Ccr4 (C-C motif chemokine receptor 4) - Rat Genome Database

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Gene: Ccr4 (C-C motif chemokine receptor 4) Mus musculus
Analyze
Symbol: Ccr4
Name: C-C motif chemokine receptor 4
RGD ID: 1552492
MGI Page MGI
Description: Enables C-C chemokine receptor activity. Acts upstream of or within several processes, including homeostasis of number of cells; interneuron migration; and tolerance induction. Located in external side of plasma membrane. Is expressed in several structures, including central nervous system; gut; limb; liver and biliary system; and reproductive system. Orthologous to human CCR4 (C-C motif chemokine receptor 4).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: C-C chemokine receptor type 4; C-C CKR-4; CC CKR-4; CC-CKR-4; CCR-4; chemokine (C-C motif) receptor 4; chemokine (C-C) receptor 4; CHEMR1; Cmkbr; Cmkbr4; fusin; LESTR; leukocyte-expressed seven-transmembrane-domain receptor; MGC151418; Sdf1r
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399114,319,384 - 114,334,544 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9114,319,384 - 114,333,984 (-)EnsemblGRCm39 Ensembl
GRCm389114,490,316 - 114,505,476 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9114,490,316 - 114,504,916 (-)EnsemblGRCm38mm10GRCm38
MGSCv379114,399,434 - 114,405,662 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369114,340,320 - 114,345,244 (-)NCBIMGSCv36mm8
Celera9114,964,557 - 114,970,802 (-)NCBICelera
Cytogenetic Map9F3NCBI
cM Map964.49NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (EXP)
1-chloro-2,4-dinitrobenzene  (EXP)
1-nitropyrene  (ISO)
17alpha-ethynylestradiol  (EXP)
2,3',4,4',5-Pentachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
3,3'-diindolylmethane  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
5-aza-2'-deoxycytidine  (ISO)
aflatoxin B1  (EXP)
alpha-amanitin  (EXP)
alpha-hexylcinnamaldehyde  (EXP)
alpha-Zearalanol  (ISO)
ammonium chloride  (ISO)
Aroclor 1254  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
asbestos  (ISO)
asperentin  (EXP)
atrazine  (ISO)
benzalkonium chloride  (EXP)
benzo[a]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bisphenol A  (ISO)
Brevianamide A  (EXP)
cadmium dichloride  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
capsaicin  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
cis-caffeic acid  (EXP)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
dextran sulfate  (EXP)
fingolimod hydrochloride  (ISO)
flavonoids  (ISO)
fumonisin B1  (ISO)
glyphosate  (ISO)
kojic acid  (ISO)
lead diacetate  (EXP)
lipopolysaccharide  (ISO)
mevalonic acid  (ISO)
mycotoxin  (EXP)
N-nitrosodiethylamine  (ISO)
naproxen  (ISO)
nickel atom  (EXP)
nonanoic acid  (EXP)
ozone  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (EXP)
phthalaldehyde  (EXP)
pirinixic acid  (EXP)
Ptaquiloside  (EXP)
resveratrol  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
simvastatin  (ISO)
sodium arsenite  (EXP)
sterigmatocystin  (EXP)
sulforaphane  (ISO)
sumatriptan  (ISO)
titanium dioxide  (EXP)
TMC-120A  (EXP)
trans-caffeic acid  (EXP)
trimellitic anhydride  (EXP)
triptonide  (EXP)
zearalenone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. A key role for CC chemokine receptor 4 in lipopolysaccharide-induced endotoxic shock. Chvatchko Y, etal., J Exp Med 2000 May 15;191(10):1755-64.
2. Expression of MDC/CCL22 and its receptor CCR4 in rheumatoid arthritis, psoriatic arthritis and osteoarthritis. Flytlie HA, etal., Cytokine. 2010 Jan;49(1):24-9. doi: 10.1016/j.cyto.2009.10.005. Epub 2009 Nov 25.
3. Mononuclear cell-infiltrate inhibition by blocking macrophage-derived chemokine results in attenuation of developing crescentic glomerulonephritis. Garcia GE, etal., Am J Pathol. 2003 Apr;162(4):1061-73.
4. Molecular cloning of murine CC CKR-4 and high affinity binding of chemokines to murine and human CC CKR-4. Hoogewerf A, etal., Biochem Biophys Res Commun 1996 Jan 5;218(1):337-43.
5. MGDs mouse GO annotations MGD data from the GO Consortium
6. MGD IEA MGD IEA
7. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
8. Mouse MP Annotation Import Pipeline RGD automated import pipeline
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Elevated expression of TARC (CCL17) and MDC (CCL22) in models of cigarette smoke-induced pulmonary inflammation. Ritter M, etal., Biochem Biophys Res Commun. 2005 Aug 19;334(1):254-62.
11. Expression of CXCR4 and CXCL12 (SDF-1) in human prostate cancers (PCa) in vivo. Sun YX, etal., J Cell Biochem. 2003 Jun 1;89(3):462-73.
12. Negative immune factors might predominate local tumor immune status and promote carcinogenesis in cervical carcinoma. Zhao M, etal., Virol J. 2017 Jan 13;14(1):5. doi: 10.1186/s12985-016-0670-8.
13. Synthesis of some CC chemokines and their receptors in the synovium in rheumatoid arthritis. Zhebrun DA, etal., Bull Exp Biol Med. 2014 Dec;158(2):192-6. doi: 10.1007/s10517-014-2720-9. Epub 2014 Nov 29.
Additional References at PubMed
PMID:8955194   PMID:8962122   PMID:9103415   PMID:9192769   PMID:9261443   PMID:10349636   PMID:10475688   PMID:10479460   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11465103  
PMID:11724798   PMID:12154006   PMID:12464673   PMID:12477932   PMID:12555662   PMID:15593118   PMID:15608062   PMID:15795234   PMID:15809349   PMID:16129397   PMID:16141072   PMID:16141073  
PMID:16239514   PMID:16262623   PMID:16602821   PMID:16951380   PMID:17114422   PMID:17339428   PMID:17548518   PMID:17548521   PMID:17878364   PMID:17949991   PMID:18052724   PMID:18287559  
PMID:18403600   PMID:18621704   PMID:18624303   PMID:18765730   PMID:18768889   PMID:19008373   PMID:19062085   PMID:19303390   PMID:19386638   PMID:19843945   PMID:20190758   PMID:20368416  
PMID:20421491   PMID:20548030   PMID:20631725   PMID:21177120   PMID:21206747   PMID:21224060   PMID:21267068   PMID:21345872   PMID:21435448   PMID:21537081   PMID:21575994   PMID:21633167  
PMID:21641376   PMID:21873635   PMID:21945175   PMID:22355103   PMID:23390295   PMID:23477966   PMID:23960189   PMID:24069263   PMID:24200330   PMID:24238232   PMID:24333113   PMID:24339934  
PMID:24583145   PMID:24700244   PMID:24990081   PMID:25245466   PMID:25264308   PMID:26070483   PMID:26197455   PMID:26417005   PMID:27022143   PMID:27132989   PMID:27469058   PMID:27530322  
PMID:27760760   PMID:28134623   PMID:29361236   PMID:29469612   PMID:29510192   PMID:30037996   PMID:30183073   PMID:30337650   PMID:30584243   PMID:30982091   PMID:31085832   PMID:31537642  
PMID:31611578   PMID:32052476   PMID:32439173   PMID:32461237   PMID:32592824   PMID:32783091   PMID:33243932   PMID:33597749   PMID:33662381   PMID:34210974   PMID:35046040   PMID:35997787  
PMID:36494354   PMID:37266571   PMID:37279584   PMID:38348028   PMID:38702399   PMID:38924414  


Genomics

Comparative Map Data
Ccr4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399114,319,384 - 114,334,544 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9114,319,384 - 114,333,984 (-)EnsemblGRCm39 Ensembl
GRCm389114,490,316 - 114,505,476 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9114,490,316 - 114,504,916 (-)EnsemblGRCm38mm10GRCm38
MGSCv379114,399,434 - 114,405,662 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369114,340,320 - 114,345,244 (-)NCBIMGSCv36mm8
Celera9114,964,557 - 114,970,802 (-)NCBICelera
Cytogenetic Map9F3NCBI
cM Map964.49NCBI
CCR4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38332,951,644 - 32,956,349 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl332,951,644 - 32,957,120 (+)EnsemblGRCh38hg38GRCh38
GRCh37332,993,136 - 32,997,841 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36332,968,070 - 32,971,407 (+)NCBINCBI36Build 36hg18NCBI36
Build 34332,968,069 - 32,971,407NCBI
Celera332,935,667 - 32,939,047 (+)NCBICelera
Cytogenetic Map3p22.3NCBI
HuRef332,932,639 - 32,935,976 (+)NCBIHuRef
CHM1_1332,943,070 - 32,946,407 (+)NCBICHM1_1
T2T-CHM13v2.0332,953,438 - 32,958,143 (+)NCBIT2T-CHM13v2.0
Ccr4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88123,054,505 - 123,060,244 (-)NCBIGRCr8
mRatBN7.28114,176,291 - 114,182,033 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8114,176,974 - 114,178,056 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8119,794,265 - 119,795,347 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08117,993,504 - 117,994,586 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08115,836,327 - 115,837,409 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08122,530,152 - 122,535,959 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8122,530,624 - 122,532,070 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08121,843,005 - 121,848,545 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48118,883,148 - 118,884,230 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18118,902,602 - 118,903,685 (-)NCBI
Celera8113,423,300 - 113,424,382 (-)NCBICelera
Cytogenetic Map8q32NCBI
Ccr4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955421205,297 - 210,944 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955421205,297 - 210,944 (+)NCBIChiLan1.0ChiLan1.0
CCR4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2232,932,455 - 32,940,505 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1332,937,251 - 32,945,223 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0332,882,419 - 32,887,442 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1333,186,607 - 33,189,969 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl333,188,482 - 33,189,564 (+)Ensemblpanpan1.1panPan2
CCR4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1233,844,072 - 3,847,770 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl233,844,173 - 3,845,255 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha233,888,073 - 3,889,155 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0234,104,026 - 4,108,984 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl234,104,026 - 4,108,978 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1233,939,579 - 3,940,661 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0234,070,639 - 4,071,721 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0234,040,101 - 4,041,183 (-)NCBIUU_Cfam_GSD_1.0
Ccr4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118190,182,355 - 190,183,764 (+)NCBIHiC_Itri_2
SpeTri2.0NW_00493647323,321,167 - 23,323,075 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CCR4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1318,860,730 - 18,865,983 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11318,860,596 - 18,865,987 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
CCR4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11577,435,195 - 77,439,164 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1577,437,265 - 77,438,347 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604150,813,078 - 50,816,866 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ccr4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478810,966,207 - 10,971,180 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478810,965,226 - 10,974,215 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ccr4
343 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:360
Count of miRNA genes:274
Interacting mature miRNAs:302
Transcripts:ENSMUST00000054414
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357461Idd2_minsulin dependent diabetes susceptibility 2 (mouse)Not determined982792386116792481Mouse
18182932Metl3_mmetabolite locus 3, N-acetylglutamate (mouse)989440541123440541Mouse
1301649Psl1_mpromotion susceptibility QTL 1 (mouse)Not determined989289476123289595Mouse
1302103Dob2_mdietary obesity 2 (mouse)Not determined986121898120118690Mouse
1357648Obq18_mobesity QTL 18 (mouse)Not determined9101829255124359700Mouse
12904961Gmmq7_mgastrocnemius muscle mass QTL 7 (mouse)991560372124359700Mouse
1300884Sluc11_msusceptibility to lung cancer 11 (mouse)Not determined982792386116792481Mouse
10412242Alpq8_malcohol preference QTL 8 (mouse)Not determined989162124123162124Mouse
1357657Pymr_mPlasmodium yoelli malaria resistance (mouse)Not determined989859058118767089Mouse
1301789Pbwg4_mpostnatal body weight growth 4 (mouse)Not determined9103118511124359700Mouse
14746992Manh67_mmandible shape 67 (mouse)993865836124359700Mouse
10766454Char10_mP. chabaudi malaria resistance QTL 10 (mouse)982792386116792481Mouse
4141545Tailaq2_mtail length adjusted QTL 2 (mouse)Not determined63239711120191934Mouse
1300549Bbaa17_mB. burgdorferi-associated arthritis 17 (mouse)Not determined986107600120107729Mouse
1357635Splq4_mspleen weight QTL 4 (mouse)Not determined963239711120191934Mouse
10412290Pvacm1l_mplasma vascular cell adhesion molecule 1 levels (mouse)Not determined9103118511124359700Mouse
12879896Berr3_mberghei resistance locus 3 (mouse)9103118511124359700Mouse
12880422V25Dq6_mvitamin D inactive form serum level QTL 6 (mouse)987677199121677199Mouse
1302001Bdln5_mbody length 5 (mouse)Not determined993591658124359700Mouse
1301297Lcho1_mliver cholesterol 1 (mouse)Not determined9100889929124359700Mouse
11537364Cnes5_mC. neoformans susceptibility locus 5 (mouse)996746658124359700Mouse
12904937Edlmmq9_mextensor digitorum longus muscle mass QTL 9 (mouse)991560372124359700Mouse
11251716Siim2_mstress induced immobility 2 (mouse)986625682120625682Mouse
1357627Tgq2_mtriglyceride QTL 2 (mouse)Not determined9101829255124359700Mouse
12910773Splic3_mspleen iron content 3 (mouse)991291078124359700Mouse
12910772Lvic6_mliver iron content 6 (mouse)991291078124359700Mouse
13463480Mchcq2_mmean corpuscular hemoglobin concentration QTL 2 (mouse)991518283124359700Mouse
4141833W10q13_mweight 10 weeks QTL 13 (mouse)Not determined63239711120191934Mouse
1301732Char1_mP. chabaudi malaria resistance QTL 1 (mouse)Not determined981680321115680445Mouse
12910770Splic1_mspleen iron content 1 (mouse)991291078124359700Mouse
12904947Tammq7_mtibialis anterior muscle mass QTL 7 (mouse)991560372124359700Mouse
1558767Skmw11_mskeletal muscle weight 11 (mouse)Not determined991518283124359700Mouse
13463477Rbc9_mred blood cell count 9 (mouse)991518283124359700Mouse
13463478Mchq18_mmean corpuscular hemoglobin QTL 18 (mouse)991518283124359700Mouse
1301487Nociq1_mnociceptive sensitivity inflammatory QTL 1 (mouse)Not determined984406017118406120Mouse
13515058Adip20d_madiposity 20d (mouse)9108744078118744078Mouse
13463475Hctq7_mhematocrit QTL 7 (mouse)991518283124359700Mouse
13463474Hbbcq5_mhemoglobin concentration QTL 5 (mouse)991518283124359700Mouse
1301484Bwq6_mbody weight (mouse)Not determined993591658124359700Mouse

Markers in Region
Cmkbr4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm389114,491,786 - 114,491,859UniSTSGRCm38
MGSCv379114,400,904 - 114,400,977UniSTSGRCm37
Celera9114,966,024 - 114,966,097UniSTS
Cytogenetic Map9F3UniSTS
cM Map961.0UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000054414   ⟹   ENSMUSP00000062677
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl9114,319,384 - 114,325,630 (-)Ensembl
GRCm38.p6 Ensembl9114,490,316 - 114,496,562 (-)Ensembl
Ensembl Acc Id: ENSMUST00000215425   ⟹   ENSMUSP00000150002
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl9114,320,847 - 114,325,106 (-)Ensembl
GRCm38.p6 Ensembl9114,491,779 - 114,496,038 (-)Ensembl
Ensembl Acc Id: ENSMUST00000215959   ⟹   ENSMUSP00000150441
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl9114,321,968 - 114,333,984 (-)Ensembl
GRCm38.p6 Ensembl9114,492,900 - 114,504,916 (-)Ensembl
RefSeq Acc Id: NM_009916   ⟹   NP_034046
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399114,319,384 - 114,325,612 (-)NCBI
GRCm389114,490,316 - 114,496,544 (-)NCBI
MGSCv379114,399,434 - 114,405,662 (-)RGD
Celera9114,964,557 - 114,970,802 (-)RGD
cM Map9 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006511932   ⟹   XP_006511995
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399114,320,690 - 114,334,544 (-)NCBI
GRCm389114,491,622 - 114,505,476 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006511933   ⟹   XP_006511996
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399114,320,690 - 114,325,250 (-)NCBI
GRCm389114,491,622 - 114,496,182 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006511934   ⟹   XP_006511997
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399114,320,690 - 114,334,544 (-)NCBI
GRCm389114,491,622 - 114,505,476 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011242933   ⟹   XP_011241235
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399114,320,690 - 114,329,880 (-)NCBI
GRCm389114,491,622 - 114,500,812 (-)NCBI
Sequence:
RefSeq Acc Id: NP_034046   ⟸   NM_009916
- UniProtKB: Q14A03 (UniProtKB/Swiss-Prot),   P51680 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006511995   ⟸   XM_006511932
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006511997   ⟸   XM_006511934
- Peptide Label: isoform X2
- UniProtKB: Q14A03 (UniProtKB/Swiss-Prot),   P51680 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006511996   ⟸   XM_006511933
- Peptide Label: isoform X2
- UniProtKB: Q14A03 (UniProtKB/Swiss-Prot),   P51680 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011241235   ⟸   XM_011242933
- Peptide Label: isoform X2
- UniProtKB: Q14A03 (UniProtKB/Swiss-Prot),   P51680 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000062677   ⟸   ENSMUST00000054414
Ensembl Acc Id: ENSMUSP00000150441   ⟸   ENSMUST00000215959
Ensembl Acc Id: ENSMUSP00000150002   ⟸   ENSMUST00000215425

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P51680-F1-model_v2 AlphaFold P51680 1-360 view protein structure

Promoters
RGD ID:8671112
Promoter ID:EPDNEW_M13586
Type:initiation region
Name:Ccr4_1
Description:Mus musculus chemokine (C-C motif) receptor 4 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm389114,496,544 - 114,496,604EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:107824 AgrOrtholog
Ensembl Genes ENSMUSG00000047898 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000054414 ENTREZGENE
  ENSMUST00000054414.5 UniProtKB/Swiss-Prot
  ENSMUST00000215425 ENTREZGENE
  ENSMUST00000215425.2 UniProtKB/Swiss-Prot
  ENSMUST00000215959.2 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot
InterPro Chemokine_CCR4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Chemokine_rcpt UniProtKB/Swiss-Prot
  GPCR1 UniProtKB/Swiss-Prot
  GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
KEGG Report mmu:12773 UniProtKB/Swiss-Prot
MGD MGI:107824 ENTREZGENE
NCBI Gene 12773 ENTREZGENE
PANTHER CELL ADHESION MOLECULE UniProtKB/Swiss-Prot
  PTHR10489:SF608 UniProtKB/Swiss-Prot
Pfam 7tm_1 UniProtKB/Swiss-Prot
PhenoGen Ccr4 PhenoGen
PRINTS CCCHEMOKINER UniProtKB/Swiss-Prot
  CHEMOKINER4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot
UniProt A0A1L1STS0_MOUSE UniProtKB/TrEMBL
  CCR4_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q14A03 ENTREZGENE
UniProt Secondary Q14A03 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-07-04 Ccr4  C-C motif chemokine receptor 4  Ccr4  chemokine (C-C motif) receptor 4  Symbol and/or name change 5135510 APPROVED