Gamt (guanidinoacetate N-methyltransferase) - Rat Genome Database

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Gene: Gamt (guanidinoacetate N-methyltransferase) Rattus norvegicus
Analyze
Symbol: Gamt
Name: guanidinoacetate N-methyltransferase
RGD ID: 2659
Description: Enables guanidinoacetate N-methyltransferase activity and identical protein binding activity. Involved in S-adenosylmethionine metabolic process; carboxylic acid metabolic process; and embryonic liver development. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in amino acid metabolic disorder and guanidinoacetate methyltransferase deficiency. Orthologous to human GAMT (guanidinoacetate N-methyltransferase); PARTICIPATES IN creatine metabolic pathway; homocysteine metabolic pathway; methionine cycle/metabolic pathway; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: GMT; guanidinoacetate methyltransferase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8710,099,267 - 10,102,083 (+)NCBIGRCr8
mRatBN7.279,448,590 - 9,451,413 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl79,448,628 - 9,451,778 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx712,331,403 - 12,334,202 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0714,206,743 - 14,209,542 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0712,068,078 - 12,070,877 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0712,314,848 - 12,317,998 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl712,314,848 - 12,317,998 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0712,484,097 - 12,487,698 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4710,959,990 - 10,962,720 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1710,959,989 - 10,962,720 (+)NCBI
Celera77,625,330 - 7,628,480 (+)NCBICelera
Cytogenetic Map7q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,2-dichloroethane  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-chloropropane-1,2-diol  (EXP,ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (ISO)
amiodarone  (EXP)
amitrole  (EXP)
ammonia  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
benzbromarone  (EXP)
benzo[a]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bromobenzene  (EXP)
butanal  (ISO)
carbon nanotube  (ISO)
carmustine  (ISO)
chlordecone  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
clofibrate  (EXP,ISO)
cobalt dichloride  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
dexamethasone  (EXP)
dibutyl phthalate  (EXP,ISO)
diiodine  (EXP)
diquat  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
epoxiconazole  (ISO)
ethyl methanesulfonate  (ISO)
gentamycin  (EXP)
glycidol  (ISO)
glyphosate  (ISO)
Heliotrine  (ISO)
hydralazine  (ISO)
indometacin  (EXP)
irinotecan  (EXP)
ivermectin  (ISO)
L-ascorbic acid  (ISO)
L-ethionine  (EXP)
lead(0)  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-nitrosodiethylamine  (EXP)
omeprazole  (EXP)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
phenobarbital  (EXP)
phenylephrine  (EXP)
pirinixic acid  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
propanal  (ISO)
rac-lactic acid  (ISO)
SB 431542  (ISO)
Senkirkine  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (ISO)
sodium perchlorate  (EXP)
sulfadimethoxine  (EXP)
tauroursodeoxycholic acid  (EXP)
testosterone  (EXP,ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
thiram  (ISO)
Triptolide  (ISO)
urethane  (ISO)
ursodeoxycholic acid  (EXP)
valproic acid  (EXP,ISO)
vancomycin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA)
nucleus  (IBA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Creatine synthesis and transport during rat embryogenesis: spatiotemporal expression of AGAT, GAMT and CT1. Braissant O, etal., BMC Dev Biol. 2005 May 26;5:9.
2. Homoarginine levels are regulated by L-arginine:glycine amidinotransferase and affect stroke outcome: results from human and murine studies. Choe CU, etal., Circulation. 2013 Sep 24;128(13):1451-61. doi: 10.1161/CIRCULATIONAHA.112.000580. Epub 2013 Sep 4.
3. The Effects of Early-Onset Pre-Eclampsia on Placental Creatine Metabolism in the Third Trimester. Ellery SJ, etal., Int J Mol Sci. 2020 Jan 26;21(3):806. doi: 10.3390/ijms21030806.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
7. Catalytic mechanism of guanidinoacetate methyltransferase: crystal structures of guanidinoacetate methyltransferase ternary complexes. Komoto J, etal., Biochemistry 2004 Nov 16;43(45):14385-94.
8. Crystal structure of guanidinoacetate methyltransferase from rat liver: a model structure of protein arginine methyltransferase. Komoto J, etal., J Mol Biol 2002 Jul 5;320(2):223-35.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. Molecular cloning, sequence analysis, and expression in Escherichia coli of the cDNA for guanidinoacetate methyltransferase from rat liver. Ogawa H, etal., Proc Natl Acad Sci U S A 1988 Feb;85(3):694-8.
12. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
13. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
14. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
15. GOA pipeline RGD automated data pipeline
16. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Comprehensive gene review and curation RGD comprehensive gene curation
19. Guanidinoacetate methyltransferase deficiency: the first inborn error of creatine metabolism in man. Stockler S, etal., Am J Hum Genet. 1996 May;58(5):914-22.
20. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
21. Myocellular creatine and creatine transporter serine phosphorylation after starvation. Zhao CR, etal., J Surg Res 2002 Jun 1;105(1):10-6.
Additional References at PubMed
PMID:1446073   PMID:1990977   PMID:3419933   PMID:8889548   PMID:12925789   PMID:15028668   PMID:23376485   PMID:25896543  


Genomics

Comparative Map Data
Gamt
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8710,099,267 - 10,102,083 (+)NCBIGRCr8
mRatBN7.279,448,590 - 9,451,413 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl79,448,628 - 9,451,778 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx712,331,403 - 12,334,202 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0714,206,743 - 14,209,542 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0712,068,078 - 12,070,877 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0712,314,848 - 12,317,998 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl712,314,848 - 12,317,998 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0712,484,097 - 12,487,698 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4710,959,990 - 10,962,720 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1710,959,989 - 10,962,720 (+)NCBI
Celera77,625,330 - 7,628,480 (+)NCBICelera
Cytogenetic Map7q11NCBI
GAMT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38191,397,026 - 1,401,542 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl191,397,026 - 1,401,570 (-)EnsemblGRCh38hg38GRCh38
GRCh37191,397,025 - 1,401,541 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36191,348,088 - 1,352,552 (-)NCBINCBI36Build 36hg18NCBI36
Build 34191,349,607 - 1,352,552NCBI
Celera191,331,366 - 1,335,830 (-)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef191,171,878 - 1,176,401 (-)NCBIHuRef
CHM1_1191,397,126 - 1,401,670 (-)NCBICHM1_1
T2T-CHM13v2.0191,367,024 - 1,371,540 (-)NCBIT2T-CHM13v2.0
Gamt
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391080,093,985 - 80,096,846 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1080,093,985 - 80,096,846 (-)EnsemblGRCm39 Ensembl
GRCm381080,258,151 - 80,261,025 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1080,258,151 - 80,261,012 (-)EnsemblGRCm38mm10GRCm38
MGSCv371079,720,896 - 79,723,713 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361079,661,328 - 79,664,141 (-)NCBIMGSCv36mm8
Celera1081,273,024 - 81,275,841 (-)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
Gamt
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554956,536,544 - 6,539,424 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554956,536,541 - 6,539,424 (+)NCBIChiLan1.0ChiLan1.0
GAMT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2205,743,093 - 5,749,393 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1194,980,010 - 4,986,337 (-)NCBINHGRI_mPanPan1
PanPan1.1191,371,043 - 1,375,514 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl191,371,312 - 1,375,461 (-)Ensemblpanpan1.1panPan2
GAMT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12057,440,698 - 57,442,588 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2057,231,269 - 57,233,795 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02058,170,588 - 58,173,114 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2058,170,577 - 58,173,106 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12057,226,557 - 57,229,082 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02057,706,242 - 57,708,766 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02057,908,247 - 57,910,773 (+)NCBIUU_Cfam_GSD_1.0
Gamt
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118217,110,293 - 217,113,339 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936588721,313 - 724,524 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936588721,436 - 724,475 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GAMT
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl277,076,566 - 77,079,759 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1277,076,566 - 77,079,751 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2277,968,844 - 77,972,039 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GAMT
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.161,165,016 - 1,178,458 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl61,164,259 - 1,178,354 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660817,693,065 - 7,697,357 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gamt
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248287,294,327 - 7,297,303 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248287,294,380 - 7,297,787 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gamt
4 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:54
Count of miRNA genes:49
Interacting mature miRNAs:52
Transcripts:ENSRNOT00000028969
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7127829089Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7131962314Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7131962314Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134000259Rat
2317047Wbc4White blood cell count QTL 40.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)7135342956Rat
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7144782185Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7144822433Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)766427026029351Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
10755438Coatc9Coat color QTL 90coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7352928048529280Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7532901950329019Rat
10755440Coatc10Coat color QTL 100coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7749649952496499Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7757398552573985Rat

Markers in Region
PMC311070P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.279,450,396 - 9,451,177 (+)MAPPERmRatBN7.2
Rnor_6.0712,316,617 - 12,317,397NCBIRnor6.0
Rnor_5.0712,486,317 - 12,487,097UniSTSRnor5.0
RGSC_v3.4710,961,757 - 10,962,537UniSTSRGSC3.4
Celera77,627,099 - 7,627,879UniSTS
Cytogenetic Map7q11UniSTS
Gamt  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.279,449,970 - 9,450,417 (+)MAPPERmRatBN7.2
Rnor_6.0712,316,191 - 12,316,637NCBIRnor6.0
Rnor_5.0712,485,891 - 12,486,337UniSTSRnor5.0
RGSC_v3.4710,961,331 - 10,961,777UniSTSRGSC3.4
Celera77,626,673 - 7,627,119UniSTS
Cytogenetic Map7q11UniSTS
RH135445  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.279,450,540 - 9,450,764 (+)MAPPERmRatBN7.2
Rnor_6.0712,316,761 - 12,316,984NCBIRnor6.0
Rnor_5.0712,486,461 - 12,486,684UniSTSRnor5.0
RGSC_v3.4710,961,901 - 10,962,124UniSTSRGSC3.4
Celera77,627,243 - 7,627,466UniSTS
RH 3.4 Map725.5UniSTS
Cytogenetic Map7q11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 37 56 41 18 41 8 11 46 35 39 11 8
Low 6 1 1 28 2
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000028969   ⟹   ENSRNOP00000036927
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl79,448,628 - 9,451,778 (+)Ensembl
Rnor_6.0 Ensembl712,314,848 - 12,317,998 (+)Ensembl
RefSeq Acc Id: NM_001402213   ⟹   NP_001389142
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8710,099,284 - 10,102,083 (+)NCBI
mRatBN7.279,448,614 - 9,451,413 (+)NCBI
RefSeq Acc Id: NM_012793   ⟹   NP_036925
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8710,099,284 - 10,102,083 (+)NCBI
mRatBN7.279,448,614 - 9,451,413 (+)NCBI
Rnor_6.0712,314,848 - 12,317,998 (+)NCBI
Rnor_5.0712,484,097 - 12,487,698 (+)NCBI
RGSC_v3.4710,959,990 - 10,962,720 (+)RGD
Celera77,625,330 - 7,628,480 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039078453   ⟹   XP_038934381
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8710,099,267 - 10,101,490 (+)NCBI
mRatBN7.279,448,590 - 9,450,702 (+)NCBI
RefSeq Acc Id: XM_063263010   ⟹   XP_063119080
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8710,099,273 - 10,101,720 (+)NCBI
RefSeq Acc Id: NP_036925   ⟸   NM_012793
- Peptide Label: isoform 1
- UniProtKB: P10868 (UniProtKB/Swiss-Prot),   G3V960 (UniProtKB/TrEMBL),   A6K8N3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000036927   ⟸   ENSRNOT00000028969
RefSeq Acc Id: XP_038934381   ⟸   XM_039078453
- Peptide Label: isoform X2
RefSeq Acc Id: NP_001389142   ⟸   NM_001402213
- Peptide Label: isoform 2
RefSeq Acc Id: XP_063119080   ⟸   XM_063263010
- Peptide Label: isoform X1
- UniProtKB: P10868 (UniProtKB/Swiss-Prot)
Protein Domains
RMT2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P10868-F1-model_v2 AlphaFold P10868 1-236 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695029
Promoter ID:EPDNEW_R5552
Type:initiation region
Name:Gamt_1
Description:guanidinoacetate N-methyltransferase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0712,314,870 - 12,314,930EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2659 AgrOrtholog
BioCyc Gene G2FUF-34927 BioCyc
BioCyc Pathway GLYCGREAT-PWY [creatine biosynthesis] BioCyc
BioCyc Pathway Image GLYCGREAT-PWY BioCyc
Ensembl Genes ENSRNOG00000024577 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000028969 ENTREZGENE
  ENSRNOT00000028969.5 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.150 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro GuanidinoAc_N-MeTrfase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RMT2_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SAM-dependent_MTases UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25257 UniProtKB/TrEMBL
NCBI Gene 25257 ENTREZGENE
PANTHER GUANIDINOACETATE N-METHYLTRANSFERASE UniProtKB/Swiss-Prot
  GUANIDINOACETATE N-METHYLTRANSFERASE UniProtKB/Swiss-Prot
  GUANIDINOACETATE N-METHYLTRANSFERASE UniProtKB/TrEMBL
  GUANIDINOACETATE N-METHYLTRANSFERASE UniProtKB/TrEMBL
PhenoGen Gamt PhenoGen
PIRSF GAMT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE SAM_RMT2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000024577 RatGTEx
Superfamily-SCOP SSF53335 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC230598
UniProt A6K8N3 ENTREZGENE, UniProtKB/TrEMBL
  A6K8N4_RAT UniProtKB/TrEMBL
  G3V960 ENTREZGENE, UniProtKB/TrEMBL
  GAMT_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-10-17 Gamt  guanidinoacetate N-methyltransferase  Gamt  guanidinoacetate methyltransferase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Gamt  Guanidinoacetate methyltransferase      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression abundant in liver 632754