Ccr4 (C-C motif chemokine receptor 4) - Rat Genome Database

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Gene: Ccr4 (C-C motif chemokine receptor 4) Rattus norvegicus
Analyze
Symbol: Ccr4
Name: C-C motif chemokine receptor 4
RGD ID: 620594
Description: Predicted to enable C-C chemokine binding activity and C-C chemokine receptor activity. Involved in several processes, including positive regulation of positive chemotaxis; response to antibiotic; and response to bacterium. Located in neuronal cell body. Biomarker of asthma and pulmonary fibrosis. Orthologous to human CCR4 (C-C motif chemokine receptor 4); PARTICIPATES IN chemokine mediated signaling pathway; cytokine mediated signaling pathway; INTERACTS WITH ammonium chloride; atrazine; cadmium dichloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: C-C chemokine receptor 4; C-C chemokine receptor type 4; chemokine (C-C motif) receptor 4; chemokine (C-C) receptor 4; Cmkbr4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Ccr4m1Mcwi  
Genetic Models: FHH-Ccr4m1Mcwi
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.28114,176,256 - 114,182,155 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8114,176,974 - 114,178,056 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8119,794,265 - 119,795,347 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.08117,993,504 - 117,994,586 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.08115,836,327 - 115,837,409 (-)NCBIRnor_WKY
Rnor_6.08122,530,152 - 122,535,959 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8122,530,624 - 122,532,070 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08121,843,005 - 121,848,545 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48118,883,148 - 118,884,230 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18118,902,602 - 118,903,685 (-)NCBI
Celera8113,423,300 - 113,424,382 (-)NCBICelera
Cytogenetic Map8q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. A key role for CC chemokine receptor 4 in lipopolysaccharide-induced endotoxic shock. Chvatchko Y, etal., J Exp Med 2000 May 15;191(10):1755-64.
2. Expression of MDC/CCL22 and its receptor CCR4 in rheumatoid arthritis, psoriatic arthritis and osteoarthritis. Flytlie HA, etal., Cytokine. 2010 Jan;49(1):24-9. doi: 10.1016/j.cyto.2009.10.005. Epub 2009 Nov 25.
3. Mononuclear cell-infiltrate inhibition by blocking macrophage-derived chemokine results in attenuation of developing crescentic glomerulonephritis. Garcia GE, etal., Am J Pathol. 2003 Apr;162(4):1061-73.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Caffeic acid phenethyl ester modifies the Th1/Th2 balance in ileal mucosa after gamma-irradiation in the rat by modulating the cytokine pattern. Gremy O, etal., World J Gastroenterol. 2006 Aug 21;12(31):4996-5004.
6. Acute and persisting Th2-like immune response after fractionated colorectal gamma-irradiation. Gremy O, etal., World J Gastroenterol. 2008 Dec 14;14(46):7075-85.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. Chemokines and glycoprotein120 produce pain hypersensitivity by directly exciting primary nociceptive neurons. Oh SB, etal., J Neurosci. 2001 Jul 15;21(14):5027-35.
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. GOA pipeline RGD automated data pipeline
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Comprehensive gene review and curation RGD comprehensive gene curation
14. Elevated expression of TARC (CCL17) and MDC (CCL22) in models of cigarette smoke-induced pulmonary inflammation. Ritter M, etal., Biochem Biophys Res Commun. 2005 Aug 19;334(1):254-62.
15. Expression of CXCR4 and CXCL12 (SDF-1) in human prostate cancers (PCa) in vivo. Sun YX, etal., J Cell Biochem. 2003 Jun 1;89(3):462-73.
16. Th1- and Th2-related chemokine and chemokine receptor expression on the ocular surface in endotoxin-induced uveitis. Trinh L, etal., Mol Vis. 2008;14:2428-34. Epub 2008 Dec 19.
17. Effect of the resection of the sciatic nerve on the Th1/Th2 balance in the synovia of the ankle joint of adjuvant arthritic rats. Wu Z, etal., Histochem Cell Biol. 2004 Feb;121(2):141-7. Epub 2004 Jan 15.
18. Negative immune factors might predominate local tumor immune status and promote carcinogenesis in cervical carcinoma. Zhao M, etal., Virol J. 2017 Jan 13;14(1):5. doi: 10.1186/s12985-016-0670-8.
19. Synthesis of some CC chemokines and their receptors in the synovium in rheumatoid arthritis. Zhebrun DA, etal., Bull Exp Biol Med. 2014 Dec;158(2):192-6. doi: 10.1007/s10517-014-2720-9. Epub 2014 Nov 29.
Additional References at PubMed
PMID:15809349   PMID:16262623   PMID:19008373   PMID:22664869   PMID:24069263  


Genomics

Comparative Map Data
Ccr4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.28114,176,256 - 114,182,155 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8114,176,974 - 114,178,056 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8119,794,265 - 119,795,347 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.08117,993,504 - 117,994,586 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.08115,836,327 - 115,837,409 (-)NCBIRnor_WKY
Rnor_6.08122,530,152 - 122,535,959 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8122,530,624 - 122,532,070 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08121,843,005 - 121,848,545 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48118,883,148 - 118,884,230 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18118,902,602 - 118,903,685 (-)NCBI
Celera8113,423,300 - 113,424,382 (-)NCBICelera
Cytogenetic Map8q32NCBI
CCR4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38332,951,644 - 32,956,349 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl332,951,644 - 32,956,349 (+)EnsemblGRCh38hg38GRCh38
GRCh37332,993,136 - 32,997,841 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36332,968,070 - 32,971,407 (+)NCBINCBI36Build 36hg18NCBI36
Build 34332,968,069 - 32,971,407NCBI
Celera332,935,667 - 32,939,047 (+)NCBICelera
Cytogenetic Map3p22.3NCBI
HuRef332,932,639 - 32,935,976 (+)NCBIHuRef
CHM1_1332,943,070 - 32,946,407 (+)NCBICHM1_1
T2T-CHM13v2.0332,953,438 - 32,958,143 (+)NCBIT2T-CHM13v2.0
Ccr4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399114,319,384 - 114,334,544 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9114,319,384 - 114,333,984 (-)EnsemblGRCm39 Ensembl
GRCm389114,490,316 - 114,505,476 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9114,490,316 - 114,504,916 (-)EnsemblGRCm38mm10GRCm38
MGSCv379114,399,434 - 114,405,662 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369114,340,320 - 114,345,244 (-)NCBIMGSCv36mm8
Celera9114,964,557 - 114,970,802 (-)NCBICelera
Cytogenetic Map9F3NCBI
cM Map964.49NCBI
Ccr4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955421205,297 - 210,944 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955421205,297 - 210,944 (+)NCBIChiLan1.0ChiLan1.0
CCR4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1333,186,607 - 33,189,969 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl333,188,482 - 33,189,564 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0332,882,419 - 32,887,442 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
CCR4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1233,844,072 - 3,847,770 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl233,844,173 - 3,845,255 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha233,888,073 - 3,889,155 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0234,104,026 - 4,108,984 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl234,104,026 - 4,108,978 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1233,939,579 - 3,940,661 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0234,070,639 - 4,071,721 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0234,040,101 - 4,041,183 (-)NCBIUU_Cfam_GSD_1.0
Ccr4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118190,182,355 - 190,183,764 (+)NCBIHiC_Itri_2
SpeTri2.0NW_00493647323,321,167 - 23,323,075 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CCR4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1318,860,730 - 18,865,983 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11318,860,596 - 18,865,987 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
CCR4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11577,435,195 - 77,439,164 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1577,437,265 - 77,438,347 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604150,813,078 - 50,816,866 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ccr4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478810,966,207 - 10,971,180 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478810,965,226 - 10,974,215 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ccr4
33 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:33
Count of miRNA genes:32
Interacting mature miRNAs:32
Transcripts:ENSRNOT00000013705
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)846531639119088624Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)846531639119088624Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)846531639119088624Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)846531639119088624Rat
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)861290298119084929Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)870513503118219066Rat
8694446Bw170Body weight QTL 17012.070.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)871888757116888757Rat
9590292Uminl3Urine mineral level QTL 33.620.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)871888757116888757Rat
8694200Abfw4Abdominal fat weight QTL 49.070.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)871888757116888757Rat
8694392Bw161Body weight QTL 1618.060.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)871888757116888757Rat
1549909Stresp11Stress response QTL 116.830.0019stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)873473045118473045Rat
2300181Bmd55Bone mineral density QTL 555.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)876468691121468691Rat
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)882460758122812818Rat
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)893535351123900184Rat
1358893Bp263Blood pressure QTL 2635.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
1358903Bp252Blood pressure QTL 25270.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
738014Anxrr15Anxiety related response QTL 153.60.005locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)895718998123900184Rat
2300182Bmd56Bone mineral density QTL 565.4femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)895718998123900184Rat
724539Cm19Cardiac mass QTL 192.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)8100149864120994388Rat
1599689Iddm24Insulin dependent diabetes mellitus QTL 244.720.001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)8112834440118649220Rat


Genetic Models
This gene Ccr4 is modified in the following models/strains

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system nervous system renal system reproductive system respiratory system
High
Medium 2 2
Low 2 6 14 2 7 6
Below cutoff 1 3 22 18 3 18 10 9 14 5

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000013705   ⟹   ENSRNOP00000013705
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8114,176,974 - 114,178,056 (-)Ensembl
Rnor_6.0 Ensembl8122,530,624 - 122,532,070 (-)Ensembl
RefSeq Acc Id: NM_133532   ⟹   NP_598216
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.28114,176,974 - 114,178,056 (-)NCBI
Rnor_6.08122,530,806 - 122,531,888 (-)NCBI
Rnor_5.08121,843,005 - 121,848,545 (-)NCBI
RGSC_v3.48118,883,148 - 118,884,230 (-)RGD
Celera8113,423,300 - 113,424,382 (-)RGD
Sequence:
RefSeq Acc Id: XM_006243915   ⟹   XP_006243977
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.28114,176,256 - 114,182,155 (-)NCBI
Rnor_6.08122,530,152 - 122,535,959 (-)NCBI
Rnor_5.08121,843,005 - 121,848,545 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_598216 (Get FASTA)   NCBI Sequence Viewer  
  XP_006243977 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAL30398 (Get FASTA)   NCBI Sequence Viewer  
  AAL30399 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_598216   ⟸   NM_133532
- UniProtKB: G3V7C3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006243977   ⟸   XM_006243915
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000013705   ⟸   ENSRNOT00000013705
Protein Domains
G_PROTEIN_RECEP_F1_2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-G3V7C3-F1-model_v2 AlphaFold G3V7C3 1-360 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620594 AgrOrtholog
BioCyc Gene G2FUF-28924 BioCyc
Ensembl Genes ENSRNOG00000010315 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000013705 ENTREZGENE
  ENSRNOP00000013705.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000013705 ENTREZGENE
  ENSRNOT00000013705.4 UniProtKB/TrEMBL
InterPro 7TM_GPCR_Rhodpsn UniProtKB/TrEMBL
  Chemokine_CCR4 UniProtKB/TrEMBL
  Chemokine_rcpt UniProtKB/TrEMBL
  GPCR_Rhodpsn_supfam UniProtKB/TrEMBL
KEGG Report rno:171054 UniProtKB/TrEMBL
NCBI Gene 171054 ENTREZGENE
PANTHER PTHR10489:SF608 UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/TrEMBL
PhenoGen Ccr4 PhenoGen
PRINTS CCCHEMOKINER UniProtKB/TrEMBL
  CHEMOKINER4 UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
SMART 7TM_GPCR_Srsx UniProtKB/TrEMBL
UniProt G3V7C3 ENTREZGENE, UniProtKB/TrEMBL
  Q91ZH4_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-22 Ccr4  C-C motif chemokine receptor 4  Ccr4  chemokine (C-C motif) receptor 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Ccr4  chemokine (C-C motif) receptor 4    chemokine (C-C) receptor 4  Name updated 1299863 APPROVED
2004-09-10 Ccr4  chemokine (C-C) receptor 4  Cmkbr4    Symbol and Name updated 1299863 APPROVED
2002-08-07 Cmkbr4  chemokine (C-C) receptor 4      Symbol and Name status set to provisional 70820 PROVISIONAL