens) | 6480464 | cobaltous chloride results in increased expression of WAPL mRNA | CTD | PMID:19376846 | Wapl | Rat | coumarin | decreases phosphorylation | ISO | WAPL (Homo sapiens) | 6480464 | coumarin results in decreased phosphorylation of WAPL protein | CTD | PMID:35688186 | Wapl | Rat | cyclosporin A | increases expression | ISO | WAPL (Homo sapiens) | 6480464 | Cyclosporine results in increased expression of WAPL mRNA | CTD | PMID:20106945 | Wapl | Rat | decabromodiphenyl ether | decreases expression | ISO | WAPL (Homo sapiens) | 6480464 | decabromobiphenyl ether results in decreased expression of WAPL protein | CTD | PMID:31675489 | Wapl | Rat | diarsenic trioxide | increases expression | ISO | WAPL (Homo sapiens) | 6480464 | Arsenic Trioxide results in increased expression of WAPL mRNA | CTD | PMID:20458559 | Wapl | Rat | dimethyl sulfoxide | increases expression | ISO | WAPL (Homo sapiens) | 6480464 | Dimethyl Sulfoxide results in increased expression of WAPL mRNA | CTD | PMID:15797623 | Wapl | Rat | enzyme inhibitor | multiple interactions | ISO | WAPL (Homo sapiens) | 6480464 | [Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of WAPL protein | CTD | PMID:23301498 | Wapl | Rat | ethanol | affects splicing | ISO | Wapl (Mus musculus) | 6480464 | Ethanol affects the splicing of WAPL mRNA | CTD | PMID:30319688 | Wapl | Rat | fenthion | increases expression | ISO | Wapl (Mus musculus) | 6480464 | Fenthion results in increased expression of WAPL mRNA | CTD | PMID:34813904 | Wapl | Rat | flutamide | increases expression | EXP | | 6480464 | Flutamide results in increased expression of WAPL mRNA | CTD | PMID:24136188 | Wapl | Rat | folic acid | multiple interactions | ISO | Wapl (Mus musculus) | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in increased expression of WAPL mRNA | CTD | PMID:22206623 | Wapl | Rat | folic acid | decreases expression | ISO | Wapl (Mus musculus) | 6480464 | Folic Acid results in decreased expression of WAPAL mRNA | CTD | PMID:25629700 | Wapl | Rat | formaldehyde | decreases expression | ISO | WAPL (Homo sapiens) | 6480464 | Formaldehyde results in decreased expression of WAPL mRNA | CTD | PMID:20655997 and PMID:23649840 | Wapl | Rat | FR900359 | affects phosphorylation | ISO | WAPL (Homo sapiens) | 6480464 | FR900359 affects the phosphorylation of WAPL protein | CTD | PMID:37730182 | Wapl | Rat | indometacin | decreases expression | ISO | WAPL (Homo sapiens) | 6480464 | Indomethacin results in decreased expression of WAPL mRNA | CTD | PMID:16984733 | Wapl | Rat | irinotecan | decreases expression | ISO | WAPL (Homo sapiens) | 6480464 | Irinotecan analog results in decreased expression of WAPL mRNA | CTD | PMID:18927307 | Wapl | Rat | ivermectin | decreases expression | ISO | WAPL (Homo sapiens) | 6480464 | Ivermectin results in decreased expression of WAPL protein | CTD | PMID:32959892 | Wapl | Rat | lead(0) | affects expression | ISO | WAPL (Homo sapiens) | 6480464 | Lead affects the expression of WAPL mRNA | CTD | PMID:28903495 | Wapl | Rat | leflunomide | increases expression | EXP | | 6480464 | leflunomide results in increased expression of WAPL mRNA | CTD | PMID:24136188 | Wapl | Rat | methidathion | increases expression | ISO | Wapl (Mus musculus) | 6480464 | methidathion results in increased expression of WAPL mRNA | CTD | PMID:34813904 | Wapl | Rat | methotrexate | increases expression | ISO | WAPL (Homo sapiens) | 6480464 | Methotrexate results in increased expression of WAPL mRNA | CTD | PMID:24449571 | Wapl | Rat | nefazodone | increases expression | EXP | | 6480464 | nefazodone results in increased expression of WAPL mRNA | CTD | PMID:24136188 | Wapl | Rat | oxaliplatin | multiple interactions | EXP | | 6480464 | [oxaliplatin co-treated with Topotecan] results in decreased expression of WAPL mRNA | CTD | PMID:25729387 | Wapl | Rat | paracetamol | decreases expression | ISO | WAPL (Homo sapiens) | 6480464 | Acetaminophen results in decreased expression of WAPL mRNA | CTD | PMID:21420995 | Wapl | Rat | perfluorohexanesulfonic acid | decreases expression | ISO | Wapl (Mus musculus) | 6480464 | perfluorohexanesulfonic acid results in decreased expression of WAPL mRNA | CTD | PMID:37995155 | Wapl | Rat | perfluorooctane-1-sulfonic acid | multiple interactions | ISO | Wapl (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of WAPL mRNA | CTD | PMID:36331819 | Wapl | Rat | quercetin | decreases phosphorylation | ISO | WAPL (Homo sapiens) | 6480464 | Quercetin results in decreased phosphorylation of WAPL protein | CTD | PMID:35688186 | Wapl | Rat | rac-lactic acid | decreases expression | ISO | WAPL (Homo sapiens) | 6480464 | Lactic Acid results in decreased expression of WAPL mRNA | CTD | PMID:30851411 | Wapl | Rat | sodium arsenite | affects methylation | ISO | WAPL (Homo sapiens) | 6480464 | sodium arsenite affects the methylation of WAPL gene | CTD | PMID:28589171 | Wapl | Rat | sodium arsenite | increases expression | ISO | WAPL (Homo sapiens) | 6480464 | sodium arsenite results in increased expression of WAPL mRNA | CTD | PMID:38568856 | Wapl | Rat | thimerosal | decreases expression | ISO | WAPL (Homo sapiens) | 6480464 | Thimerosal results in decreased expression of WAPL mRNA | CTD | PMID:27188386 | Wapl | Rat | titanium dioxide | decreases methylation | ISO | Wapl (Mus musculus) | 6480464 | titanium dioxide results in decreased methylation of WAPAL gene and titanium dioxide results in decreased methylation of WAPAL promoter | CTD | PMID:35295148 | Wapl | Rat | topotecan | decreases expression | EXP | | 6480464 | Topotecan results in decreased expression of WAPL mRNA | CTD | PMID:25729387 | Wapl | Rat | topotecan | multiple interactions | EXP | | 6480464 | [oxaliplatin co-treated with Topotecan] results in decreased expression of WAPL mRNA | CTD | PMID:25729387 | Wapl | Rat | trimellitic anhydride | increases expression | ISO | Wapl (Mus musculus) | 6480464 | trimellitic anhydride results in increased expression of WAPL mRNA | CTD | PMID:19042947 | Wapl | Rat | triptonide | increases expression | ISO | Wapl (Mus musculus) | 6480464 | triptonide results in increased expression of WAPL mRNA | CTD | PMID:33045310 | Wapl | Rat | valproic acid | affects expression | ISO | WAPL (Homo sapiens) | 6480464 | Valproic Acid affects the expression of WAPL mRNA | CTD | PMID:25979313 | Wapl | Rat | vitamin E | decreases expression | ISO | WAPL (Homo sapiens) | 6480464 | Vitamin E results in decreased expression of WAPL mRNA | CTD | PMID:19244175 | Wapl | Rat | zinc atom | multiple interactions | ISO | WAPL (Homo sapiens) | 6480464 | [PCI 5002 co-treated with Zinc] results in increased expression of WAPL mRNA | CTD | PMID:18593933 | Wapl | Rat | zinc(0) | multiple interactions | ISO | WAPL (Homo sapiens) | 6480464 | [PCI 5002 co-treated with Zinc] results in increased expression of WAPL mRNA | CTD | PMID:18593933 | |